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Logo of bmcpsycBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Psychiatry
 
BMC Psychiatry. 2011; 11: 74.
Published online May 4, 2011. doi:  10.1186/1471-244X-11-74
PMCID: PMC3113739
A comparative study on long-term evoked auditory and visual potential responses between Schizophrenic patients and normal subjects
Min-Wei Huang,1,3 Frank Huang-Chih Chou,2 Pei-Yu Lo,1 and Kuo-Sheng Chengcorresponding author1
1Institute of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan
2Kai-Suan Psychiatric Hospital, Kaohsiung 802, Taiwan
3Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chia-Yi 600, Taiwan
corresponding authorCorresponding author.
Min-Wei Huang: hminwei/at/gmail.com; Frank Huang-Chih Chou: f50911.tw/at/yahoo.com.tw; Pei-Yu Lo: peiyulo/at/gmail.com; Kuo-Sheng Cheng: kscheng/at/mail.ncku.edu.tw
Received September 10, 2010; Accepted May 4, 2011.
Abstract
Background
The electrical signals measuring method is recommended to examine the relationship between neuronal activities and measure with the event related potentials (ERPs) during an auditory and a visual oddball paradigm between schizophrenic patients and normal subjects. The aim of this study is to discriminate the activation changes of different stimulations evoked by auditory and visual ERPs between schizophrenic patients and normal subjects.
Methods
Forty-three schizophrenic patients were selected as experimental group patients, and 40 healthy subjects with no medical history of any kind of psychiatric diseases, neurological diseases, or drug abuse, were recruited as a control group. Auditory and visual ERPs were studied with an oddball paradigm. All the data were analyzed by SPSS statistical software version 10.0.
Results
In the comparative study of auditory and visual ERPs between the schizophrenic and healthy patients, P300 amplitude at Fz, Cz, and Pz and N100, N200, and P200 latencies at Fz, Cz, and Pz were shown significantly different. The cognitive processing reflected by the auditory and the visual P300 latency to rare target stimuli was probably an indicator of the cognitive function in schizophrenic patients.
Conclusions
This study shows the methodology of application of auditory and visual oddball paradigm identifies task-relevant sources of activity and allows separation of regions that have different response properties. Our study indicates that there may be slowness of automatic cognitive processing and controlled cognitive processing of visual ERPs compared to auditory ERPs in schizophrenic patients. The activation changes of visual evoked potentials are more regionally specific than auditory evoked potentials.
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