The title compound, C29H37NO2, crystallized with two independent molecules in an asymmetric unit in which the conformation of the cyclohexyl ring of the pregnene moiety bonded to the 3α-(1,3-dioxoisoindolin-2-yl)- ring system differs: in one molecule it is in a chair conformation, while in the other it exhibits a half-chair conformation. The other six-membered rings in the pregnene moiety are in chair conformations and the five-membered rings are in envelope forms in both molecules. In both molecules, the 3α-(1,3-dioxoisoindolin-2-yl)- ring systems are individually approximately planar, with r.m.s. devtaions 0.0148 and 0.0264 Å. The structure is consolidated by intermolecular C—HO hydrogen-bonding interactions involving the carbonyl O atoms and methyl, methylene and methylidyne groups, resulting in a two-dimensional structure.