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Front Neurol. 2011; 2: 77.
Published online 2011 December 20. doi:  10.3389/fneur.2011.00077
PMCID: PMC3243025

New Standards for Intracranial Atherosclerotic Disease Treatment

The stenting versus aggressive medical therapy for intracranial artery stenosis (SAMMPRIS) trial compared aggressive medical therapy to aggressive medical therapy and percutaneous angioplasty and stenting (PTAS) in patients with symptomatic intracranial atherosclerotic disease (ICAD; Chimowitz et al., 2011). The trial was halted when a higher 30-day rate of stroke and death was present in the PTAS compared to the aggressive medical therapy group (14.7 vs. 5.8%, p = 0.002).

SAMMPRIS highlights the evolving definition and improving efficacy of aggressive medical therapy including aspirin and clopidogrel, statin, and antihypertensive treatments. SAMMPRIS sets the new standard for periprocedural stroke and death rates which neurointerventionalists and devices must achieve to demonstrate superiority of PTAS to aggressive medical therapy. The data from SAMMPRIS may allow a better understanding of underlying mechanism for adverse events such as intracranial hemorrhages related to PTAS and result in new strategies for preventing such events.

The results should not undermine the high risk of recurrent stroke in patients with symptomatic ICAD despite aggressive medical treatment. Several subgroups of ICAD patients at high risk of ischemic events have been identified such as those with high grade stenosis, posterior circulation involvement, precipitation of ischemic symptoms by systemic blood pressure changes, and recurrent ischemic events (Thijs and Albers, 2000). Until the next stent emerges, intracranial angioplasty (Marks et al., 2005; Nguyen et al., 2011) may be an alternative for this subgroup and should be evaluated against aggressive medical therapy in a randomized trial.


  • Chimowitz M. I., Lynn M. J., Derdeyn C. P., Turan T. N., Fiorella D., Lane B. F., Janis S., Lutsep H. L., Barnwell S. L., Waters M. F., Hoh B. L., Hourihane J. M., Levy E. I., Alexandrov A. V., Harrigan M. R., Chiu D., Klucznik R. P., Clark J. M., McDougall C. G., Johnson M. D., Pride L., Torbey M. T., Zaidat O. O., Rumboldt Z., Cloft H. J., SAMMPRIS Trial Investigators (2011). Stenting versus aggressive medical therapy for intracranial artery stenosis. N. Engl. J. Med. 365, 993–100310.1056/NEJMoa1105335 [PubMed] [Cross Ref]
  • Marks M. P., Marcellus M. L., Do H. M., Schraedley-Desmond P. K., Steinberg G. K., Tong D. C., Albers G. W. (2005). Intracranial angioplasty without stenting for symptomatic atherosclerotic stenosis: long-term follow-up. Am. J. Neuroradiol. 26, 525–530 [PubMed]
  • Nguyen T., Zaidat O. O., Gupta R., Nogueira R. G., Tariq N., Kalia J. S., Norbash A. M., Qureshi A. I. (2011). Balloon angioplasty for intracranial atherosclerotic disease. Stroke 42, 107–11110.1161/STROKEAHA.110.583245 [PubMed] [Cross Ref]
  • Thijs V. N., Albers G. W. (2000). Symptomatic intracranial atherosclerosis: outcome of patients who fail antithrombotic therapy. Neurology 55, 490–498 [PubMed]

Articles from Frontiers in Neurology are provided here courtesy of Frontiers Media SA