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Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
 
J Laparoendosc Adv Surg Tech A. 2009 April; 19(2): 135–139.
PMCID: PMC3157335

Laparoscopic Revision of Failed Fundoplication and Hiatal Herniorraphy

Abstract

Objective

The aim of this study was to evaluate the mechanisms of failure after laparoscopic fundoplication and the results of revision laparoscopic fundoplication.

Background

Laparoscopic Nissen fundoplication has become the most commonly performed antireflux procedure for the treatment of gastroesophageal reflux disease, with success rates from 90 to 95%. Persistent or new symptoms often warrant endoscopic and radiographic studies to find the cause of surgical failure. In experienced hands, reoperative antireflux surgery can be done laparoscopically. We performed a retrospective analysis of all laparoscopic revision of failed fundoplications done by the principle author and the respective fellow within the laparoscopic fellowship from 1992 to 2006.

Methods

A review was performed on patients who underwent laparoscopic revision of a failed primary laparoscopic fundoplication.

Results

Laparoscopic revision of failed fundoplication was performed on 68 patients between 1992 and 2006. The success rate of the laparoscopic redo Nissen fundoplication was 86%. Symptoms prior to the revision procedure included heartburn (69%), dysphagia (8.8%), or both (11.7%). Preoperative evaluation revealed esophagitis in 41%, hiatal hernia with esophagitis in 36%, hiatal hernia without esophagitis in 7.3%, stenosis in 11.74%, and dysmotility in 2.4%. The main laparoscopic revisions included fundoplication alone (41%) or fundoplication with hiatal hernia repair (50%). Four gastric perforations occurred; these were repaired primarily without further incident. An open conversion was performed in 1 patient. Length of stay was 2.5 ± 1.0 days. Mean follow-up was 22 months (range, 6–42), during which failure of the redo procedure was noted in 9 patients (13.23%).

Conclusion

Laparoscopic redo antireflux surgery, performed in a laparoscopic fellowship program, produces excellent results that approach the success rates of primary operations.

Introduction

The numbers of fundoplications performed in the United States in 1993, 1998, and 2002 were 22,000, 40,000, and 41,000,1 respectively, suggesting that there has been a leveling off in the number of these procedures performed after the initial surge that was associated with the advent of minimally invasive fundoplication in the early 1990s.2 The reason for this stabilization is multifactorial, but it may be, in part, due to a perception in the medical community of mediocre results after minimally invasive fundoplication.3 This perception has been perpetuated by one specific study of questionable design.4 However, the success rate of laparoscopic fundoplication in specialty centers is 90–95%.5

Due to the increase in primary fundoplications performed, there has been an increase in the number of failed procedures. The reoperative rate after primary laparoscopic fundoplication in specialty centers was 2.8% in a collection of over 10,000 reported cases.5 Revisional fundoplication procedures occurred during the era of open antireflux surgery.6 There had been a previous assumption that failure after primary laparoscopic procedures should be treated with an open revision. During the latter 1990s, however, a number of reports of laparoscopic revision fundoplications demonstrated the feasibility of minimally invasive revision after the failure of both open and laparoscopic antireflux procedures.5,79 We reviewed our experience in the reconstruction of laparoscopic fundoplication with or without hiatal hernia repair following a failed primary operation. Our aim in this study was to describe the patterns of failure seen after primary laparoscopic fundoplication, to examine our own results after minimally invasive revision, and to make recommendations based on what we observed.

Materials and Methods

A retrospective analysis of all patients who underwent a laparoscopic reconstruction of fundoplication with or without herniorraphy, under a single attending surgeon (CTF) within an academic residency-fellowship program over a 14-year period (1992–2006), was performed. All patients considered for revisional surgery underwent a preoperative esophagogastroduodenoscopy (EGD) and upper gastrointestinal series (UGI). Manometry was performed selectively in patients with symptoms of dysphagia/odynophagia and/or with evidence of abnormal motility on UGI.10

Our technique for both primary and reoperative laparoscopic Nissen fundoplication with hiatal herniorraphy has been described.9,11,12 Briefly, the abdomen was entered with an optical trocar. Adhesions were invariably present between the undersurface of the left lobe of the liver and the gastric wall. These adhesions were taken down cautiously to avoid inadvertent injury to the stomach or excess bleeding from capsular liver tears. A lighted bougie was placed by the anesthesiologist to assist in the identification of the esophagus. Next, the right and left bundle of the right crus were dissected away from the esophagogastric junction and fundoplication.

In the majority of cases, the fundoplication was then identified and the plication stitches were divided to restore the normal anatomic position of the fundus. The short gastric vessels were ligated by using the Harmonic Scalpel (Ethicon Endo-Surgery, Inc., Cincinnati, OH), if not already performed during the primary procedure. The esophagus was mobilized so that 3–4 cm lay intra-abdominally without tension. If necessary, a posterior cruroplasty then was performed with interrupted 2-0 polyester sutures. If the hiatal defect was greater than 8 (1992–2000) or 5 cm (2000–2006), then a polytetrafluoroethylene (DualMesh; W.L. Gore and Associates, Flagstaff, AZ) onlay mesh patch was placed, as described before.11,13 The procedure was completed with a loose three-stitch, 2–3 cm, 360-degree wrap; the most cephalad stitch incorporated the anterior arch of the right crus. The esophagus was not incorporated into the anchoring sutures. All patients had an esophagogram with water-soluble contrast (gastrograffin) on the first postoperative day.

A soft diet (with avoidance of gas-producing food and carbonation) was begun on postoperative day 1; the patient was discharged when he or she had an adequate oral intake. Follow-up consisted of clinic appointments at 1 week, 1, 3, 6 months, and yearly thereafter. Diagnostic studies, such as EGD or UGI, were ordered during follow-up if a patient developed symptoms.

Results

Revision laparoscopic fundoplication was undertaken in 68 patients; 7 of these had their primary procedure performed by the senior author.10,14 The mean age was 42 (range, 23–78). The primary procedure either was a laparoscopic Nissen (n = 61) or laparoscopic Toupet (n = 7) fundoplication. The presenting symptoms and results of diagnostic evaluation are given in Tables 1 and and2,2, respectively. Two manometries were performed in patients whose dysphagia could not be explained by findings of the EGD and/or UGI.

Table 1.
Preoperative Symptoms Before Laparoscopic Revision of Failed Fundoplication and Hiatal Herniorraphy
Table 2.
Results of Preoperative Evaluation (Endoscopy, Esophagogram, Manometry)

The duration of surgery was 2.6 ± 0.4 hours (range, 0.7–4.5). Conversion to open occurred in (1.4%) 1 patient secondary to dense adhesions. The intraoperative findings with respect to each patient are displayed in Table 3. Hiatal hernia, whether alone or in combination with another finding, was present in (51%) 35 patients; similar totals for fundoplication slippage and malpositioned fundoplication were 8 (11.7%) and 11 patients (16%), respectively. Malpositioning findings included a fundus sutured to the greater or lesser curvature or the corpus of the stomach. Twenty-one of the hiatal hernias had a defect of ≥5 cm; 19 of these were repaired with a polytetrafluoroethylene (PTFE) reinforcement of the hiatal herniorraphy. Mesh was not used on the other 2 large-defect hernias because of intraoperative gastric perforation. No esophageal lengthening procedures (i.e., Collis gastroplasty) were performed, since adequate intra-abdominal mobilization of the esophagus was achieved in all patients, which mimics our experience in primary fundoplication cases.15

Table 3.
Intraoperative Findings During Laparoscopic Revision of Failed Fundoplication and Hiatal Herniorraphy

The revisional procedures performed are listed in Table 4. The vast majority of patients (63; 92.6%) required complete deconstruction and reconstruction of the fundoplication; however, removal or addition of sutures to the existing fundoplication or cruroplasty was sufficient in 5 patients. Intraoperative complications consisted of 4 patients with gastric perforation. These perforations were sutured laparoscopically and did not require conversion. There was no adverse outcome from these perforations. There was no esophageal perforation. The length of stay was 2.5 ± 1.0 days (range, 1–6). Perioperative mortality was zero.

Table 4.
Procedures Performed During Reoperation

Median follow-up was 27 months (range, 6–42). Procedure failure was noted in 9 patients (13.2%); the hiatal hernia recurred in 6 patients, while fundoplication failure occurred in 3. All fundoplication and hiatal herniorraphy failures occurred within the first 6 months. The control of symptoms in the other 59 patients has been good to excellent (Visick I–II). Two of the patients with recurrent hiatal hernia did not have a mesh repair during the redo procedure because of an intraoperative gastric perforation. The other recurrent hiatal hernias were in 3 patients that had a repair with a simple cruroplasty and in 1 patient who had a mesh reinforcement. The reoccurrence in the patient with the mesh reinforcement was through the keyhole of the mesh that, apparently, was constructed too largely. None of the patients in this series has undergone a third antireflux procedure.

Discussion

We had previously published a preliminary report on nine reconstructions of failed antireflux procedures.9 The most common etiology of failure in our prior report was malpositioning of the fundoplication to the body of the stomach. In the present report, the incidence of a malpositioned fundoplication was 16%, which was lower than the initial report (56%). Hiatal hernia recurrence was the single most common finding in the present report (51%). In fact, recurrent hiatal hernia is currently recognized as the most common cause of failure after an antireflux procedure with an incidence of approximately 50%.5,1623 Others have noted issues with the hiatal disruption during laparoscopic revision fundoplication.8,16,18,19,22,2434 Herniation of the wrap, whether due to short esophagus or inadequate repair of the hiatus, is a primary mechanism of failure after minimally invasive fundoplication. We feel that this is almost always secondary to an inadequate repair of the esophageal hiatus or insufficient esophageal mobilization, as opposed to a shortened esophagus.

Laparoscopic revision appears to be associated with less complication, compared to the open-approach era.35 Gastric perforation was the most common intraoperative complication. This complication can be minimized with the use of atraumatic graspers.16,24

We and others advocate the use of mesh reinforcement of hiatal hernia repair in order to decrease the hernia recurrence.13,17,3638 The efficacy of PTFE reinforcement in hiatal herniorraphy has been demonstrated in a randomized trial.13 Our current indication for mesh utilization is a hiatal defect greater than 5 cm. In addition, weak crural tissue should be another indication for the use of mesh, especially in reoperations for failed hiatal hernia. We hypothesize that being more liberal in the utilization of mesh with our reconstruction of hiatal herniorraphies would have decreased the rate of recurrences. There has been concern that placement of prosthesis at the esophageal hiatus will invite an erosive complication. We have not observed any such complication in our patients with mesh at the hiatus, and we are aware of only one case report when PTFE is used.40 We, therefore, feel that any theoretic risk of luminal erosion after the placement of a PTFE mesh at the hiatus is offset by the marked reduction in hiatal herniation.

After hiatal hernia recurrence, the next most common finding associated with failure was wrap slippage. We perform routine fixation of the fundoplication to the anterior arch of the right crus, but we avoid incorporating the esophagus into the wrap. We feel that such incorporation might increase the chance for subsequent dysphagia. While this is difficult to prove with our current data, we have not seen a significant long-term postoperative dysphagia with this technique, compared to others, after primary fundoplication.4043 Wrap mal-positioning was another common finding. We and others believe that this result can be avoided by the complete division of the short gastric vessels and the unequivocal identification of the angle of His.28,44 These maneuvers will help the surgeon to perform a fundus-to-fundus wrap, as opposed to a fundus-to-body wrap.

It is of the utmost importance that an extensive evaluation should be done to identify the cause of failure preoperatively. We found, through the course of treating patients with failed fundoplications and hiatal hernias, that a very important component of preoperative evaluation of these patients is an experienced upper gastrointestinal radiologist. Fluoroscopic evaluation of these patients, when placed in different positions on the radiology table, and when pressure is exerted on the abdomen, can help diagnose the cause of failure. At times, however, the diagnosis of the cause of failure is made intraoperatively.

A somewhat controversial issue is the intraoperative use of a bougie, that has been argued, by others, to potentially cause esophageal perforation. We find the use of the lighted bougie very helpful in identifying the position of the esophagus, once the left lobe of the liver has been mobilized. The introduction of this lighted bougie should be done very carefully by an experienced anesthesiologist or a senior member of the surgical team.

The intermediate success rate of our revisional fundoplication procedures was 86%, which is lower than the reported 90–95% success rate of primary procedures.5 The 4% disparity between the primary fundoplications and revisions may be explained by the fact that the latter are more demanding technically, in addition to the fact that tissue integrity may have been compromised with the first procedure. One may claim that a more liberal use of mesh reinforcement of cruroplasty during reoperations may reduce the recurrence rate, but this is only speculative.

Conclusion

Our success rate in the revision procedure is comparable with that reported from other groups, many of which have found lower success in revision procedures.5,1619,2022,26,27,30,31,4549 The aggregate of published evidence suggests that revision laparoscopic fundoplication and hiatal herniorraphy is effective, but technically challenging; thus, these revisional procedures should probably be performed in specialty centers. More important, however, are lessons learned in minimizing failure after primary operation. These would include 1) careful construction of the wrap, 2) complete mobilization of fundus by division of the short gastric vessels, 3) visualization of the angle of His, 4) adequate esophageal mobilization, 5) posterior cruroplasty, and 6) consideration for mesh reinforcement of the cruroplasty in the face of a large hiatal defect.

Acknowledgment

MAC was supported by a grant from the National Institutes of Health (NIH; Bethesda, MD; K08 GM00703).

Disclosure Statement

No competing financial interests exist.

References

1. Detailed Diagnoses Procedures. National Hospital Discharge Survey (1993, 1998, and 2002) Atlanta, GA: Centers for Disease Control and Prevention; [Dec 14;2008 ].
2. Dallemagne B. Weerts JM. Jehaes C. Markiewicz S. Lombard R. Laparoscopic Nissen fundoplication: Preliminary report. Surg Laparosc Endosc. 1991;1:138–143. [PubMed]
3. Hogan WJ. Shaker R. Life after antireflux surgery. Am J Med. 2000;108(Suppl 4a):181S–191S. [PubMed]
4. Spechler SJ. Lee E. Ahnen D. Goyal RK. Hirano I. Ramirez F. Raufman JP. Sampliner R. Schnell T. Sontag S. Vlahcevic ZR. Young R. Williford W. Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: Follow-up of a randomized, controlled trial. JAMA. 2001;285:2331–2338. [PubMed]
5. Carlson MA. Frantzides CT. Complications and results of primary minimally invasive antireflux procedures: A review of 10,735 reported cases. J Am Coll Surg. 2001;193:428–439. [PubMed]
6. Stirling MC. Orringer MB. Surgical treatment after the failed antireflux operation. J Thoracic Cardiovasc Surg. 1986;92:667–672. [PubMed]
7. Curet MJ. Josloff RK. Schoeb O. Zucker KA. Laparoscopic reoperation for failed antireflux procedures. Arch Surg. 1999;134:559–563. [PubMed]
8. DePaula AL. Hashiba K. Bafutto M. Machado CA. Laparoscopic reoperations after failed and complicated antireflux operations. Surg Endosc. 1995;9:681–686. [PubMed]
9. Frantzides CT. Carlson MA. Laparoscopic redo Nissen fundoplication. J Laparoendosc Adv Surg Tech A. 1997;7:235–239. [PubMed]
10. Frantzides CT. Carlson MA. Madan AK. Stewart ET. Smith C. Selective use of esophageal manometry and 24-hour pH monitoring before laparoscopic fundoplication. J Am Coll Surg. 2003;197:358–363. discussion, 363–364. [PubMed]
11. Frantzides CT. Carlson MA. Prosthetic reinforcement of posterior cruroplasty during laparoscopic hiatal herniorrhaphy. Surg Endosc. 1997;11:769–771. [PubMed]
12. Frantzides CT. Carlson MA. Paraesophageal herniation. In: Baker RJ, editor; Fischer JE, editor. Mastery of Surgery. Philadelphia, PA: Lippincott Williams & Wilkins; >2001. pp. 721–736.
13. Frantzides CT. Madan AK. Carlson MA. Stavropoulos GP. A prospective, randomized trial of laparoscopic polytetrafluoroethylene (PTFE) patch repair versus simple cruroplasty for large hiatal hernia. Arch Surg. 2002;137:649–652. [PubMed]
14. Frantzides CT. Richards C. A study of 362 consecutive laparoscopic Nissen fundoplications. Surgery. 1998;124:651–654. discussion, 654–655. [PubMed]
15. Madan AK. Frantzides CT. Patsavas KL. The myth of the short esophagus. Surg Endosc. 2004;18:31–34. [PubMed]
16. Coelho JC. Goncalves CG. Claus CM. Andrigueto PC. Ribeiro MN. Late laparoscopic reoperation of failed antire-flux procedures. Surg Laparosc Endosc Percutan Tech. 2004;14:113–117. [PubMed]
17. Granderath FA. Kamolz T. Schweiger UM. Pointer R. Laparoscopic refundoplication with prosthetic hiatal closure for recurrent hiatal hernia after primary failed antireflux surgery. Arch Surg. 2003;138:902–907. [PubMed]
18. Hatch KF. Daily MF. Christensen BJ. Glasgow RE. Failed fundoplications. Am J Surg. 2004;188:786–791. [PubMed]
19. Papasavas PK. Yeaney WW. Landreneau RJ. Hayetian FD. Gagne DJ. Caushaj PF. Macherey R. Bartley S. Maley RH., Jr Keenan RJ. Reoperative laparoscopic fundoplication for the treatment of failed fundoplication. J Thorac Cardiovasc Surg. 2004;128:509–516. [PubMed]
20. Power C. Maguire D. McAnena O. Factors contributing to failure of laparoscopic Nissen fundoplication and the predictive value of preoperative assessment. Am J Surg. 2004;187:457–463. [PubMed]
21. Rosemurgy AS. Arnaoutakis DJ. Thometz DP. Binitie O. Giarelli NB. Bloomston M. Goldin SG. Albrink MH. Reoperative fundoplications are effective treatment for dysphagia and recurrent gastroesophageal reflux. Am Surg. 2004;70:1061–1067. [PubMed]
22. Watson AJ. Krukowski ZH. Revisional surgery after failed laparoscopic anterior fundoplication. Surg Endosc. 2002;16:392–394. [PubMed]
23. Watson DI. Jamieson GG. Devitt PG. Mitchell PC. Game PA. Paraoesophageal hiatus hernia: An important complication of laparoscopic Nissen fundoplication. Br J Surg. 1995;82:521–523. [PubMed]
24. Neuhauser B. Hinder RA. Laparoscopic reoperation after failed antireflux surgery. Semin Laparosc Surg. 2001;8:281–286. [PubMed]
25. Heniford BT. Matthews BD. Kercher KW. Pollinger H. Sing RF. Surgical experience in fifty-five consecutive reoperative fundoplications. Am Surg. 2002;68:949–954. discussion, 954. [PubMed]
26. Serafini FM. Bloomston M. Zervos E. Muench J. Albrink MH. Murr M. Rosemurgy AS. Laparoscopic revision of failed antireflux operations. J Surg Res. 2001;95:13–18. [PubMed]
27. Oelschlager BK. Lal DR. Jensen E. Cahill M. Quiroga E. Pellegrini CA. Medium- and long-term outcome of laparoscopic redo fundoplication. Surg Endosc. 2006;20:1817–1823. [PubMed]
28. Soper NJ. Dunnegan D. Anatomic fundoplication failure after laparoscopic antireflux surgery. Ann Surg. 1999;229:669–676. discussion, 676–677. [PubMed]
29. Awad ZT. Anderson PI. Sato K. Roth TA. Gerhardt J. Filipi CJ. Laparoscopic reoperative antireflux surgery. Surg Endosc. 2001;15:1401–1407. [PubMed]
30. Hunter JG. Smith CD. Branum GD. Waring JP. Trus TL. Cornwell M. Galloway K. Laparoscopic fundoplication failures: Patterns of failure and response to fundoplication revision. Ann Surg. 1999;230:595–604. discussion, 604–606. [PubMed]
31. Luketich JD. Fernando HC. Christie NA. Buenaventura PO. Ikramuddin S. Schauer PR. Outcomes after minimally invasive reoperation for gastroesophageal reflux disease. Ann Thorac Surg. 2002;74:328–331. discussion, 331–332. [PubMed]
32. Richardson WS. Laparoscopic reoperative surgery after laparoscopic fundoplication: An initial experience. Curr Surg. 2004;61:583–586. [PubMed]
33. Floch NR. Hinder RA. Klingler PJ. Branton SA. Seelig MH. Bammer T. Filipi CJ. Is laparoscopic reoperation for failed antireflux surgery feasible? Arch Surg. 1999;134:733–737. [PubMed]
34. Horgan S. Pohl D. Bogetti D. Eubanks T. Pellegrini C. Failed antireflux surgery: What have we learned from reoperations? Arch Surg. 1999;134:809–815. discussion, 815–817. [PubMed]
35. Rieger NA. Jamieson GG. Britten-Jones R. Tew S. Reoperation after failed antireflux surgery. Br J Surg. 1994;81:1159–1161. [PubMed]
36. Basso N. De Leo A. Genco A. Rosato P. Rea S. Spaziani E. Primavera A. A 360-degree laparoscopic fundoplication with tension-free hiatoplasty in the treatment of symptomatic gastroesophageal reflux disease. Surg Endosc. 2000;14:164–169. [PubMed]
37. Champion JK. Rock D. Laparoscopic mesh cruroplasty for large paraesophageal hernias. Surg Endosc. 2003;17:551–553. [PubMed]
38. Gryska PV. Vernon JK. Tension-free repair of hiatal hernia during laparoscopic fundoplication: A ten-year experience. Hernia. 2005;9:150–155. [PubMed]
39. Coluccio G. Ponzio S. Ambu V. Tramontano R. Cuomo G. [Dislocation into the cardial lumen of a PTFE prosthesis used in the treatment of voluminous hiatal sliding hernia: A case report] Minerva Chir. 2000;55:341–345. [PubMed]
40. Frantzides CT. Carlson MA. Zografakis JG. Moore RE. Zeni T. Madan AK. Postoperative gastrointestinal complaints after laparoscopic nissen fundoplication. J Soc Lap Surg. 2006;10:39–42. [PMC free article] [PubMed]
41. Herron DM. Swanstrom LL. Ramzi N. Hansen PD. Factors predictive of dysphagia after laparoscopic Nissen fundoplication. Surg Endosc. 1999;13:1180–1183. [PubMed]
42. Bais JE. Wijnhoven BP. Masclee AA. Smout AJ. Gooszen HG. Analysis and surgical treatment of persistent dysphagia after Nissen fundoplication. Br J Surg. 2001;88:569–576. [PubMed]
43. Gott JP. Polk HC., Jr Repeat operation for failure of antireflux procedures. Surg Clin North Am. 1991;71:13–32. [PubMed]
44. Hunter JG. Swanstrom L. Waring JP. Dysphagia after laparoscopic antireflux surgery. The impact of operative technique. Ann Surg. 1996;224:51–57. [PubMed]
45. Watson AJ. Krukowski ZH. Revisional surgery after failed laparoscopic anterior fundoplication. Surg Endosc. 2002;16:392–394. [PubMed]
46. Granderath FA. Kamolz T. Schweiger UM. Pointner R. Long-term follow-up after laparoscopic refundoplication for failed antireflux surgery: Quality of life, symptomatic outcome, and patient satisfaction. J Gastrointest Surg. 2002;6:812–818. [PubMed]
47. Watson DI. Jamieson GG. Game PA. Williams RS. Devitt PG. Laparoscopic reoperation following failed antireflux surgery. Br J Surg. 1999;86:98–101. [PubMed]
48. Byrne JP. Smithers BM. Nathanson LK. Martin I. Ong HS. Gotley DC. Symptomatic and functional outcome after laparoscopic reoperation for failed antireflux surgery. Br J Surg. 2005;92:996–1001. [PubMed]
49. Khaitan L. Bhatt P. Richards W. Houston H. Sharp K. Holzman M. Comparison of patient satisfaction after redo and primary fundoplications. Surg Endosc. 2003;17:1042–1045. [PubMed]

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