PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of eurspinejspringer.comThis journalThis journalToc AlertsSubmit OnlineOpen Choice
 
Eur Spine J. 2011 June; 20(6): 846–859.
Published online 2010 September 23. doi:  10.1007/s00586-010-1577-5
PMCID: PMC3099151

Pedicle screw insertion accuracy with different assisted methods: a systematic review and meta-analysis of comparative studies

Abstract

Studies revealed that navigation systems that provided intraoperative assistance might improve pedicle screw insertion accuracy, and also implied that different systems provided different pedicle screw insertion accuracy. A systematic review and meta-analysis was conducted to focus on the pedicle screw insertion accuracy with or without the assistance of image-guided system, and the variance among the different navigation systems. Comparative studies were searched on pedicle screw insertion accuracy between conventional and navigated method, and among different navigation systems. A total of 43 papers, including 28 clinical, 14 cadaveric and 1 model studies, were included in the current study. For clinical articles, there were 3 randomized clinical trials, 4 prospective comparative studies and 21 retrospective comparative studies. The incidence of pedicle violation among computer tomography-based navigation method group was statistically significantly less than that observed among the conventional group (OR 95% CI, in vivo: 0.32–0.60; in vitro: 0.24–0.75 P < 0.01). Two-dimensional fluoroscopy-based navigation system (OR 95% CI, in vivo: 0.27–0.48; in vitro: 0.43–0.88 P < 0.01) and three-dimension fluoroscopy-based navigation system (OR 95% CI, in vivo: 0.09–0.38; in vitro: 0.09–0.36 P < 0.01) also obtained significant reduced screw deviation rate over traditional methods. Between navigated approaches, statistically insignificant individual and pooled RR values were observed for all in vivo subgroups. Pooled estimate of in vitro studies show that computer tomography-based and three-dimension fluoroscopy-based navigation system provided more accurate pedicle screw insertion over two-dimension fluoroscopy-based navigation system. Our review showed that navigation provided a higher accuracy in the placement of pedicle screws compared with conventional methods. The superiority of navigation systems was obvious when they were applied to abnormal spinal structure. Although no strong in vivo evidence has detected significantly different pedicle screw placement accuracy among the three major navigation systems, meta-analysis revealed the variance in pedicle screw insertion accuracy with different navigation methods.

Keywords: Navigated spine surgery, Pedicle screw, Computer tomography, Fluoroscopy, Accuracy

Introduction

On account of its three-column control and good fixation for the vertebral body, transpedicle screw fixation has been widely used in spinal surgeries [1, 856]. However, pedicle violation resulted from malpositioned screw leading to potential harm to nearby vital structures, which prompted surgeons to search for the perfect strategy. Though alternative methods (e.g., transarticular screw [2], lateral mass [3], extrapedicular screw fixation [4, 5]) were developed for better surgical outcome, surgeons were more prone to improve the pedicle screw insertion accuracy by trying various supporting methods (e.g., intraoperative monitoring [6, 7], anatomical markers [13, 24, 26, 47]). Nevertheless, none of the conventional methods was considered as the perfect intraoperative assisting method.

Many researches have revealed that navigation systems that provided intraoperative assistance obtained the potential to improve pedicle screw insertion accuracy [11, 13, 15, 17, 19, 2224, 26, 28, 32, 33, 35, 36, 39, 41, 4450, 54, 55]. Studies also implied that different power was observed in providing pedicle screw insertion accuracy among various navigational methods [1113, 15, 30, 3941, 49, 55]. No matter which method was used to assist pedicle screw insertion, surgeons cared more about the placing accuracy, because surgical outcomes such as neurological complications and health outcome scores were usually correlated with the screw insertion accuracy. As a result, the primary purpose of current analysis was to assess the accuracy of pedicle screw placement with different assisting methods. We focused on the application of navigation systems in the pedicle screw insertion surgeries and the difference of pedicle screw placement accuracy between navigated and conventional method, and the variance among the different navigation systems.

Methods

As a small number of randomized controlled trials were anticipated, comparative studies (prospective and retrospective) were also included in the current review. Inclusion criteria were established before the search. To be included in the study, the following criteria were used: (1) the paper must include a navigated pedicle screw insertion comparative design; (2) pedicle screw placement accuracy was to be analyzed. Exclusion criteria were: (1) pedicle screw inserted but no navigation employed or applied, and no postoperative accuracy assessment conducted; (2) repetitive studies.

A literature search was conducted spanning from January 1990 to May 2010 using OVID, Springer, EMBASE, MEDLINE and China National Knowledge Infrastructure databases. We screened the title, subtitle and abstract by combining the term pedicle screw with each of the following keywords: computer assisted/assistance/aided, image guided/guiding/guidance, navigation and navigated. A manual search of reference lists of previous systematic reviews and relevant trials was conducted.

Two reviewers (Z.P, Z.Y.) independently extracted data using a standardized form. Inconsistencies between reviewers’ data were resolved through discussion until a consensus was reached. Papers obtained were categorized into levels of evidence according to those published in the Journal of Bone and Joint Surgery (American).

We extracted data on study design, patient characteristics, interventions, outcome measurements (pedicle screw violation) and conclusions from the original papers. In the current review, a unified method was used to extract pedicle screws that were inserted without deviation from total screws of each study (if such data were not available, we extracted the pedicle screws that were most perfectly inserted based on the researchers’ definition). Pedicle violation rate was summarized using relative risk (RR) and 95% confidence intervals (CIs). The level of significance was set at P < 0.05. Heterogeneity was evaluated by using the χ2 test. A value of P < 0.1 was considered to be significant for heterogeneity. Fixed-effect models were used unless statistical heterogeneity was significant, in which case a random-effects model was used. Analysis was performed using the statistical software Review Manager Version 4.2 (Cochrane Collaboration, Software Update, Oxford, UK).

Results

The search strategy resulted in 89 studies, which used navigated pedicle screw insertion design and had insertion accuracy assessed. Of these, 46 were excluded because they were case series. The remaining 43 papers [1151, 54, 55] included 28 clinical [1238, 55], 14 cadaveric [3951, 54] and 1 model [11] study. Based on study design, the clinical articles could be classified into 3 randomized clinical trials [18, 23, 37], 4 prospective comparative studies [22, 25, 27, 29] and 21 retrospective comparative studies [1217, 1921, 24, 26, 28, 3036, 38, 55].

Analysis

Navigation methods for pedicle screw insertion

Since the introduction of navigation techniques into the field of orthopedic surgery, the surgical methods for this area have been greatly increased. Based on intraoperative assisting method, computer-assisted surgery could be subclassified into three types including volumetric image-based navigation, fluoroscopic navigation and imageless navigation [57]. The first one uses preoperative images such as CT and MRI, while the second one utilizes intraoperative two-dimensional or three-dimensional fluoroscopic images. Imageless navigation makes use only of intraoperative anatomical information and is mainly employed to assist total hip/knee arthroplasty [57]. In our review, we found three major navigation systems that had been used to assist pedicle screw insertion including computer tomography-based navigation system (CT Nav), two-dimension fluoroscopy-based navigation system (2D FluoroNav) and three-dimension fluoroscopy-based navigation system (3D FluoroNav). CT Nav requires preoperative CT scan of the target bone. The data have to be transferred to the navigational system. After matching and registration, the preoperative anatomical information is then used to assist pedicle screw insertion. In contrast to CT Nav, 2D FluoroNav does not need registration. It uses intraoperative two-dimensional images and provides real-time intraoperative visualization of spinal anatomy. With the development of the 3-D C-arm, 3D FluoroNav gradually gained popularity in spinal surgeries. Though its image quality is lower than that of CT, 3D FluoroNav provides real-time three-dimensional images, which serves as both C-arm and CT-based navigation, and does not need registration [57, 58].

Meta-analysis for pedicle screw insertion accuracy

Kosmopoulos and Schizas [8] conducted a meta-analysis by pooling published literature studying the accuracy of pedicle screw placement in the human spine with or without the assistance of navigation systems. By using a descriptive statistical method, the study revealed that the median placement accuracy for the in vivo assisted navigation subgroup was higher than that of the subgroup without the use of navigation. Navigation provided a higher accuracy in the placement of pedicle screws for most of the subgroups presented. In a pooled analysis of 14 comparative studies on pedicle screw insertion, Verma et al. [56] also demonstrated a significant advantage in terms of accuracy of navigation over conventional methods. The limitation was that the two reviews analyzed different navigation methods together, and drew pooled navigated pedicle screw insertion accuracy. The concerns regarding these studies were whether there was any difference among various navigation methods and whether each of them provided better screw insertion over conventional methods. The questions lead to our reanalysis.

In the present study, based on the study population and navigation method, the incidence of pedicle violation among the computer tomography-based navigation method group was statistically significantly less than that observed among the conventional group (OR 95% CI, in vivo: 0.32–0.60; in vitro: 0.24–0.75, P < 0.01). Two-dimensional fluoroscopy-based navigation system (OR 95% CI, in vivo: 0.27–0.48; in vitro: 0.43–0.88, P < 0.01) and three-dimensional fluoroscopy-based navigation system (OR 95% CI, in vivo: 0.09–0.38; in vitro: 0.09–0.36, P < 0.01) also obtained significant reduced screw deviation rate over traditional methods. In conclusion, both in vivo and in vitro subgroups revealed that navigation method obtained a significant lesser pooled risk of pedicle violation compared with the conventional method (P < 0.05). The results were consistent with those of Kosmopoulos and Schizas, Verma et al. [8, 56] (Fig. 1). In our previous meta-analysis [9], we analyzed the accuracy of pedicle screw insertion with different navigation methods using a similar method as Kosmopoulos and Schizas [8]. The median placement accuracy for the CT-based navigation subgroup was higher than that with the use of 2D FluoroNav for both in vivo and in vitro subgroups. In vivo subgroup analysis indicated that 3D FluoroNav obtained the most improved screw insertion accuracy. In the current study, the pooled RR values also indicated that CT Nav provided a little higher accuracy than the 2D FluoroNav subgroup (CT Nav vs. 2D FluoroNav: in vivo OR = 0.64, P > 0.05; in vitro OR = 0.37, P < 0.05), but provided a lower accuracy than the 3D FluoroNav subgroup (3D FluoroNav vs. 2D FluoroNav: in vivo OR = 0.65, P > 0.05; in vitro OR = 0.80, P > 0.05). Overall, the pooled relative risks of all in vivo subgroups were statistically insignificant (P > 0.05), whereas RR values of two in vitro subgroups were statistically significant (P < 0.05; Fig. 2; Tables 1, ,22).

Fig. 1
Pedicle screw insertion accuracy: navigation versus non-navigation. Computed tomography-based navigation (CT Nav), two-dimensional fluoroscopy-based navigation (2D FluoroNav), and three-dimensional fluoroscopy-based navigation (3D FluoroNav)
Fig. 2
Pedicle screw insertion accuracy: navigation versus navigation. Computed tomography-based navigation (CT Nav), two dimensional fluoroscopy-based navigation (2D FluoroNav), and three-dimensional fluoroscopy-based navigation (3D FluoroNav)
Table 1
Description of included clinical studies
Table 2
Description of included experimental studies

Computer tomography-based navigation system

CT-assisted pedicle screw insertion accuracy

The first generation of navigation applied to spinal surgery was the computer tomography-assisted system. CT image provided precise three-dimensional anatomy information, which allowed for intraoperative guidance. Many studies have indicated the potential in the use of this system [11, 13, 19, 2224, 26, 28, 32, 35, 39, 41, 4451]. A randomized control study was conducted including 100 patients comparing the pedicle screw insertion accuracy between conventional and CT-based navigation method [23]. The pedicle perforation rate was significantly higher in the conventional group (13.4%) compared with 4.6% in the computer-assisted group (P = 0.006). Pedicle perforations of more than 4 mm were found in 1.4% (4/277) of the screw insertions in the conventional group and none in the computer-assisted group, whereas another RCT conducted by Li et al. [37] reported that no significant accuracy difference was found between the conventional and navigated groups. In the current review, by reanalyzing the pedicle perforation rate of CT Nav over the conventional approaches for the in vivo population, except for two studies [27, 37], all papers [13, 15, 1926, 28, 29, 32, 35, 38] implied that CT Nav obtained a lesser risk compared with the conventional methods, and nine [13, 19, 2224, 26, 28, 32, 35] of them were statistically significant (Fig. 1). For the in vitro studies [11, 39, 41, 4450], five studies [11, 41, 47, 49, 50] indicated the statistically improved accuracy (Fig. 1).

CT-assisted pedicle screw insertion in scoliosis correction surgeries

Pedicle screw fixation has gained popularity in deformity correcting surgeries, as it enables a shorter fusion length and a better correction. However, significant deformity increased the pedicle drift rate, which raised the potential risk to nearby neurovascular and visceral structures. To avoid screw misplacement, the CT-based navigation system was applied in many studies as it provided intraoperative three-dimensional images [10, 21, 24, 26, 35]. Merloz et al. [24] found 4 incorrectly placed screws of the 28 inserted pedicle screws for scoliosis with the help of the CT Nav, and there were no neurologic complications in all patients. In a larger population with 264 pedicle screws inserted, only 11 were classified as total deviation based on Neo classification, and no neurovascular complications were found during or after surgery in any of the cases [10]. By comparing the pedicle screw placement accuracy in posterior scoliosis surgery between conventional fluoroscopic and computer-assisted surgical techniques in a retrospective cohort study, Kotani et al. [21] discovered that perforation was as high as 11% in the conventional group compared with only 1.8% in the navigated group. A retrospective comparative study conducted by Yang et al. [35] in ten patients also revealed that CT-based navigation significantly enhanced the accuracy of pedicle screw insertion in adolescent scoliosis patients. Another paper reported that the pedicle violation rate was 28.0% in the control group and 11.4% in the navigation group; it was noteworthy that the difference was statistically significant, though a much higher pedicle violation rate was detected for both groups compared with other similar studies [26]. Overall, CT-based navigation provided a higher accuracy in scoliosis correction surgeries and avoided potential risk to vital structure, which might result from intraoperative visual anatomy of the abnormal pedicles.

CT-assisted pedicle screw insertion into previously fused spines

Many conventional methods usually relied on crucial anatomic landmarks to place the screw into the pedicle [13, 24, 26, 47]. As a result, it would be a challenge when the pedicle screw was to be inserted through a posterolateral fusion mass, where the traditional posterior spinal landmarks were often obscured or completely absent and the tactile feedback from the native cortical/cancellous bone was lost. CT-based navigation was able to generate multiplanar cross-sectional images that provided intraoperative visualization of cross-sectional anatomy, which would not be interfered by abnormal structures [39, 52]. In vitro test verified the great potential of applying the systems in such cases. Austin et al. [35] compared conventional open laminoforaminotomy and two image-guided (CT Nav and 2D FluoroNav) techniques for pedicle screw placement in posterolateral fusion and nonfusion models. The study showed that the accuracy of pedicle screw placement was improved with the use of image-guided methods, particularly guidance by computed tomography. It was noteworthy that all screws in the study were accurately inserted without deviation from the fusion mass group with CT assistance [35]. In a clinical study, the system also obtained improved results: Lim et al. [52] analyzed the postoperative CT scans of 35 patients and found only 5 (4.1%) of the 122 pedicle screws placed into previously fused levels having unintentional cortical violations.

Two-dimension fluoroscopy-based navigation system

Concerns about the CT-based navigation system that involved a large extent of extra preoperational preparation including preoperative computed tomography with a specific protocol, data acquisition and transfer, and patient registration prevented this technique from being widely adopted [12, 40]. 2D FluoroNav appeared to solve the above problem. The equipment did not require registration; it reduced imaging time and radiation dosage, and avoided repeated C-arm movements during surgery because visualization of the surgical instruments in relation to the patient’s anatomy in all the desired image planes was possible from the beginning.

Two in vitro [11, 51] and four in vivo studies [15, 17, 33, 36] comparing the pedicle screw insertion accuracy between conventional and 2D FluoroNav methods indicated that such assistance could provide significantly more accurate pedicle screw placing (Fig. 1). Five in vitro papers also revealed that 2D FluoroNav obtained a lesser, but insignificant, perforation risk compared with the conventional methods (Fig. 1) [39, 4143, 54].

Four cadaveric [12, 13, 15, 30], one model [11], and four in vivo studies [3941, 49] have applied two navigation systems (CT Nav vs. 2D FluoroNav) in their researches. On further analysis, we found most studies [1113, 30, 3941, 49] implied that CT Nav obtained a lesser but insignificant risk compared with 2D FluoroNav (Fig. 2), which indicated that 2D FluoroNav obtained similar potential to CT Nav in pedicle screw insertion assistance.

Besides the better outcome obtained in the application of 2D FluoroNav in conventional spinal surgeries, the system has proved to be well used in revision surgeries, as assessed by Rampersaud et al. [53] who studied the accuracy of fluoroscopy-based navigation for the placement of thoracolumbar pedicle screws through a mature posterolateral fusion mass. Overall, 81.4% of screws were completely within the pedicle. Relative to the total number of screws, pedicle breaches were graded II (<2 mm) in 13.5%, III (2–4 mm) in 2.9%, and IV (>4 mm) in 2.0% of screws. The study indicated that the use of fluoroscopy-assisted navigation was safe and effective for the placement of thoracolumbar (T10-S1) pedicle screws through a posterolateral fusion mass without performing laminoforaminotomies [53]. Navigation systems provided the surgeon with a virtual “road map” of a patient’s anatomy in relationship to the position of surgical instruments. Theoretically, it could be better used to assist minimally invasive surgery. von Jako et al. evaluated the accuracy and time efficiency of 2D FluoroNav compared with a conventional fluoroscopy method for percutaneous placement of Kirschner wires. A higher proportion of ideal trajectories were achieved in the 2D FluoroNav group. Moreover, the study indicated significant reduced screw placement times and shorter fluoroscopy times for the navigation group [54].

Three-dimension fluoroscopy-based navigation system

The 2D FluoroNav system provided only two-dimensional images, and there were no extra pictures in different reformatted plane that could be used intraoperatively to assist pedicle screw insertion. The development of 3D FluoroNav appeared to combine the advantages of CT and 2D fluoroscopy-based assistances [12, 1416]. Such a system provided three-dimensional images, as well as reduced extra preoperative preparation. Though studies on 3D FluoroNav were fewer than those on CT Nav or 2D FluoroNav, most studies indicated the potential advantage of 3D FluoroNav over the other two guiding systems. Like CT Nav, 3D FluoroNav provided intraoperative three-dimensional images, which could be used to assist pedicle screw insertion into abnormal pedicles or guide minimally invasive spinal surgeries. Rajasekaran et al. [18] carried out a randomized clinical trial to study the pedicle screw insertion accuracy with or without the assistance of 3D FluoroNav in patients with scoliosis or kyphosis. A total of 54 (23%) pedicle breaches were found in the non-navigation group as compared to only 5 (2%) in the navigation group (P < 0.001). Moreover, 38 screws (16%) in the non-navigation group had penetrated the anterior or lateral cortex compared to 2 screws (0.8%) in the navigation group [18]. The study also revealed that the navigation system reduced surgical time and radiation in thoracic deformity correction surgeries [18]. Nakashima et al. evaluated 300 percutaneous pedicle screws under assistance of either Iso-C three-dimensional navigation or conventional fluoroscopy. The difference in frequency of screw misplacement was statistically significant (Iso-C: 11/150 vs. fluoroscopy, 23/150; P < 0.05) [55].

The 3D FluoroNav possessed the advantage of both CT Nav and 2D FluoroNav; theoretically, it could gain better outcome compared with other navigation methods. In a large patient cohort study, 1,084 screws were placed with the assistance of either CT-based (perforation rate 9.2%) or 3D fluoroscopy-based navigation (perforation rate 6.6%) and the difference in breach rates between these two groups was statistically insignificant (P = 0.0936) [16]. A retrospective study comparing the 2D and 3D FluoroNav systems indicated that both systems were found to be comparably safe and accurate, and the choice of image-guidance modality may be determined by the level of surgeon comfort and/or availability of the system [14]. Gruetzner et al. [15] reported the remarkable improved precision of pedicle screw insertion with the assistance of 3D FluoroNav when compared with conventional, CT Nav and 2D FluoroNav methods. Moreover, they noted that the lowest average fluoroscopy time was achieved during the placement of pedicle screws on the spine with 3D FluoroNav at a comparable average operating room duration compared to the conventional approach and other computer-assisted procedures [15].

Other perioperative findings

Other than accuracy, spine surgeons also care about perioperative outcomes such as surgical time consumed, radiation exposure, blood loss and patients’ functional outcome. On comparing the navigated and conventional methods, most studies indicated that CTNav increased the time for spinal surgeries [15, 23, 26, 37, 41, 44]. This might be attributed to extra protocols such as preoperative images, modeling and simulation, and registration [12, 40, 57, 58]. One of the drawbacks of the CTNav is the considerable learning curve in the registration process. A quick registration requires an intimate knowledge of surgical anatomy and good cooperation between the surgeon and the navigation system [58]. FluoroNav that does not require registration might reduce surgical time. However, some authors pointed out that extra time was needed for the setup of the system, placing the transmitter and acquiring suitable images for navigation, which would not significantly reduce the total insertion time per screw [15, 17, 4143].

CTNav needs preoperative CT scanning. The radiation exposure of the patients mainly depends on the CT protocol [5961]. By analyzing the radiation of three different CT protocols-based navigation system, Slomczykowski et al. [59] noted that when CTNav was to be used, the spiral mode of CT scanning was recommended. Theoretically, FluoroNav could reduce the radiation running time compared with conventional fluoroscopy method, because such systems do not need repeated movement of the C-arm intraoperatively. In the prospective study conducted by Gebhard et al., 2D FluoroNav was found to produce less radiation than conventional C-arm, but more radiation than CTNav. Moreover, 3D FluoroNav was observed to have a further reduction of intraoperative radiation dosage compared with other navigation methods [59].

In the current review, navigational surgeries seemed not to significantly reduce blood loss compared with that without navigation assistance. A meta-analysis on functional outcome also indicated that navigation did not significantly reduce neurological complications and sufficient data were not available to draw a conclusion on other functional outcomes [56].

Conclusions

Compared to conventional methods, navigation provided a higher accuracy in the placement of pedicle screws. The superiority of navigation systems was obvious when they were applied to deformed spinal structure. Among the three different navigation methods, cumulative analysis implied that CT Nav provided a little higher accuracy than 2D FluoroNav subgroup, but provided a lower accuracy than the 3D FluoroNav subgroup.

Acknowledgments

Conflict of interest None of the authors received financial support for this study.

References

1. Harrington PR, Tullos HS. Reduction of severe spondylolisthesis in children. South Med J. 1969;62:1–7. doi: 10.1097/00007611-196901000-00001. [PubMed] [Cross Ref]
2. Xu R, Zhao L, Chai B, et al. Lateral radiological evaluation of transarticular screw placement in the lower cervical spine. Eur Spine J. 2009;18:392–397. doi: 10.1007/s00586-008-0861-0. [PMC free article] [PubMed] [Cross Ref]
3. Bayley E, Zia Z, Kerslake R, et al. Lamina-guided lateral mass screw placement in the sub-axial cervical spine. Eur Spine J. 2010;19:660–664. doi: 10.1007/s00586-009-1228-x. [PMC free article] [PubMed] [Cross Ref]
4. Husted DS, Yue JJ, Fairchild TA, et al. An extrapedicular approach to the placement of screws in the thoracic spine: an anatomic and radiographic assessment. Spine. 2003;28:2324–2330. doi: 10.1097/01.BRS.0000085361.32600.63. [PubMed] [Cross Ref]
5. Tian NF, Xu HZ, Wang XY, et al. Morphometric comparisons between the pedicle and the pedicle rib unit in the immature Chinese thoracic spine: a computed tomographic assessment. Spine. 2010;35:1514–1519. doi: 10.1097/BRS.0b013e3181c6d9ae. [PubMed] [Cross Ref]
6. Lo YL, Dan YF, Teo A, et al. The value of bilateral ipsilateral and contralateral motor evoked potential monitoring in scoliosis surgery. Eur Spine J. 2008;17:S236–S238. doi: 10.1007/s00586-007-0498-4. [PMC free article] [PubMed] [Cross Ref]
7. Sutter M, Eggspuehler A, Grob D, et al. The diagnostic value of multimodal intraoperative monitoring (MIOM) during spine surgery: a prospective study of 1,017 patients. Eur Spine J. 2007;16:S162–S170. doi: 10.1007/s00586-007-0418-7. [PMC free article] [PubMed] [Cross Ref]
8. Kosmopoulos V, Schizas C. Pedicle screw placement accuracy: a meta-analysis. Spine. 2007;32:E111–E120. doi: 10.1097/01.brs.0000254048.79024.8b. [PubMed] [Cross Ref]
9. Tian NF, Xu HZ. Image-guided pedicle screw insertion accuracy: a meta-analysis. Int Orthop. 2009;33:895–903. doi: 10.1007/s00264-009-0792-3. [PMC free article] [PubMed] [Cross Ref]
10. Nakanishi K, Tanaka M, Misawa H, et al. Usefulness of a navigation system in surgery for scoliosis: segmental pedicle screw fixation in the treatment. Arch Orthop Trauma Surg. 2009;129:1211–1218. doi: 10.1007/s00402-008-0807-3. [PubMed] [Cross Ref]
11. Arand M, Schempf M, Fleiter T, et al. Qualitative and quantitative accuracy of CAOS in a standardized in vitro spine model. Clin Orthop Relat Res. 2006;450:118–128. doi: 10.1097/01.blo.0000218731.36967.e8. [PubMed] [Cross Ref]
12. Fu TS, Wong CB, Tsai TT, et al. Pedicle screw insertion: computed tomography versus fluoroscopic image guidance. Int Orthop. 2008;32:517–521. doi: 10.1007/s00264-007-0358-1. [PMC free article] [PubMed] [Cross Ref]
13. Lee GY, Massicotte EM, Rampersaud YR. Clinical accuracy of cervicothoracic pedicle screw placement: a comparison of the “open” lamino-foraminotomy and computer-assisted techniques. J Spinal Disord Tech. 2007;20:25–32. doi: 10.1097/01.bsd.0000211239.21835.ad. [PubMed] [Cross Ref]
14. Lekovic GP, Potts EA, Karahalios DG, et al. A comparison of two techniques in image-guided thoracic pedicle screw placement: a retrospective study of 37 patients and 277 pedicle screws. J Neurosurg Spine. 2007;7:393–398. doi: 10.3171/SPI-07/10/393. [PubMed] [Cross Ref]
15. Gruetzner PA, Waelti H, Vock B, et al. Navigation using fluoro-CT technology, concept and clinical experience in a new method for intraoperative navigation. Eur J Trauma. 2004;30:161–170. doi: 10.1007/s00068-004-1328-6. [Cross Ref]
16. Nottmeier EW, Seemer W, Young PM. Placement of thoracolumbar pedicle screws using three-dimensional image guidance: experience in a large patient cohort. J Neurosurg Spine. 2009;10:33–39. doi: 10.3171/2008.10.SPI08383. [PubMed] [Cross Ref]
17. Merloz P, Troccaz J, Vouaillat H, et al. Fluoroscopy-based navigation system in spine surgery. Proc Inst Mech Eng [H] 2007;221:813–820. [PubMed]
18. Rajasekaran S, Vidyadhara S, Ramesh P, et al. Randomized clinical study to compare the accuracy of navigated and non-navigated thoracic pedicle screws in deformity correction surgeries. Spine. 2007;32:E56–E64. doi: 10.1097/01.brs.0000252094.64857.ab. [PubMed] [Cross Ref]
19. Amiot LP, Lang K, Putzier M, et al. Comparative results between conventional and computer-assisted pedicle screw installation in the thoracic, lumbar, and sacral spine. Spine. 2000;25:606–614. doi: 10.1097/00007632-200003010-00012. [PubMed] [Cross Ref]
20. Ito H, Neo M, Yoshida M, et al. Efficacy of computer-assisted pedicle screw insertion for cervical instability in RA patients. Rheumatol Int. 2007;27:567–574. doi: 10.1007/s00296-006-0256-7. [PubMed] [Cross Ref]
21. Kotani Y, Abumi K, Ito M, et al. Accuracy analysis of pedicle screw placement in posterior scoliosis surgery: comparison between conventional fluoroscopic and computer-assisted technique. Spine. 2007;32:1543–1550. doi: 10.1097/BRS.0b013e318068661e. [PubMed] [Cross Ref]
22. Laine T, Schlenzka D, Mäkitalo K, et al. Improved accuracy of pedicle screw insertion with computer-assisted surgery. A prospective clinical trial of 30 patients. Spine. 1997;22:1254–1258. doi: 10.1097/00007632-199706010-00018. [PubMed] [Cross Ref]
23. Laine T, Lund T, Ylikoski M, et al. Accuracy of pedicle screw insertion with and without computer assistance: a randomised controlled clinical study in 100 consecutive patients. Eur Spine J. 2000;9:235–240. doi: 10.1007/s005860000146. [PubMed] [Cross Ref]
24. Merloz P, Tonetti J, Pittet L, et al. Pedicle screw placement using image guided techniques. Clin Orthop Relat Res. 1998;354:39–48. doi: 10.1097/00003086-199809000-00006. [PubMed] [Cross Ref]
25. Richter M, Cakir B, Schmidt R. Cervical pedicle screws: conventional versus computer-assisted placement of cannulated screws. Spine. 2005;30:2280–2287. doi: 10.1097/01.brs.0000182275.31425.cd. [PubMed] [Cross Ref]
26. Sakai Y, Matsuyama Y, Nakamura H, et al. Segmental pedicle screwing for idiopathic scoliosis using computer-assisted surgery. J Spinal Disord Tech. 2008;21:181–186. doi: 10.1097/BSD.0b013e318074d388. [PubMed] [Cross Ref]
27. Arand M, Hartwig E, Hebold D, et al. Precision analysis of navigation-assisted implanted thoracic and lumbar pedicled screws. A prospective clinical study. Unfallchirurg. 2001;104:1076–1081. doi: 10.1007/s001130170023. [PubMed] [Cross Ref]
28. Schnake KJ, König B, Berth U, et al. Accuracy of CT-based navigation of pedicle screws in the thoracic spine compared with conventional technique. Unfallchirurg. 2004;107:104–112. doi: 10.1007/s00113-003-0720-8. [PubMed] [Cross Ref]
29. Seller K, Wild A, Urselmann L, et al. Prospective screw misplacement analysis after conventional and navigated pedicle screw implantation. Biomed Tech (Berl) 2005;50:287–292. doi: 10.1515/BMT.2005.043. [PubMed] [Cross Ref]
30. Huang Y, Kong R, Fang SY, et al. Comparison study between C-arm X-ray and 3D CT in guiding thoracolumbar pedicle screw fixation. Shandong Med J (Chin) 2009;49:5–7.
31. Li Y (2007) The study of clinical anatomy of cervical pedicle with Iso-C arm and clinical application of Iso-C navigation system. Master’s Thesis, Shandong University (Chin) (5)
32. Liu YJ, Tian W, Liu B, et al. Accuracy of CT-based navigation of pedicle screws implantation in the cervical spine compared with X-ray fluoroscopy technique. Chin J Surg (Chin) 2005;43:1328–1330. [PubMed]
33. Yang YH, Ye H, Zheng J, et al. Application of orthopaedic guidance for pedicle screw fixation of spine. Orthop J Chin (Chin) 2005;13:75–76.
34. Xu L, Yu X, Zheng DB, et al. Preliminary application of spinal navigation with the intra-operative 3D-imaging modality in pedicle screw fixation. Orthop J Chin (Chin) 2004;12:1895–1897.
35. Yang LL, Chen HJ, Chen DY, et al. Clinical applications of computer assisted navigation technique in scoliosis surgery. Orthop J Chin (Chin) 2007;15:1773–1776.
36. Zhang DS, Yuan JT, Zheng J, et al. Pedicle screw placement under the guidance of computer-assisted navigation system. Chin J Min Inv Surg (Chin) 2008;8:544–546.
37. Li SG, Sheng L, Zhao H, et al. Computer-assisted navigation technique in the spinal pedicle screw internal fixation. J Clin Rehabil Tissue Eng Res (Chin) 2009;13:3365–3369.
38. Tian W, Liu B, Li Q, et al. Experience of pedicle screw fixation in the cervical spine using navigation system. J Spinal Surg (Chin) 2003;1:15–18.
39. Austin MS, Vaccaro AR, Brislin B, et al. Image-guided spine surgery: a cadaver study comparing conventional open laminoforaminotomy and two image-guided techniques for pedicle screw placement in posterolateral fusion and nonfusion models. Spine. 2002;27:2503–2508. doi: 10.1097/00007632-200211150-00015. [PubMed] [Cross Ref]
40. Choi WW, Green BA, Levi AD. Computer-assisted fluoroscopic targeting system for pedicle screw insertion. Neurosurgery. 2000;47:872–878. doi: 10.1097/00006123-200010000-00017. [PubMed] [Cross Ref]
41. Mirza SK, Wiggins GC, Kuntz C, et al. Accuracy of thoracic vertebral body screw placement using standard fluoroscopy, fluoroscopic image guidance, and computed tomographic image guidance: a cadaver study. Spine. 2003;28:402–413. [PubMed]
42. Sagi HC, Manos R, Park SC, et al. Electromagnetic field-based image-guided spine surgery part two: results of a cadaveric study evaluating thoracic pedicle screw placement. Spine. 2003;28:E351–E354. doi: 10.1097/01.BRS.0000086822.76638.76. [PubMed] [Cross Ref]
43. Sagi HC, Manos R, Benz R, et al. Electromagnetic field-based image-guided spine surgery part one: results of a cadaveric study evaluating lumbar pedicle screw placement. Spine. 2003;28:2013–2018. doi: 10.1097/01.BRS.0000087851.51547.00. [PubMed] [Cross Ref]
44. Assaker R, Reyns N, Vinchon M, et al. Transpedicular screw placement: image-guided versus lateral-view fluoroscopy: in vitro simulation. Spine. 2001;26:2160–2164. doi: 10.1097/00007632-200110010-00024. [PubMed] [Cross Ref]
45. Hart RA, Hansen BL, Shea M, et al. Pedicle screw placement in the thoracic spine: a comparison of image-guided and manual techniques in cadavers. Spine. 2005;30:E326–E331. doi: 10.1097/01.brs.0000166621.98354.1d. [PubMed] [Cross Ref]
46. John PS, James C, Antony J, et al. A novel computer-assisted technique for pedicle screw insertion. Int J Med Robot. 2007;3:59–63. [PubMed]
47. Ludwig SC, Kramer DL, Balderston RA, et al. Placement of pedicle screws in the human cadaveric cervical spine: comparative accuracy of three techniques. Spine. 2000;25:1655–1667. doi: 10.1097/00007632-200007010-00009. [PubMed] [Cross Ref]
48. Ludwig SC, Kowalski JM, Edwards CC, et al. Cervical pedicle screws: comparative accuracy of two insertion techniques. Spine. 2000;25:2675–2681. doi: 10.1097/00007632-200010150-00022. [PubMed] [Cross Ref]
49. Tian W, Liu YJ, Liu B, et al. Experimental study and clinical applications of computer assisted navigation technique in spinal surgery. Chin J Orthop (Chin) 2006;26:671–675.
50. He XS, Yang HL, Zhu RF, et al. Study on pedicle screw fixation of cervical spine assisted CT-based navigation system compared with the individual cervical peddle screws placement technique. Suzhou Univ J Med Sci (Chin) 2008;28:415–417.
51. Xia Q, Yan SJ, Chen TY, et al. Application of computer-assisted fluoroscopic navigation based on the C-arm X-ray in pedicle screw fixation. Fudan Univ J Med Sci (Chin) 2007;34:873–876.
52. Lim MR, Girardi FP, Yoon SC, et al. Accuracy of computerized frameless stereotactic image-guided pedicle screw placement into previously fused lumbar spines. Spine. 2005;30:1793–1798. doi: 10.1097/01.brs.0000171905.38459.b7. [PubMed] [Cross Ref]
53. Rampersaud YR, Lee KS. Fluoroscopic computer-assisted pedicle screw placement through a mature fusion mass: an assessment of 24 consecutive cases with independent analysis of computed tomography and clinical data. Spine. 2007;32:217–222. doi: 10.1097/01.brs.0000251751.51936.3f. [PubMed] [Cross Ref]
54. Jako RA, Carrino JA, Yonemura KS, et al. Electromagnetic navigation for percutaneous guide-wire insertion: accuracy and efficiency compared to conventional fluoroscopic guidance. Neuroimage. 2009;47:T127–T132. doi: 10.1016/j.neuroimage.2009.05.002. [PubMed] [Cross Ref]
55. Nakashima H, Sato K, Ando T, et al. Comparison of the percutaneous screw placement precision of isocentric C-arm 3-dimensional fluoroscopy-navigated pedicle screw implantation and conventional fluoroscopy method with minimally invasive surgery. J Spinal Disord Tech. 2009;22:468–472. doi: 10.1097/BSD.0b013e31819877c8. [PubMed] [Cross Ref]
56. Verma R, Krishan S, Haendlmayer K, et al. Functional outcome of computer-assisted spinal pedicle screw placement: a systematic review and meta-analysis of 23 studies including 5,992 pedicle screws. Eur Spine J. 2010;19:370–375. doi: 10.1007/s00586-009-1258-4. [PMC free article] [PubMed] [Cross Ref]
57. Sugano N. Computer-assisted orthopedic surgery. J Orthop Sci. 2003;8:442–448. doi: 10.1007/s10776-002-0623-6. [PubMed] [Cross Ref]
58. Kendo D, Citak M, Hüfner T, et al. Current concepts and applications of computer navigation in orthopedic trauma surgery. Central Eur J Med. 2007;2:392–403. doi: 10.2478/s11536-007-0042-2. [Cross Ref]
59. Slomczykowski M, Roberto M, Schneeberger P, et al. Radiation dose for pedicle screw insertion. Fluoroscopic method versus computer-assisted surgery. Spine. 1999;24:975–982. doi: 10.1097/00007632-199905150-00009. [PubMed] [Cross Ref]
60. Gebhard FT, Kraus MD, Schneider E, et al. Does computer-assisted spine surgery reduce intraoperative radiation doses? Spine. 2006;31:2024–2027. doi: 10.1097/01.brs.0000229250.69369.ac. [PubMed] [Cross Ref]
61. Tjardes T, Shafizadeh S, Rixen D, et al. Image-guided spine surgery: state of the art and future directions. Eur Spine J. 2010;19:25–45. doi: 10.1007/s00586-009-1091-9. [PMC free article] [PubMed] [Cross Ref]

Articles from European Spine Journal are provided here courtesy of Springer-Verlag