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Logo of canjgastroThe Canadian Journal of Gastroenterology HomepageSubscription PageSubmissions Pagewww.pulsus.comThe Canadian Journal of Gastroenterology
Can J Gastroenterol. 2011 March; 25(3): 157–160.
PMCID: PMC3076034

Language: English | French

Acute liver failure caused by ‘fat burners’ and dietary supplements: A case report and literature review

Y Radha Krishna, MBBS,1 V Mittal, MD,1 P Grewal, MD,1 MI Fiel, MD,2 and T Schiano, MD1


Globally, people are struggling with obesity. Many effective, non-conventional methods of weight reduction, such as herbal and natural dietary supplements, are increasingly being sought. Fat burners are believed to raise metabolism, burn more calories and hasten fat loss. Despite patient perceptions that herbal remedies are free of adverse effects, some supplements are associated with severe hepatotoxicity. The present report describes a young healthy woman who presented with fulminant hepatic failure requiring emergent liver transplantation caused by a dietary supplement and fat burner containing usnic acid, green tea and guggul tree extracts. Thorough investigation, including histopathological examination, revealed no other cause of hepatotoxicity. The present case adds to the increasing number of reports of hepatotoxicity associated with dietary supplements containing usnic acid, and highlights that herbal extracts from green tea or guggul tree may not be free of adverse effects. Until these products are more closely regulated and their advertising better scrutinized, physicians and patients should become more familiar with herbal products that are commonly used as weight loss supplements and recognize those that are potentially harmful.

Keywords: Dietary supplements, Hepatotoxicity, Liver failure, Liver transplantation


Sur la scène mondiale, les gens luttent contre l’obésité. Ils se tournent de plus en plus vers de nombreuses méthodes efficaces et non conventionnelles de réduction du poids, telles que les suppléments alimentaires naturels et à base de plantes médicinales. Ils pensent que les brûleurs de graisse activent le métabolisme, brûlent plus de calories et accélèrent la perte de matières grasses. Malgré les perceptions des patients selon lesquelles les produits à base de plantes médicinales ne provoquent pas d’effets secondaires, certains suppléments s’associent à une grave hépatotoxicité. Le présent rapport décrit le cas d’une jeune femme en santé qui a consulté en raison d’une insuffisance hépatique foudroyante exigeant une greffe du foie d’urgence, consécutive à la consommation d’un supplément alimentaire contenant de l’acide usnique, du thé vert et des extraits de guggul. Un examen approfondi, y compris un examen histopathologique, n’a révélé aucune autre cause d’hépatotoxicité. Ce cas s’ajoute au nombre croissant de rapports d’hépatotoxicité associée à des suppléments alimentaires contenant de l’acide usnique et attire l’attention sur le fait que des plantes médicinales extraites du thé vert ou du guggul peuvent entraîner des effets secondaires. Tant que ces produits ne feront pas l’objet d’une réglementation plus stricte et que leur publicité ne sera pas mieux évaluée, les médecins et les patients devraient se familiariser avec les plantes médicinales couramment utilisées comme suppléments de perte de poids et repérer ceux qui ont un potentiel nuisible.

In recent years, there has been an alarming increase in obesity worldwide. Growing numbers of obese individuals are struggling to find the best way to lose weight. This has created an enormous industry for weight loss and related health products. Because they are not subject to regulatory testing by the United States Food and Drug Administration (FDA), herbal remedies continue to be a popular choice due to their perceived safety and easy availability. Among the more popular remedies are the ‘fat burners’. These supplements are advertised to work by increasing thermogenesis and the basal metabolic rate, thus, mimicking exercise. Despite the common perception that these natural supplements are free of side effects, some are associated with severe toxicities including hepatotoxicity.

Several slimming aids and herbal medications associated with severe hepatotoxicity have been reported in the literature. The list is long, and examples of a few are the following: Chaso, Onshind, Sennomotounou (Japan); Green tea extracts (eg, Exolise [ArkoPharma-France]); Hydroxycut (Iovate, Canada); The Right Approach (Pharmanex-USA); LipoKinetix (Syntrax, USA); Ma Hung; Pure usnic acid; Kombucha mushroom; Teucrium chamaedrys (germander); Teucrium capitum; and Teucrium polium (golden germander) (14).

The present report describes a case of acute liver failure in a young healthy female taking herbal supplements containing usnic acid, green tea and guggul tree extracts.


A previously healthy 28-year-old female bodybuilder with no risk factors for liver disease presented to her local emergency centre with fatigue, malaise, inability to exercise and new-onset jaundice. Her symptoms worsened over a span of one week before hospitalization. Initially, she was confused, and over two days became obtunded and eventually required intubation for airway protection before her transfer to The Mount Sinai Medical Center (New York, USA) for liver transplant evaluation.

The patient was a professional bodybuilder taking a multi-ingredient, nonstimulant health supplement and fat burner (Somalyz and Lipolyz, Species Nutrition, USA). Somalyz contains usnic acid (4 mg), propionyl-L-carnitine (167 mg), phosphatidylcholine/phosphatidylethanolamine (50 mg), gamma-aminobutyric acid (667 mg) and vitamin E (27 IU) per capsule. Lipolyz contains usnic acid (12 mg), propionyl-L-carnitine (500 mg), green tea extract (300 mg), guggulsterone Z and guggulster-one E (10 mg), cyclic adenosine monophosphate (2 mg) and vitamin E (20 IU) per capsule (Table 1). She was taking one to two capsules of Somalyz at bedtime and one capsule of Lipolyz with meals three times a day as recommended for one month before illness. Her other medications included over-the-counter calcium and fibre supplements, and caffeine tablets.

Composition of dietary supplements taken by the patient

On evaluation at The Mount Sinai Medical Center, there were no stigmata of chronic liver disease. Blood work revealed a total serum bilirubin level of 82.08 mmol/L (normal range 1.71 mmol/L to 20.5 mmol/L), a direct bilirubin level of 47.88 mmol/L (1.71 mmol/L to 13.6 mmol/L), a serum alanine aminotransferase level of 1220 U/L (1 U/L to 53 U/L), a serum aspartate aminotransferase level of 577 U/L (1 U/L to 50 U/L), an alkaline phosphatase level of 111U/L (30 U/L to 110 U/L), a gamma-glutamyl transferase level of 125 U/L (8 U/L to 35 U/L), an international normalized ratio of 2.6 and a serum creatinine level of 53.04 μmol/L (44.2 μmol/L to 106.2 μmol/L). Her hematological markers, electrolyte levels, metabolic profile, amylase levels and lipase values were unremarkable.

Etiological workup included the following: negative viral serology (hepatitis A virus immunoglobulin M, hepatitis B virus surface antigen and core antibody, hepatitis C virus antibody [polymerase chain reaction assay], cytomegalovirus DNA and Epstein-Barr virus immunoglobulin M); negative syphilis rapid plasma regain; negative autoimmune markers (antinuclear antibody, antiliver kidney muscle antibody, antimitochondrial antibody and antismooth muscle antibody); and normal serum gamma globulins. Extensive toxicology screening was negative, with no features of acetaminophen toxicity (acidosis, high lactate or renal failure). She had normal levels of ferritin, ceruloplasmin and alpha-1 antitrypsin. A pregnancy test was negative. A computed tomography scan of her abdomen revealed a normal size liver with a patent portal vein, hepatic artery, hepatic vein and normal biliary anatomy. Her spleen was normal and no ascites was noted.

The patient’s encephalopathy worsened and she remained unresponsive. A computed tomography scan of her head was normal. An intracranial pressure monitor was placed, which measured an intracranial pressure of 19 mmHg and a cerebral perfusion pressure of 77 mmHg to 82 mmHg. She underwent successful cadaveric orthotopic liver transplantation on hospital day 2. By postoperative day 4, she was awake and alert. She experienced no significant postoperative complications and was discharged home for outpatient follow-up.

Histopathological examination of the liver explant showed massive hepatic necrosis and parenchymal collapse, with a few islands of ductular regeneration (Figures 1 and and22).

Figure 1)
A section from the native explanted liver demonstrating extensive collapse of the parenchyma (seen as hemorrhagic areas) with intervening geographic yellow-tan areas of viable and regenerating parenchyma (arrows)
Figure 2)
Histology of the native explanted liver. A Low-power magnification showing confluent necrosis resulting in parenchymal collapse (hematoxylin and eosin stain, original magnification ×40). B Reticulin stain confirming the extensive parenchymal collapse ...


Usnic acid is a component of nutritional supplements that are promoted for weight loss and have been associated with liver-related adverse events including mild hepatic toxicity, chemical hepatitis and liver failure requiring liver transplantation. Usnic acid is derived from a lichen species of the genus Usnea. It has been investigated for diverse uses as an antimicrobial, an anti-inflammatory, an antioxidant, an analgesic/antipyretic, an antiproliferative and as a natural supplement for weight loss. There are no adequate or well-controlled trials to substantiate any claims of effectiveness in humans for any indication (5).

Several previous reports described liver failure associated with the use of LipoKinetix, a multi-ingredient preparation containing usnic acid (68). In 2002, Favreau et al (6) reported on seven patients who developed acute hepatitis after using LipoKinetix. This dietary supplement contains sodium usniate, norephedrine, yohimbine, 3-5-diiodothyronine and caffeine; both usnic acid and ephedra alkaloids have been associated with severe hepatotoxicity. LipoKinetix withdrew the product from the market.

Durazo et al (7) reported on a healthy 28-year-old woman who developed acute liver failure within one month of commencing usnic acid (Pure Usnic acid, Industrial strength; AAA Services, USA) 500 mg/day for two weeks (7).

Sanchez et al (8) reported severe hepatotoxicity in a husband and wife (both 38 years of age) who were bodybuilders taking the multi-ingredient health supplement UCP-1 (BDC Nutrition, USA) for three months. UCP-1 contains usnic acid (150 mg), L-carnitine (525 mg) and calcium pyruvate (1050 mg) per capsule. The wife developed fulminant hepatic failure requiring liver transplantation. The husband experienced submassive necrosis but did not require liver transplantation. Another herbal remedy containing usnic acid – well known to be hepatotoxic – is kombucha tea. This is a beverage made by brewing kombucha mushrooms in sweet black tea (9).

Usnic acid has been shown to uncouple oxidative phosphorylation in a murine model, with resultant loss of mitochondrial respiratory control and inhibition of ATP synthesis. A direct hepatotoxic effect analogous to carbon tetrachloride-induced liver toxicity has also been described (10). Based on a case report (11) detailing three sisters with acute hepatitis after consumption of a ‘fat burner’ herb containing usnic acid, it was suggested that an inherent susceptibility was present.

Usnic acid is a weak inhibitor of cytochrome CYP2D6 and a potent inhibitor of cytochrome CYP2C19. Based on potent inhibition of CYP2C enzymes, usnic acid has significant potential to interact with other medications (5). Hepatotoxicity due to usnic acid appears to be idiosyncratic and is possibly due to a ‘convergence of risk factors’ (12).

Chinese green tea extracts are derivatives of the leaves of Camellia sinensis, which belongs to the aceae family. Green tea extracts have been marketed as effective weight-loss supplements, and for the prevention and cure of solid tumours. Although there is little scientific evidence supporting the effectiveness of green tea extracts, serious side effects, including acute liver failure, are increasingly being reported (13,14). Similar cases have been reported from France and Spain resulting in the removal of the green tea extract ‘Exolise’ from the market (15). Two cases of fulminant hepatic failure associated with green tea extracts have been reported (16,17). Mitochondrial toxicity and the formation of reactive oxygen species have been demonstrated with epigallocatechin-3-gallate, a key constituent of green tea extracts. The possibility of an allergic reaction to green tea itself has also been reported (18).

Gum guggul and its constituents are increasingly being used as dietary supplements. Gum guggul is the oleoresin of Commiphora mukul, a plant native to India. Its extracts include compounds known for their hypolipidemic properties – the Z and E isomers of guggulsterone and its regulated guggulsterols. Human exposure to gum guggul most often occurs from ingesting herbal remedies or pharmaceuticals, and from the use of cosmetics. Side effects include skin rashes, irregular menstruation, diarrhea, headache, mild nausea and, with very high doses, liver toxicity. Guggulsterol was associated with acute hepatitis in a 63-year-old woman taking the natural lipid-lowering agent Equisterol (Istituto Farmacoterapico Italiano SpA, Italy), which also contains red yeast rice extract (19).

Based on the temporal relationship between the use of the dietary supplements and onset of liver failure, literature supporting reports of hepatotoxicity associated with dietary supplements and exclusion of other causes, it is fair to assume that the patient developed fulminant hepatic failure due to dietary supplements. In view of the bulk of the literature, of all the ingredients, usnic acid may have been predominantly responsible for the hepatoxicity. Although usnic acid was the main hepatotoxic agent, its effect was possibly perpetuated by other hepatotoxins, including green tea and gum guggul, also contained in the dietary supplements taken by the patient.

According to the Dietary Supplement Health and Education Act of 1994, dietary supplements are regulated as foods and are not subject to regulation as drugs by the FDA; manufacturers are not compelled to provide safety data to the FDA. However, increasing reports of liver failure due to usnic acid have triggered a regulatory warning and one voluntary product withdrawal (LipoKinetix) (20). Usnic acid is still available and advertised on the Internet as an ingredient in various other dietary supplements and fat burners. Usnic acid, green tea and guggul tree extracts are a few of the many herbal and dietary supplements associated with significant liver injury.


CONFLICTS OF INTEREST: The authors have no financial disclosures or conflicts of interest to declare.


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