Author affiliations: Department of Genetics, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey (Tara C. Matise, Steven Buyske); Information Sciences Institute, University of Southern California, Marina del Rey, California (Jose Luis Ambite); Department of Statistics, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey (Steven Buyske); Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas (Shelley A. Cole); Department of Molecular Physiology and Biophysics and Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee (Dana C. Crawford, Marylyn D. Ritchie, Jonathan L. Haines); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (Christopher A. Haiman); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Gerardo Heiss, Kari E. North); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington (Christopher S. Carlson, Charles Kooperberg, Ulrike Peters); Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii (Loic Le Marchand); and Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (Teri A. Manolio, Lucia A. Hindorff).
The Population Architecture using Genomics and Epidemiology (PAGE) Study is a collaboration between the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, the Multiethnic Cohort Study, the Women's Health Initiative (WHI), and the Genetic Epidemiology of Causal Variants Across the Life Course (CALiCo) consortium, which comprises the Atherosclerosis Risk in Communities (ARIC) Study, the Coronary Artery Risk Development in Young Adults (CARDIA) Study, the Cardiovascular Health Study, the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), and the Strong Heart Study. A complete list of members of the PAGE consortium can be found at http://www.pagestudy.org
PAGE is funded by the National Human Genome Research Institute (NHGRI) and is supported by National Institutes of Health grants U01HG004803 (CALiCo), U01HG004798 (EAGLE), U01HG004802 (Multiethnic Cohort Study), U01HG004790 (WHI), and U01HG004801 (Coordinating Center).
The EAGLE Study is funded through the NHGRI PAGE program (grant U01HG004798). The study participants were derived from the National Health and Nutrition Examination Surveys, which are supported by the Centers for Disease Control and Prevention. (The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention).
Characterization of epidemiological architecture in the Multiethnic Cohort Study is funded through the NHGRI PAGE program (grant U01HG004802). The Multiethnic Cohort Study is funded by the National Cancer Institute (grants R37CA54281, R01 CA63, P01CA33619, U01CA136792, and U01CA98758).
Funding for the study of the epidemiology of putative genetic variants in the WHI is provided through the NHGRI PAGE program (grant U01HG004790). The WHI is funded by the National Heart, Lung, and Blood Institute (NHLBI) and the US Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221. (The authors thank the WHI investigators and staff for their dedication). A full listing of WHI investigators can be found at http://www.whiscience.org/publications/WHI_investigators_shortlist.pdf
Funding for the CALiCo consortium was provided through the NHGRI PAGE program (grant U01HG004803). The ARIC Study is carried out as a collaborative study supported by NHLBI contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022. The CARDIA Study is supported by the following NHLBI contracts: N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, N01-HC-05187, and N01-HC-45205. The Cardiovascular Health Study is supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01-HC-15103, N01 HC-55222, N01-HC-75150, and N01-HC-45133 and grants U01HL080295 and R01 HL087652 from the NHLBI, with an additional contribution from the National Institute of Neurological Disorders and Stroke. Genome-wide association study DNA handling and genotyping in the Cardiovascular Health Study was supported in part by National Center for Research Resources grant M01-RR00425 to the Cedars-Sinai General Clinical Research Center genotyping core and by National Institute of Diabetes and Digestive and Kidney Diseases grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The HCHS/SOL is supported by NHLBI contracts N01-HC65233, N01-HC65234, N01-HC65235, N01-HC65236, and N01-HC65237. The following institutes/centers/offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: the National Center on Minority Health and Health Disparities, the National Institute on Deafness and Other Communication Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. The Strong Heart Study is supported by NHLBI grants U01 HL65520, U01 HL41642, U01 HL41652, U01 HL41654, and U01 HL65521. (The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Indian Health Service).
Assistance with phenotype harmonization; single nucleotide polymorphism selection and annotation; data cleaning; data management, integration, and dissemination; and general study coordination is provided by the PAGE Coordinating Center (grant U01HG004801). The National Institute of Mental Health also provides financial support for the Coordinating Center.
The PAGE investigators thank the staff of all PAGE studies for their important contributions. The authors thank Julia Higashio for editing assistance.
The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Conflict of interest: none declared.