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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Pain Med. Author manuscript; available in PMC Jun 1, 2012.
Published in final edited form as:
PMCID: PMC3117100
NIHMSID: NIHMS280647
Prescription Analgesic Use Among Young Adults: Adherence to Physician Instructions and Diversion
Amelia M. Arria, Ph.D.,1,2* Laura M. Garnier-Dykstra, M.A.,1 Kimberly M. Caldeira, M.S.,1 Kathryn B. Vincent, M.A.,1 and Kevin E. O’Grady, Ph.D.3
1 Center on Young Adult Health and Development, University of Maryland School of Public Health, Department of Family Science, College Park, MD
2 Treatment Research Institute, Philadelphia, PA
3 Department of Psychology, University of Maryland, College Park, MD
* Corresponding Author and Reprint Requests: Amelia M. Arria, Director, Center on Young Adult Health and Development, 8400 Baltimore Avenue, Suite 100, College Park, MD 20740, USA. Phone: 1-301-405-9795; Fax: 1-301-314-1013; aarria/at/umd.edu
Objectives
To understand the extent to which medication adherence was related to diversion of prescription analgesics.
Design
Cross-sectional analyses of data from the College Life Study, a prospective study of young adults.
Setting
Participants were originally sampled as incoming first-time first-year college students from one large public university in the mid-Atlantic U.S.
Participants
192 young adults aged 21 to 26 who were prescribed an analgesic to treat acute pain in the past year.
Outcome Measure
Diversion of prescription analgesics. The study tested two competing hypotheses: 1) individuals who skip doses (Under-Users) are at greatest risk for diversion because they have leftover medication; and 2) individuals who over-use their prescriptions (Over-Users) are at greatest risk for diversion, perhaps because of a general propensity to engage in deviant behavior.
Results
58% followed physician’s instructions regarding their prescription analgesic medication;27% under-used and 16% over-used their prescribed medication. Twenty-seven percent of the total sample diverted their medication, with Over-Users being the most likely to divert (63%). Holding constant demographic characteristics and perceived harmfulness of nonmedical use, Over-Users were almost five times as likely as Adherent Users to divert analgesic medications (P<.05).
Conclusions
Further research is needed to better understand the relationship between adherence and diversion. If these findings are replicated, physicians who are involved in pain management for acute conditions among young adults should take steps to monitor adherence and reduce diversion of prescription analgesics.
Keywords: Diversion, Medication Adherence, Opioids, Prescription Analgesics, Young Adults
Analgesic medications are one of the most commonly prescribed classes of drugs in the U.S. (1, 2), with a total of 230.7 million prescriptions written in 2006 (3). In the wake of pain management awareness initiatives and the “pain as the 5th vital sign” campaign, prescribing of both nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids (including strong opioids) to treat acute pain has increased over the past several decades (4). An estimated 19% of the U.S. population purchased at least one prescription analgesic medication in 2006 (3). While these medications are generally highly effective for pain management, serious medical consequences have been noted (57), including overdose deaths (810). Recent research suggests that prescription analgesics are the most commonly diverted class of medication (11), with one study showing that among college students prescribed an analgesic in the past year, 26% were approached to divert their medication (12). In another recent study, 35% of college students had diverted a prescription analgesic in their lifetime (13).
It is plausible that diversion is related to the extent to which patients adhere to their prescribing physicians’ instructions. Surprisingly little research has investigated the connection between medication adherence and diversion of prescription analgesics. Additionally, despite a growing body of literature examining adherence and misuse among chronic pain patients (1419), little is known about medication adherence in patients with acute pain, especially among young adults—the age group at highest risk for nonmedical use of prescription analgesics (20).
The present study had two aims: 1) to understand the extent to which young adults followed physician instructions with regard to a prescription for analgesic medications; and 2) to describe the association between medication adherence and diversion. Prior research has demonstrated that non-adherence can take two forms: skipping doses (under-use) and taking more than prescribed (over-use). In this study, we tested two competing hypotheses: 1) individuals who skip doses are at greatest risk for diversion, since they would tend to have extra unused doses available; and 2) individuals who over-use their own prescriptions might be at greater risk for diversion because they might tend to engage in deviant behavior and perceive nonmedical use as less harmful than adherent users.
Parent Study Design
Data were derived from the College Life Study, an ongoing longitudinal prospective study of 1,253 young adults originally sampled as incoming first-year college students at a large public university in the mid-Atlantic region of the U.S. During summer orientation in 2004, students were recruited to participate in the study. Students who used an illicit drug or nonmedically used a prescription drug at least once during high school were deliberately oversampled. Sometime during their first year of college, they completed a two-hour interview, which was repeated annually, regardless of continued college enrollment. Details of recruitment and interview procedures can be found elsewhere (21). Interviews were administered by trained interviewers. The study was approved by the University Institutional Review Board and a Federal Certificate of Confidentiality was obtained. Data for the present analyses are taken from interviews conducted during Years 5, 6, and 7. Incentive payments varied by assessment; at Year 5, participants received $70, plus a $20 bonus for on-time completion. The on-time completion bonus was increased to $30 for Years 6 and 7.
Participants
The analytic sample consisted of 192 individuals, ages 21 to 26, inclusive, who were prescribed an analgesic in the past year at one or more of the three assessments. Individuals with a past-year analgesic prescription at more than one time point were only counted once, using the first year in which they had a prescription. Of the 192, the majority (89%, n=171) were prescribed opioid analgesics, 12 (6%) were prescribed non-opioids (primarily NSAIDs), and 9 (5%) could not remember the name of their medication. All 192 had acute pain conditions [e.g., surgeries (including dental procedures), broken bones, torn ligaments, muscle spasms]; none had chronic pain conditions. A wide variety of medications were prescribed, the most common of which were hydrocodone/acetaminophen combinations and oxycodone/acetaminophen combinations. The sample was 50% male, 71% White, and did not differ demographically from participants not prescribed an analgesic.
Measures
Demographics
Race was self-reported. Family income was approximated by the mean adjusted gross income for each participant’s home ZIP code during their last year in high school (22).
Diversion
Participants were asked how many times in the past year they had shared, sold, and/or traded their prescription analgesic medication. Individuals who reported any of these behaviors were categorized as past-year diverters.
Defining adherence
Participants were asked about the instructions their physician gave them regarding how to take their analgesic medication. Most were able to recall a specific amount (e.g., “one tablet”) and frequency (e.g., “every four to six hours”). Participants were then asked to describe their actual use. Adherence was defined as agreement between the physician’s instructions and the individual’s behavior. Individuals were divided into three adherence categories: 1) Under-Users, who took medication either less often than was prescribed, sporadically (e.g., when they remembered), or not at all; 2) Adherent Users, who took their medication as prescribed; and 3) Over-Users, who took their medication more often than prescribed.
Perceived harmfulness of nonmedical use of prescription analgesics
At Year 4, perceived harmfulness was assessed via a question adapted from the Monitoring the Future survey (23): “How much do you think people risk harming themselves(physically or in other ways) by taking someone else’s prescription pain relievers occasionally?” Responses were dichotomized into “moderate/great risk” and “no/slight risk”. Three individuals who responded “can’t say/drug unfamiliar” were grouped into the latter category on the assumption that if they were unfamiliar with the drug, they were unlikely to believe it was harmful.
Statistical Analysis
Fisher’s exact tests were used to compare the prevalence of diversion among the three groups. Multivariate logistic regression analyses were performed to examine whether differences between groups remained statistically significant after adjusting for sex, race, family income, perceived harmfulness of nonmedical use, and type of analgesic (i.e., non-opioid, opioid analgesic). The nine individuals who did not know the type of analgesic that they were prescribed were dropped from the statistical model [i.e., it predicted “failure” (diversion) perfectly].
Over half of the sample met our criteria for adherent use of their prescription analgesics in the past year (58%, n=111). The remaining 42%(n=81) used their prescribed analgesic inconsistently with their physician’s instructions, either by under-use (27%, n=51) or over-use (16%, n=30). The three groups were similar with respect to demographic characteristics and perceived harmfulness of nonmedical use (Table 1).
Table 1
Table 1
Demographic characteristics by adherence grouping and logistic regression examining associations between diversion and adherence
Overall, more than a quarter (27%, n=51) of participants (29% of those prescribed opioids and 17% of those prescribed non-opioids) diverted their prescribed analgesic. As shown in Figure 1, Over-Users had the highest proportion of diverters (63%). Table 1 shows that, even after controlling for demographic characteristics, perceived harmfulness of nonmedical use, and type of analgesic prescribed, Over-Users were significantly more likely than Adherent Users to divert their analgesic medication (AOR=4.99, 95%CI=1.88–13.26; P=.001). Under-Users did not statistically differ from Adherent Users with respect to their likelihood to divert. Over-Users were more than eight times as likely as Under-Users to divert their medication (AOR=8.03, 95%CI=2.52–25.59; P<0.001; data not shown in table).
Figure 1
Figure 1
Diversion of prescription analgesics by adherence grouping among young adults prescribed an analgesic medication in the past year (n=192).
The finding that 42% of the sample used their analgesic medication in a way that was inconsistent with their physician’s instructions (27% under-used, 16% over-used) comports with prior evidence from chronic pain patients (18, 2426). We found no support for our first hypothesis that Under-Users would be more likely to divert due to having extra unused doses. However, the second hypothesis was supported, with Over-Users almost five times as likely as Adherent Users and more than eight times as likely as Under-Users to share, sell, or trade their medication. Particularly concerning is that these individuals had sufficient medication from the prescription to both over-use it and divert it.
Limitations
The study results may not be generalizable to all young adult populations. Because data were obtained by self-report, the findings are subject to recall bias, although this problem was minimized by focusing on the individual’s most recent analgesic prescription in the past year. To provide a more nuanced view of analgesic medication adherence, future studies should collect more detailed information about the exact number of pills prescribed and used. It would be helpful to know the final disposition of all unused doses. Even among Under-Users who are unlikely to divert their medication, unused doses that have not been properly disposed of provide an ongoing opportunity for nonmedical use by someone else via theft or other means. More detailed information regarding the outcome of these unused does in addition to how doses were diverted (e.g., sharing, selling, trading) and to whom would also be valuable.
Implications
Additional research is warranted to better understand the relationships between medication adherence, diversion, and nonmedical use. Future research should investigate more details regarding adherence behavior, including history of adherence to physician instructions, the number of pills prescribed for various conditions, and patient attitudes regarding diversion.
The findings of this study should be tempered with caution because of the homogenous nature of the sample (young adults with acute pain) and the small sample size. If replicated, these results could have significant implications for clinical practice for physicians with young adult patients. Because many analgesic medications have addiction potential, it is important to balance necessary pain management with “judicious dosing”, as suggested by McLellan and Turner (1) to minimize the risk of diversion and subsequent nonmedical use. Given that dental pain/surgery were reported reasons for being prescribed an analgesic and wisdom tooth extraction is a common procedure for young adults, developing specific prescribing guidelines for dentists and oral surgeons to reduce diversion might be beneficial. Aside from serious concerns about the potential for diversion and nonmedical use, excessive dosing is at odds with efforts to control health care costs, which have become a national priority.
Prior research with adolescents and young adults has identified that individuals with a history of conduct problems and illicit drug involvement are at increased risk for diversion of prescription medications (13); thus, close oversight, including follow-up visits (27), are recommended for individuals with these characteristics. However, these characteristics might not be identifiable to clinicians outside of psychiatric service settings. Therefore monitoring for adherence to physician’s instructions when given a prescription for opioid analgesics and cautioning against diversion in all patients might be necessary. Given that the prevalence of over-use was low among those prescribed a non-opioid analgesic, these drugs should be considered as an alternative to opioid analgesics in cases of acute pain to decrease the likelihood of over-use. Because of concerns regarding opioid use, prescribing of NSAID analgesics in all but severe pain cases is still advocated as the first course of action in treating acute pain, to be followed by prescription opioids if needed (28, 29).
Acknowledgments
This study was funded by the National Institute on Drug Abuse (R01DA14845, Dr. Arria, PI). Special thanks are extended to Emily Winick, the interviewing team, and the participants.
Footnotes
Disclosure
None of the authors has any financial disclosures to report.
1. McLellan AT, Turner BJ. Chronic noncancer pain management and opioid overdose: Time to change prescribing practices. Ann Intern Med. 2010;152:123–24. [PubMed]
2. Kuehn BM. Opioid prescriptions soar: Increase in legitimate use as well as abuse. JAMA. 2007;297:249–51. [PubMed]
3. Stagnitti MN. Trends in outpatient prescription analgesics utilization and expenditures for the U.S. civilian noninstitutionalized population, 1996 and 2006. Rockville, MD: Agency for Healthcare Research and Quality; 2009.
4. Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain. 2004;109:514–19. [PubMed]
5. Coben JH, Davis SM, Furbee PM, Sikora RD, Tillotson RD, Bossarte RM. Hospitalizations for poisoning by prescription opioids, sedatives, and tranquilizers. Am J Prev Med. 2010;38:517–24. [PubMed]
6. Manchikanti L, Fellows B, Ailinani H, Pampati V. Therapeutic use, abuse, and nonmedical use of opioids: a ten-year perspective. Pain Physician. 2010;13:401–35. [PubMed]
7. Drug Abuse Warning Network. The New DAWN Report: Emergency department visits involving nonmedical use of selected pharmaceuticals. Substance Abuse and Mental Health Services Administration; 2006.
8. Paulozzi LJ, Budnitz DS, Xi Y. Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006;15:618–27. [PubMed]
9. Dunn KM. Opioid prescriptions for chronic pain and overdose: A cohort study. Ann Intern Med. 2010;152:85–92. [PMC free article] [PubMed]
10. Okie S. A flood of opioids, a rising tide of deaths. N Engl J Med. 2010:1981. [PubMed]
11. Inciardi JA, Surratt HL, Kurtz SP, Burke JJ. The diversion of prescription drugs by health care workers in Cincinnati, Ohio. Subst Use Misuse. 2006;41:255–64. [PubMed]
12. McCabe SE, Teter CJ, Boyd CJ. Medical use, illicit use, and diversion of abusable prescription drugs. J Am Coll Health. 2006;54:269–78. [PMC free article] [PubMed]
13. Garnier LM, Arria AM, Caldeira KM, Vincent KB, O’Grady KE, Wish ED. Sharing and selling of prescription medications in a college student sample. J Clin Psychiatry. 2010;71:262–69. [PMC free article] [PubMed]
14. Kouyanou K, Pither CE, Wessely S. Medication misuse, abuse and dependence in chronic pain patients. J Psychosom Res. 1997;43:497–504. [PubMed]
15. Lai Y-H, Keefe FJ, Sun W-Z, Tsai L-Y, Cheng P-L, Chiou J-F, et al. Relationship between pain-specific beliefs and adherence to analgesic regimens in Taiwanese cancer patients: A preliminary study. J Pain Symptom Manage. 2002;24:415–23. [PubMed]
16. Manchikanti L, Manchukonda R, Pampati V, Damron KS. Evaluation of abuse of prescription and illicit drugs in chronic pain patients receiving short-acting (hydrocodone) or long-acting (methadone) opioids. Pain Physician. 2005;8:257–61. [PubMed]
17. Ives TJ, Chelminski PR, Hammett-Stabler CA, Malone RM, Perhac JS, Potisek NM, et al. Predictors of opioid misuse in patients with chronic pain: A prospective cohort study. BMC Health Serv Res. 2006;6:46–46. [PMC free article] [PubMed]
18. Dobkin PL, Sita A, Sewitch MJ. Predictors of adherence to treatment in women with fibromyalgia. Clin J Pain. 2006;22:286–94. [PubMed]
19. Berndt S, Maier C, Schultz HW. Polymedication and medication compliance in patients with chronic non-malignant pain. Pain. 1993;52:331–39. [PubMed]
20. Substance Abuse and Mental Health Services Administration. The NSDUH Report. Rockville, MD: Office of Applied Studies; 2009. Trends in nonmedical use of prescription pain relievers: 2002 to 2007.
21. Arria AM, Caldeira KM, O’Grady KE, Vincent KB, Fitzelle DB, Johnson EP, et al. Drug exposure opportunities and use patterns among college students: Results of a longitudinal prospective cohort study. Subst Abus. 2008;29:19–38. [PMC free article] [PubMed]
22. MelissaDATA. Income tax statistics lookup. 2003.
23. Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE. College students and adults ages 19–45 (NIH Publication No. 08-6418B) II. Bethesda, MD: National Institute on Drug Abuse; 2008. Monitoring the Future national survey results on drug use, 1975–2007; pp. 1–342.
24. de Klerk E, van der Linden S. Compliance monitoring of NSAID drug therapy in ankylosing spondylitis, experiences with an electronic monitoring device. Br J Rheumatol. 1996;35:60–65. [PubMed]
25. Deyo RA, Inui TS, Sullivan B. Noncompliance with arthritis drugs: Magnitude, correlates, and clinical implications. J Rheumatol. 1981;8:931–36. [PubMed]
26. Sewitch MJ, Dobkin PL, Bernatsky S, Baron M, Starr M, Cohen M, et al. Medication non-adherence in women with fibromyalgia. Rheumatology. 2004;43:648–54. [PubMed]
27. McLellan AT, Turner BJ. Prescription opioids, overdose deaths, and physician responsibility. JAMA. 2008;300:2672–73. [PubMed]
28. Bartels CL. Nonsteroidal anti-inflammatory drugs in acute pain management. Journal of Pharmaceutical Care in Pain & Symptom Control. 1993;1:21–38.
29. Phero JC, Becker DE, Dionne RA. Contemporary trends in acute pain management. Curr Opin Otolaryngol Head Neck Surg. 2004;12:209–16. [PubMed]