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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Sex Transm Infect. Author manuscript; available in PMC 2012 February 1.
Published in final edited form as:
PMCID: PMC3103105

Ocular syphilis among HIV-infected patients: a systematic analysis of the literature



Ocular syphilis among HIV-infected patients continues to be a problem in the highly active antiretroviral therapy (HAART) era. However, outside of case reports or small case series, little is known about the clinical, laboratory, and treatment outcomes of these patients.


To examine the literature on HIV-infected patients and determine the results of treatment.


Systematic review of cases series and case reports among HIV-infected individuals with ocular syphilis. Reviews, languages other than English and pre-1980 reports were excluded. The effect of CD4 count and virological suppression on clinical manifestations and diagnostic laboratory values was evaluated.


A total of 101 HIV-infected individuals in case series and case reports were identified. Ocular syphilis led to the HIV diagnosis in 52% of cases, including patients with CD4 count >200 cells/mm3. Posterior uveitis was significantly more common in individuals with CD4 count <200 cells/mm3 (p=0.002). Three patients with confirmed ocular syphilis had negative non-treponemal tests. Ninety-seven per cent of patients with visual impairment improved following intravenous penicillin or ceftriaxone.


Non-treponemal tests may be negative in HIV-infected patients with ocular syphilis. Ocular syphilis remains an important clinical manifestation that can lead to initial HIV diagnosis.


Unlike the incidence of cytomegalovirus retinitis which decreased after highly active antiretroviral therapy (HAART) became widely available,1 the incidence of ocular syphilis has not decreased in the HAART era.2 While there have been a number of case reports reporting the significance of ocular syphilis in HIV-infected patients,315 there have been no studies with more than 13 patients.

Ocular syphilis is a well-described entity that can result from acquired or congenital infection. Studies from the pre-antibiotic era16 as well as more recently2 show that ocular syphilis is one of the most common manifestations of neurosyphilis. In cases of both early and late syphilis, anterior uveitis is the most commonly observed ocular manifestation. 17,18 Several case reports have suggested that posterior uveitis is more common among those with HIV infection,19,20 but few data are available. An enormous variety of clinical manifestations of early syphilis within the eye has been reported, including the following: papulosquamous lesions of the skin of the lids, temporary loss of eyebrows, diffuse papillary conjunctivitis, scleroconjunctivitis, interstitial keratitis, iritis, chorioretinitis and optic neuritis. Studies of ocular syphilisamong HIV-negative individuals have found frequent cerebrospinal fluid (CSF) abnormalities that are consistent with neurosyphilis,2123 and no substantial differences in CSF characteristics between HIV-infected and uninfected individuals.22,23

This systematic review analysed the clinical manifestations, immunological status, and treatment response of patients with HIV with ocular syphilis. The goal of this study is to better understand the clinical picture and laboratory findings of ocular syphilis in the HIV era, focusing on the effects of CD4 count and antiretroviral therapy.


We followed PRISMA guidelines for the search strategy, study selection, data abstraction, analysis and presentation (figure 1). PubMed, Science Direct and NLM Gateway online databases were searched using the following terms: (‘syphilis’ OR ‘Treponema pallidum’) AND (‘HIV’ OR ‘AIDS’) AND (‘eye’ OR ‘ocular’, ‘iridocyclitis’, ‘chorioretinitis’, ‘uveitis’, ‘retinitis’, ‘optic neuritis’, OR ‘conjunctivitis.’) PubMed was searched by titles while Science Direct and NLM Gateway were searched by abstracts, keywords and authors.

Figure 1
Search algorithm outlining strategy for identifying case series of HIV-infected individuals with ocular syphilis.

All manuscripts that reported case series or case reports of HIV-infected patients with ocular syphilis were included. Reviews, languages other than English and pre-1980 reports were excluded. No other restrictions were put on location, study design or type of ocular manifestation. All descriptions of ocular findings were examined by two reviewers, including one ophthalmologist (AML). Data on the following covariates were examined: demographic, clinical and laboratory characteristics (including diagnostic syphilis titres, immunological profiles and ocular manifestations), antibiotic treatment and response to treatment.

The case definition included: (1) HIV-infected patients as demonstrated by ELISA with confirmatory western blot; (2) evidence of syphilis infection defined by a positive serum treponemal test; (3) formal ophthalmological examination documenting ocular inflammation. Eye findings were reviewed by an ophthalmologist and grouped into four general categories as follows: anterior uveitis included keratitis, scleritis, iritis and iridocyclitis with or without keratic precipitates; posterior uveitis included vitritis, chorioretinitis, necrotising (and non-necrotising) retinitis, retinal vasculitis/periphlebitis, serous retinal detachment or papillitis; panuveitis included both anterior and posterior segment inflammation; optic neuritis included retrobulbar optic neuritis and optic perineuritis. CSF white blood cell (WBC) counts were dichotomised into normal and raised based on a threshold of >5 WBCs/mm3. CSF total protein counts were dichotomised based on a threshold of 60 mg/100 ml The following covariates were analysed: CD4 cell count (cells/mm3), HIV-1 RNA (copies/ml), ocular findings (anterior uveitis, posterior uveitis, panuveitis, optic neuritis), clinical manifestations (rash consistent with secondary syphilis, constitutional symptoms), serum rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) titres, CSF variables (WBC count, total protein and VDRL test), visual acuity before and after treatment and treatment course.

Differences in the clinical and laboratory findings of patients by CD4 count and viral load suppression were examined using Wilcoxon rank sum test for continuous variables and Fisher’s exact test for categorical variables. Data analysis used SPSS 18.0. This study was approved by the Partners Human Research Committee and the Massachusetts Eye and Ear Infirmary Institutional Review Board.


Three hundred and four abstracts were retrieved using our search criteria, and 32 manuscripts met all inclusion criteria and were examined in detail (figure 1). Among these manuscripts, five had incomplete data.2428 Lack of follow-up ophthalmological examination or CD4 count data were the most common reasons for excluding studies. A total of 101 patients from case series9,19,20,22,26,2937 and case reports315 were included in the final analysis. All selected studies were retrospective case series from the United States and Europe (table 1). For those who had available data, ocular syphilis was the presenting symptom of HIV infection in 28 out of 54 cases (52%). In pre-HAARTera case series, 11/17 (65%) patients had ocular syphilis as the presenting symptom of HIV infection. Among studies done after the advent of HAART, 17/37 (46%) patients had ocular syphilis as the presenting symptom of HIV infection. In the studies with available data, follow-up times ranged from 5 to 45 months.

Table 1
Characteristics of the ocular syphilis studies among HIV-infected patients

The median age of patients was 38.5 years (range 23–62), and 96.9% of patients were male. The median CD4 cell count was 348 cells/mm3 (range 4–1435), and 17% (17/101) of patients had a CD4 cell count <200 cells/mm3. The median HIV-1 RNA was 1800 copies/ml. A summary of the ocular findings is presented in table 2. Thirty-nine per cent (21/54) of cases had only visual symptoms, and 62% (32/52) of cases had a rash consistent with secondary syphilis infection. Seventy-four per cent (46/62) of ocular syphilis cases had an elevated CSF WBC count, and 75% (33/44) had an elevated total protein. The CSF VDRL test was positive in 57% (37/65) of all cases where a VDRL test was performed on CSF fluid.

Table 2
Pooled data of HIV-infected patients with ocular syphilis

Patients with ocular syphilis with CD4 cell count <200 cells/ mm3 were found to have a significantly greater risk of posterior uveitis (p=0.002, table 2). Patients with CD4 cell count <200 cells/mm3 also tended to have a lower risk of panuveitis and anterior uveitis (p=0.055 and p=0.1, respectively). The majority of patients in both groups had relatively high RPR/VDRL titres (median 1:128), suggesting that they may have been in the early stages of infection when they presented (figure 2).

Figure 2
Range of RPR/VDRL titres comparing patients with CD4>200 cells/ml (white bars) with those with CD4<200 cells/ml (black bars). NR, non-reactive; RPR, rapid plasma reagin; VDRL, Venereal Disease Research Laboratory.

Eleven individuals had HIV-1 RNA levels under the limit of detection. In these patients, there was a trend towards less frequent reactive CSF VDRL titres (20% vs 63%, p=0.051), less frequent leucocytosis (40% vs 76%, p=0.10) and less frequent elevated total protein (29% vs 75%, p=0.13) when compared to patients who had detectable viraemia. No significant differences were seen in the CD4 count or clinical findings between these two groups.

Three cases of ocular syphilis with a negative serum RPR or VDRL test were identified. All three patients were found to have positive treponemal tests and serial assessment following treatment. Of these three cases, two had documented improvement in visual acuity19,20 and one had a post-treatment repeat lumbar puncture showing the CSF WBC count decreasing from 393 to 14 cells/µl (unpublished data). Among these three patients, two had never had been diagnosed with syphilis before, one had been successfully treated for syphilis in the past. One of the patients presented with necrotising retinitis and retinal detachment. Another patient had a rash, bilateral posterior uveitis and a positive CSF VDRL test that became negative after treatment. The CD4 cell counts in these three patients were 56, 158 and 574 cells/µl.

Almost all patients were given 10–21 days of intravenous penicillin or ceftriaxone. Although some patients had poor follow-up, there were no confirmed cases of intravenous penicillin or ceftriaxone failure. Thirty-four out of 35 patients who had follow-up visual acuity formally assessed by an ophthalmologist were found to have either normal visual acuity or an improvement after treatment. One patient had stable visual acuity (20/20) after treatment. However, in the study with the longest follow-up (Li et al), three patients required re-treatment for syphilis, including one for recurrent ocular syphilis. All of these individuals were at risk for reinfection owing to persistent high-risk sexual behaviours.


The literature on ocular syphilis among HIV-infected individuals is limited. In this systematic analysis, we report the clinical and laboratory findings associated with 101 cases of ocular syphilis among HIV-infected individuals. Although this was a systematic review, there was a large amount of heterogeneity in the quality of data and follow-up.

The age, sex, CD4 profile and HIV-1 RNA measurements are consistent with data from US studies of neurosyphilis.27,38 Rash consistent with secondary syphilis was described in a majority of patients, which is similar to a study of neurosyphilis among patients with HIV38 and earlier pre-HIV era studies.39,40 In addition, the high RPR/VDRL titres in the majority of patients suggest that most patients were in the earlier stages of infection. Since the onset of symptoms was not clear in most cases, a more precise discrimination of syphilis stage was not possible. These findings are also consistent with the pre-HIV literature that found a relationship between higher non-treponemal test results and neurosyphilis.41

While a wide range of serum RPR titres have been observed in neurosyphilis studies,27,38 we were able to uncover three cases of ocular syphilis with negative serum RPR/VDRL titres. Although further information about prozone phenomena or the presence of non-syphilis treponeme might explain these cases, there were limited available data on prozone phenomena from the primary manuscripts and follow-up inquiries. Negative non-treponemal tests in the setting of ocular syphilis have been reported among HIV uninfected individuals related to prozone phenomena21 and to other causes,42,43 suggesting that this may not be unique to HIV-infected individuals. These three cases suggest that ocular syphilis may occur in the setting of a negative serum non-treponemal test, emphasising the need for treponemal diagnostic testing and, possibly, lumbar puncture in patients suspected of having ocular syphilis.

This study found a trend towards higher CSF WBC counts in patients with lower CD4 counts (p=0.055). At the same time, seven patients with ocular syphilis and HIV infection had normal CSF white blood cell count, total protein and CSF VDRL titres; all these patients were from the HAART era. This correlated with the finding that those with suppressed viraemia were less likely to have a reactive CSF VDRL test. Syphilis literature from the 1980s suggested that most patients with ocular syphilis had an elevated CSF white blood cell count and total protein,43 consistent with our results. There are conflicting data about the CSF VDRL test among patients who have ocular syphilis. While one study from the pre-HIV era found that none of 50 individuals with ocular syphilis had a reactive CSF VDRL test,43 a greater number of reactive CSF VDRL positive cases were found in an HIV-era study32 and our pooled data.

Several previous case series of ocular syphilis among HIVinfected patients have noted a tendency towards posterior uveitis19,20,31,37 and panuveitis,35 but our analysis supported only the association between posterior uveitis and low CD4 counts. It is unclear why posterior uveitis appears more commonly in HIV-infected patients with low CD4 cell counts. Most patients with uveitis secondary to syphilis have good visual prognosis. Patients with posterior uveitis with central chorioretinal lesions and optic neuritis have poorer prognosis than patients with anterior uveitis and other categories of inflammation.

Persistent symptoms are common among HIV-infected patients with neurosyphilis. A prospective study of 41 HIV-infected patients with neurosyphilis found that patients’ main complaint persisted at 1 year in 38% of cases,27 and another study found that 30% of treated cases had persistent symptoms. 38 However, the patients with ocular syphilis in our analysis had good response to treatment based on repeat examination. Although data are available for only 35 patients, 97% of the cases showed definitive improvement or normal visual acuity on follow-up.

While visual improvement was rapid in most patients after treatment, a small number of patients had persistent visual acuity problems. There were limited data on follow-up and also on the use of steroids which may help prevent visual acuity problems. The importance of completing an adequate course of intravenous antibiotics for all patients with neurosyphilis cannot be overstated.44 The US CDC recommends 10–14 days of intravenous penicillin, although these guidelines are based on limited data.45 A full course of intravenous penicillin may be especially important in patients who may have a compromised immune system.3 Several studies noted early administration of steroids in patients with uveitis in order to prevent an ocular Jarisch–Herxheimer reaction46,47 and prevent further inflammation related to uveitis.48

This study has several limitations worthy of consideration. There was substantial heterogeneity in the quality of the data and follow-up in the analysed literature. Publication bias probably revealed a greater number of severe cases, although based on laboratory abnormalities and clinical course, this group of patients with ocular syphilis and HIV probably has less severe disease than other cohorts with neurosyphilis.27,38 Since RPR and VDRL tests were done at different laboratories, comparison of values must be interpreted with caution. Not all patients underwent lumbar puncture and were followed up for repeat visual acuity examination, but patients who had persistent visual problems would probably be followed up. In addition, the CSF WBC cut-off point of 5 WBC/mm3 was chosen because most studies reported that value. Among HIV-infected people, this cut-off point may have lower specificity when diagnosing neurosyphilis.41

Despite the advent of HAART, ocular syphilis remains an important clinical concern among patients with HIV infection. It can occur in patients with negative serum RPR or VDRL test and clinicians must obtain serum treponemal tests when the suspicion of ocular syphilis is high. Lumbar puncture is recommended for the evaluation of all patients with ocular syphilis as a substantial proportion will have evidence of neurosyphilis. Although the visual recovery of patients who completed 10–21 days of intravenous antibiotic therapy was good, behavioural counselling and close follow-up are advised. More research is needed to better understand ocular syphilis among HIV-infected patients.


Special thanks to the MGH Syphilis Working Group. Thanks to Seth Cohen and Kate Mooney for administrative support.

Funding Support from the National Institutes of Health (T32 AI07387, JL), US NIH Fogarty International Clinical Fellowship (R24TW007988, JT) and the American Society of Tropical Medicine and Hygiene (JT).


Competing interests None.

Ethics approval This study was conducted with the approval of the Partners Human Subjects Research Committee and the Massachusetts Eye and Ear Infirmary Institutional Review Board.

Contributors JDT contributed to data interpretation, drafting the article and revising it critically for important intellectual content. JZL contributed to acquisition and interpretation of data, drafting the article and revising it critically for important intellectual content. GKR contributed to the conception and design of the study, interpretation of the data, drafting the article and revising it for important intellectual content. BTD contributed to the conception and design of the study and interpretation of the data. AML contributed to acquisition and interpretation of data, drafting the article and revising it critically for important intellectual content. JL contributed to acquisition and interpretation of data, drafting the article and revising it critically for important intellectual content. GNP contributed to the conception and design of the study and interpretation of the data. MLD contributed to the conception and design of the study, interpretation of the data, drafting the article and revising it for important intellectual content. DF contributed to the conception and design of the study, interpretation of the data, drafting the article and revising it for important intellectual content.

Provenance and peer review Not commissioned; externally peer reviewed.


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