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Bispecific adapter targeting principle and composition. (a) Principle of targeting viruses towards tumor cells using bispecific adapters. (b) Typical examples of virus-binding moieties (left) and cell-binding moieties (right) of bispecific adapters. In theory, all combinations of virus-binding and cell-binding arms are possible. An overview of the composition of the bispecific adapters used to target particular viruses to tumor cells is provided in Table 1.