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Nucleic Acids Res. 1987 November 11; 15(21): 8957–8962.
PMCID: PMC306415

Linkage of TNF genes to the HLA-B locus.


Pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) alpha and beta genes. They were shown to be linked to the HLA-B locus; analogous to their location in mouse, between the complement (class III) region and H-2D. However, the distance between the TNF genes and the class I region was much greater in man, namely about 260 kb, compared to 70 kb in the mouse. This finding may have implications for some HLA associated diseases.

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