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Eur Spine J. 2011 July; 20(Suppl 2): 176–179.
Published online 2010 June 20. doi:  10.1007/s00586-010-1484-9
PMCID: PMC3111511

Spontaneous cervical epidural hematoma during pregnancy: case report and literature review

Abstract

Spontaneous spinal epidural hematoma (SSEH) during pregnancy is rare and may result in permanent damage if not promptly treated. There were few studies discussing the etiology, presentation and treatment of SSEH during pregnancy. The authors describe a case of spontaneous cervical epidural hematoma during pregnancy, which was diagnosed by magnetic resonance imaging (MRI) and managed with surgical evacuation. A retrospective review of a case of spontaneous epidural hematoma of spine during pregnancy was performed. The clinical features, diagnoses, treatments and outcomes of all cases were analyzed. Precise diagnosis without delay and rapid surgical treatment are essential for the management of SSEH during pregnancy.

Keywords: Epidural hematoma, Spine, Spontaneous, Pregnancy

Introduction

Spontaneous epidural hematoma of the spine is uncommon. Since Jackson [1] reported the first case of SSEH in 1869, approximately 400 cases have been reported [2], only 11 of which occurred during pregnancy. Because of its rarity and atypical symptoms, its prompt diagnosis is difficult and its etiology remains unclear.

We describe a rare case of acute SSEH during pregnancy, and discuss the etiology, presentation and management of this entity based on the histological findings of this patient and the retrospective review of other similar cases.

Case report

A healthy 29-year-old woman was admitted at 40 weeks 2 days of gestation with a complete paraplegia and weakness of the upper extremities. Seventeen hours before her admission she noted the sudden onset of severe neck pain not associated with any physical activity. Nine hours before admission she developed progressive weakness in extremities along with sensory loss in her legs and torso extending from the nipple line downward. She was taking only prenatal vitamins before admission. Her past medical history was unremarkable.

On admission, the patient’s neurological examination was remarkable for grade 3/5 weakness in deltoids, biceps, and grade 0/5 weakness in wrist extensors, finger intrinsics, triceps and lower extremities. The patient had a loss of sensation to pinprick and light touch below T4 level and a loss of proprioception in her lower extremities. She had no volitional rectal tone.

Laboratory studies, including platelet count, prothrombin time and protime, were all within normal limits. An urgent MRI of spine was performed, which demonstrated an intraspinal mass located within the posterior spinal canal at C5–C7 level. The signal characteristics of the mass suggested a well-defined epidural hematoma (Fig. 1a, b).

Fig. 1
Sagittal (a) and axial (b) T1-weighted MRI of the cervical spine showing an epidural hematoma (arrowhead) compressing the spinal cord from the C5 to the C7 level. c Intraoperative finding: a thick hematoma (ellipse) existed from the C5 to the C7 level ...

An obstetrical consultation was obtained, and the gestational age of 40 weeks was confirmed. A decision was made to first proceed with a cesarean section under local anesthesia followed by a cervical laminectomy for removal of the epidural hematoma. The cesarean section was uneventful, and a healthy female infant was delivered. The patient was then turned into the prone position, and a laminectomy was performed at C4–C6 level. An acute hematoma was found, gently manipulated with a never hook and removed (Fig. 1c, d). No overt bleeding source was identified within the spinal canal. Histopathologic examination of the removed clot revealed “a simple hematoma” (Fig. 2). There was no evidence for a vascular malformation.

Fig. 2
Histopathologic examination (Hematoxylin and Eosin stain ×10) of the surgical specimen showing hemorrhagic material (black arrow) and vascular cluster coagulation (white arrow)

By postoperative day 1, the patient rapidly regained both superficial sensation and proprioception with some movement in her distal lower extremities. 2 months after surgery, she regained some movement in her wrist extensors, finger intrinsics, triceps and distal lower extremities. In follow-up 6 months post-surgery, MR imaging showed successful decompression of the spinal cord and revealed a spinal parenchymal change at C6 level (Fig. 1e, f). The patient still has impaired sensation in fingers, but is able to walk without assistance.

Discussion

The SSEH is a rare but important neurological emergency, which represents 0.3–0.9% of all epidural space-occupying lesions [3]. The etiology of SSEH is generally unknown. Some predisposing factors include anticoagulant therapy [4], vascular malformation [5], hemophilia [6] and cocaine abuse [7], all suggested to be correlated with SSEH.

Spontaneous epidural hematomas of the spine during pregnancy have been infrequently reported. A PubMed review of the English literature from January 1966 to December 2009 for the terms “Spontaneous spinal epidural hematoma” and “Pregnancy” yielded only 11 reported cases (Table 1). The etiology in most cases remains unknown and may be multifactorial. However, the most widely accepted hypothesis is that of venous bleeding. Epidural veins belong to primitive valveless system. Sudden changes in central venous pressure, such as those that can occur with straining or coughing, can be transmitted directly from visceral cavities to epidural veins. Nystrom [8] found that increased intraabdominal pressure indeed elevates porcine epidural venous pressure. In the 12 reported cases (including current report), 10 cases occurred in the late stages of pregnancy. During the late stages of pregnancy, as the uterus and fetus enlarge, the abdominal/pelvic venous dynamics are altered. This fluctuation in venous pressures has been reported to potentially lead to a rupture of a preexisting pathologic venous wall [9].

Table 1
Summary of report cases of spontaneous spinal epidural hematoma during pregnancy

In most SSEH cases, clinical manifestations typically include acute and significant back or neck pain with an associated progressive neurological deficit depending on the spinal level of involvement as well as the degree of neural compression. MRI is the diagnostic imaging modality of choice, which will provide information about location, extent of the hematoma and the degree of cord compression. The SSEH most often is located in the thoracic region because the epidural venous plexus is mostly prominent in the thoracic spine [10]. In our case hematoma located in cervical region, which is different from most other cases, may result in more serious damage.

Numerous studies have stated that only a short time interval from the onset of symptoms to the decompression of the spinal cord correlates with good neurological outcome. Groen [11] reviewed 330 cases of spontaneous epidural hematomas, and concluded that treatment outcome was favorable for patients with incomplete preoperative sensorimotor deficit, and recovery was significantly improved when decompression was performed within 36 h in patients with complete deficits and within 48 h in patients with incomplete deficits. Based on our experience and the previously published case, no harm came to the fetuses despite the surgery for spinal cord decompression. Therefore, we advocate aggressive surgical management for SSEH during pregnancy as soon as possible. Surgical decision-making should involve a multidisciplinary team including members from obstetrics, anesthesia and spine surgery. Treatment decisions during pregnancy depend on the fetal maturity. Cesarean delivery followed by surgical spinal decompression may be advantageous because the early delivery of the fetus decreases epidural venous engorgement and facilitates the performance of decompression. In our opinion, if the gestational age of the fetus permits cesarean section, delivery of the fetus should be performed immediately prior to the spinal decompression. Otherwise, spinal decompression should be performed first without taking the consideration of fetus’ age for cesarean operation. In the latter case, we would adopt a watch-and-wait policy in monitoring the fetus. The risk/benefit decision on whether steroids should be used to enhance fetal maturation should be made in close liaison between the spinal surgeons and obstetricians. Protocols for close monitoring of the patient’s neurological status and the fetal maturity should be implanted. Once the fetal maturates, vaginal delivery or cesarean section will be performed. In the 12 cases (including current report), 9 cases were performed cesarean section first, followed by laminectomy and evacuation of hematoma, resulting in improved neurologic status. However, all reported cases had not fully recovered neurologically at the time of discharge and required a long-term prognosis to rehabilitate.

Conclusion

The SSEH during pregnancy is an acute neurologic emergency that mandates prompt recognition and treatment. The diagnosis should be suspected in the setting of acute and significant back or neck pain with an associated progressive neurological deficit. MRI plays an especially important diagnostic role. Functional recovery is related directly to the interval between symptom onset and surgical decompression. Emergent surgical decompression should be performed as rapidly as possible.

Conflict of interest statement

None of the authors has any potential conflict of interest.

Contributor Information

Peng Wang, pwang120/at/gmail.com.

Xiao-tang Xin, Phone: +86-631-5287489, Fax: +86-631-5287489, xinxiaotang/at/gmail.com.

References

1. Jackson R. Case of spinal apoplexy. Lancet. 1869;94(2392):5–6. doi: 10.1016/S0140-6736(02)67624-X. [Cross Ref]
2. Liu Z, Jiao Q, Xu J, et al. Spontaneous spinal epidural hematoma: analysis of 23 cases. Surg Neurol. 2008;69(3):253–260. doi: 10.1016/j.surneu.2007.02.019. [PubMed] [Cross Ref]
3. Alexiadou-Rudolf C, Ernestus RI, Nanassis K, et al. Acute nontraumatic spinal epidural hematomas. An important differential diagnosis in spinal emergencies. Spine. 1998;23(1):1810–1813. doi: 10.1097/00007632-199808150-00018. [PubMed] [Cross Ref]
4. Vaya A, Resureccion M, Ricart JM, et al. Spontaneous cervical epidural hematoma associated with oral anticoagulant therapy. Clin Appl Thromb Hemost. 2001;7(2):166–168. doi: 10.1177/107602960100700215. [PubMed] [Cross Ref]
5. Miyagi Y, Miyazono M, Kamikaseda K. Spinal epidural vascular malformation presenting in association with a spontaneously resolved acute epidural hematoma. J Neurosurg. 1998;88(5):909–911. doi: 10.3171/jns.1998.88.5.0909. [PubMed] [Cross Ref]
6. Leach M, Makris M, Hampton KK, et al. Spinal epidural haematoma in haemophilia A with inhibitors—efficacy of recombinant factor VIIa concentrate. Haemophilia. 1999;5(3):209–212. doi: 10.1046/j.1365-2516.1999.00301.x. [PubMed] [Cross Ref]
7. Samkoff LM, Daras M, Kleiman AR, et al. Spontaneous spinal epidural hematoma. Another neurologic complication of cocaine? Arch Neurol. 1996;53(8):819–821. [PubMed]
8. Nystrom EU, Blomberg SG, Buffington CW, et al. Transmural pressure of epidural veins in the thoracic and lumbar spine of pigs. Anesthesiology. 1998;89(2):449–455. doi: 10.1097/00000542-199808000-00022. [PubMed] [Cross Ref]
9. Yonekawa Y, Mehdorn HM, Nishikawa M, et al. Spontaneous spinal epidural hematoma during pregnancy. Surg Neurol. 1975;3(6):327–328. [PubMed]
10. Groen RJ, Groenewegen HJ, Alphen HA, et al. Morphology of the human internal vertebral venous plexus: a cadaver study after intravenous araldite CY 221 injection. Anat Rec. 1997;249(2):285–294. doi: 10.1002/(SICI)1097-0185(199710)249:2<285::AID-AR16>3.0.CO;2-K. [PubMed] [Cross Ref]
11. Groen RJ, Alphen HA, et al. Operative treatment of spontaneous spinal epidural hematomas: a study of the factors determining postoperative outcome. Neurosurgery. 1997;39(3):494–508. [PubMed]
12. Bidzinski J (1966) Spontaneous spinal epidural hematoma during pregnancy. Case report. J Neurosurg 24(6):1017. [PubMed]
13. Carroll SG, Malhotra R, Eustace D et al (1997) Spontaneous spinal extradural hematoma during pregnancy. J Matern Fetal Med 6(4):218–219. [PubMed]
14. Steinmetz MP, Kalfas IH, Willis B et al (2003) Successful surgical management of a case of spontaneous epidural hematoma of the spine during pregnancy. Spine J 3(6):539–542. [PubMed]
15. Masski G, Housni B, Ibahiouin K et al (2004) Spontaneous cervical epidural haematoma during pregnancy. Int J Obstet Anesth 13(2):103–106. [PubMed]
16. Cywinski JB, Parker BM, Lozada LJ (2004) Spontaneous spinal epidural hematoma in a pregnant patient. J Clin Anesth 16(5):371–375. [PubMed]
17. Szkup P, Stoneham G (2004) Case report: spontaneous spinal epidural haematoma during pregnancy: case report and review of the literature. Br J Radiol 77(922):881–884. [PubMed]
18. Kelly ME, Beavis RC, Hattingh S (2005) Spontaneous spinal epidural hematoma during pregnancy. Can J Neurol Sci 32(3):361–365. [PubMed]
19. Jea A, Moza K, Levi AD et al (2005) Spontaneous spinal epidural hematoma during pregnancy: case report and literature review. Neurosurgery 56(5):E1156. [PubMed]
20. Doblar DD, Schumacher SD (2005) Spontaneous acute thoracic epidural hematoma causing paraplegia in a patient with severe preeclampsia in early labor. Int J Obstet Anesth 14(3):256–260. [PubMed]
21. Case AS, Ramsey PS (2005) Spontaneous epidural hematoma of the spine in pregnancy. Am J Obstet Gynecol 193(3 Pt 1):875–877. [PubMed]

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