Search tips
Search criteria 


Logo of jophthJournal's HomeManuscript SubmissionAims and ScopeAuthor GuidelinesEditorial BoardHome
J Ophthalmol. 2011; 2011: 753741.
Published online 2011 July 10. doi:  10.1155/2011/753741
PMCID: PMC3136150

Using Spectral-Domain Optical Coherence Tomography to Follow Outer Retinal Structure Changes in a Patient with Recurrent Punctate Inner Choroidopathy


Punctate inner choroidopathy (PIC) is a rare idiopathic inflammatory disorder of the retina and choroid usually affecting healthy, young, myopic females and presenting with photopsia, paracentral scotomata, and blurred vision. It is characterized by yellow-white chorioretinal lesions concentrated in the posterior pole, no vitritis, relapsing inflammatory activity of the retina and choroid, and frequent development of choroidal neovascular membranes. Here we describe a case in which spectral-domain optical coherence tomography (SD-OCT) imaging was used to monitor outer retinal structure changes associated with recurrent PIC over time. SD-OCT, which is both quantative and objective, provides an efficient, non-invasive way to follow recurrent inflammatory chorioretinal lesion activity, choroidal neovascular membrane development, and treatment response in patients with recurrent PIC.

1. Report of a Case:

A 21-year-old white myopic female with a history of symptomatic punctate inner choroidopathy (PIC) presented with new photopsias and scotoma in her left eye for several days. She had been symptomatic in her right eye for one year with documented new chorioretinal lesion formation and development of a choroidal neovascular membrane (CNVM) successfully treated with photodynamic therapy (PDT), intravitreal triamcinolone, and intravitreal bevacizumab (Avastin, Genentech, South San Francisco, Calif). Past ocular history was significant for herpetic keratitis for which she was taking acyclovir 400 mg daily.

On exam, visual acuity was 20/20 OU with myopic correction. Anterior chamber and vitreous were without inflammation. Funduscopy showed multiple yellowish-white chorioretinal lesions and a pigmented scar from the CNVM localized within the posterior pole in the right eye, and a focal chorioretinal lesion with fluid just nasal to the fovea in her left eye (Figure 1). When compared to previous fundus photos, the lesion in the left eye was new. No peripheral lesions were present. Fluorescein Angiogram (FA) showed focal leakage, left eye, consistent with CNVM. Indocyanine green (ICG) showed hypofluorescent spots corresponding to the chorioretinal lesions consistent with PIC [1] in both eyes, and a focal area of hyperfluorescence at the edge of the hypofluorescent spot in the left eye, suggesting a CNVM.

Figure 1
Right and left fundus photos of patient with recurrent punctate inner choroidopathy. Right fundus shows multiple yellowish-white chorioretinal lesions, some appear atrophic, localized to the posterior pole. Just inferior to the fovea is a pigmented scar ...

Spectralis spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA; Heldelberg Engineering, Heidelberg, Germany) of the left eye at the initial visit showed retinal pigment epithelium (RPE) elevation with surrounding intraretinal fluid (IRF) consistent with CNVM (Figure 2(b)). Two weeks after treatment with intravitreal bevacizumab, SD-OCT showed resolution of IRF (Figure 2(d)).

Figure 2
Spectralis spectral-domain optical coherence tomography (SD-OCT) images taken at the same location of both eyes over a 5.5-month period in a patient with recurrent punctate inner choroidopathy. (a) and (b) Initial visit. (b) Shows outer retinal irregularity ...

Over the next 2 months, the patient continued to have symptomatic photopsias in both eyes. Clinical exam continued to show no anterior chamber inflammation or vitritis. She was placed on an extended oral prednisone taper. While still on 30 mg of oral prednisone, she experienced an acute increase in photopsias in her right eye. Four days earlier, she had run out of oral acyclovir. SD-OCT was suggestive of recurrent inflammatory lesion activity with new homogeneous outer retinal thickening overlying chorioretinal lesions but with no IRF (Figure 2(e)). The patient was treated with a higher dose of oral prednisone, oral valacyclovir (Valtrex, GlaxoSmithKline, Research Triangle Park, NC, USA), and two intravitreal bevacizumab injections over the next 2 months. Her symptoms resolved, and SD-OCT showed improvement in thickening over the chorioretinal lesions. Vision is still 20/20 OU.

2. Discussion

First described by Watzke et al. in 1984, PIC is a rare idiopathic inflammatory disorder of the retina and choroid usually affecting healthy, young, myopic females and presenting with photopsia, paracentral scotomata, and blurred vision [2]. Initial symptoms are usually unilateral although exam shows bilateral disease [2, 4]. Clinically, yellow-white chorioretinal lesions ranging in size from 100 to 300 microns are concentrated in the posterior pole and there is no vitreous inflammation [3].

Vision loss with PIC is usually secondary to development of CNVMs which can occur in 40–76% of patients [25]. Recently, intravitreal anti vascular endothelial growth factor (anti-VEGF) agents has been shown to be very effective in the treatment of CNVM associated with PIC [68]. SD-OCT imaging in our patient documented a great treatment response after intravitreal bevacizumab injection with resolution of IRF just 2 weeks after treatment.

PIC is characterized by relapsing inflammatory activity of the retina and choroid [9]. Unlike with CNVM where IRF was visualized, SD-OCT showed a homogenous thickening over the chorioretinal lesions with recurrent inflammatory activity. In this patient, her recurrent PIC may be associated with a viral etiology, as symptoms increased and SD-OCT documented outer retinal changes suggesting recurrent inflammatory activity shortly after cessation of chronic antiviral therapy. After restarting both immunosuppressive and antiviral therapy, both symptoms and SD-OCT findings improved.

SD-OCT gives excellent detail of outer retinal structures in patients with PIC. In this patient with recurrent PIC, SD-OCT imaging provided a quantitative and objective way to monitor outer retinal structure changes associated with CNVM development, treatment response, and recurrent inflammatory chorioretinal lesion activity. Given it is noninvasive, SD-OCT may prove to be a very effective way to monitor and better understand pathology in patients with PIC who develop CNVM and/or recurrent inflammatory activity.


This work was supported in part by an unrestricted grant from Research to Prevent Blindness, the Thomas M. Aaberg, Sr., Retina Research Fund and National Institutes of Health grant P30EY001931. This investigation was conducted in a facility constructed with support from the Research Facilities Improvement Program, grant number C06 RR-RR016511, from the National Center for Research Resources, National Institutes of Health. Dr. Carroll is the recipient of a career development award from Research to Prevent Blindness.


1. Levy J, Shneck M, Klemperer I, Lifshitz T. Punctate inner choroidopathy: resolution after oral steroid treatment and review of the literature. Canadian Journal of Ophthalmology. 2005;40(5):605–608. [PubMed]
2. Watzke RC, Packer AJ, Folk JC, Benson WE, Burgess D, Ober RR. Punctate inner choroidopathy. American Journal of Ophthalmology. 1984;98(5):572–584. [PubMed]
3. Kedhar SR, Thorne JE, Wittenberg S, Dunn JP, Jabs DA. Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation. Retina. 2007;27(9):1174–1179. [PubMed]
4. Brown J, Jr., Folk JC, Reddy CV, Kimura AE. Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. Ophthalmology. 1996;103(7):1100–1105. [PubMed]
5. Gerstenblith AT, Thorne JE, Sobrin L, et al. Punctate inner choroidopathy. A survey analysis of 77 persons. Ophthalmology. 2007;114(6):e1201–e1204. [PubMed]
6. Chan WM, Lai TYY, Liu DTL, Lam DSC. Intravitreal bevacizumab (Avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. American Journal of Ophthalmology. 2007;143(6):977–e1. [PubMed]
7. Mangat SS, Ramasamy B, Prasad S, Walters G, Mohammed M, McKibbin M. Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. Seminars in Ophthalmology. 2011;26(1):1–3. [PubMed]
8. Menezo V, Cuthbertson F, Susan DM. Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. Retina. 2010;30(9):1400–1404. [PubMed]
9. Cirino AC, Mathura JR, Jr., Jampol LM. Resolution of activity (choroiditis and choroidal neovascularization) of chronic recurrent punctate inner choroidopathy after treatment with interferon B-1A. Retina. 2006;26(9):1091–1092. [PubMed]

Articles from Journal of Ophthalmology are provided here courtesy of Hindawi Publishing Corporation