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Nucleic Acids Res. 1994 September; 22(17): 3640–3659.
PMCID: PMC308336

Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases.


Restriction endonucleases have site-specific interactions with DNA that can often be inhibited by site-specific DNA methylation and other site-specific DNA modifications. However, such inhibition cannot generally be predicted. The empirically acquired data on these effects are tabulated for over 320 restriction endonucleases. In addition, a table of known site-specific DNA modification methyltransferases and their specificities is presented along with EMBL database accession numbers for cloned genes.

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