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Logo of anclinmicBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAnnals of Clinical Microbiology and Antimicrobials
 
Ann Clin Microbiol Antimicrob. 2012; 11: 1.
Published online 2012 January 11. doi:  10.1186/1476-0711-11-1
PMCID: PMC3268740

Enteric alpha defensins in norm and pathology

Abstract

Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.

Keywords: Enteric alpha defensins, Paneth cells, innate immunity, IBD, colon cancer

Articles from Annals of Clinical Microbiology and Antimicrobials are provided here courtesy of BioMed Central