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Comorbid depression is common among adults with painful osteoarthritis (OA). We evaluated the relationship between depressed mood and receipt of mental health (MH) care services.
In a cohort with OA, annual interviews assessed comorbidity, arthritis severity, and MH (SF-36 mental health score). Surveys were linked to administrative health databases to identify mental health-related visits to physicians in the two years following the baseline interview (1996-98). Prescriptions for anti-depressants were ascertained for participants aged 65+ years (eligible for drug benefits). The relationship between MH scores and MH-related physician visits was assessed using zero-inflated negative binomial regression, adjusting for confounders. For those aged 65+ years, logistic regression examined the probability of receiving any MH-related care (physician visit or anti-depressant prescription).
Analyses were based on 2,005 (90.1%) individuals (mean age 70.8 years). Of 576 (28.7%) with probable depression (MH score < 60/100), 42.5% experienced one or more MH-related physician visits during follow-up. The likelihood of a physician visit was associated with sex (adjusted OR women vs. men = 5.87, p = 0.005) and MH score (adjusted OR per 10-point decrease in MH score = 1.63, p = 0.003). Among those aged 65+, 56.7% with probable depression received any MH care. The likelihood of receiving any MH care exhibited a significant interaction between MH score and self-reported health status (p = 0.0009); with good general health, worsening MH was associated with increased likelihood of MH care; as general health declined, this effect was attenuated.
Among older adults with painful OA, more than one-quarter had depressed mood, but almost half received no mental health care, suggesting a care gap.
Osteoarthritis (OA) is a common, disabling, and costly disease[1-3]. Treatment has focused on ameliorating pain and reducing accompanying functional limitations. Less attention has been given to the downstream effects of pain and disability on mood - yet population and clinical studies consistently suggest that OA pain and disability are found together with depression more frequently than would be expected by chance[6-9]. Prospectively, we have shown that painful OA leads to depressed mood through the mediating effects of pain on fatigue and disability. For those with painful OA, concomitant depression is associated with greater pain and disability, worse outcomes following knee replacement surgery, and greater health care use. In other chronic pain conditions, comorbid depression has been linked to reduced adherence to pain interventions and when used, reduced effectiveness of these therapies. Thus, recognition and treatment of comorbid depression has the potential to improve outcomes for people with chronic painful OA . Yet, mental health (MH) conditions are under-recognized and consequently, under-treated in older adults, the same population disproportionately affected by OA[17-19].
Despite the documented link between pain and depressed mood, few studies have examined the diagnosis and treatment of depressed mood in the setting of painful OA. The primary objective of this study was to evaluate, in a Canadian cohort with chronic symptomatic hip and knee OA, the relationship between depressed mood and mental health-related physician visits and anti-depressant prescription. A priori, we were interested in the proportion of participants who met criteria for probable depression who received any mental health-related care. We hypothesized that the prevalence of depressed mood would be high, but that the associated frequency of mental health-related physician visits would suggest under-recognition of concomitant depression.
Participants were members of a longitudinal cohort of individuals with moderate-to-severe hip or knee OA. Details of cohort recruitment have been published previously. Briefly, participants were recruited between 1996 and 1998 through a screening survey of 100% of the population 55+ years residing in two regions of Ontario, Canada, one rural and one urban. Individuals were selected for cohort inclusion if they: i) reported difficulty in the last three months with each of the following: stair climbing, rising from a chair, standing and walking; ii) swelling, pain or stiffness in any joint lasting at least six weeks; and iii) indicated on a diagram that a hip or knee had been 'troublesome'. Based on these criteria, a cohort of 2,411 individuals with arthritis was established. In a subsequent validation study, following re-administration of the screening questions, trained physiotherapists conducted a standardized examination of the hips and knees in 475 survey respondents (375 with and 100 without hip/knee complaints). Of the 372 validation study participants who met our screening criteria for hip/knee arthritis, 96% had clinical signs of hip and/or knee arthritis on examination.
Participation rates for the initial baseline surveys were 80.6% and 75.4% for the rural and urban regions, respectively. Follow-up, conducted annually by standardized telephone interviews, obtained information on sociodemographics (age, sex, race, level of education, annual household income, living circumstances), body mass index and severity of hip/knee symptoms and disability using the Western Ontario McMaster Universities OA Index (WOMAC) pain and function subscale and summary scores, for which higher scores indicate worse symptoms or disability. The SF-36, a self-administered multidimensional questionnaire, was used to assess health-related quality of life. Participants indicated if they had seen a physician or taken any medication in the past year for each of 13 health problems. Prior treatment for depression or another mental health condition was also assessed. Ethical approval was obtained from Women's College Hospital Research Ethics Board and informed consent was acquired from all participants.
Mental health was assessed at baseline and then annually over the two-year study period using the mental health subscale of the SF-36 (MH score); higher scores indicate better mental health. Friedman et al.  have shown that MH scores < 60/100 are associated with clinical depression, as defined using the Mini-International Neuropsychiatric Interview-Major Depressive Episode module (MINI-MDE) (sensitivity = 78.7%, specificity = 72.1%). At one time-point during follow-up, data were obtained from cohort participants for both the MH score and the Center for Epidemiologic Studies Depression Scale (CES-D). The CES-D is a valid and reliable measure of depressed mood; higher scores indicate more depressed mood. The Spearman correlation between SF-36 MH and CES-D scores was -0.77, p < 0.0001; further, a CES-D score ≥16, considered indicative of possible depression, corresponded to an SF-36 MH score ≤68. For the present study, a conservative cut-point score of 60 on the MH scale was used to categorize cohort participants as having depressed (scores < 60/100) or non-depressed mood (scores ≥60/100). Those meeting criteria for depressed mood were considered to have probable depression.
Participants' survey data were linked to provincial administrative databases using unique anonymous patient identifiers. In Ontario, visits to physicians are funded by the single-payer Ontario Health Insurance Plan (OHIP); further, the primary care physician (PCP) acts as the gatekeeper to specialized health care services, such that visits to mental health specialists are only accessible via referral from the PCP. For all cohort participants, we ascertained physician services (PCPs, and psychiatrists) using claims recorded in the OHIP Physician and Laboratory Billing Records. Each claim includes a patient identifier, date of visit, service code, diagnostic code, and the specialty of the physician providing the service. We identified all office visits made by cohort members to a PCP or psychiatrist within two years of the baseline cohort interview. Mental health-related visits to a PCP were identified using a validated algorithm based on the service and diagnosis codes found in the claims record. The positive predictive value for identifying a mental health related primary care visit using this algorithm is 84.9%; sensitivity and specificity are 80.7% and 97.0%, respectively. Mental health-related visits to a psychiatrist were those claims submitted by a psychiatrist for a core mental health service.
In addition, for cohort members aged 65+ years at baseline, and thus covered by the Ontario Drug Benefit (ODB) Program, we ascertained use of prescription anti-depressants. A comprehensive list of all prescription medications used to treat depression was compiled with input from a clinical pharmacologist and psychiatrist (Additional File 1: Appendix 1). The ODB database was searched to identify prescriptions for anti-depressant medications in the two-year period following the baseline assessment. Whenever possible, prescriptions were linked to a physician database to determine the prescriber's specialty.
WOMAC and SF-36 scores were rescaled to a 0-100 scale. Individuals with probable depression (MH subscale score < 60) were compared to those without depression using chi-square tests (categorical characteristics), Wilcoxon rank sum tests (ordinal/skewed variables), and t-tests (normally distributed variables). The proportion with probable depression that experienced one or more mental-health related PCP visit was calculated with 95% confidence intervals.
For the full cohort, we examined the relationship between MH scores and mental health-related visits to a PCP or specialist using zero-inflated negative binomial (ZINB) regression to adjust for both over dispersion and the "excess" zeros in the data. The ZINB model simultaneously models the contribution of the independent variables on: (1) the probability of having any mental health visits at all; and (2) the number of visits, given that the person has at least one visit. For those aged 65+ years at baseline, logistic regression was used to examine the probability that an individual received any mental health-related care (one or more mental-health related visits to a PCP or psychiatrist, or filling one or more prescriptions for an anti-depressant therapy).
Each model adjusted for other variables that have been shown to be related to health care use[13,29]: female sex, older age, urban versus rural region of residence, a greater number of comorbidities and worse general health status (SF-36 general health subscale score), lower income and education, residing in long term care, and greater OA severity. Education and income were included in the regression models as categorical variables. For each of these variables, people with missing information were retained in the analyses by including a separate 'missing' category. Adjusted models included interactions between the MH subscale score and other covariates, allowing the effect of mood to vary by subgroup. Analyses were conducted using SAS Version 9.2 (SAS Institute, Cary, North Carolina). A two-tailed level of significance of 0.05 was used.
Participants with inflammatory arthritis (n = 186), missing MH scores (n = 63), or who died within the two years following the baseline interview (n = 159) were excluded; analyses are based on 2,005 (90.1%) cohort participants with OA. Participant characteristics are shown in Table Table1:1: mean age was 70.7 years, and most were female (73.2%) and Caucasian (93.0%), with low income (52.4% reported an annual income ≤ $20,000) and low education (83.2% reported ≤ high school education). WOMAC pain, disability and summary scores indicated moderate-to-severe OA pain and disability. One-fifth (19.2%) reported 3 or more comorbid conditions.
Participants' mean MH score was 68.5 (SD 20.4); 576 (28.7%) had a score < 60, indicating probable depression. Among all participants, 329 (16.4%) self-reported 'ever' having been diagnosed or treated for depression or another major mental health condition, while 9.2% reported receiving treatment in the past year. Those classified as having probable depression were younger, more likely to reside in the urban region, reported lower income and less education, and had worse OA pain and disability and a greater number of comorbidities (all p < 0.05). Among the 576 participants with 'probable depression', 226 (39.2%) reported 'ever' having been diagnosed or treated for a mental health problem (24.1% in the past year) compared with 7.2% (3.2%), respectively, among those without probable depression (both p < 0.0001; see Table Table11).
Most study participants (95.2%) experienced one or more PCP visit over the two-year study period; in total, cohort members experienced 34,000 PCP visits. Over one-quarter (28.9%) experienced one or more mental health-related PCP visit (Table (Table2).2). Fewer participants (5.3%) experienced one or more visit to a psychiatrist (n = 106). Among those with probable depression, 39.1% experienced a mental health-related PCP visit and 10.1% saw a psychiatrist. Overall, 618 participants (30.8%) experienced one or more mental health related physician visit (PCP or psychiatrist) in the two-year period (42.5% of those with depressed mood). In those who experienced a mental-health related physician visit, only 19 (5.1%) of the 373 with depressed mood saw only a psychiatrist.
Of the 2005 study participants, 1425 (71.1%) were aged 65+ years at baseline and thus eligible for drug benefits coverage; of these, 376 (26.4%) met the criteria for probable depression. Mental-health related physician visits and prescriptions for anti-depressants are shown in Table Table2.2. Overall, 329 participants (23.1%) filled one or more prescriptions for an anti-depressant; in total, 2540 prescriptions were filled. Specialty was missing for 14.7% of these prescriptions; where not missing, 86.4% of the prescriptions were written by a PCP, 8.2% by a psychiatrist, and 2.8% by a geriatrician or general internist. Individuals with probable depression were more likely to fill a prescription (36.2% versus 18.4%, p < 0.0001). Among those 65 years and older at baseline, 579/1,425 (40.6%) received any mental health care (saw a PCP or psychiatrist and/or filled a prescription for an anti-depressant); 56.7% with probable depression received care.
Unadjusted for other factors, a 10-point worsening of the MH score was associated with increased odds of having one or more mental health-related physician visit (odds ratio, OR, 2.14, p = 0.03) (Table (Table3).3). In the adjusted model, the likelihood of experiencing one or more mental health-related physician visit was significantly and independently associated with female sex (adjusted OR women vs. men = 5.87, p = 0.005) and MH score (adjusted OR per 10-point decrease in MH score = 1.63, p = 0.003). Among those who experienced at least one mental health visit, significant, independent predictors of the number of mental health visits were MH score, region of residence, and level of education. Every 10-point deterioration in MH score was associated with a 22.4% increase in the number of mental-health visits (p < 0.0001). The number of mental health-related visits was 106% higher among urban than rural residents (p < 0.0001), and 58.0% higher among those with some post-secondary education than among those who had not completed high school.
Unadjusted for other factors, among those 65 years or older at baseline, a 10-point worsening of the MH score was associated with increased odds of receiving one or more mental health service (OR 1.30, p < 0.0001) (Table (Table4).4). In the adjusted model, significant, independent predictors of the likelihood of experiencing one or more mental health service were: younger age (adjusted OR per 10-year increase in age = 0.80, p = 0.01), female sex (adjusted OR women vs. men = 1.79, p < 0.0001), region of residence (adjusted OR urban vs. rural = 1.36, p = 0.008), and an interaction between MH score and self-reported general health status (p-value for the interaction = 0.0009), such that the likelihood of receiving at least one mental health service was greatest for those with low self-rated general health and worse MH scores, but the effect of worsening MH scores declined with declining general health status (Figure (Figure11).
In a population cohort with symptomatic hip and knee OA, we examined the relationship between depressed mood, evaluated using the SF-36 MH score, and mental health-related health care use. Controlling for potential confounders, worsening MH scores were significantly and independently predictive of a greater likelihood of receiving mental health services. However, consistent with previous studies in other clinical populations[17,30], and despite mounting evidence of a strong association between chronic pain conditions, like arthritis, and depression[8,9,31,32], substantial care gaps remained. Fewer than half with depressed mood, as we defined it, experienced one or more mental health-related physician visit to a PCP or psychiatrist; among those aged 65+ years, who were eligible for drug benefits coverage, the proportion receiving any care (physician visit and/or prescription for an anti-depressant) was only modestly higher at 56.7%.
Among our participants, more than one-quarter (29%) had MH scores below our cut-point, indicating probable depression. Probable depression was more common among those who were younger, resided in the urban region, had lower income and education, greater OA severity and greater comorbidity. These findings are consistent with those of others. A cross-sectional analysis of the 2002 US National Health Interview Survey found that 26.2% with physician-diagnosed arthritis reported frequent anxiety or depression in the previous 12 months; 5.6% met criteria for 'serious psychological distress', which was significantly and independently associated with younger age, lower socioeconomic status, divorce/separated marital status, greater pain and functional limitations, and comorbidity. A smaller UK study found that 40.7% of 54 participants with lower limb OA met criteria for clinically significant anxiety or depression, with worse scores significantly related to greater OA pain.
Depressed mood in the setting of chronic pain has been linked with greater pain intensity, anxiety, sleep disturbances, decreased energy, decline in cognitive function and poor medication adherence, each of which may increase health care use. In the current study, depressed mood predicted a greater number of visits to both PCPs and psychiatrists and a greater likelihood of receiving an anti-depressant prescription. Katon et al.  similarly found that, among primary care patients aged 60+ years, and controlling for age, sex, and comorbidity, inpatient and outpatient health care utilization, including PCP and specialty medical visits and prescriptions for anti-depressants, were higher among those who did versus did not screen positive for clinical depression on a structured clinical interview. However, consistent with our findings, only 45% of the individuals with depression experienced any mental health care.
Although women were not more likely than men to be classified as having probable depression, women were more likely to receive mental health care. A similar relationship has been shown by others[19,29] and may be related to a greater propensity to seek treatment for mental health problems among women than men.
Among those 65 and older at baseline, the probability of receiving mental health care decreased with increasing age. One potential explanation is that the greater comorbidity that accompanies increasing age is perceived as precluding the safe use of anti-depressant therapies. However, among our study participants, while the number of reported comorbid conditions did increase with increasing age, age was a significant predictor of the probability of receiving mental health care and remained significant even after controlling for the number of comorbid conditions, suggesting that the effect of age was not simply as a proxy for greater comorbidity. Other potential explanations include under-recognition of depression among older adults, possibly resulting from differences in the clinical presentation of depression by age, and/or a higher threshold for seeking mental health care among older individuals[39,40]. Further, self-reported general health status modified the relationship between MH scores and likelihood of receiving mental health care. Among those with relatively good general health status, worsening mental health was associated with an increased likelihood of receiving mental health care, but as general health status declined, this effect was attenuated. One explanation for this finding is that, in the setting of multiple medical conditions, for which poor self-reported general health status may be a proxy, the management of some conditions may be neglected if others consume attention. Alternatively, these individuals may have their mental health care needs addressed within the context of physician visits coded for their other health care problems. Further research is warranted to disentangle the influences of general health and mental health status on provision of mental health care.
Among those who received at least one mental health-related physician visit, the number of visits experienced was significantly greater in urban residents and those with more education. It has previously been shown that urban residence is associated with greater use of mental health specialist services, likely related to greater access to these services. The association with higher socioeconomic status is concerning in light of the documented higher risk for depression among older adults with lower socioeconomic status. This finding may reflect differences by socioeconomic status in perceptions of need, health-seeking behaviours, likelihood of receiving treatment from a physician, and adherence to recommended therapies once prescribed. Additional research is warranted to determine if inequities in care provision exist.
Taken together, our findings suggest under-treatment of depressed mood among older adults with painful OA. Identified barriers to the diagnosis and treatment of depression in the primary care setting, where most mental health care was received by our participants, include: barriers to help-seeking for mental health issues due to the stigma attached to these conditions[38,43] and the perception that a depressive state is a normal part of aging; physicians' attitudes, knowledge and skills with respect to mental health diagnosis and management[17,45]; the complexity of depression management in the elderly[17,45,46]; and difficulty discriminating the clinical symptoms of OA from those of depression[39,40]. Strategies are needed to address these barriers as effective therapies exist [47,48] since, in the setting of painful OA, improved treatment of depression may reduce not only depressive symptoms, but also arthritis pain, activity limitations, and overall quality of life.
This was a retrospective cohort study in which we utilized previously completed questionnaires, which incorporated the SF-36. As such, we did not have access to the medical records of the participants, nor would we be able to retrospectively evaluate whether or not the participants we categorized as having 'probable depression' met DSM-IV criteria for clinical depression at that time. For this reason, we have been careful to use the term 'depressed mood' as opposed to 'clinical depression' to describe these individuals. However, despite this limitation, we would argue that individuals who have sufficient symptoms of depression to meet our criteria for 'probable depression' would warrant a closer look by the family doctor and/or a referral to a specialist, even if a psychiatrist decided that the patient did not meet the DSM-IV definition. Study strengths include the large sample recruited from the community and use of linked survey and administrative data. However, there are also potential study limitations. First, we defined depressed mood using a validated cut-point on the SF-36 MH subscale, shown to have 78.7% sensitivity and 72.1% specificity for clinical depression based on clinical interview using the MINI-MDE module. Thus, there remains the potential for misclassification of depressed mood in our cohort. Second, the validated algorithm used to identify mental health-related PCP visits using administrative data has high specificity, but only 80% sensitivity . Thus, we may have underestimated mental health-related PCP visits, and thus overestimated the depression-care gap. Third, since Ontario drug benefits are restricted to individuals aged 65 years and older, we were only able to examine use of medications for depression among those aged 65+ years at baseline. However, this subgroup represented over 70% of our total sample. Fourth, for almost one-third of anti-depressant prescriptions identified in this cohort subgroup (30.4%), the 'days supplied' variable was missing; thus, we relied on the filling of a prescription as a proxy for the participant taking the medication. Finally, we made the assumption that anti-depressants were prescribed for the management of depressed mood; some may have been prescribed instead for the management of chronic arthritis pain and/or associated fibromyalgia. Both these decisions may have resulted in over-estimation of receipt of mental health care.
Among older adults living with painful OA, depressed mood is common and associated with increased mental health-related health care, including visits to primary care physicians and psychiatrists, and prescriptions for anti-depressant therapies. Despite this, as many as half with comorbid depressed mood received no mental health care over the two year study period, indicating under-diagnosis and under-treatment. Our results further suggest that the care gap may be relatively greater among men, those living in rural regions, those with less education, and the very old. As effective therapies exist for the treatment of depression among older adults[47,48] and effective treatment of depression in OA may reduce pain and improve quality of life, the documented care gap is concerning. Our findings underscore the need for improved identification and management of depressed mood in the growing population with painful OA.
The authors declare that they have no competing interests.
Study design and concept: YG, RC, JH, GAH. Acquisition of subjects and data: YG, RC, JH, GAH. Analysis and interpretation of data: YG, RC, JH, GAH. Preparation of manuscript: YG, RC, JH, GAH. All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
Appendix 1. List of Prescription Medications Considered Treatment for Depression.
We thank Brogan Inc., Ottawa for use of their Drug Product and Therapeutic Class Database. This study was supported by the Institute for Clinical Evaluative Sciences (ICES), which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results and conclusions reported in this paper are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred.
This project was funded by the Canadian Institutes of Health Research and the Canadian Arthritis Network as a New Emerging Team Grant in Pain and Fatigue in Osteoarthritis [Grants: FRN 15468, NEO 66210 and SRI-OA-03].