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Cell Stress Chaperones. Sep 1997; 2(3): 162–167.
PMCID: PMC312993
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury
J.-C. L. Plumier,1 A. M. Krueger,1 R. W. Currie,1 D. Kontoyiannis,2 G. Kollias,2 and G. N. Pagoulatos3
1Laboratory of Molecular Neurobiology, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
2Department of Molecular Genetics, Hellenic Pasteur Institute, Athens 11521, Greece
3Laboratory of General Biology, University of Ioannina Medical School, Ioannina 45332, Greece
Received February 12, 1997; Revised April 14, 1997; Accepted April 23, 1997.
Using transgenic mice constitutively expressing the human inducible Hsp70, we examined the role of Hsp70 on cell survival after focal cerebral oschemia. Twenty-four hours after premanent occlusion of the middle cerebral artery, no difference in infarct area was detected between Hsp70-transgenic and non-transgenic mice. In the non-transgenic mice, many pyramidal neurons of the ipsilateral hippocampus were observed to be pykontic. However, in all Hsp70-transgenic mice, hippocampal pyramidal neurons showed normal morphology and no evidence of pyknosis. This suggests that constitutive expression of Hsp70 reduces the extent of damage following permanent middle cerebral artery occlusion.
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