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Nucleic Acids Res. Nov 11, 1987; 15(21): 8957–8962.
PMCID: PMC306415
Linkage of TNF genes to the HLA-B locus.
H Inoko and J Trowsdale
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Abstract
Pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) alpha and beta genes. They were shown to be linked to the HLA-B locus; analogous to their location in mouse, between the complement (class III) region and H-2D. However, the distance between the TNF genes and the class I region was much greater in man, namely about 260 kb, compared to 70 kb in the mouse. This finding may have implications for some HLA associated diseases.
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