Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
1Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
2Inserm U744, F-59019 Lille, France.
3Institut Pasteur de Lille, F-59019, Lille, France.
4Université de Lille Nord de France, F-59000 Lille, France.
5Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA.
6National Institute for Health Research Biomedical Research Centre for Mental Health at the South London and Maudsley National Health Service Foundation Trust and Institute of Psychiatry, Kings College, London, UK.
7Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK.
8Institute of Public Health, University of Cambridge, Cambridge, UK.
9Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
10Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
11Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.
12Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, UK.
13Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
14Neurodegeneration and Mental Health Research Group, School of Community Based Medicine, University of Manchester, Hope Hospital, Stott Lane, Salford, Manchester, UK.
15Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, John Radcliffe Hospital, Oxford, UK.
16Nuffield Department of Clinical Medicine, Medical Sciences Division. University of Oxford, Headington, Oxford. OX3 7BN. UK.
17Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK.
18Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, LIGHT Laboratories, University of Leeds, LS2 9JT, UK
19Cerebral Function Unit, Salford Royal NHS Trust, Stott Lane, Salford, M6 8HD, UK.
20Department of Molecular Neuroscience, Institute of Neurology, London, UK.
21Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.
22Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
23Department of Psychiatry, University of Bonn, Bonn, Germany.
24German Centre for Neurodegenerative Diseases, Bonn, Bonn, Germany.
25Institute for Molecular Psychiatry, University of Bonn, Bonn, Germany.
26Department of Psychiatry, University of Göttingen, Germany.
27Department of Psychiatry, Royal Derby Hospital, Derby, DE22 3WQ, UK.
28Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany.
29Department of Psychiatry, Charité Berlin, Berlin, Germany.
30Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany.
31Landschaftsverband Rheinland-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Essen, Germany.
32Department of Neurology, Klinikum der Universität München, Munich, Germany.
33Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
34Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
35Department of Psychiatry, Psychsomatic Medicine and Psychotherapy, Johann Wolfgang Goethe-University, Frankfurt, Germany.
36Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, UK.
37Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA.
38Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.
39Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA.
40Department of Biology, Brigham Young University, Provo, Utah, USA.
41Institute Born-Bunge and University of Antwerp, Antwerpen, Belgium.
42Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.
43Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium.
44Department of Mental Health Sciences, University College London, UK.
45The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
46MRC Centre for Neurodegeneration Research, Department of Clinical Neuroscience, King’s College London, Institute of Psychiatry, London, UK.
47Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
48Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
49Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
50Institute of Human Genetics, University of Bonn, Bonn, Germany.
51Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
52Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
53Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
54Klinikum Grosshadern, Munich, Germany.
55Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
56Department of Neurology, St. Olav’s Hospital, Edvard Griegs Gate 8, 7006 Trondheim, Norway.
57Department of Neuroscience, Norwegian University of Science and Technology, NTNU, 7491 Trondheim, Norway.
58Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
59Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
60Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
61Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Data used in the preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (www.loni.ucla.edu\ADNI
). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. ADNI investigators include (complete listing available at www.loni.ucla.edu\ADNI\Collaboration\ADNI_Authorship_list.pdf
63Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
64Netherlands Consortium for Healthy Aging, The Netherlands.
65Departments of Neurology and Biostatistics, Boston University School of Medicine, Boston, Massachussets, USA.
66The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachussets, USA.
67Department of Epidemiology, University of Washington, Seattle, Washington, USA.
68Department of Neurology, The Alzheimer’s Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
69Department of Psychiatry, The Alzheimer’s Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
70Neuroepidemiology Section, Laboratory of Epidemiology, Demography and Biometry (LJL), National Institute on Aging, Washington DC, USA.
71Department of Neurology, Boston University School of Medicine, Boston, Massachussets, USA.
72Inserm U888, Hôpital La Colombière, Montpellier, France.
73Inserm U614, Faculté de Médecine-Pharmacie de Rouen, Rouen, France.
74UMR 894, Inserm Faculté de Médecine, Université Paris Descartes, Paris, France.
75Inserm U897, Victor Segalen University, Bordeaux, France.
76Inserm U708, Paris, France.
77Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry, France.
78Fondation Jean Dausset- CEPH, Paris, France.
79Department of Psychiatry and Psychotherapy, Universitätsklinikum des Saarlandes, Universität des Saarlandes, Germany.
80Institute of Medical Informatics and Statistics, Christian-Albrechts-University, Kiel, Germany.
81Biobank Popgen, Institute of Experimental Medicine, Section of Epidemiology, Christian-Albrechts University, Kiel, Germany
82Institute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
83Inst. of Medical Statistics and Epidemiology; Klinikum Rechts der Isar, TU-München, Germany.
84deCODE Genetics, Reykjavik, Iceland.
85deCODE Genetics and University of Iceland, Faculty of Medicine, Reykjavik, Iceland.
86Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
87Department of Neurology, University of Eastern Finland and Kuopio University Hospital, 70211, Kuopio, Finland.
88Neurology Service, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain.
89CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain.
90Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry, France.
91Centro de Biologia Molecular Severo Ochoa (CSIC-UAM, Universidad Autonoma, Campus de Cantoblanco, S-28049, Madrid, Spain.
92Centre Hospitalier Régional Universitaire de Lille, Lille, France.
93Servicio de Neurologia, Hospital Universitario La Paz (UAM) 28034 Madrid, Spain.
94Department of Experimental Pathology, School of Medicine, University of Bologna, Italy.
95Departement de Geriatrie, CHU de Dijon, F-21000, Dijon, France.
96Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain.
97IRCCS Oasi Maria SS, 94018 Troina , Italy
98Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy.
99Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari , Italy.
100Department of Neurological and Psychiatric Sciences, University of Florence, 50134 Florence, Italy.
101Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma, Italy.
102Lab of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy.
103Department of Internal Medicine, Università degli Studi di Milano, Fondazione IRCCS, Ospedale Maggiore, Mangiagalli e Regina Elena, Milan Italy.
104Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy.
105Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy.
106Dept. of Neurological Sciences, University of Milan, 35 via F. Sforza, Milan, 20122, Italy.
107Inserm, UMR_S679, Hopital de la salpétirère, 75651 Paris, France.
108Inserm U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France.