Hum Mol Genet. Jun 1, 2011; 20(11): 2285–2295.
© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: firstname.lastname@example.org
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium
1Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA,
2Department of Medicine, and
3McKusick—Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA,
4Department of Medicine, and
5School of Nursing, University of Mississippi Medical Center, Jackson, MS, USA,
6The Institute for Translational Medicine and Therapeutics, and
7Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA,
8Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA,
9Department of Epidemiology and Preventive Medicine, Loyola University Stritch School of Medicine, Maywood, IL, USA,
10Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USA,
11Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA,
12Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas at Houston, Houston, TX, USA,
13Broad Institute of Harvard and MIT, Massachusetts General Hospital,
14Department of Medicine, and
15Children's Hospital Boston, Department of Genetics, Harvard University, Boston, MA, USA,
16Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,
17Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA,
18Medical College of Georgia, Augusta, GA, USA,
19Department of Medicine, Boston University School of Medicine, Framingham, MA, USA,
20Department of Radiology, Tufts-New England Medical Center, Boston, MA, USA,
21Department of Medicine, Columbia University, New York, NY, USA,
22Division of Epidemiology and Clinical Applications, and
23Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA,
24Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA,
25Pacific Health Research Institute, Honolulu, HI, USA,
26Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA,
27Division of Biology and Medicine, Brown University, Providence, RI, USA, and
28Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, CA, USA
Received November 21, 2010; Revised February 24, 2011; Accepted March 15, 2011.
CARe. The authors wish to acknowledge the support of the National Heart, Lung, and Blood Institute. The following nine parent studies have contributed parent study data, ancillary study data, and DNA samples through the Broad Institute (N01-HC-65226) to create this genotype/phenotype database for wide dissemination to the biomedical research community: Atherosclerotic Risk in Communities (ARIC): University of North Carolina at Chapel Hill (N01-HC-55015), Baylor Medical College (N01-HC-55016), University of Mississippi Medical Center (N01-HC-55021), University of Minnesota (N01-HC-55019), Johns Hopkins University (N01-HC-55020), University of Texas, Houston (N01-HC-55017), University of North Carolina, Forsyth County (N01-HC-55018); Cardiovascular Health Study (CHS): University of Washington (N01-HC-85079), Wake Forest University (N01-HC-85080), Johns Hopkins University (N01-HC-85081), University of Pittsburgh (N01-HC-85082), University of California, Davis (N01-HC-85083), University of California, Irvine (N01-HC-85084), New England Medical Center (N01-HC-85085), University of Vermont (N01-HC-85086), Georgetown University (N01-HC-35129), Johns Hopkins University (N01 HC-15103), University of Wisconsin (N01-HC-75150), Geisinger Clinic (N01-HC-45133), University of Washington (N01 HC-55222, U01 HL080295); Cleveland Family Study (CFS): Case Western Reserve University (RO1 HL46380-01-16); Cooperative Study of Sickle Cell Disease (CSSCD): University of Illinois (N01-HB-72982, N01-HB-97062), Howard University (N01-HB-72991, N01-HB-97061), University of Miami (N01-HB-72992, N01-HB-97064), Duke University (N01-HB-72993), George Washington University (N01-HB-72994), University of Tennessee (N01-HB-72995, N01-HB-97070), Yale University (N01-HB-72996, N01-HB-97072), Children's Hospital-Philadelphia (N01-HB-72997, N01-HB-97056), University of Chicago (N01-HB-72998, N01-HB-97053), Medical College of Georgia (N01-HB-73000, N01-HB-97060), Washington University (N01-HB-73001, N01-HB-97071), Jewish Hospital and Medical Center of Brooklyn (N01-HB-73002), Trustees of Health and Hospitals of the City of Boston, Inc. (N01-HB-73003), Children's Hospital-Oakland (N01-HB-73004, N01-HB-97054), University of Mississippi (N01-HB-73005), St. Luke's Hospital-New York (N01-HB-73006), Alta Bates-Herrick Hospital (N01-HB-97051), Columbia University (N01-HB-97058), St. Jude's Children's Research Hospital (N01-HB-97066), Research Foundation, State University of New York-Albany (N01-HB-97068, N01-HB-97069), New England Research Institute (N01-HB-97073), Interfaith Medical Center-Brooklyn (N01-HB-97085); Coronary Artery Risk in Young Adults (CARDIA): University of Alabama at Birmingham (N01-HC-48047), University of Minnesota (N01-HC-48048), Northwestern University (N01-HC-48049), Kaiser Foundation Research Institute (N01-HC-48050), University of Alabama at Birmingham (N01-HC-95095), Tufts-New England Medical Center (N01-HC-45204), Wake Forest University (N01-HC-45205), Harbor-UCLA Research and Education Institute (N01-HC-05187), University of California, Irvine (N01-HC-45134, N01-HC-95100); Framingham Heart Study (FHS): Boston University (N01-HC-25195); Jackson Heart Study (JHS): Jackson State University (N01-HC-95170), University of Mississippi (N01-HC-95171), Tougaloo College (N01-HC-95172); Multi-Ethnic Study of Atherosclerosis (MESA): University of Washington (N01-HC-95159),Regents of the University of California (N01-HC-95160), Columbia University (N01-HC-95161), Johns Hopkins University (N01-HC-95162), University of Minnesota (N01-HC-95163), Northwestern University (N01-HC-95164), Wake Forest University (N01-HC-95165), University of Vermont (N01-HC-95166), New England Medical Center (N01-HC-95167), Johns Hopkins University (N01-HC-95168),Harbor-UCLA Research and Education Institute (N01-HC-95169); Sleep Heart Health Study (SHHS): Johns Hopkins University (U01 HL064360), Case Western University (U01 HL063463), University of California, Davis (U01 HL053916), University of Arizona (U01 HL053938), University of Minnesota (relocating in 2006 to University Arizona) (U01 HL053934), University of Pittsburgh (U01 HL077813), Boston University (U01 HL053941), MedStar Research Institute (U01 HL063429), Johns Hopkins University (U01 HL053937).
Maywood African-American and Nigeria studies are supported by the National Institutes of Health, grant numbers HL074166 and HL53353 from the National Heart, Lung, and Blood Institute. Y.L. and X.Z. are supported by HL086718 from the National Heart, Lung, and Blood Institute and HG003054 from the National Human Genome Research Institute.
Genetic Epidemiology Network of Arteriopathy (GENOA) study is supported by the National Institutes of Health, grant numbers HL087660 and HL100245 from the National Heart, Lung, and Blood Institute.
The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts N01WH22110, 24152, 32100–32102, 32105, 32106, 32108–32109, 32111–32113, 32115, 32118, 32119, 32122, 42107–42126, 42129–42132, and 44221.