Among all enrolled consecutive patients between January and November 2009, there were 111 with GERD and 44 normal cases. Patients’ characteristics and endoscopic reflux esophagitis severity are shown in Table . Among the patients with GERD, there were 78 patients (70.3%) in the younger group and 33 cases (29.7%) in the elderly group. A similar duration of symptoms was noted between the younger cases (mean 2.82 years) and the elderly cases (mean 2.50 years). Comparing the gender of each group, there were significantly more female patients (60.3%) in the younger group, and more male patients (72.7%) in the elderly group. The elderly patients had greater endoscopic disease severity than the younger patients, based on the Los Angeles classification.
Characteristics and endoscopic symptoms in younger and elderly cases with gastroesophageal reflux disease
The presentation of the younger and elderly patients with GERD in our study are summarized in Table , which show the results of the GERD impact scale. As shown in Table , the young cases had a higher prevalence of typical symptoms than the elderly patients, including burning (48.7% vs 15.2%, P = 0.005), pain in chest (64.3% vs 33.3%, P = 0.001), regurgitation of food (79.5% vs 54.6%, P = 0.058), hoarseness (73.1% vs 39.4%, P = 0.010) and chronic conditions related to heartburn (44.8% vs 33.3%, P = 0.708).
Symptom presentation measured by gastroesophageal reflux disease impact scale in younger and elderly patients
The quality of life results in the two groups measured by the GERD impact scale are shown in Table , and the SF-36 questionnaire results are shown in Table and Figure . As shown in Table , significantly impaired activities of daily living, including sleep disturbance (52.6% vs 18.2%, P = 0.004), feeding and drinking problems (64.1% vs 12.1%, P = 0.001), and impact on social activites (43.6% vs 15.2%, P = 0.005), were noted in the younger patients.
Quality of life measured by quality of life of gastroesophageal reflux disease impact scale in younger and elderly cases
Scores of SF36 questionnaire in younger and elderly cases with gastroesophageal reflux disease
Figure 1 Scores of SF36 questionnaire among the control cases, and younger and elderly cases with gastroesophageal reflux disease. T: Total SF36 scores; P: Total physical health scores; M: Total metal health scores; RP: Role-physical; RF: Physical functioning; (more ...)
As shown in Figure , comparing the quality of life between cases with and without GERD, patients with GERD had lower scores in all items of the SF-36 questionnaire, except physical functioning. With regard to age, as shown in Table , younger patients had higher scores than elderly patients in the items of physical functioning (mean 90.26 vs 86.39, P = 0.342), role-physical limitations (mean 72.76 vs 71.21, P = 0.853), and total physcial health status (mean 64.54 vs 60.03, P = 0.240). In contrast, younger patients had lower scores than elderly patients for the following items: bodily pain (mean 62.70 vs 69.18, P = 0.089), general perception of health (mean 46.47 vs 58.09, P = 0.005), vitality (mean 51.22 vs 61.36, P = 0.013), social functioning (mean 72.18 vs 76.76, P = 0.263), emotional limitations (mean 66.24 vs 76.82, P = 0.203), mental health status (mean 54.77 vs 66.18, P = 0.001), total mental health status (mean 58.15 vs 67.76, P = 0.011), and total health status (mean 64.58 vs 70.73, P = 0.106).