PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

Logo of bfgLink to Publisher's site
 
From:
Published online Jan 21, 2011. doi: 10.1093/bfgp/elr002
An external file that holds a picture, illustration, etc.
Object name is elr002f1.jpg Object name is elr002f1.jpg
Figure 1:
Structure of the most frequent fusion proteins in AML. PML–RARα, AML1–ETO, CBFβ-MYH11 and the different chromosomal translocations involving the N-terminus domain of MLL are the main AML-associated oncofusion proteins. Ring, really interesting gene; B1 and B2, B-boxes 1 and 2; CC, coiled-coil; DBD, DNA-binding domain; LBD, ligand-binding domain; RHD, Runt homology domain; NHR, nervy homology regions; HABD, high-affinity binding domain; ATH, AT-hook motifs; SNL, speckled nuclear localization sites; RD, repression domain. Note that the MLL fusion is not depicted in scale.
Articles from Briefings in Functional Genomics are provided here courtesy of
Oxford University Press