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Published online 2011 January 21. doi: 10.1093/bfgp/elr002

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AML development as a multistage process. Chromosomal translocations in either HSCs or committed progenitors induce a pre-leukemic state in which further mutations will lead to AML development. Within the AML cell population carrying the mutations implicated in the pathogenesis, the LSCs subpopulation will maintain and propagate the AML phenotype.

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