Typical DF are usually smaller than 3 cm. Usually, the clinical and histological diagnosis is simple, but distinguishing it from other cutaneous tumors can be difficult in atypical cases and rare variants. Giant DF is a rare clinical variant of DF which is characterized by its unusually large size. The following characteristics have been accepted for giant DF [1
]: (a) a size of =5 cm, (b) pedunculated appearance, (c) benign biological behavior despite its size, and (d) the same histopathological characteristics as conventional DF. If those criteria are applied, only 23 cases of giant DF have been described previously in the literature. They usually present as exophytic lesions, up to half of which are pedunculated. Most frequently, they are located on the legs, especially below the knee and on the foot, followed by location on the back [1
]. Because of their large size, the correct diagnosis is frequently not reached from clinical examination alone, and a diagnosis of malignancy is often made. The differential diagnosis usually includes malignant lesions such as basal cell or epidermoid carcinoma, dermatofibrosarcoma protuberans or other sarcomas. However, histopathological study confirms the diagnosis by demonstrating the typical characteristics of DF. The varied histological spectrum seen in usual DF can also be seen in giant DF [4
]. Xanthomatous cells are present in up to half of the cases [2
Giant DF have also been reported with atypical/pleomorphic, lipidized, granular cells [6
] and combined histological characteristics [2
]. Some alleged cases of giant DF reported in the literature are in fact aneurysmal DFs [7
]. This is another uncommon histologic variant. It is usually larger than typical DF and may show rapid growth, mainly due to the presence of numerous blood-filled cavernous cavities and hemorrhage, often within the background of a hemosiderotic DF. In our case, the macroscopic brown color and numerous hemosiderophages seen microscopically correspond to a hemosiderotic variant.
The histopathological features of several variants may also coexist in the same lesion and may correspond to different stages of the same disease. Some authors consider hemosiderotic DF a precursor lesion in the development of aneurysmal DF [9
]. Our case, illustrating a giant hemosiderotic DF, is in agreement with this theory. To our knowledge, only one case of hemosiderotic giant DF has been reported but has not been illustrated previously [1
]. Giant DF can appear de novo or secondary from a preexisting and longstanding smaller lesion [5
] such as was the case in our patient. The origin (reactive or neoplastic) of DF including its giant variant is still unclear and debated. Some authors think that it is neoplastic because of the persistent nature of the lesion and the fact that the proliferating cells are clonal [11
]. However, clonality can also be seen in reactive and inflammatory conditions, including atopic dermatitis, lichen sclerosis, and psoriasis. Because of its fibrohistiocytic nature, the persistence of the lesion is not proof of its neoplastic nature and may be partly attributed to intrinsic fibrosis which does not usually regress, as it is the case for scars; neither is the fact that some DF can be gigantesque and larger than 5 cm decisive in that question since large size and rapid growth can be seen in other reactive processes/tumors such as nodular fasciitis. It is likely that DF is a heterogeneous process. The clonal genotype found in DF with histiocytoid or predominant histiocytoid features suggests that histiocytoid cells probably represent the neoplastic component [12
]. Conversely, the fibroblastic form of DF may represent a reactive fibroblastic proliferation. Alternatively, it may represent a true neoplasm whose neoplastic cell type has been obscured by a prominent reactive fibroblastic component [12
]. No recurrence has been reported after complete surgical excision of giant DF.
In conclusion, we report another rare and interesting variant of giant DF, which is extremely difficult to diagnose clinically but not histologically, with an excellent clinical outcome.