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Logo of bmcclpaBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Clinical Pathology
 
BMC Clin Pathol. 2011; 11: 10.
Published online 2011 August 25. doi:  10.1186/1472-6890-11-10
PMCID: PMC3176470
Copyright ©2011 Arakelyan et al; licensee BioMed Central Ltd.
Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia
Arsen Arakelyan,1 Roksana Zakharyan,1,2 Aren Khoyetsyan,1 David Poghosyan,1 Rouben Aroutiounian,1,3 Frantisek Mrazek,2 Martin Petrek,2 and Anna Boyajyancorresponding author1
1Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, 7 Hasratyan St., 0014, Yerevan, Armenia
2Faculty of Medicine and Dentistry, Palacky University, 6 I. P. Pavlova St., 775 20, Olomouc, Czech Republic
3Biological Faculty of Yerevan State University, 1 Al. Manoogian St., 0025, Yerevan, Armenia
corresponding authorCorresponding author.
Arsen Arakelyan: aarakelyan/at/sci.am; Roksana Zakharyan: r_zakharyan/at/mb.sci.am; Aren Khoyetsyan: akhoyetyan/at/mb.sci.am; David Poghosyan: d_poghosyan/at/mb.sci.am; Rouben Aroutiounian: genetik/at/ysu.am; Frantisek Mrazek: frantisek.mrazek/at/fnol.cz; Martin Petrek: martin.petrek/at/fnol.cz; Anna Boyajyan: aboyajyan/at/sci.am
Received June 7, 2011; Accepted August 25, 2011.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background
Whereas the complement system alterations contribute to schizophrenia, complement receptors and regulators are little studied. We investigated complement receptor type 1 (CR1) expression on blood cells, the levels of circulating immune complexes (CIC) containing ligands of CR1, C1q complement protein and fragments of C3 complement protein (C1q-CIC, C3d-CIC), and CR1 C5507G functional polymorphism in schizophrenia patients and controls.
Results
We found an increased C1q-CIC level and CR1 expression on blood cells, elevated number of CR1 positive erythrocytes and reduced number of CR1 positive lymphocytes and monocytes in patients compared to controls. No difference in the levels of C3d-CIC between groups was observed. Higher CR1 expression on erythrocytes in CC genotype versus CG+GG for both groups was detected, whereas no difference was observed for other cell populations. Our results indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level.
Conclusions
Our study for the first time indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Further studies in other ethnic groups are needed to replicate these findings.
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