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Int J Ayurveda Res. 2010 Oct-Dec; 1(4): 271–273.
PMCID: PMC3059452

Role of honey (Madhu) in the management of wounds (Dushta Vrana)


Application of Madhu (honey) is one among the Shashthi Upakrama (sixty treatment modalities) described by Sushruta. Clinical observation has shown its effectiveness in treatment of Dushta Vrana (chronic wounds). We report a case of Dushta Vrana on the anterior aspect of the right leg that was treated successfully with local application of Madhu and Neem (Azadirachata indica) bark decoction.

Keywords: Dushta Vrana, Madhu, Neem bark, Shashthi Upakrama


In spite of the advances that have been made, the management of chronic wounds is still a challenge for the clinician. Sushruta was quite aware of the importance of wound management and has described Shashthi Upakramas (sixty measures) for Vrana Ropana (wound healing), of which the application of Madhu is one.[1] Many research studies have been carried out to examine the value of topical application of honey for wound healing.[25] Madhu is commonly used as Anupana (i.e., given along with active medication to enhance activity) and also, sometimes, for its primary medical property systemically as well as locally, either alone or in combination with other drugs. It has been described to have properties like Lekhana (scraping), Sandhana (union), Shodhana (purification), Ropana (healing), and Tridoshaghna (pacifying all three Doshas: Vata, Pitta, and Kapha).[6] It is used as an external application in Vrana (wound), either alone or in combination with Sarpi (Goghrita, i.e., ghee made from cow's milk).[7,8]

Honey is hygroscopic in nature, with a pH of 3.2–4.5.[911] It prevents colonization and bacterial growth in tissues due to this acidic nature. Most microorganisms do not grow in pure honey because of its low water activity (aw) of 0.6.[1213] Honey also has antibacterial properties[1418] The presence of hydrogen peroxide[19,20] and a high osmotic pressure[21] also contribute to the antibacterial effect of honey. These natural properties of Madhu are said to make it suitable for use in wound management. We present a case where a chronic wound healed after the application of honey.


A 70-year-old female patient of Vata-Kaphaja Prakriti presented to us for treatment of a chronic infected wound that involved entire anterior tibial aspect of the right lower limb. She complained of burning pain in the wound as a result of a drug reaction, foul-smelling pus discharge, difficulty in walking, and occasional fever. On examination a large (22 × 4.5 cm) ugly-looking ulcer was present on the anterior aspect of the right leg, extending from the knee to the ankle joint. There was foul-smelling pus discharge and local swelling [Figure 1]. The pus culture report showed presence of Staphylococcus aureus. The patient had no systemic disease. She had been taking treatment for the wound without any relief. She had history of hypersensitivity reactions to ibuprofen and cotrimoxazole. All laboratory investigations were in the normal range. She was admitted in the female Shalya ward for further investigations and management.

Figure 1
Dushta Vrana on the anterior aspect of the right leg before treatment at the first consultation on 19-09-2009. The characteristics of Dushta Vrana are Ativivrita (broad base), Bhairav (ugly look), Putipuyamansa (pus discharge), Gandha (foul smell), Vedana ...

Every morning the wound was first treated with freshly prepared lukewarm Neem bark decoction, which was poured on the wound while it was simultaneously cleaned with sterile swabs. After cleaning, Madhu (Dabur India Ltd., Solan, H.P., India) was applied in adequate quantity with the help of a spatula and the wound was covered with sterile gauze and loosely bandaged.

Along with the local wound treatment, the following drugs were given orally in powdered form 12 hourly: Yashtimadhu (Glycyrrhiza glabra Linn.) 2 g, Shatavari (Asparagus racemosus Willd.) 2 g, Gokshura (Tribulus terrestris) 2 g, and Guduchi [Tinispora cardifolia Willd (Miers)] 2 g. The drugs were administered along with lukewarm water. At the end of the 5th week (the 35th day) the wound had healed completely, leaving only a minimal scar [Figure 2].

Figure 2
Healed scar on the anterior aspect of the right leg after treatment (on 23-10-2009).


Madhu has Vranaropak properties as per the principles of the sixty Upakramas of Vrana management described in the Sushruta Samhita. Madhu[22] is believed to act by ‘pacifying’ the three vitiated Doshas, i.e,. Vata, Pitta, and Kapha by multiple actions attributable to its Madhura (sweet) Rasa, Kashaya (astringent) Uparasa, Ruksha (dry) Guna, Sheeta (cold) Virya, Madhura Vipaka, and Sukshma Marga Anusari (ability to permeate in microchannels) Prabhava. Madhura Rasa gives nutrition to the tissue, which helps in granulation tissue formation, while Kashaya Rasa provides Lekhana (scraping) that helps in desloughing, preparing the wound for healing. Thus, Madhu has excellent properties to heal the wound by virtue of its Sodhana (purification), Ropana (healing), and Sandhana (union) actions.

At the time of presentation, the patient had pain, discharge, discoloration, etc., with predominating Vata Dosha. The Madhura Rasa of the honey reduced the vitiated Vata Dosha, leading to reduced pain and enhanced healing. Madhu has been described as having the ability to promote phagocytosis, detoxification, and proteolyses, all of which assist in cleaning the wound.[23,24] Further, Madhu pacifies Pitta Dosha by virtue of its Madhura Rasa and Sheeta Guna.[25,26] Kapha is taken care of with Kashaya Rasa and Ruksha Guna, which accelerate healing. Daily dressing of the wound with Neem bark decoction helped to inhibit the growth of microorganisms.[2730]

Honey is a hyperosmolar medium, preventing bacterial growth. Because of its high viscosity it forms a physical barrier, and the presence of the enzyme catalase gives honey antioxidant properties.[31] Honey has been shown to be useful in the prevention of hypertrophic scarring and post-burn contractures.[32] Honey is a very effective agent for dressing of split-thickness skin graft.[33] In our patient, healing occurred with minimal scar formation. The drugs that were administered internally in powdered form (Yashtimadhu, Shatavari, Gokshura, and Guduchi) have antioxidant, immunomodulating, and adaptogenic properties.[34,35] These compounds exerts a Rasayana effect. As the patient was elderly, we gave Rasayana drugs to improve Rasa, Rakta, and Mamsa Dhatus (tissues). This might have contributed to the wound healing[36,37] and helped the patient to attain and maintain good health.

There were no adverse events throughout the management and healing occurred uneventfully. The mode of treatment was found to be cost-effective, safe, and easy to implement.[38]


Source of Support: Nil

Conflict of Interest: None declared


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