Search tips
Search criteria 


Logo of stemcellresBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleStem Cell Research & TherapyJournal Front Page
Published online 2011 January 31. doi: 10.1186/scrt44

Figure 2

An external file that holds a picture, illustration, etc.
Object name is scrt44-2.jpg

Substrate rigidity regulates muscle stem cell self-renewal in culture. A biomimetic biomaterials approach in conjunction with functional assays in mice demonstrated that muscle stem cell (MuSC) self-renewal can be maintained in culture if cells are propagated upon a substrate that recapitulates the mechanical properties of the native skeletal muscle tissue, a physical property of the stem cell niche [9]. Pliant culture substrates enabled propagation of additional Pax7 (green) expressing MuSCs and improved survival (middle), while culture on softer (left) or stiffer (right) matrices decreased cell survival (gray) and promoted differentiation. Image is courtesy of Stephane Corbel, Blau Laboratory.

Images in this article

  • Figure 1
  • Figure 2
  • Figure 3
Click on the image to see a larger version.