We sought to prospectively duplicate our retrospective findings showing prestorage leukoreduction (PS-LR) blunts the detrimental effect of aging on banked packed red blood cells (PRBCs) transfused after injury.
Over 19 months, trauma patients transfused > 4 units PRBCs and surviving at least 24 hours were followed. The age of each unit was collected.
The cohort consisted of 153 patients. All models showed no association between advancing blood age and the likelihood of developing multiorgan dysfunction syndrome (MODS) or infections regardless of whether mean age of blood was analyzed as a continuous variable, as a percentage of blood received which was <14 days old, or as a dichotomized value above or below 14 days old.
This prospective study duplicates our retrospective findings of an abrogation of the detrimental effects of advancing mean PRBC age on outcomes after trauma by performing PS-LR.
WORDS FOR INDEXING: Trauma, leukoreduction, outcomes, transfusion