We thank O. Hurtado, K. Eken, K. Richter, and A. Gupta for microfabrication support. We thank C. Vanderburg for help with nucleic acid analysis and use of the Harvard NeuroDiscovery Ceneter Agilent Bioanalyzer 2100. We thank the UF technical staff (A. Abouhamze, C. Tannahill, and R. Ungaro) for managing clinical implementation of the microfluidic devices. K.T.K. was supported with a US National Institutes of Health (NIH) training grant T32 GM-007035-32. These studies were supported by the US NIH, “Inflammation and the Host Response to Injury Large Scale Collaborative Project”, U54 GM-062119, and BioMEMS Resource Center, P41 EB-002503, and Proteomics Research Resource for Integrative Biology, RR018522. The proteomics work was performed in the Environmental Molecular Sciences Laboratory, a U.S. Department of Energy (DOE) Office of Biological and Environmental Research national scientific user facility on the PNNL campus. PNNL is multi-program national laboratory operated by Battelle for the DOE under Contract No. DE-AC05-76RLO 1830.
The magnitude of the clinical and genomic and proteomic data reported here required the efforts of many individuals at participating institutions. In particular, we wish to acknowledge the supportive research environment created and sustained by the participants in the Glue Grant Program:
Henry V. Baker, Ph.D.1, Ulysses G.J. Balis, M.D.2, Timothy R. Billiar, M.D.3, Steven E. Calvano, Ph.D.5, Irshad H. Chaudry, Ph.D.6, J. Perren Cobb, M.D.4, Joseph Cuschieri, M.D.7, Celeste C. Finnerty, Ph.D.9, Richard L. Gamelli10, M.D., Nicole S. Gibran, M.D.7, Brian G. Harbrecht, M.D.11, Douglas L. Hayden, M.A.12, Laura Hennessy, R.N.7, David N. Herndon, M.D.9, Marc G. Jeschke, M.D., Ph.D. 9, Jeffrey L. Johnson, M.D.13, Matthew B. Klein, M.D.7, James A. Lederer, Ph.D.14, Stephen F. Lowry, M.D.2, Ronald V. Maier, M.D.7, John A. Mannick, M.D.14, Philip H. Mason, Ph.D.12, Grace P. McDonald-Smith, M.Ed.12, Joseph P. Minei, M.D.15, Ernest E. Moore, M.D.13, Avery B. Nathens, M.D., Ph.D., M.P.H.16, Grant E. O’Keefe, M.D., M.P.H.7, Laurence G. Rahme, Ph.D.12, Daniel G. Remick, M.D.17, David A. Schoenfeld, Ph.D.12, Michael B. Shapiro, M.D.19, Geoffrey M. Silver, M.D.10, Jason Sperry, M.D., Ph.D.3, John D. Storey, Ph.D.20, Robert Tibshirani, Ph.D.8, H. Shaw Warren, M.D.12, Michael A. West, M.D., PhD.18, and Bram Wispelwey, M.S.12
1 University of Florida, Gainesville, FL 32610, 2 University of Michigan School of Medicine, Ann Arbor, MI 48109, 3 University of Pittsburgh Medical Center, Pittsburgh, PA 15213, 4 Washington University School of Medicine, St. Louis, MO 63110, 5 University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, 6 University of Alabama Medical School, Birmingham, AL 35294, 7 University of Washington, Seattle, WA 98195, 8 Stanford University, Palo Alto, CA 94304, 9 University of Texas Medical Branch, Galveston, TX 77550, 10 Loyola University School of Medicine, Maywood, IL 60153, 11 University of Louisville, Louisville, KY 40292, 12 Massachusetts General Hospital, Boston, MA 02114,13 University of Colorado Health Sciences Center, Denver, CO 80204, 14 Brigham & Women’s Hospital, Boston, MA 02115, 15 University of Texas Southwestern Medical School, Dallas, TX 75390, 16 St. Michael’s Hospital, Toronto, Ontario, CA M5B 1W8, 17 Boston University School of Medicine, Boston, MA 02118, 18 San Francisco General Hospital, San Francisco, CA 04110, 19 Northwestern University, Chicago, IL 60611, 20 Princeton University, Princeton, NJ 08544