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Published online 2011 January 21. doi: 10.1093/bfgp/elr002

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Main epigenetic mechanisms of transcription deregulation by AML fusion proteins. The aberrant recruitment of epigenetic machineries to the promoters of key genes in differentiation by fusion proteins is a central step to disrupt normal gene transcription regulation and thus trigger AML. The mechanisms to deregulate transcription are specific for each oncofusion protein, being determined by the characteristics of its moieties.

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