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Int J Ayurveda Res. 2011 Jan-Mar; 2(1): 65.
PMCID: PMC3157117

Authors’ reply

Sir,

We are thankful for your interest in our article.[1]

The same dose of Tulsi was used in the previous studies showing the effect of Tulsi on sperm count.[2] LD50 of Ocimum sanctum extract is 4.5 g/kg by oral route.[3] We have used 2 g of fresh leaves per day which is equal to ~ 0.8 g dry weight which is much less than the LD50. We do not wish to create a scare regarding use of Tulsi but the study is a preliminary observation showing the effect of Tulsi on reproductive hormones. Further research is needed on extracts of Tulsi which cause this effect and potential use of Tulsi extracts in oral male contraceptives.

REFERENCES

1. Sethi J, Yadav M, Sood S, Dahiya K, Singh V. Effect of Tulsi (Ocimum sanctum Linn) on sperm count and reproductive hormones in male albino rabbits. Int J Ayurveda Res. 2010;1:208–10. [PMC free article] [PubMed]
2. Khanna S, Gupta SK, Grover JK. Effect of long term feeding of Tulsi (Ocimum sanctum L) on reproductive performance of adult albino rats. Indian J Exp Biol. 1986;24:302–4. [PubMed]
3. Sembulingam K, Sembulingam P, Namasivayam A. Effect of Ocimum sanctum Linn on noise induced changes in plasma corticosterone level. Indian J Physiol Pharmacol. 1997;41:139–43. [PubMed]

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