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From:
Published online 2011 April 29. doi: 10.3390/ijerph8051324

Table 3.

Individual pulmonary function tests as predictors of radiographic emphysema.

CriteriaSensitivity % (95% CI)Specificity % (95% CI)LR+LR−PPV %NPV %
FEV1/FVC < 70%79 (71–85)75 (65–82)3.090.297975
FEV1/FVC < LLN (NHANES)73 (65–80)74 (64–81)2.760.377768
FEV1< LLN67 (59–75)74 (64–81)2.540.457565
FEV3/FVC < LLN62 (53–70)71 (62–79)2.110.547161
FEF25–75 < LLN68 (59–76)43 (34–53)0.682.325954
RV > ULN52 (43–61)92 (86–96)6.640.528962
TLC > ULN22 (16–30)98 (94–100)11.380.799352
RV/TLC > ULN46 (38–55)94 (88–98)7.870.579060
DLCO < LLN91 (84–95)23 (16–33)0.914.265968

LLN: lower limit of normal; ULN: upper limit of normal; CI: confidence interval; LR+: positive likelihood ratio; LR−: negative likelihood ratio; PPV: positive predictive value; NPV: negative predictive value; %FEV1: forced expiratory volume in 1 second, % of predicted (post-bronchodilator); FVC: forced vital capacity; FEV3: forced expiratory volume in 3 seconds; FEF25–75: forced expiratory flow between 25% and 75% of expired FVC; RV: residual volume; TLC: total lung capacity, % of predicted; %DLCO: diffusing capacity for carbon monoxide, % of predicted.