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Logo of anclinmicBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAnnals of Clinical Microbiology and Antimicrobials
 
Ann Clin Microbiol Antimicrob. 2012; 11: 1.
Published online Jan 11, 2012. doi:  10.1186/1476-0711-11-1
PMCID: PMC3268740
Enteric alpha defensins in norm and pathology
Nikolai A Lisitsyn,corresponding author1 Yulia A Bukurova,1 Inna G Nikitina,1 George S Krasnov,1 Yuri Sykulev,2 and Sergey F Beresten1
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation
2Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
corresponding authorCorresponding author.
Nikolai A Lisitsyn: niklisitsyn/at/yahoo.com; Yulia A Bukurova: nelson-cat/at/yandex.ru; Inna G Nikitina: nikitinainna87/at/yandex.ru; George S Krasnov: gskrasnov/at/gmail.com; Yuri Sykulev: ysykulev/at/KimmelCancerCenter.org; Sergey F Beresten: sberesten/at/gmail.com
Received September 13, 2011; Accepted January 11, 2012.
Abstract
Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.
Keywords: Enteric alpha defensins, Paneth cells, innate immunity, IBD, colon cancer
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