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Fig. 6.

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Genes activated by HIRA are enriched in histone H3.3. (A) Heat map showing H3.3 enrichment on genes ordered by fold change after HIRA or CABIN1 knockdown versus siNTG and mean fold change of the two independent knockdowns versus siNTG. On the y axis, genes are rank ordered by fold change; on the x axis, positions along the gene are shown in 1-kb windows from 5 kb upstream of the gene to the transcription start site (TSS) and 1-kb windows from the transcription end site (TES) to 5 kb downstream of the gene. Within the gene bodies, windows of 5% of the length of the gene were used. (B) Average histone H3.3 enrichment over three classes of genes, defined according to their response to HIRA knockdown. x axis, position along the gene in 1-kb windows from 5 kb upstream of the gene to the transcription start site (TSS) and 1-kb windows from the TES to 5 kb downstream of the gene. Within the gene bodies, windows of 5% of the length of the gene were used. (C) Average histone H3.3 enrichment over three classes of genes, defined according to their response to CABIN1 knockdown. Results are color coded as in panel B. (D) Average histone H3.3 enrichment over three classes of genes, defined according to their averaged response to HIRA and CABIN1 knockdown. Results are color coded as in panel B.

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