Liposarcoma is diagnosed when there is convincing evidence of the synthesis and storage of fat by tumor cells, the hallmark of which are the lipoblasts1
. Lipoblasts are immature fat cells characterized by a hyperchromatic nucleus that is indented or scalloped by cytoplasmic fat vacuoles. Other histopathological appearances are highly variable and depend on the particular subtype. Immunohistochemistry is of limited value in the diagnosis of liposarcoma, although it may help to reveal the identities of various sarcomas such as malignant schwannoma, rhabdomyosarcoma, and leiomyosarcoma. The pathological classification of liposarcomas have undergone change. In 1994, five histopathological subtypes were recognized as well-differentiated, myxoid, round cell, dedifferentiated and pleomorphic variants by the World Health Organization (WHO)2
. Myxoid liposarcoma resembles immature fat and small, uniformly bland spindle cells set in a myxoid matrix with plexiform vessels. Round cell liposarcoma is characterized by sheets of primitive round cell and commonly coexist with myxoid variants. Even if still classified by the WHO as two distinct subtypes, myxoid and round cell liposarcoma share both clinical and morphologic features, and lesions combining both patterns are frequent. In 2004, newer classification of liposarcomas was made, which divided them into three biologic types encompassing five subtypes based on strict morphologic features, natural history and cytogenic aberrations: (1) myxoid/round cell, (2) well-differentiated/dedifferentiated, and (3) pleomorphic4,5
. Both myxoid and round cell liposarcomas show a specific, reciprocal, chromosomal translocation, most commonly t(12;16)(q13;p1), which results in rearrangement of the CHOP gene6
Myxoid and round cell liposarcoma account for about 30~35% of all liposarcomas. The tumors generally affect young to middle-aged adults with a peak in the fourth to fifth decade and a slight male predominance2
. The clinical manifestation of this variant presents as a large, painless mass located in deep soft tissue and involves the thigh in over two-thirds of cases. The tumor is described as dome-shaped or polypoid, and measures between 1 and 19.5 cm7
. In cases of typical myxoid and round cell liposarcoma at deeper soft tissue, it is necessary to distinguish the tumor from intramuscular and juxta-articular myxoma, aggressive angiomyxoma, myxofibrosarcoma and myxoid chondrosarcoma8
. Interestingly, our case differed from previous reports in that it was detected on the upper subcutis of the flank in a relatively young male and accompanied with pain. Indeed, its clinical presumptive diagnosis was a subcutaneous benign mass such as a lipoma, angiolipoma, leiomyoma or neurilemmoma. Lipoma is the most common soft tissue tumor with a predilection for the trunk and proximal limbs. Morphologically, angiolipoma is similar to lipoma, but intermittently painful. These characteristics could explain why we were unable to identify what the tumor was before the histology was obtained from the biopsy.
Liposarcoma are on a morphological continuum in which tumor progression from low-grade myxoid to high grade hypercellular or round cell areas may be observed. Wide agreement exists in considering round cell liposarcoma as a poorly differentiated myxoid liposarcoma4
. Purely myxoid lesions are characterized by a 5-year survival rate of approximately 70%, which drops to approximately 20% in the case of round cell tumors. Two independent studies have demonstrated that the presence of a round cell component ranging between 5 and 25% is associated with a significant worsening of prognosis when compared to pure myxoid lesions7,9
. In addition, patients who present with multifocal disease have a poor prognosis and the presence of necrosis and p53 overexpression have been found to be independent predictors of poor prognosis10
. There is no significant relationship between tumor size and clinical outcome. Local recurrence has been reported with an unusually high incidence of soft tissue and bone metastases to the lung. However, in 1998, Dei Tos et al.3
reported their personal experience that liposarcoma occurs primarily in the skin, and that despite an apparent tendency to show high-grade morphological features, it appears to behave in a relatively benign fashion, in stark contrast to their deep-seated counterparts.
Surgery remains the mainstay of therapy for liposarcoma Vol. 23, No. 3, 2011 341 in the control of local disease. Excision needs to be carefully planned using CT or magnetic resonance imaging11
. Liposarcoma can often be managed if surgical treatment is carefully planned and adequate clean margins are achieved. Nevertheless, patients with round cell and pleomorphic liposarcoma will develop distant metastasis, usually to the lungs, bone or fat pad sites in the retroperitoneum and trunk. Since the high rate of response of myxoid/round cell liposarcoma to ifosfamide-based chemotherapy has been observed in the metastatic setting, neoadjuvant or adjuvant chemotherapy for high-risk primary liposarcoma may help decrease the frequency of distant metastases, and thus increase overall survival. To lower the recurrence or distant metastasis rates, radiotherapy is also recommended before or after surgery12
Liposarcoma is rarely reported in the Korean dermatologic literature, and only five cases of liposarcoma have been described since 199613-16
. All of these cases involved the extremities, especially the thigh, and with the exception of one case in the dermis, all of these cases occurred in the deep soft tissue. If liposarcoma is detected in the trunk of young adults, it can be easily mistaken for a benign tumor such as a lipoma or angiolipoma. Herein, we report a case of myxoid and round cell liposarcoma affecting the subcutis of the left flank. To avoid missing the optimal timing for treatment, clinicians should be aware of the possibility of malignant diseases, especially when rapid growth of the subcutaneous tumor is observed.