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One day cuff implantation. Rats (n = 6) were implanted with a cuff on day 0, and the cuff was removed on day 1. Paw withdrawal thresholds were measured using von Frey filament stimulation. There was a significant decrease in withdrawal thresholds on days 5 and 8 compared to pre-induction baseline values (^P < 0.01 compared to days–2 or –1). All subsequent values were not significantly different from pre-induction baselines.
Note: Values are shown as means ± standard error of the mean of the ipsilateral paw.