Author affiliations: Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland (Gareth J. McKay, Ian S. Young, Chris C. Patterson); Centre for Vision and Vascular Science, Queen's University Belfast, Belfast, Northern Ireland (Giuliana Silvestri, Usha Chakravarthy, Shilpa Dasari); Institute of Human Genetics, University of Regensburg, Regensburg, Germany (Lars G. Fritsche, Bernhard H. Weber); Department of Ophthalmology, University Hospital Würzburg, Würzburg, Germany (Claudia N. Keilhauer); Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon (Michael L. Klein, Peter J. Francis); Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands (Johannes R. Vingerling, Lintje Ho); Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, the Netherlands (Caroline C. Klaver); Netherlands Institute for Neuroscience, Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands (Paulus T. D. V. De Jong); Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands (Paulus T. D. V. De Jong); Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland (Michael Dean, Julie Sawitzke); Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia (Paul N. Baird, Robyn H. Guymer); Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania (Dwight Stambolian, Anton Orlin); Department of Ophthalmology, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts (Johanna M. Seddon); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (Inga Peter); MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom (Alan F. Wright, Caroline Hayward); Clinical Neurosciences Division, School of Medicine, University of Southampton, Southampton, United Kingdom (Andrew J. Lotery); Southampton Eye Unit, Southampton General Hospital, Southampton, United Kingdom (Andrew J. Lotery); Genetic Epidemiology and Bioinformatics Group, Human Genetics Division, University of Southampton, Southampton, United Kingdom (Sarah Ennis); Departments of Ophthalmology and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California (Michael B. Gorin); Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania (Daniel E. Weeks, Chia-Ling Kuo); University Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom (Aroon D. Hingorani, Reecha Sofat); Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan (Anand Swaroop, Mohammad Othman); Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, Maryland (Anand Swaroop, Atsuhiro Kanda); Center for Statistical Genetics, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan (Wei Chen, Goncalo R. Abecasis); Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom (John R. Yates); Institute of Ophthalmology, University College London, London, United Kingdom (John R. Yates, Andrew R. Webster, Anthony T. Moore, Valentina Cipriani); Moorfields Eye Hospital, London, United Kingdom (John R. Yates, Andrew R. Webster, Anthony T. Moore, Valentina Cipriani); Eye Department, Stavanger University Hospital, University of Bergen, Stavanger, Norway (Johan H. Seland); Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallinn, Estonia (Mati Rahu); Clinique Ophthalmologique, Universitaire de Creteil, Paris, France (Gisele Soubrane); Clinica Oculistica, Unversità degli Studi di Verona, Verona, Italy (Laura Tomazzoli); Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece (Fotis Topouzis); Departamento Salud Publica, University Miguel Hernandez, Alicante, Spain (Jesus Vioque); Consorcio de Investigación Biomédica en Red Especializado en Epidemiología y Salud Pública (CIBERESP), Alicante, Spain (Jesus Vioque); and Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom (Astrid E. Fletcher).
Funding was provided by the Guide Dogs for the Blind Association (Reading, United Kingdom) (grants 2008-5a [Giuliana Silvestri] and OR2006-02d [John R. Yates]); the United Kingdom Medical Research Council (grant G0000067 [John R. Yates]); the Estonian Ministry of Science and Education (grant SF0940026s07 [Mati Rahu]); the Research and Development Office of Northern Ireland Health Personal Social Services (grant RRG 4.5 [Giuliana Silvestri]); EVI-GENORET, an integrated project funded through the European Union Research Project (grant FP6 [Usha Chakravarthy]); the Deutsche Forschungsgemeinschaft (grants WE1259/18-1 and WE1259/19-1 [Bernhard H. Weber]); the Alcon Research Institute and the Ruth and Milton Steinbach Foundation (New York, New York) (Bernhard H. Weber); a Russo Grant from Tufts University School of Medicine (Johanna M. Seddon); the Macular Degeneration Research Fund–Tufts Medical Center (Johanna M. Seddon); the Massachusetts Lions Eye Research Fund (Johanna M. Seddon); Research to Prevent Blindness USA (Michael L. Klein, Peter J. Francis); the Foundation Fighting Blindness (Peter J. Francis); financial support from the United Kingdom Department of Health through an award made by the National Institute for Health Research to Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology for a Specialist Biomedical Research Centre for Ophthalmology (John R. Yates); the JACOM Foundation (Paul N. Baird); and a National Health and Medical Research Council (Canberra, Australia) Practitioner Award (Robyn H. Guymer). The Centre for Eye Research Australia receives operational infrastructure support from the Victorian government (Paul N. Baird, Robyn H. Guymer), the Macular Disease Society (Gareth J. McKay, Andrew J. Lotery), the T. F. C. Frost Charity (Andrew J. Lotery), and the British Council for the Prevention of Blindness (Andrew J. Lotery). Genetic analysis in the European Eye Study was supported by an MRC Biomarker Award (grant G0601354 [Aroon D. Hingorani, Astrid E. Fletcher]).
Conflict of interest: none declared.