PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Eur J Cardiovasc Nurs. Author manuscript; available in PMC 2013 December 1.
Published in final edited form as:
PMCID: PMC3106140
NIHMSID: NIHMS273362

Modifiable Factors Associated with Sleep Dysfunction in Adults with Heart Failure

Barbara Riegel, DNSc, RN, FAAN, FAHA, Professor, Dale Glaser, PhD, Principal—Glaser Consulting, Kathy Richards, PhD, RN, FAAN, Professor, Steven L. Sayers, PhD, Associate Professor, Amy Marzolf, RN, Heart Failure Nurse Coordinator, William S. Weintraub, MD, Chief of Cardiology, and Lee R. Goldberg, MD, MPH, Associate Professor

Abstract

Background

Sleep dysfunction contributes to poor quality of life in adults with heart failure (HF). The purpose of this study was to identify factors associated with sleep dysfunction that may be modifiable.

Methods

Data were collected from 266 subjects enrolled from three sites in the U.S. Sleep dysfunction was measured over the past month with the Pittsburgh Sleep Quality Index, using a score >10 to indicate sleep dysfunction. Potentially modifiable clinical, behavioral, and psychological factors thought to be associated with sleep dysfunction were analyzed with hierarchical logistic regression analysis.

Results

When covariates of age, gender, race, data collection site, and New York Heart Association (NYHA) functional class were entered on the first step, only NYHA was a significant correlate of sleep dysfunction. When the clinical, behavioral, and psychological factors were entered, correlates of sleep dysfunction were the number of drugs known to cause daytime somnolence (OR = 2.08), depression (OR = 1.83), worse overall perceived health (OR = 1.64), and better sleep hygiene (OR = 1.40). Although most (54%) subjects had sleep disordered breathing (SDB), SDB was not a significant predictor of sleep dysfunction.

Discussion

Factors associated with sleep dysfunction in HF include medications with sleepiness as a side-effect, depression, poorer health perceptions, and better sleep hygiene. Sleep dysfunction may motivate HF patients to address sleep hygiene. Eliminating medications with sleepiness as a side-effect, treating depression and perceptions of poor health may improve sleep quality in HF patients.

Keywords: heart failure, sleep, sleep dysfunction, perceived health, medications, sleep hygiene, depression

Introduction

Heart failure (HF) remains a persistent contributor to frequent hospitalizations, high mortality, and escalating health care costs.1 2 Quality of life is worse for HF patients than the general population, patients with other chronic diseases, and patients with other cardiac diseases (e.g., myocardial infarction).35 Poor sleep quality is also common in adults with HF. Several investigators have shown that poor sleep quality is a contributor to poor quality of life in adults with HF.69

Sleep dysfunction has been defined as encompassing the domains of insomnia, sleep adequacy, and somnolence.10 The focus of this study is on sleep adequacy, defined as difficulty in initiating or maintaining sleep.11 There is surprisingly little research describing the factors associated with sleep adequacy in adults with HF. Therefore, the purpose of this study was to identify the factors associated with self-reported sleep dysfunction. If mild, sleep dysfunction may not impair social or occupational functioning, although it may cause feelings of restlessness, irritability, mild anxiety, daytime fatigue, and tiredness.11 Moderate vs. severe sleep dysfunction is a matter of degree; complaints of relatively less sleep are typically accompanied by increasing complaints of daytime dysfunction.

Sleep dysfunction is common in adults. In a cross-sectional study of 25,579 adults from France, the U.K., Germany, Italy, Portugal, Spain and Finland, 34.5% of the sample reported difficulty initiating or maintaining sleep or non-restorative sleep at least 3 nights per week.12 In a random sample of 4,885 adults from just the U.K., 37% reported sleep dysfunction.13 In the 2002 National Health Interview Survey (NHIS), an annual in-person survey of the civilian, non-institutionalized U.S. population, only 17.4% of 31,044 adults reported trouble sleeping.14 But in the 2002 Sleep in America poll, complaints of difficulty falling asleep, waking a lot during the night, waking up too early and not being able to get back to sleep, and waking up feeling unrefreshed were reported by 58% of respondents; 35% reported at least one of these four symptoms of sleep dysfunction every night or almost every night in the past year.15 Sleep dysfunction is more common in elders,13 16 although significant variability exists.17 For unknown reasons, sleep dysfunction is more prevalent in females than males, regardless of age.15

Sleep dysfunction is also a common complaint of chronically ill patient populations. In a cohort (n=3,445) of patients with hypertension, diabetes, HF, myocardial infarction, and/or depression, 16% had severe insomnia and 34% had mild insomnia. Sleep dysfunction was most common in individuals with a diagnosis of depression, HF, obstructive airway disease, back, hip, or prostate problems.18

Few investigators have studied sleep dysfunction in adults with HF. In one sample of 223 adults with HF, 36% reported not getting enough sleep.7 The factor interfering the most with sleep was nocturia; 90% of the men and 80% of women reported nocturia. Anxiety (22%) and nocturnal ruminations (16%) were also common. In an earlier study from the same group, 20 HF patients (13 men) reported that their sleep was affected by demands of daily activities and the disease itself, in addition to cardiac symptoms such as nocturnal dyspnea, cough, and palpitations.19 Interestingly, although the severity of sleep disordered breathing (SDB) is positively associated with objective evidence of sleep quality and efficiency, SDB is not necessarily associated with subjective complaints of sleep dysfunction or excessive daytime sleepiness.20 21

In summary, although sleep dysfunction appears to be common in older adults with chronic illness and sleep problems are associated with poor quality of life in the HF population, few investigators have described the factors causing sleep dysfunction in adults with HF. Thus, we remain uncertain exactly how prevalent sleep dysfunction is in HF patients and what causes their difficulties in initiating and maintaining sleep. Without such knowledge, the ability to design interventions to improve sleep is limited to addressing specific symptoms in individual patients. Thus, we sought to identify the factors associated with self-reported symptoms of sleep dysfunction in a large sample of adults with HF, focusing on factors that are potentially modifiable with the intention of designing an intervention.

Methods

The methods used in this study have been reported previously,22 but in brief, a cross-sectional observational design was used to analyze data from a consecutive sample of 266 adults with HF was enrolled from three outpatient settings in Philadelphia, Pennsylvania and Newark, Delaware. The local Institutional Review Board of each site approved the study. All subjects provided informed consent. Research assistants collected data during home visits. Clinical information was abstracted from the medical record by registered nurses. This analysis used data collected between 2007 and 2009.

Individuals were included in the study if they had chronic Stage C HF confirmed through a review of the medical record. Patients with both systolic (left ventricular ejection fraction < 40%) and preserved left ventricular systolic function (diastolic HF) were included. Participants had to have visual acuity sufficient to read the study materials, hearing sufficient to engage in a dialogue, and be fluent in English. Exclusion criteria were working nights or rotating shifts, major depression, significant cognitive impairment, stage 5 chronic kidney disease, an imminently terminal illness, plans to move out of the area, or a recent history of serious drug or alcohol abuse. Institutionalized individuals were excluded because the primary goal of the study was to explore the effect of sleep problems on the ability to perform self-care; institutional individuals are not usually responsible for independent self-care. Cognitive impairment was screened using the Telephone Interview of Cognitive Status (TICS);23 anyone with a score <24 was excluded. This cut-point was chosen to accommodate a broad range of HF patients, many of whom have mild cognitive impairment (TICS score of 21–25).24 Major depression was screened in the medical record. Patients noted to have severe depressive illness were not contacted. In addition, all consenting patients were further screened with the Patient Health Questionnaire (PHQ-9).25 We excluded individuals reporting 5 or more of the 9 symptoms on the PHQ-9 more than half the days in the past 2 weeks; 1 of the symptoms had to be depressed mood or anhedonia. For those who passed screening, we continued to use data from a subset of the PHQ-9, the PHQ-2, to measure mild depressive symptoms.

In this analysis we explored potentially modifiable clinical, behavioral, and psychological factors thought to be associated with sleep dysfunction. These factors were chosen based on clinical experience with this population and on published literature describing factors associated with sleep dysfunction. Clinical factors tested were number of prescription medications26 and the number of drugs known to cause daytime somnolence,27 quality of the treatment regimen,28 systolic blood pressure, 29 obesity,30 clinical factors that disturb sleep such as pain,18 and the presence and severity of SDB.27 Systolic blood pressure was included because short sleep duration is associated with high blood pressure.29 Waist circumference was used because it is thought to be a more sensitive indicator of obesity than body mass index.31 Behavioral factors included exercise,26 alcohol use,26 27 smoking,26 and sleep hygiene measures.32 Psychosocial factors included depressive symptoms,18 perceived overall health,33 and social support.26

Measurement

Sleep dysfunction was measured over the past month using the Pittsburgh Sleep Quality Index (PSQI).34 The PSQI measures the domains of subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. Each subscale was scored 0 (not in the past month) to 3 (three or more times a week) and added to produce the sleep dysfunction score. Internal consistency of the full 19 item PSQI is usually in the range of 0.77 to 0.83;34 reliability of the PSQI was 0.73 in this study. A score of >10 was used to classified participants as having sleep dysfunction.35

The medication information used in testing the model was obtained by research assistants (RAs) who reviewed medicine bottles, interviewed subjects about their medicines, or reviewed medicine lists to obtain information on all prescription and over-the-counter medicines taken by participants. All drugs prescribed by a licensed provider were included in the number of prescription medications, even if the drug was obtainable over-the-counter (e.g., antihistamines). Each drug listed was compared to a detailed list of drugs associated with daytime somnolence to identify the number of medicines taken that are known to sleep dysfunction. Quality of the treatment regimen was judged by registered nurses using performance standards devised from the 2006 Heart Failure Society of America Comprehensive HF Guidelines, the most up-to-date clinical guidelines in place at the time.36 The proportion (0 – 100%) of evidence-based treatments prescribed was used in analysis. Blood pressure was measured by the RAs using standardized procedures.37 Waist circumference was measured as specified by the National Heart, Lung and Blood Institute (http://www.nhlbi.nih.gov/guidelines/obesity/e_txtbk/txgd/4142.htm).

A physician-diagnosis of sleep disordered breathing (SDB) based on polysomnography was obtained from the medical record at the time of enrollment. If no documentation of recent sleep testing was found in the medical record, sleep was assessed in the home using an unattended sleep study device, the Embletta (Medcare, Buffalo, NY). The Embletta is a pocket-sized digital recorder that provides data on position and activity, leg movement, oxygen saturation, pulse, oral flow, snoring, and respiratory effort. The Embletta software is known to overestimate the apnea-hypopnea index (AHI),38 so rather than using AHI from these two different sources in the analysis, the AHI was dichotomized. Individuals with an AHI ≥ 5 were considered to have SDB.39

Exercise frequency, alcohol use, and smoking behavior were collected as self-report data. Sleep hygiene behaviors such as keeping a routine bedtime and engaging in relaxing activities prior to sleep were scored on a 0 (never) to 3 (every night) scale, with higher scores indicating better sleep hygiene. The raw score (range: 0 to 12) was used in analysis.

Depression was assessed using the two items in the PHQ-9 that focus on the classic symptoms of depression: depressed mood and anhedonia. The PHQ-2 has been used in other studies.40 This abbreviated version was used because 3 items on the PHQ-9 address sleep and fatigue (i.e., trouble falling or staying asleep or sleeping too much; feeling tired or having little energy), introducing a confounding between cause and effect. Scores on the PHQ-2 range from 0 to 6, with higher scores indicating more depression. Perceived overall health was measured using a single item from the Medical Outcomes Study:41 In general, would you say your health is poor, fair, good, very good, or excellent? Social support was assessed using the Multidimensional Scale of Perceived Social Support (MSPSS),42 a 12-item tool assessing support from family, friends, and a significant other. Total support scores were used in analysis. The reliability of this scale was reported to be 0.91 by the instrument authors. In this study, the alpha coefficient was 0.90.

Analysis

Standard descriptive statistics of central tendency and dispersion were used to characterize the sample of 266. A two-step hierarchical approach to multiple binary logistic regression was used to identify the best predictors of sleep dysfunction. Covariates used in analysis were age, gender, race, and data collection site. Others have noted that sleep dysfunction is more common in HF patients with worsening functional class,43 so New York Heart Association (NYHA) functional class also was used as a covariate. Information needed to rate NYHA functional class was obtained with a standardized interview44 and scored by a single board-certified cardiologist to avoid known issues with interrater reliability.45

In the first step of the analysis, covariates were entered into the model. Then, the 13 variables theoretically anticipated to be associated with sleep dysfunction were entered in the second step. Chi-square analysis was used to determine if the set of clinical, behavioral, and psychosocial factors significantly improved model fit over and beyond the set of covariates. The Hosmer and Lemeshow test was assessed, noting that a nonsignificant result supports model fit. At the predictor level, the logit coefficients are reported for all of the explanatory variables, including odds ratios (OR) and the 95% confidence interval (CI) around the OR. Both sensitivity and specificity are reported. All analyses were conducted with the SPSS v. 18.0.2 software (Chicago, IL). An α of .05 was predetermined as the level of significance.

Results

The sample of 266 was predominately white (63%) and male (64%); mean age was 62 ± 12 years. Many subjects rated their health as fair or poor (54%). Only 12 individuals (4.5%) were not taking a medication known to be associated with sleepiness; 55.6% (n = 148) were taking 1 such medication but one subject was taking 7 such medicines. When a score of >10 on the PSQI was used to classify participants as having significant sleep dysfunction, 21.8% (n = 58) of the sample had sleep dysfunction (Table 1).

Table 1
Characteristics of the sample overall. Mean ± standard deviation or n (%) is reported.

The slight majority of the sample (n=151, 54%) had SDB. Of these, only 75 (49.7%) had been treated with CPAP and of these, only 35 (47.3%) reported using it ≥ 6 hours per night in the past week. In univariate analysis, adjusting for continuous positive airway pressure (CPAP) use, SDB was not significantly associated with sleep dysfunction (p=0.77). The correlation between perceived health and depression measured with the PHQ-2 was only 0.19 (p=0.002).

When the covariates were entered at the first step, the model was significant (χ2(7) = 25.35, p = .001) and model fit was adequate (χ2(8) = 13.13, p = .107). At this initial step, the only significant covariate was NYHA (p = .001; OR = 2.06); a higher (worse) NYHA score was associated with twice the odds of having sleep dysfunction. Sensitivity was poor at this step (6.9%), but specificity was high (98.6%), with an overall accuracy of 78.6%.

At the second step, the addition of the 13 explanatory variables significantly improved model fit (χ2(13) = 53.13, p < .05). The Hosmer and Lemeshow test confirmed good model fit (χ2(8) = 3.93, p = .864). NYHA was no longer significant in the full model (b = .454, p = .054). Significant correlates of sleep dysfunction were a higher number of drugs causing daytime somnolence, more depressive symptoms, worse perceived health, and better sleep hygiene. Sensitivity improved to 39.7% and specificity remained high (94.2%), with an overall accuracy of 82.3% (Table 2).

Table 2
Hierarchical Multiple Logistic Regression (n = 266)

Discussion

The major findings of this study were that a higher number of drugs causing daytime somnolence, more depressive symptoms, and poorer overall perceived health increased the likelihood of having sleep dysfunction. Surprisingly higher sleep hygiene scores were associated with more sleep dysfunction in these patients, suggesting that HF patients may not bother with sleep hygiene until they have fairly significant sleep dysfunction. The model of covariates and 13 explanatory factors was specific (% of true negatives) but sensitivity (% of true positives) was low, suggesting that other important factors influence sleep dysfunction in adults with HF. Presumably many of the other factors associated with sleep dysfunction are not potentially modifiable and thus were not tested. Importantly, SDB was not a significant determinant of sleep dysfunction in this sample.

The finding that drugs with sleepiness listed as a common side-effect disrupt sleep is not really surprising but it does serve to remind clinicians to consider the side-effect profile of prescribed medications. A distressing number of people were taking such medications. It should be noted, however, that others have found little relationship between the medication profile of HF patients and sleep dysfunction.46 The difference in results may be that we assessed the entire medication regimen, not just the cardiac medications prescribed to HF patients.

Other investigators have found a relationship between depression and sleep dysfunction in the general population as well as in those with HF.47 Both the NIHS14 and the survey of adults with chronic illnesses18 described above noted the relationship between depression and sleep dysfunction. This is an important finding because major depression was an exclusion criterion and the vast majority of subjects had no depression or only minor depressive symptoms. Our results suggest that even mild depression is associated with sleep dysfunction.

Our finding that self-reported perceived health was a significant determinant of sleep dysfunction is interesting because this variable has been found previously to be associated with functional outcomes,48 49 health care utilization,50 and even mortality in other populations.51 52 In a sample of HF patients, those with poor perceived health were more likely to be hospitalized over a 12 week period.53 Others have found that perceived health was an independent predictor of cardiovascular mortality and HRQL in elders with HF.54 55 Further, perceived health is commonly unrelated to health as rated by a physician. For example, 17% to 21% of prior samples have been shown to perceive themselves to be in poor health, despite objectively good physical health.56 57 The manner in which health perceptions influence sleep dysfunction is unclear and requires further research.

Another interesting finding was that better sleep hygiene was associated with more sleep dysfunction. As this was cross-sectional data, we suspect that the patients were devoting relatively more effort to basic sleep hygiene measures because of the sleep dysfunction.

Functional status was associated with sleep dysfunction in the first step of the analysis, with a trend remaining after the 13 predictors were added to the model. Finding NYHA to be associated with sleep quality was not surprising, as Principe-Rodiguez and colleagues previously found that worse NYHA was associated with insomnia.43 The sleep disruption associated with functional status may reflect nocturnal fluid shifts.

Although it may appear counterintuitive that SDB was not associated with sleep dysfunction, this finding is similar to that of other investigators.58 59 For example, Johansson and colleagues60 found that only difficulty initiating sleep was associated with SDB. In another population of patients referred for polysomnography, most (54.9%) reported sleep dysfunction.61 There was no association between sleep dysfunction and SDB, however. In fact, sleep dysfunction was more common in patients without SDB, which the authors speculated may reflect coexisting factors such as psychiatric disorders and chronic pain.

We suspected that a variety of other factors would be associated with sleep dysfunction, but none of those factors was a significant determinant of sleep dysfunction in this sample. For example, the NHIS found that hypertension and obesity were associated with sleep dysfunction,14 which we did not find in the current study. The survey of adults with chronic conditions discussed above18 found no significant trends for smoking status, alcohol use, or body mass index in relation to sleep dysfunction, as we found.

Limitations of this study include that the diagnosis of SDB was obtained from the medical record on many of the subjects and those with a previous diagnosis of SDB as well as those with a new diagnosis established as a part of the study were combined in these analyses. However, as only confirmed diagnoses of SDB were used and those in doubt were validated with a home sleep study, this is not seen as a major limitation. Finally, although the quality of the treatment regimen was scored as a proportion, relatively few treatments are advocated in the clinical guidelines for preserved systolic function, so the scores for that group could be inflated.

In summary, the results of this study have provided a set of potentially modifiable contributors to acute insomnia in adults with HF including use of medicines known to cause somnolence, depression, and perceptions of poor health. Our next step will be to design and test an intervention intended to decrease sleep dysfunction by addressing the medication regimen, depression, and health perceptions, with the goal of potentially improving outcomes in this large and growing patient population.

Acknowledgments

The authors gratefully acknowledge Thomas A. Gillespie, MD, FACC for scoring the New York Heart Association (NYHA) interviews.

This work was funded by a grant from the National Heart, Lung & Blood Institute (RO1 HL084394-01A1) and by the Philadelphia Veterans Affairs Medical Center, VISN 4 Mental Illness Research, Education, and Clinical Center (MIREC).

Footnotes

Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Contributor Information

Barbara Riegel, University of Pennsylvania School of Nursing.

Dale Glaser, San Diego, CA Adjunct Associate Professor of Statistics, University of San Diego School of Nursing.

Kathy Richards, University of Pennsylvania School of Nursing.

Steven L. Sayers, University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs Medical Center.

Amy Marzolf, Heart Failure and Transplant Center, University of Pennsylvania.

William S. Weintraub, Director of Christiana Care Center for Outcomes Research Christiana Care Health System, Newark, DE.

Lee R. Goldberg, University of Pennsylvania School of Medicine.

References

1. Gwadry-Sridhar FH, Flintoft V, Lee DS, Lee H, Guyatt GH. A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Archives of internal medicine. 2004;164(21):2315–20. [PubMed]
2. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Heart Disease and Stroke Statistics--2010 Update. A Report From the American Heart Association. Circulation. 2010 [PubMed]
3. Heo S, Moser DK, Lennie TA, Zambroski CH, Chung ML. A comparison of health-related quality of life between older adults with heart failure and healthy older adults. Heart Lung. 2007;36(1):16–24. [PubMed]
4. Jolly M. How does quality of life of patients with systemic lupus erythematosus compare with that of other common chronic illnesses? J Rheumatol. 2005;32(9):1706–8. [PubMed]
5. Dixon T, Lim LL, Oldridge NB. The MacNew heart disease health-related quality of life instrument: reference data for users. Qual Life Res. 2002;11(2):173–83. [PubMed]
6. Redeker NS, Hilkert R. Sleep and quality of life in stable heart failure. J Card Fail. 2005;11(9):700–4. [PubMed]
7. Brostrom A, Stromberg A, Dahlstrom U, Fridlund B. Sleep difficulties, daytime sleepiness, and health-related quality of life in patients with chronic heart failure. The Journal of cardiovascular nursing. 2004;19(4):234–42. [PubMed]
8. Martin-Pfitzenmeyer I, Gauthier S, Bailly M, Loi N, Popitean L, d’Athis P, et al. Prognostic factors in stage D heart failure in the very elderly. Gerontology. 2009;55(6):719–26. [PubMed]
9. Gau FY, Chen XP, Wu HY, Lin ML, Chao YF. Sleep-related predictors of quality of life in the elderly versus younger heart failure patients: A questionnaire survey. Int J Nurs Stud. 2010 [PubMed]
10. Devine EB, Hakim Z, Green J. A systematic review of patient-reported outcome instruments measuring sleep dysfunction in adults. Pharmacoeconomics. 2005;23(9):889–912. [PubMed]
11. The International Classification of Sleep Disorders, Revised, Diagnostic and Coding Manual. 2. Westchester, IL: American Academy of Sleep Medicine; 2005.
12. (SN *Cognition Disorders/et [Etiology] Female *Heart/ph [Physiology] *Heart Transplantation Hemodynamics Human Male Middle Age Neuropsychological Tests *Postoperative Complications Socioeconomic Factors Ventricular Function).
13. Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR. Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30(3):274–80. [PubMed]
14. Pearson NJ, Johnson LL, Nahin RL. Insomnia, trouble sleeping, and complementary and alternative medicine: Analysis of the 2002 national health interview survey data. Archives of internal medicine. 2006;166(16):1775–82. [PubMed]
15. National Sleep Foundation. 2002 Sleep in America Poll, Executive Summary. National Sleep Foundation; 2002. p. 44.
16. Ancoli-Israel S, Cooke JR. Prevalence and comorbidity of insomnia and effect on functioning in elderly populations. J Am Geriatr Soc. 2005;53(7 Suppl):S264–71. [PubMed]
17. Buysse DJ, Cheng Y, Germain A, Moul DE, Franzen PL, Fletcher M, et al. Night-to-night sleep variability in older adults with and without chronic insomnia. Sleep Med. 2010;11(1):56–64. [PMC free article] [PubMed]
18. Katz DA, McHorney CA. Clinical correlates of insomnia in patients with chronic illness. Archives of Internal Medicine. 1998;158(10):1099–107. [PubMed]
19. Brostrom A, Stromberg A, Dahlstrom U, Fridlund B. Patients with congestive heart failure and their conceptions of their sleep situation. Journal of Advanced Nursing. 2001;34(4):520–9. [PubMed]
20. Redeker NS, Muench U, Zucker MJ, Walsleben J, Gilbert M, Freudenberger R, et al. Sleep disordered breathing, daytime symptoms, and functional performance in stable heart failure. Sleep. 2010;33(4):551–60. [PubMed]
21. Arzt M, Young T, Finn L, Skatrud JB, Ryan CM, Newton GE, et al. Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. [see comment] Archives of internal medicine. 2006;166(16):1716–22. [PubMed]
22. Riegel B, Moelter ST, Ratcliffe SJ, Pressler SJ, De Geest S, Potashnik S, et al. Excessive Daytime Sleepiness is Associated with Poor Medication Adherence in Adults with Heart Failure. Journal Cardiac Failure. in press. [PMC free article] [PubMed]
23. Buckwalter JG, Crooks VC, Petitti DB. A preliminary psychometric analysis of a computer-assisted administration of the Telephone Interview of Cognitive Status-modified. J Clin Exp Neuropsychol. 2002;24(2):168–75. [PubMed]
24. Pressler SJ. Cognitive functioning and chronic heart failure: a review of the literature (2002-July 2007) J Cardiovasc Nurs. 2008;23(3):239–49. [PubMed]
25. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine. 2001;16(9):606–13. [PMC free article] [PubMed]
26. Whitney CW, Enright PL, Newman AB, Bonekat W, Foley D, Quan SF. Correlates of daytime sleepiness in 4578 elderly persons: the Cardiovascular Health Study. Sleep. 1998;21(1):27–36. [PubMed]
27. Pack AI, Dinges DF, Gehrman PR, Staley B, Pack FM, Maislin G. Risk factors for excessive sleepiness in older adults. Ann Neurol. 2006;59(6):893–904. [PubMed]
28. Martinez FA. Aldosterone inhibition and cardiovascular protection: more important than it once appeared. Cardiovasc Drugs Ther. 2010;24(4):345–50. [PubMed]
29. Knutson KL, Van Cauter E, Rathouz PJ, Yan LL, Hulley SB, Liu K, et al. Association between sleep and blood pressure in midlife: the CARDIA sleep study. Arch Intern Med. 2009;169(11):1055–61. [PMC free article] [PubMed]
30. Kim H, Young T. Subjective daytime sleepiness: dimensions and correlates in the general population. Sleep. 2005;28(5):625–34. [PubMed]
31. Iwao S, Iwao N, Muller DC, Elahi D, Shimokata H, Andres R. Does waist circumference add to the predictive power of the body mass index for coronary risk? Obes Res. 2001;9(11):685–95. [PubMed]
32. Petit L, Azad N, Byszewski A, Sarazan FF, Power B. Non-pharmacological management of primary and secondary insomnia among older people: review of assessment tools and treatments. Age Ageing. 2003;32(1):19–25. [PubMed]
33. Enright PL, Newman AB, Wahl PW, Manolio TA, Haponik EF, Boyle PJ. Prevalence and correlates of snoring and observed apneas in 5, 201 older adults. Sleep. 1996;19(7):531–8. [PubMed]
34. Buysse D, Reynolds CF, 3d, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatr Res. 1989;28:193–213. [PubMed]
35. Okun ML, Kravitz HM, Sowers MF, Moul DE, Buysse DJ, Hall M. Psychometric evaluation of the Insomnia Symptom Questionnaire: a self-report measure to identify chronic insomnia. Journal of Clinical Sleep Medicine. 2009;5(1):41–51. [PubMed]
36. Heart Failure Society of America. HFSA 2006 Comprehensive Heart Failure Practice Guideline. Journal of Cardiac Failure. 2006;12(1):e86–e103. [PubMed]
37. Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, et al. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension. 2005;45(1):142–61. [PubMed]
38. Smith LA, Chong DWS, Vennelle M, Denvir MA, Newby DE, Douglas NJ. Diagnosis of sleep-disordered breathing in patients with chronic heart failure: evaluation of a portable limited sleep study system. Journal of Sleep Research. 2007;16(4):428–35. [PubMed]
39. Ruehland WR, Rochford PD, O’Donoghue FJ, Pierce RJ, Singh P, Thornton AT. The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index. Sleep. 2009;32(2):150–7. [PubMed]
40. Pedersen SS, Denollet J, de Jonge P, Simsek C, Serruys PW, van Domburg RT. Brief depression screening with the PHQ-2 associated with prognosis following percutaneous coronary intervention with paclitaxel-eluting stenting. J Gen Intern Med. 2009;24(9):1037–42. [PMC free article] [PubMed]
41. Ware J. SF-36 Health Survey: Manual and interpretation guide. Boston: The Health Institute, New England Medical Center; 1993.
42. Zimet GD, WDN, GZS, KFG Multidimensional Scale of Perceived Social Support. Journal of Personality Assessment. 1988;52:30–41.
43. Principe-Rodriguez K, Strohl KP, Hadziefendic S, Pina IL. Sleep symptoms and clinical markers of illness in patients with heart failure. Sleep Breath. 2005;9(3):127–33. [PubMed]
44. Kubo S, Schulman S, Starling R, Jessup M, Wentworth D, Burkhoff D. Development and validation of a patient questionnaire to determine New York Heart Association Classification. Journal of Cardiac Failure. 2004;10(3):228–35. [PubMed]
45. Bennett JA, Riegel B, Bittner V, Nichols J. Validity and reliability of the NYHA classes for measuring research outcomes in patients with cardiac disease. Heart & Lung: Journal of Acute & Critical Care. 2002;31(4):262–70. [PubMed]
46. Hayes D, Jr, Anstead MI, Ho J, Phillips BA. Insomnia and chronic heart failure. Heart Fail Rev. 2009;14(3):171–82. [PubMed]
47. Asplund R. Nocturia in relation to sleep, health, and medical treatment in the elderly. BJU Int. 2005;96 (Suppl 1):15–21. [PubMed]
48. Hillen T, Davies S, Rudd AG, Kieselbach T, Wolfe CD. Self-ratings of health predict functional outcome and recurrence free survival after stroke. Journal of Epidemiology and Community Health. 2003;57(12):960–66. [PMC free article] [PubMed]
49. Mansson NO, Rastam L. Self-rated health as a predictor of disability pension and death - A prospective study of middle-aged men. Scandinavian Journal of Public Health. 2001;29:151–58. [PubMed]
50. Menec VH, Chipperfield JG. A prospective analysis of the relation between self-rated health and health care use among elderly Canadians. Canadian Journal on Aging. 2001;20:293–306.
51. Ford J, Spallek M, Dobson A. Self-rated health and a healthy lifestyle are the most important predictors of survival in elderly women. Age and Ageing. 2002;37(2):194–200. [PubMed]
52. Wang C, Satariano WA. Self-rated current and future health independently predict mortality in an aging population. Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. 2007;62A(12):1428–34. [PubMed]
53. Havranek EP, Lapuerta P, Simon TA, L’Italien G, Block AJ, Rouleau JL. A health perception score predicts cardiac events in patients with heart failure: results from the IMPRESS trial. Journal of Cardiac Failure. 2001;7(2):153–7. [PubMed]
54. Johansson P, Brostrom A, Dahlstrom U, Alehagen U. Global perceived health and ten-year cardiovascular mortality in elderly primary care patients with possible heart failure. Eur J Heart Fail. 2008;10(10):1040–7. [PubMed]
55. Johansson P, Brostrom A, Dahlstrom U, Alehagen U. Global perceived health and health-related quality of life in elderly primary care patients with symptoms of heart failure. Eur J Cardiovasc Nurs. 2008;7(4):269–76. [PubMed]
56. Connelly JE, Wofford AB, Philbrick JT. Healthy patients who perceive poor health: why are they worried sick? Am J Med Sci. 2000;320(1):36–42. [PubMed]
57. Connelly JE, Smith GR, Philbrick JT, Kaiser DL. Healthy patients who perceive poor health and their use of primary care services. J Gen Intern Med. 1991;6(1):47–51. [PubMed]
58. Redeker NS, Jeon S, Muench U, Campbell D, Walsleben J, Rapoport DM. Insomnia symptoms and daytime function in stable heart failure. Sleep. 2010;33(9):1210–6. [PubMed]
59. Johansson P, Alehagen U, Svensson E, Svanborg E, Dahlstrom U, Brostrom A. Determinants of global perceived health in community-dwelling elderly screened for heart failure and sleep-disordered breathing. J Cardiovasc Nurs. 2010;25(5):E16–26. [PubMed]
60. Johansson P, Alehagen U, Svanborg E, Dahlstrom U, Brostrom A, Johansson P, et al. Sleep disordered breathing in an elderly community-living population: Relationship to cardiac function, insomnia symptoms and daytime sleepiness. Sleep Medicine. 2009;10(9):1005–11. [PubMed]
61. Krell SB, Kapur VK. Insomnia complaints in patients evaluated for obstructive sleep apnea. Sleep Breath. 2005;9(3):104–10. [PubMed]