Trial management group T S Maughan (chair), M T Seymour, R H Wilson, R A Adams, H Wasan, A Madi, J Cassidy, MJ Kennedy, E Hodgkinson, P Rogers, M Pope.
MRC Clinical Trials Unit A M Meade, R Kaplan, D Fisher, S L Kenny, J K Mitchell, L Nichols, L Harper, B Sydes, E Kay, L Thompson, L Clement, C Courtney, G Griffiths, C Murphy, M Parmar.
Genetic analysis C G Smith, R Harris, S Idziaszczyk, B Claes, D Lambrechts, J P Cheadle.
EGFR immunohistochemistry B Jasani, S Storkel, R Adams, M James.
Data monitoring committee J Northover (chair), J Brown, M Aapro, R Stout.
Trial steering committee C Parker (current chair), M Mason, R Rudd, P W M Johnson, J Whelan.
Sponsor Medical Research Council.
Clinical investigators (Institution [number of patients contributed]) C Lowdell, R H Phillips, R Ahmad, P Riddle, A Creak (Charing Cross Hospital, London, UK ); J Cassidy, A McDonald, A Waterston, N Mohammed, J White, H Yosef, A Hennessy (Beatson Oncology Centre, Glasgow, UK ); E M Bessell, V Potter (Nottingham City Hospital, Nottingham, UK ); M Seymour, A Anthoney, A Melcher, R Cooper, D Sebag-Montefiore (St James' University Hospital, Leeds, UK ); P Ross, M Leslie, N Maisey, A Gaya, G Mikhaeel (Guy's and St Thomas's Hospitals, London, UK ); J Summers, M Hill, R James (Maidstone Hospital, Maidstone, UK ); T S Maugham, A Brewster, T Crosby, S Mukherjee, N Iqbal (Velindre Hospital, Cardiff, UK ); J Wadsley, D Furniss, S Pledge, J Hornbuckle, S Clenton (Weston Park Hospital, Sheffield, UK ); R Glynne-Jones, M Harrison, S Mawdsley, N Anyamene, R Hughes (Mount Vernon Hospital, UK ); D Propper, C Cottrill (St Bartholomew's Hospital, London, UK ); D Smith, S Myint, N Ali, M Iqbal, P Clark, B Haylock (Clatterbridge Centre for Oncology, UK ); T Iveson, A Bateman, C Baughan (Southampton Hospital, UK ); S Falk, K Hopkins (Bristol Oncology Centre, Bristol, UK ); J Bridgewater, S Karp (North Middlesex Hospital, London, UK ); C Topham, G Middleton, S Essapen, S Cummins (Royal Surrey County Hospital, UK ); B Sizer (Essex County Hospital, UK ); S Gollins (Glan Clwyd Hospital, UK ); A Maraveyas (Castle Hill Hospital, Hull, UK ); S Tahir (Broomfield Hospital, Essex, UK ); J Bridgewater (Princess Alexandra Hospital, UK ); C Blesing (Great Western Hospital, Swindon, UK ); H Wasan (Hammersmith Hospital, London, UK ); M Tighe, S Falk (Musgrove Park Hospital, Taunton ); R Ellis (Royal Cornwall Hospital, UK ); J Dent, JK Joffe (Huddersfield Royal Infirmary, UK ); S Shepherd, K Benstead, D Farrugia (Cheltenham General Hospital, UK ); P Mack, A Hamid, M Butt, R Roy (Diana, Princess of Wales Hospital, Grimsby, UK ); T Hickish (Royal Bournemouth Hospital, UK ); H Yosef (Hairmyres Hospital, UK ); D Tsang, P Leonard, J Prejbisz (Southend Hospital, UK ); J Ledermann, J Bridgewater (University College London Hospital, London, UK ); T Hickish, R Osborne (Poole Hospital, Dorset, UK ); A O'Callaghan, S R Muthuramalingam (Portsmouth Oncology Centre, Queen Alexandra Hospital, UK ); F Adab (University Hospital of North Staffordshire NHS Trust, UK ); N J Wadd, J Van der Voet, D Wilson (James Cook University Hospital, UK ); J Wagstaff, C Askill (Singleton Hospital, UK ); I Pedley, A Azzabi (Sunderland Royal Hospital, UK ); E Marshall (Whiston Hospital, UK ); R James (Kent and Canterbury Hospital, UK ); F Daniel (Derriford Hospital, Plymouth, UK ); R Osborne (Dorset County Hospital, UK ); T J Iveson (Salisbury District Hospital, UK ); D Jodrell, C McLean, S Clive, L Dawson, H A Philips (Western General Hospital, Edinburgh, UK ); S Falk (Yeovil District Hospital, UK ); R James (Queen Elizabeth, The Queen Mother Hospital, UK ); P Chakraborti, R Kulkarni (Royal Derby Hospital, UK ); L M Samuel, G MacDonald (Aberdeen Royal Infirmary, UK ); C Bradley, C Twelves (Bradford Royal Infirmary, UK ); S Giridharan, F Adab (Staffordshire General Hospital, UK ); S Myint (Southport & Formby District General Hospital, UK ); S Gollins (Wrexham Maelor Hospital, UK ); N Stuart, C Bale (Ysbyty Gwynedd Hospital, UK ); (William Harvey Hospital, UK ); J Valle, M Saunders, G Wilson (Christie Hospital, Manchester, UK ); A Weaver, A Jones (Churchill Hospital, Oxford, UK ); K McAdam, C Jephcott (Peterborough District Hospital, UK ); S Cleator (St Mary's Hospital, London, UK ); A Webb (Worthing Hospital, UK ); J Glaholm (Good Hope Hospital, UK ); R Hughes, P M Mulholland (Lister Hospital, UK ); N Steven (Queen Elizabeth, University Hospital, Birmingham, UK ); A Mayer, T Meyer (Royal Free Hospital ); N Lo, G Cogill, L Toy (Torbay Hospital, UK ); M Wilkins (West Wales General Hospital, UK ); C Wilson, C Palmer (Addenbrooke's Hospital, UK ); I Geh (Birmingham Heartlands Hospital, UK ); R Thomas (Bedford Hospital NHS Trust ); J Nicoll (Cumberland Infirmary, UK ); P Chakraborti (Queens Hospital, Burton Upon Trent ); A Azzabi (South Tyneside Hospital, UK ); R Wilson, M Eatock (Belfast City Hospital, UK ); A Hartley (Manor Hospital, Walsall, UK ); J Gildersleve, A Freebairn (Berkshire Cancer Centre, Berkshire, UK ); G P Deutsch, A Webb, M Wilkins (Royal Sussex County Hospital, Brighton, UK ); F McKinna (Eastbourne District General Hospital ); D Cunningham, I Chau (Royal Marsden, Sutton, UK ); S Susnerwala, M Wise, A Birtle (Royal Preston Hospital, UK ); A Hamid (Scunthorpe General Hospital, UK ); F J Lofts (St George's Hospital, London, UK ); J Kennedy (St James' Hospital, Dublin, Ireland ); D Whillis (Raigmore Hospital, UK ); S Susnerwala (Blackpool Victoria Hospital, UK ); L T Tan, C Palmer (Hinchingbrooke Hospital, UK ); N Maisey (Queen Elizabeth Hospital, UK ); M Keane (University College Hospital, Galway, Ireland ); C Macmillan, K Patel (Northampton General Hospital, UK ); D Farrugia (Worcestershire Royal Hospital, UK ); G Bertelli, V Vigneswaran (Withybush General Hospital, UK ); D Smith (Aintree, University Hospital, UK ); R McDermott (AMNCH, Tallaght Hospital, Dublin, Ireland ); S O'Reilly (Mercy Hospital, Cork, Ireland ); V Hall (Royal Hampshire County Hospital, Winchester, UK ); C Hamilton, A Dhadda (Scarborough Hospital, UK ); C Baughan (St Mary's Hospital, Isle of Wight, UK ); H Ford, M Moody (West Suffolk Hospital, UK ); M Tomlinson (Weston General Hospital, Weston Super Mare, UK ); L Grogan, O Breathnach (Beaumont Hospital, Dublin, Ireland ); R Soomal (Ipswich Hospital NHS Trust, UK ); J McCaffrey (Mater Misericordiae Private Hospital, Dublin, Ireland ); J McCaffrey (Mater Misericordiae Public Hospital, Dublin, Ireland ); C Rees (North Hampshire Hospital, Basingstoke, UK ); P J Atherton (North Tyneside General Hospital, UK ); S Beesley (Conquest Hospital, UK ); W Dobrowsky (Wansbeck General Hospital, UK ); G Leonard (Waterford Regional Hospital, Waterford, Ireland ); R Gupta (Midwestern Regional Hospital, Limerick, Ireland ); J Stewart (Milton Keynes General Hospital, UK ); D Cunningham (Royal Marsden Hospital, London, UK ).