Structure of the most frequent fusion proteins in AML. PML–RARα, AML1–ETO, CBFβ-MYH11 and the different chromosomal translocations involving the N-terminus domain of MLL are the main AML-associated oncofusion proteins. Ring, really interesting gene; B1 and B2, B-boxes 1 and 2; CC, coiled-coil; DBD, DNA-binding domain; LBD, ligand-binding domain; RHD, Runt homology domain; NHR, nervy homology regions; HABD, high-affinity binding domain; ATH, AT-hook motifs; SNL, speckled nuclear localization sites; RD, repression domain. Note that the MLL fusion is not depicted in scale.
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