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Logo of jbcThe Journal of Biological Chemistry
 
J Biol Chem. 2011 October 14; 286(41): 36162.
PMCID: PMC3195634

Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

VOLUME 279 (2004) PAGES 20941–20949

PAGE 20944:

FIGURE 3.
PKC inhibition attenuates store-operated currents. Shown are continuous current recordings at the holding potential (–50 mV). A, IP3-induced current in non-transfected control cells, which was blocked by 1 mm La3+. G, La3+ (1 mm) sensitivity of ...

PAGE 20945:

FIGURE 4.
Effect of anti-TRPC1 antibody on store-operated currents. Shown are continuous recordings of La3+-sensitive inward current at the holding potential (–50 mV). A, current recorded on intracellular application of IP3 from cells pretreated with control ...

PAGE 20948:

FIGURE 7.
Effect of inhibition of PKC on thrombin-induced decrease in transendothelial monolayer electrical resistance in cells overexpressing TRPC1. A, HMECs were transfected either with control vector or with TRPC1 cDNA (TRPC1 OE). Transfected cells were grown ...

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