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Logo of bmcpsycBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Psychiatry
BMC Psychiatry. 2011; 11: 151.
Published online Sep 21, 2011. doi:  10.1186/1471-244X-11-151
PMCID: PMC3184265
No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data
Carlos Tovilla-Zárate,corresponding author1 Isela Juárez-Rojop,2 Teresa Ramón-Frias,1 Mario Villar-Soto ,3 Sherezada Pool-García,4 Beatriz Camarena Medellín,5 Alma D Genis Mendoza,6 Lilia López Narvaez,7 and Nicolini Humberto6
1Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, México
2Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, México
3Hospital de Alta Especialidad "Gustavo A. Rovirosa P, Villahermosa, Tabasco, México
4Hospital General de Comalcalco Tabasco. Secretaría de Salud, Comalcalco, Tabasco, México
5Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", México D. F., México
6Servicios de Atención Psiquiátrica, Secretaria de Salud. México D. F., México
7Hospital General de Yajalón, Yajalón, Chiapas, México
corresponding authorCorresponding author.
Carlos Tovilla-Zárate: alfonso_tovillaz/at/; Isela Juárez-Rojop: iselajua22/at/; Teresa Ramón-Frias: teresarf/at/; Mario Villar-Soto : mariovillarsoto/at/; Sherezada Pool-García: shepoga70/at/; Beatriz Camarena Medellín: camare/at/; Alma D Genis Mendoza: genis76/at/; Lilia López Narvaez: dramarilit/at/; Nicolini Humberto: Nicolini_humbeto/at/
Received May 3, 2011; Accepted September 21, 2011.
The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.
We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases.
No significant differences were found in the distribution of alleles (χ2 = 0.33, 1 df, p = 0.56) or genotypes (χ2 = 2.36, 2 df, p = 0.26). The meta-analysis comprising 12 association studies (including the present one) showed that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-1.23), even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23).
Our results showed no association between COMTval158/met and suicidal behavior. However, more studies are necessary to determine conclusively an association between COMT and suicidal behavior.
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