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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Neuron Glia Biol. Author manuscript; available in PMC 2011 July 19.
Published in final edited form as:
Neuron Glia Biol. 2010 February; 6(1): 63–71.
Published online 2010 June 22. doi: 10.1017/S1740925X10000098

Fig. 6

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Diagram illustrating the synthesis of GABA from glutamate

Glutamate taken up by SGCs through the GLAST transporter is normally converted to glutamine via GS (see Fig. 4). Introducing the GAD65 transgene into the SGC via an adenovirus (AdGAD65) provides the pathway for the glutamate to be converted to GABA, which is then released by bulk transport to inhibit nearby primary sensory neurons by acting on GABAA receptors.

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