Model for repair of DNA breaks regulated by the Shu complex. After a DSB occurs in the DNA, the ends of the break site are resected and processed. Here we show a DSB, but this reaction can take place at any Rad51-mediated step. The Shu complex promotes Rad51 filament formation by inhibiting Srs2 recruitment to the break sites and preventing Srs2 inhibition of Rad51 filament formation. Alternatively, the Shu complex could directly promote Rad51 filament formation in a manner similar to other Rad51 paralogues (dashed line). After Rad51 filaments are formed (indicted by the beads on the single-strand tail), subsequent repair of the DNA lesion can occur via HR.
Articles from Molecular Biology of the Cell are provided here courtesy of
American Society for Cell Biology