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Neuropsychopharmacology. 2011 January; 36(1): 227–250.
Published online 2010 September 15. doi:  10.1038/npp.2010.158
PMCID: PMC3055518

Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals


Investigating how different pharmacological compounds may enhance learning, memory, and higher-order cognitive functions in laboratory animals is the first critical step toward the development of cognitive enhancers that may be used to ameliorate impairments in these functions in patients suffering from neuropsychiatric disorders. Rather than focus on one aspect of cognition, or class of drug, in this review we provide a broad overview of how distinct classes of pharmacological compounds may enhance different types of memory and executive functioning, particularly those mediated by the prefrontal cortex. These include recognition memory, attention, working memory, and different components of behavioral flexibility. A key emphasis is placed on comparing and contrasting the effects of certain drugs on different cognitive and mnemonic functions, highlighting methodological issues associated with this type of research, tasks used to investigate these functions, and avenues for future research. Viewed collectively, studies of the neuropharmacological basis of cognition in rodents and non-human primates have identified targets that will hopefully open new avenues for the treatment of cognitive disabilities in persons affected by mental disorders.

Keywords: cognitive enhancers, memory modulation, attention, working memory, response inhibition, extinction, behavioral flexibility


For nearly a century, studies of cognition have shown that certain pharmacological compounds can exert ‘pro-cognitive' and/or nootropic effects, improving cognition and memory, respectively, in otherwise normal laboratory animals. Stemming from the original published findings of Lashley (1917), there have been a plethora of studies designed to clarify the mechanisms and specific targets through which drugs may enhance cognition in experimental animals. Elucidation of the particular brain substrates through which drugs may enhance memory and cognition is of basic scientific interest in its own right, as these findings provide important insight into the brain processes underlying representational processes that are used to guide behavior. However, animal research on this topic also provides direct practical benefits that further the discovery of novel compounds, which may lessen the burden of cognitive disability associated with most neurological and psychiatric disorders. Research with animal models represents the first key step in the drug discovery process because of the demonstrable face, as well as construct, validity of many cognitive tests that are used with both animal and human subjects. Historically, the primary thrust of this research has been to develop treatments to improve memory functions in individuals afflicted with diseases that erode declarative memory functions, such as Alzheimer's dementia. More recently, however, it has become apparent that deficits in cognition, reasoning, and executive function are quite common sources of significant functional problems in a range of psychiatric disorders that include, but is not limited to, schizophrenia, bipolar disorder, major depression, attention deficit/hyperactivity disorder, and substance-use disorders (Bolla et al, 1998; Barch, 2005; Doyle, 2006; Clark et al, 2009). For those individuals affected by these conditions, cognitive impairment appears to be a quantitative indicator of liability for psychiatric disorders, as well as a primary mediator of psychosocial impairment. Thus, development of novel treatments to normalize cognitive functioning is of the highest priority in order to enhance the long-term outcome of these individuals.

In this review, we will provide an overview of research on facilitating mnemonic and cognitive processes in animals through pharmacological means. We will initially review some of the research that has concentrated on improving memory functions, as work in this area had its genesis in the study of memory enhancement. We will then discuss more recent data related to improving more complex forms of cognition, with a particular emphasis placed on those processes mediated by the frontal lobes. Specifically, this discussion will focus on three key executive functions that have been shown to be sensitive to pharmacological improvements: (1) the ability to deploy, sustain, focus, shift, and divide attentional resources; (2) working memory, the maintenance and manipulation of information about abstract rules, recent events, goals, and actions; and (3) different types of behavioral flexibility, ranging from simpler (response inhibition, extinction) to more complex (reversal learning, set-shifting) forms. An additional emphasis will be to highlight some of the procedures used to assess these functions in animals, and issues/complications related to this aspect of animal cognition research.


Normal vs Impaired Subjects

If the main aim of animal research on cognitive enhancement is to develop treatments for executive dysfunction associated with certain disease states, one issue to consider when assessing their potential benefit is how these drugs may affect cognition in normal subjects vs those with natural or experimentally induced impairments (Floresco et al, 2005). There are numerous examples where administration of a variety of compounds can improve different types of memory and cognitive functioning in normal animals. However, the cognition-enhancing effects of other drugs are only observed in subjects exhibiting poor baseline performance or experimentally induced deficits, whereas providing no measurable effects in normal animals. For example, atypical antipsychotics such as sulpiride or clozapine alleviate attentional or working memory impairments that occur following disruptions in the prefrontal cortical function, but these same drugs impair performance when administered to intact control subjects (Murphy et al, 1997; Jentsch et al, 1997; Passetti et al, 2003a, 2003b; Wolff and Leander, 2003; Baviera et al, 2008). Another classical example comes from studies with drugs that enhance mesocortical dopamine transmission. D1 receptor stimulation can have biphasic effects on functions such as working memory, improving functioning in animals when baseline levels of performance are poor, but impairing behavior when baseline performance is good (Granon et al, 2000; Chudasama and Robbins, 2004). Thus, although testing the effects of a particular drug on cognition in intact animals may be a useful initial screen for its utility in treating the cognitive deficits associated with a particular disorder, a null effect does not necessarily preclude the possibility that it would have no beneficial action on a perturbed system. Therefore, an item receiving active discussion in the field is whether interventions that will improve cognition in patients with psychiatric or neurological disorders can be successfully identified by psychopharmacological studies in normal animals, or whether these efforts require the generation of an ‘impairment model' whose cognitive deficits are being targeted or corrected by the intervention.

Arguments in favor of using normal subjects in drug discovery include: (1) the pathophysiologies of relevance to animal modeling are often not known and are difficult to mimic well when they are known, (2) ‘normal' does not equal optimal in as much as natural variation in brain function in normal animals often captures a continuum from high to low abilities and that ‘disease' is best thought of the lowest range of these continua, and consequently, (3) normal subjects often exhibit characteristic responses qualitatively identical to the ones that patients with a disorder will make. Arguments against the use of normal animals include: (1) the mean and standard deviation for performance of a cohort of normal subjects may not exhibit sufficient inter-subject variability to easily and robustly detect an improvement (‘ceiling effects' are present) and (2) the pathophysiological processes inherent in mental disorders may counteract the ability of a subject to express a pharmacological improvement observed in normal subjects.

Models of impairment come in many forms, ranging from the use of a manipulation to produce impairment (irrespective of the cause) or to the modeling of a specific, theorized disease process. One common type of impairment model that has been employed to test the potential cognitive-enhancing effects of certain drugs is the administration of muscarinic acetylcholine receptor antagonists, which impair a broad range of memory, attention, and executive function-related processes (Safer and Allen, 1971; Greenwald and Davis, 1983; Robbins et al, 1997). Whether or not cholinergic dysfunction is linked to the pathophysiology of disorders such as ADHD or schizophrenia, these models may be valuable to elicit impairments that may induce sufficient inter-subject variability to detect drug-induced improvements. Other manipulations are more biologically targeted. For example, in schizophrenia, there is strong empirical evidence linking NMDA hypofunction to the expression of cognitive impairments (Javitt and Zukin, 1991; Jentsch and Roth, 1999; Olney et al, 1999). Similarly, acute or chronic stress has long been known to exert detrimental effects on cognition in human beings and may be a contributing factor to impairments associated with numerous psychiatric disorders (Arnsten, 2007; Hains and Arnsten, 2008). Accordingly, a substantial amount of preclinical research focusing on cognitive enhancers has utilized acute or repeated administration of non-competitive NMDA receptor antagonists or physical or psychological stressors to induce temporary cognitive deficits that theoretically share biological determinants with those found in the idiopathic condition. In addition, as observed in human beings, normal aging in animals has been associated with cognitive dysfunction. Each of these manipulations induces reliable impairments across multiple domains of cognitive functioning, and as such, many of the studies discussed in this review have employed these particular models to assess the cognitive-enhancing effects of different compounds.

Although no one should ignore the strong arguments made in favor of disease modeling as an approach in the development of cognitive enhancers, there is also substantial evidence that it is not required to achieve a milestone in this effort. One clear example derives from the study of modafinil on inhibitory control processes. This drug improves the ability to stop a response in normal rats (Eagle et al, 2007), normal human beings (Turner et al, 2003), patients with schizophrenia (Turner et al, 2004b), and patients with ADHD (Turner et al, 2004a). Another example is the ADHD drug atomoxetine, which enhances inhibitory control in normal rats and monkeys (Robinson et al, 2008; Seu et al, 2009), in normal human beings (Chamberlain et al, 2007b) and in patients with ADHD (Chamberlain et al, 2007a). These efforts show the potential for identifying pharmacological enhancement of cognitive functions in normal animals and human beings that subsequently predict their clinical utility.

With that in mind, evidence is quite strong that drug discovery in normal animals is an endorsable strategy. As will be discussed in the following sections, there are many examples of pharmacological enhancement in normal animals that systematically predict these same responses in human beings. Nicotinic receptor agonists, and their effects on performance of tests of vigilance, attention, and working memory are among the clearest examples (Hahn et al, 2003; Levin and Rezvani, 2006; Sarter et al, 2009). When sufficiently sophisticated tests that challenge animal cognition in relevant ways are used, there can be ample inter-subject variability to detect their effects. That is not to say that every animal exhibits the same response. Indeed, baseline characteristics (stemming from individual variation along the continuum of function) can predict performance enhancement in cognitive tests (Eagle et al, 2007). Therefore, if a study is well designed, it uses a sufficiently validated task with appropriately parameterized features and incorporates a sufficiently large number of animals to capture the range of performance, the potential for measuring cognitive enhancement is good.

Enhancing One Function at the Cost of Another

There is considerable overlap between the neural circuitry and neurochemical systems that regulate different processes underlying memory and executive functioning. At the same time, there is ample evidence to suggest dissociable contribution by different circuits to different functions. This leads to the possibility that a particular treatment may enhance some cognitive functions at the expense of others, ameliorating dysfunction in one circuit, whereas at the same time interfering with processes mediated by others. For example, dopaminergic medication for Parkinsonian patients alleviate implicit learning and memory problems related to striatal dysfunction, but may simultaneously cause excessive activation of relatively intact prefrontal dopamine systems leading to deficits of response inhibition, behavioral flexibility, and decision making (Cools et al, 2006, 2007; Torta et al, 2009). Thus, the potential benefit of a particular treatment in improving one domain of cognition must be weighed relative to the potential for these treatments to interfere with other functions.

With these considerations in mind, we now turn to a review of available data on cognitive enhancement in laboratory animals. Of particular interest are pharmacological interventions that exert the broadest gains on multiple dimensions of cognition and that exert effects in normal subjects and models of impairment.


Pharmacological improvements in learning and memory have traditionally been assessed by treating animals before initial training on certain learning task, revealing enhanced performance upon subsequent testing in a drug-free state. This approach, in combination with a variety of discrimination, avoidance and other learning paradigms has proven fruitful in identifying drugs that may improve the formation of new memories. However, interpretation of studies that employ pre-training drug manipulations is complicated, as many drugs that may enhance memory when administered before training may also exert other, non-specific actions on sensory, motor, or motivational processes. For example, by enhancing attention or arousal, a drug may facilitate encoding-related processes. These specific effects are relevant and discussed further below, but are not synonymous with a nootropic effect. These complications in interpretation can be overcome using post-training drug manipulations, whereby subjects remain drug free during initial training and retention testing. The rationale behind this approach stems originally from Hebb's notion that memory formation progresses from labile to more stable forms, a process that may continue after initial exposure to a learning context (McGaugh and Roozendaal, 2009). Observing improved memory upon administering drugs immediately after initial training on a task (but not when drug treatment is delayed for a period after learning) provides a more conclusive demonstration that improvements in memory retention induced by a particular compound are directly attributable to augmentation of memory consolidation.

When discussing how drugs may enhance learning, it is important to emphasize the now well-established notion that there exist multiple learning systems in the brain, each of which may be characterized by fundamentally different rules of operation. Each of these systems addresses a specialized set of functional problems that cannot be solved as readily by the cognitive operations regulated by other systems and are subserved by anatomically distinct brain regions. For example, the hippocampus has long been implicated in learning about the relationship between different stimuli (eg, spatial learning) (Morris et al, 1982; Shapiro and Eichenbaum, 1999). Alternatively, acquisition of stimulus–response associations (ie, instrumental or habit learning) is mediated in part by different portions of the dorsal striatum (Packard and Knowlton, 2002). Associative learning about discrete environmental stimuli predictive of either aversive or appetitive reinforcers is critically dependent on different subregions of the amygdala (Ledoux, 2000; Baxter and Murray, 2002). Despite the differences between these systems, not only with respect to the types of information they process, but also to their cellular and neurochemical architecture, a remarkable finding is that certain classes of drugs appear to uniformly enhance learning across these different systems. For example, pre- or post-training administration of stimulant drugs, such as d-amphetamine, have been shown to enhance spatial learning (Packard and White, 1989; Brown et al, 2000), response learning (Packard and White, 1989), and the acquisition of emotional memories (Hitchcott et al, 1997; Wood and Anagnostaras, 2009). An exhaustive list of the types of compounds that can enhance acquisition/consolidation of these different types of memories goes beyond the scope of this review. However, some notable drug classes include those that enhance activity at cholinergic (Packard et al, 1990; Salinas et al, 1997), glutamatergic (Land and Riccio, 1999; Packard, 1999; Lee et al, 2006), and dopaminergic (Packard and White, 1989, 1991; Hitchcott et al, 1997) synapses.

A large area of work on pharmacological enhancement of memory has focused on identifying drugs that improve aspects of long-term declarative memories. One particularly attractive aspect of this research is that this form of memory can be assessed in both human beings and animals, adding to the construct and predictive validity of these tests. Almost all work in laboratory animals has focused on aspects of declarative memory measured by the ability to exhibit recognition, which is thought to represent the general sense of familiarity after exposure to a stimulus. In human beings, monkeys, and rats, recognition memory can be assessed by probing subjects' ability to guide choice behavior between novel and previously -experienced stimuli at test (eg, list learning in human beings, delayed non-match to sample with trial unique stimuli in monkeys, social or novel object recognition in rodents). The focus on recognition memory has stemmed from the original proposal by Tulving (Wheeler et al, 1997) that episodic memory (rich memories of personal experiences that can be flexibly recalled) is human specific, as well as from the difficulty of showing similar processes in animals. That said, recent advances showing competency in episodic memory tasks in non-human animals (Clayton and Russell, 2009) supports future research in this area.

In non-human primates, recognition memory is often assessed using procedures where subjects experience a set of stimuli, and later in time, those stimuli are presented in pairs with novel items; the subjects are trained to select the novel item in a pair in order to correctly indicate familiarity and to obtain a reward. Using procedures like this, Aigner and co-workers showed enhanced recognition memory performance after the administration of pro-cholinergic manipulations (acetylcholinesterase inhibitors) or of -cycloserine—a positive allosteric modulator of the NMDA/glutamate receptor (Aigner and Mishkin, 1986; Matsuoka and Aigner, 1996). The beneficial effects of acetylcholinesterase inhibitors may be mediated in part by the activation of muscarinic receptors, as blockade of these receptors impairs this form of memory in both human beings and animals (Aigner and Mishkin, 1986; Robbins et al, 1997), and treatment with muscarinic receptor agonists improves recognition memory in aged rats (Prediger et al, 2006). Recent work has suggested that the nootropic effects of acetylcholinesterase inhibitors may also depend upon stimulation of brain nicotinic receptors (Katner et al, 2004; Bitner et al, 2007). In the case of -cycloserine, its effects were observed in normal monkeys or in subjects exhibiting memory deficits elicited by NMDA receptor antagonists and/or muscarinic antagonists (Matsuoka and Aigner, 1996). What remains unknown, however, is what aspect of memory was enhanced, as these agents were given before list learning itself. In addition, all agents exhibited complex non-monotonic dose–response curves (inverted-U dose–effect functions), highlighting an often-observed result in studies of cognitive enhancement.

Similar paradigms have been used in rodent models, which are more amenable to routine psychopharmacological testing. Here, subjects are typically exposed to a sample stimulus, and after a delay of minutes to hours, they are presented with that stimulus plus a novel one. Memory is reflected in the tendency of rats to approach the novel stimulus in the pair (Bevins and Besheer, 2006). In most cases, pharmacological treatments are given before the ‘test' phase where the animal must retrieve and use the memory to successfully complete the task. As observed in primates, extensive data using these procedures in rats indicate that positive modulation of NMDA- or AMPA-dependent glutamate transmission and nicotinic receptor activation enhances recognition memory in normal and NMDA-antagonist-treated rats/mice (Robbins and Murphy, 2006; Bertaina-Anglade et al, 2007; Boulay et al, 2008; Smith et al, 2009; Woolley et al, 2009; Damgaard et al, 2010). Similarly, enhancing cholinergic transmission via acetylcholinesterase inhibitors can attenuate deficits in recognition memory in aged rats (Scali et al, 1997), and systemic administration of a selective muscarinic M1 agonist also enhance memory in normal rats (Bradley et al, 2010). Likewise, direct or indirect stimulation of nicotinic receptors (both beta-2- and alpha-7-containing) enhances recognition memory in normal rodents or in subjects with pharmacologically-induced impairments (Wishka et al, 2006; Boess et al, 2007; Pichat et al, 2007; Hashimoto et al, 2008; Hauser et al, 2009; Roncarati et al, 2009; Sydserff et al, 2009; Noda et al, 2010; O'Donnell et al, 2010). A key brain region where these drugs may act is the perirhinal cortex, as infusion of glutamate or muscarinic antagonists in this region impairs recognition memory in rodents (Winters et al, 2008).

More recent research has revealed several other molecular targets that may exert nootropic effects in these tasks. For example, manipulations of serotonin 5-HT6 receptors can enhance recognition memory in normal rats, and ameliorate impairments in memory induced by cholinergic or glutamatergic antagonism, aging, or early social isolation (Fone, 2008; Kendall et al, 2010). What is particularly intriguing about these studies is that memory enhancements have been observed following either blockade or stimulation of these receptors with selective antagonists or agonists. Furthermore, these effects may be mediated in part by the modulation of glutamatergic and cholinergic transmission (Kendall et al, 2010). Other promising targets for enhancing recognition memory include H3 histamine receptor antagonists (Kim et al, 2004; Southam et al, 2009; Giannoni et al, 2010), mGluR5 glutamate receptor antagonists (Ballard et al, 2005; Liu et al, 2008), inhibitors of catecholamine reuptake (Chuhan and Taukulis, 2006; Tzavara et al, 2006), and dopamine or norepinephrine receptor agonists (Roozendaal et al, 2008; Woolley et al, 2008).

As noted above, an issue that often remains to be clarified is how each of these mechanisms contributes to the discrete phases of recognition memory, including encoding during the sample phase, consolidation during the post-sample phase, and retrieval during the test phase. It is possible that some manipulations (eg, gluamatergic) increase encoding and/or consolidation while distinct mechanisms mediate retrieval; the participation of candidate neurotransmitter systems in each of these aspects of memory are not completely well known. Whether or not these compounds exert their beneficial effects by acting on temporal lobe structures such as the perirhinal cortex or other downstream nuclei also remains to be explored. In addition, the ability of agents to target attentional or arousal processes or working memory may also exert effects in recognition memory tests.

Mechanisms of Memory Enhancement

It bears mentioning that classes of drugs that can improve memory formation across different memory systems have also been shown to enhance synaptic plasticity in each of the brain regions that mediate different types of learning. For example, it is well-established that glutamate transmission is critical for increasing synaptic strengths in the hippocampus, as well as the striatum (Kombian and Malenka, 1994) and amygdala (Paré, 2004). Furthermore, cholinergic and dopaminergic transmission has also been shown to play a role in mediating long-term potentiation in each of these regions (Wickens et al, 1996; Calabresi et al, 1999, Centonze et al, 2001; Bissière et al, 2003; Park et al, 2004). Thus, from a parsimonious view, the ability of these compounds to enhance memory formation may be mediated through an enhancement of the excitability of neurons in a particular brain region that governs a certain type of learning, which in turn may enhance potentiation of synapses that were active during learning.

Like the different types of learning described above, recognition memory has also been posited to be mediated in part by increases in synaptic strengths, particularly in the perirhinal cortex (Winters et al, 2008). However, long-term depression of synaptic plasticity has also been proposed to be a key cellular mechanism that underlies this form of memory. In keeping with this notion, long-term depression in the perirhinal cortex is dependent on both glutamatergic mGluR2 and NMDA receptors, as well as cholinergic muscarinic transmission (Cho et al, 2000; Massey et al, 2001), and antagonism of each of these receptors impairs recognition memory (Barker et al, 2006; Winters et al, 2008). Thus, recognition memory may be facilitated by decreases in synaptic strengths that result in decremental neuronal responses evoked by exposure to familiar stimuli, which in turn may result in a contrasting enhancement of neural activity driven by novel stimuli (Brown and Bashir, 2002; Winters et al, 2008).

In addition to having direct actions on synaptic plasticity within a particular memory system, certain drugs may enhance consolidation through the modulation of brain systems that are capable of facilitating multiple memory systems, at once. Specifically, it has been proposed that certain drugs may activate the amygdala, which in turn may facilitate memory formation mediated by other brain regions. Thus, pharmacological activation of the amygdala can facilitate the formation of memories processed by other systems (such as hippocampally mediated spatial memories or striatal-mediated habit memories), even though the amygdala does not appear to contribute to the cognitive operations underlying these forms of learning (Packard et al, 1994; Packard and Teather, 1998; Hatfield and McGaugh, 1999). Support for this notion comes from the findings that infusions of a variety of drugs directly into the amygdala improve learning mediated by the hippocampus, striatum, as well as recognition memory mediated by the perirhinal cortex (Packard et al, 1994; Roozendaal et al, 2008). These include d-amphetamine (Packard and Teather, 1998) and agents that directly or indirectly activate adrenergic transmission (Wingard and Packard, 2008; Roozendaal et al, 2008). Importantly, lesions of the amygdala do not interfere with these forms of learning (McDonald and White, 1993), suggesting that activation of the amygdala may influence neural plasticity in other brain regions either though direct or polysynaptic pathways (McGaugh et al, 2002). Given the importance of the amygdala in emotional processes, it is plausible that this region plays a crucial role in the enhancement of memory elicited by the emotional salience of highly charged events. This notion meshes well with studies of human memory encoding, which have shown that memories associated with heightened emotional states tend to be encoded and retrieved more effectively (Cahill et al, 1994; Packard and Cahill, 2001).

Memory Retrieval

The field of drug-induced memory enhancement has focused primarily on augmenting the consolidation of new memories. In comparison, there have been relatively few studies on how drugs may enhance memory retrieval. Addressing this question is of particular relevance when it comes to devising novel approaches to ameliorating memory impairments associated with diseases such as Alzheimer's, which is associated with retrograde as well as anterograde amnesia.

Mounting evidence from human imaging and animal studies suggests that different regions of the prefrontal cortex (PFC) play a key role in retrieval of content from long-term memory. In the past 10 years, fMRI studies have showed increased activation of prefrontal networks (in particular, the lateral PFC), during retrieval of different types of memories. These include semantic (Mitchell and Johnson, 2009), episodic (Lee et al, 2000) emotional (Buchanan, 2007), and rule-related (Bunge, 2004) memories. These findings are complemented by studies in rodents, wherein subjects acquire information in an intact state and receive reversible inactivation of the medial PFC before memory retrieval. This approach has confirmed that suppression of neural activity in the PFC impairs retrieval of Pavlovian fear memories (Corcoran and Quirk, 2007), spatial memories (Jo et al, 2007; Churchwell et al, 2010), and temporal order memory (Hannesson et al, 2004). These findings would suggest that the development of drugs, which may enhance certain aspects of the prefrontal neural activity, may prove to be a fruitful strategy in designing compounds that may enhance memory retrieval.

As discussed previously, noradrenergic transmission plays a crucial role in memory consolidation, and also appears to play a critical role in the retrieval of contextual fear memories (Murchison et al, 2004). Retrieval of these memories is impaired in a selective manner when norepinephrine is genetically deleted, and it is enhanced after the administration of beta adrenoceptor agonists. The ability of beta adrenergic agonists to enhance memory retrieval, and of beta adrenergic antagonists to impair it, appears to depend on effects in both the PFC (Mueller et al, 2008) and the hippocampus (Murchison et al, 2004).

Dopaminergic mechanisms in the PFC have also been implicated in memory retrieval. For example, in one study (Floresco and Phillips, 2001), rats were well trained on delayed variant of a radial arm maze task, consisting of a training phase and test phase separated by a relatively short delay (30 min). On test day, the delay between training and retrieval phases was increased to 12 h. In control rats, increasing the delay between training and retention testing led to a degradation of a memory trace through normal temporal decay, increasing the number of retrieval phase errors relative to their performance using the shorter delay. However, infusions of a D1 receptor agonist into the medial PFC before the retrieval phase improved performance relative to controls (Figure 1). Similar enhancements in object recognition memory have been observed following systemic treatment with a D1 agonist before memory retrieval (Hotte et al, 2005). These findings further support the notion that compounds that may augment D1 receptor activity or its intracellular signaling pathways, particularly in the PFC, may serve as a useful target for facilitating memory retrieval.

Figure 1
Dopamine D1 receptor agonists improve memory retrieval. The delayed response variant of the radial-arm maze task (top) consists of a training (acquisition) and a test (retrieval) phase (a). During the training phase, the rat must retrieve four pieces ...


Many real-life problems require coordinated and simultaneous encoding and/or retrieval of different memories across multiple systems and integration of information with representations of recent experiences and abstract rules in order to solve these problems in an efficient manner. The effortful cognitive processes required under these conditions include selective allocation of attentional resources and manipulation of multiple forms of information processed by different memory systems. In addition, novel or unexpected changes in rules or reinforcement contingencies may necessitate the suppression of memories processed by one system, in order to permit learning managed by other systems to optimize behavior. These types of cognitive operations have been termed executive functions and may be defined as a collection of brain processes whose role is to execute and guide patterns of behavior in accordance with internally generated goals or plans. Often, these types of functions are engaged when it is necessary to over-ride responses that may otherwise be automatically elicited by stimuli in the external environment. It is well established that the PFC plays an essential role in mediating a variety of executive functions (Fuster, 2008). Across mammalian species, damage to the frontal lobes leads to impairments on tasks that require different aspects of executive functioning, such as selective attention, working memory, and behavioral flexibility. Furthermore, it is now commonly accepted that to affect overt changes in ongoing behaviour, information processed by the PFC interfaces with the motor and motivational systems via descending connections to the basal ganglia.

The PFC is susceptible to modulation by a diversity of neurochemical influences, each of which contributes to this brain region's functional integrity in a distinct manner. In addition to glutamate and GABA arising from afferent input and intrinsic neurons, the PFC receives innervation from all of the major ascending neuromodulatory pathways, including dopamine, serotonin (5-HT), noradrenaline, acetylcholine, histamine, etc. This arrangement, combined with the multiple receptor subtypes for each of these transmitters and their intracellular signaling pathways that are expressed in PFC neurons provide for multiple targets for pharmacological modulation that may enhance functioning of prefrontal networks and improve executive functioning. With this in mind, the remainder of this review will highlight some of the recent work in experimental animals that has showed pharmacological improvement in different types of executive functioning mediated by the PFC and its subcortical afferents.


Pharmacological modulation of the ability to deploy, sustain, focus, shift, and divide attentional resources is of significant relevance to a number of neuropsychiatric disorders in which cognitive deficits hinge, at least in part, upon deficits in the top–down control of attention (eg, ADHD, schizophrenia, autism, etc). Given the broad relevance of controlled attentional processing to a host of other cognitive mechanisms, it is widely believed that deficits in attention contribute to problems with other mnemonic and executive functions. Accordingly, it is possible that pharmacological enhancements in attention will exert broad gains to other domains of cognition.

Most high-merit pre-clinical research on attention has focused on the performance of choice or simple reaction time tasks that place demands on various aspects of attentional control. For example, in classical signal detection tasks, subjects are trained to sustain focused attention on a potential stimulus over a temporally unpredictable period. In most versions, rats watch a light bulb for a visual stimulus for a variable period of time; at some point during their waiting, two levers will be presented to the subjects. If they saw a stimulus presented during the waiting period, they press a pre-designated ‘stimulus' lever; if no stimulus was observed during the waiting period, they press a pre-designated ‘no stimulus' lever. The power of this approach is the ability to apply signal detection theory analyses to the resulting data and to characterize performance in very specific ways (eg, decreased misses vs fewer false alarms, etc). On the other hand, multiple-choice serial reaction time tasks (CSRTT) measure the ability of subjects to monitor multiple possible spatial locations for the presentation of a visual stimulus (presented on a fixed or variable time schedule) and to respond accurately to that location when the stimulus occurs (Figure 2). Although the former procedures measure the ability to sustain focused attention, the latter depends on the ability to sustain either a divided or scanning attention strategy. Importantly, both also depend a great deal on executive control of attention and behavior in order to optimize responding.

Figure 2
Diagram of the 5-choice serial reaction time tasks (CSRTT) that can be used to assess both attentional function and response inhibition (‘waiting'). The rat begins each trial with a nose poke in the food magazine located on the opposite wall of ...

Cholinergic neurons, particularly those that innervate the PFC, clearly play a role in attentional performance. For example, lesions of the basal forebrain cholinergic system, or cholinergic deafferentation in the PFC, impair attentional performance (Muir et al, 1994; McGaughy et al, 2002), and these effects are attenuated by the administration of acetylcholinesterase inhibitors (Muir et al, 1992, 1995; Balducci et al, 2003). Impairments in attentional accuracy induced by cholinergic lesions may be due, in part, to reduced muscarinic transmission, as systemic blockade of these receptors with scopolamine impairs performance on the 5-CSRTT (Mirza and Stolerman, 2000). However, a large body of work shows that systemic administration of nicotinic receptor agonists (including nicotine itself) produces their clearest and most robust performance enhancements in signal detection or choice reaction time tasks. Specifically, acute treatment with nicotine increases choice accuracy and speeds response times in both tests (Mirza and Stolerman, 1998; Stolerman et al, 2000; Hahn et al, 2002a, 2002b, 2003; Rezvani et al, 2002, 2005; Bizarro and Stolerman, 2003; Rezvani and Levin, 2003, 2004; Bizarro et al, 2004; Young et al, 2004; Hahn and Stolerman, 2005; Hoyle et al, 2006; Levin et al, 2006; Dillon et al, 2009). These effects are sustained with chronic nicotine treatment (Hahn and Stolerman, 2002; Rezvani et al, 2006, 2008; Semenova et al, 2007; Amitai and Markou, 2009). Subsequent studies with subunit-specific nicotinic receptor agonists seems to indicate that both low-affinity alpha-7-containing (Grottick and Higgins, 2000; Grottick et al, 2001, 2003) and high-affinity beta-2-containing nicotinic receptors are involved in these effects (McGaughy et al, 1999; Young et al, 2004, 2007; Hoyle et al, 2006; Rezvani et al, 2009; Howe et al, 2010; Mohler et al, 2010). The precise psychological basis of these effects has not been clearly defined, but the broad effects of nicotinic agonists in attentional tasks have been theoretically linked to an increase in the speed of processing that facilitates choice or simple reaction time performance (Mancuso et al, 2001). In contrast, acetylcholinesterase inhibitors or muscarinic receptor agonists do not share the effect of nicotinic agonists on attention in normal animals (Kirkby et al, 1996; Mirza and Stolerman, 2000). Note that M1 muscarinic receptor agonists have been reported to enhance recognition memory (Bradley et al, 2010), suggesting that the nootropic effects of these compounds are unlikely to be related to enhancements in attentional processes.

Monoaminergic systems have defined roles in the modulation of attentional performance (Robbins, 2002). Selective neurotoxic depletions of monoamine transmitters in frontostriatal circuits, coupled with behavioral pharmacological studies—often involving site-specific intra-cranial infusions, have primarily implicated catecholamine systems in attentional performance. With respect to noradrenaline, forebrain depletions of this catecholamine do not impair baseline performance in simple attentional tasks, but do impede performance under taxing conditions (distraction, unpredictable event rate) (Carli et al, 1983; Milstein et al, 2007). At the receptor level, lower doses of alpha-1 or alpha-2 receptor agonists can enhance attentional performance (Puumala et al, 1997; O'Neill et al, 2000). Despite a wealth of data implicating dopaminergic systems in working memory (see the following section), much less is known about the nature of its role in attention. Systemic administration of D1 agonists impairs CSRTT performance (Passetti et al, 2003a). However, direct intra-prefrontal application of the same agonist improves performance in poor-performing rats (Granon et al, 2000). Similarly, infusions of a low dose of the D1 agonist SKF38939 into the nucleus accumbens also improved attentional accuracy in normal rats, whereas higher doses tended to increase perseverative responding (Pezze et al, 2007). In a similar vein, impairments in 5-CSRTT performance induced by repeated amphetamine treatments have also been reported to be ameliorated by intra-PFC infusions of a D1 agonist (Fletcher et al, 2007b). These latter findings suggest that there is a non-linear function relating D1 receptor stimulation to attentional performance—a relationship that may be explained by the levels of baseline dopamine transmission at these receptors, as well as baseline variations in performance. Thus, even though systemic treatment with D1 agonists may impair attentional performance in normal rats, the possibility remains that similar treatments may improve these functions in perturbed animals.

Although the effects of catecholamine receptor agonists on attention is somewhat equivocal, studies using stimulant and non-stimulant agents that interfere with catecholamine reuptake (methylphenidate, atomoxetine) or elicit the release of monoamine transmitters (amphetamine, caffeine) can improve attentional performance, although their effects also appear to depend on task conditions and baseline performance (Grilly et al, 1989; Grilly, 2000; Grottick and Higgins, 2002; Bizarro et al, 2004; Blondeau and Dellu-Hagedorn, 2007; Higgins et al, 2007; Robinson et al, 2008; Navarra et al, 2008b; Newman et al, 2008; Robinson et al, 2008; Jentsch et al, 2009). For example, a recent study showed highly selective effects of noradrenaline reuptake blockade on attention, facilitating performance under conditions where top–down control of attentional resources was favored, whereas impairing performance when stimulus-driven responding was emphasized (Jentsch et al, 2009). As noradrenaline reuptake inhibitors increase both extracellular dopamine and noradrenaline levels in the PFC (Bymaster et al, 2002), it is not yet possible to ascribe their effects on attention to one catecholamine transmitter. Overall, these results encourage continued attempts to characterize the precise role for brain monoamine receptor subtypes as targets for attentional enhancement.

In contrast to the above-mentioned findings, depletion of serotonin in the forebrain fails to affect attentional accuracy, although it does increase anticipatory impulsive responding (Harrison et al, 1997). Furthermore, neither 5-HT2A agonists nor antagonists affect indices of attentional performance (choice accuracy) but do alter impulsive responding (Ruotsalainen et al, 1997; Koskinen and Sirvio, 2001; Higgins et al, 2003; Passetti et al, 2003b; Winstanley et al, 2004b; Carli et al, 2006; Fletcher et al, 2007a; Quarta et al, 2007). Although not having any measurable effects on attention on their own, 5-HT2A receptor antagonists are reportedly able to mitigate deficits in CSRTT performance elicited by intra-PFC blockade of NMDA receptors (Carli et al, 2006; Pozzi et al, 2010), highlighting one example of the potentially disparate results when comparing drug effects in normal vs pathological systems. Intra-PFC infusion of the 5-HT1A agonist 8-OH-DPAT has been reported to improve attentional accuracy in both normal rats (Winstanley et al, 2003) and ameliorate impairments induced by PFC NMDA receptor blockade (Carli et al, 2006). However, systemic treatment with 8-OH-DPAT reduces attentional accuracy assessed with the 5-CSRTT (Carli and Samanin, 2000). Collectively, these data indicate that targeting forebrain serotonin system may not be the most suitable strategy for enhancing attentional functions.

The histaminergic neurotransmitter system is also emerging as an important candidate. Histamine is a wake- and arousal-promoting neurotransmitter, and the wake-promoting agent, modafinil, releases histamine (among other actions) in the brain. Notably, modafinil also shows the potential to enhance attentional performance in rodents under certain circumstances (Waters et al, 2005). The connection between modafinil, histamine, and attention is further supported by the observation that H3 receptor antagonists (which increase brain histamine output since H3 is the autoreceptor for histamine) also improve attentional performance in choice reaction time tasks (Ligneau et al, 1998). In a similar vein, another wake-promoting transmitter, orexin, has also been reported to enhance attention when administered directly into the PFC, in a manner similar to nicotine (Lambe et al, 2005). These data urge focus on other than just monoamine systems in the development of attention-enhancing drugs.

Beyond the neuromodulatory transmitters, there has been an emergent interest in AMPAkines that positively modulate ionotropic glutamate receptors, metabotropic glutamate receptors, or subunit-specific GABA modulators for effecting cognitive enhancement in psychiatric disorders. Of these, metabotropic glutamate receptors have been implicated as enhancers of attentional performance in animals whose performance was impaired by treatment with NMDA receptor antagonists (Greco et al, 2005), but clearly, more systematic work in this area is required.


As discussed previously, there are multiple memory systems in the brain that mediate important aspects of adaptive behavior. The term ‘working memory' refers to a set of limited-capacity representational processes by which information about abstract rules, recent stimulus events, expected goals, and planned actions are maintained and manipulated in real time to affect on-going behavior (Baddeley and Hitch, 1974; Goldman-Rakic, 1987; Fuster, 2008; Baddeley, 2010). In that sense, it cannot be viewed as a unitary process, and indeed, cognitive psychological accounts of working memory involve a multi-component system (Baddeley and Hitch, 1974). That being said, studies in laboratory animals mostly assess the ability to use this system to rapidly encode, temporarily maintain, and utilize information in tasks that are heavy in pro-active interference in order to require the use of a limited capacity, efficiently updatable memory system. These include the so-called delayed response tasks (Fuster and Alexander, 1971; Goldman et al, 1971; Curtis and D'Esposito, 2004), in which the content being stored is either visuospatial or object oriented (spatial delayed alternation/response; delayed match/non-match to position; delayed match/non-match to sample).

Cholinergic systems have a long-studied and important role in working memory enhancement. Although acetylcholinesterase inhibitors can reduce the impairing effects of a cholinergic receptor antagonist, of normal aging or of basal forebrain damage, they do not improve working memory in normal, young animals (Dawson and Iversen, 1993; Jakala et al, 1993; Barnes et al, 2000; Bontempi et al, 2003; Tsukada et al, 2004; Lindner et al, 2006; Marighetto et al, 2008a; Cutuli et al, 2009). At the same time, nicotinic receptor agonists targeting either the high-affinity, beta-2/4-containing or low-affinity, alpha-7-containing subtypes can improve working memory performance in otherwise normal rodents and monkeys (Bontempi et al, 2001, 2003; Spinelli et al, 2006; Bitner et al, 2007; Buccafusco et al, 2007; Tietje et al, 2008). As attentional processes play a crucial role in the encoding phases of working memory, as well as the resistance to distraction-related disruptions in retention (Zanto and Gazzaley, 2009), it is possible that these reported benefits of nicotinic receptor agonists on working memory are related to their attention-enhancing effects.

A very large literature relates the catecholamine neuromodulatory systems to aspects of working memory retention. Increases in frontal cortical catecholamine levels, produced by stimulant drugs, improve working memory in normal, young animals and human beings (Mehta et al, 2000; Aultman and Moghaddam, 2001; Arnsten and Dudley, 2005; Arnsten, 2006; Berridge et al, 2006). The beneficial effects of methylphenidate on working memory have been proposed to be mediated by increased activity at both dopamine D1 and noradrenergic alpha-2 receptors (Arnsten and Dudley, 2005). However, dopamine D1 agonists given to healthy young subjects do not improve working memory per se, whereas alpha-2 agonists do (Franowicz and Arnsten, 1998, 1999; Franowicz et al, 2002; Chudasama and Robbins, 2004; Arnsten and Li, 2005), suggesting that the latter action is more crucial. In addition, alpha-2 agonists are highly effective at improving working memory performance in animals treated with NMDA receptor antagonists to simulate aspects of cognitive impairment in psychoses (Jentsch and Anzivino, 2004; Marrs et al, 2005). In addition, improvements produced by D1 or alpha-2 agonists are larger in animals with experimentally reduced prefrontal cortical catecholamine levels or transmitter depletion associated with normal aging (Brozoski et al, 1979; Arnsten and Goldman-Rakic, 1985a, 1985b, 1990; Arnsten et al, 1988, 1995, 1994; Ramos et al, 2006; Buccafusco et al, 2009).

Despite the very clear evidence that catecholamines are involved in working memory performance, serotonin plays little, if any role (Ruotsalainen et al, 1997; Robbins and Roberts, 2007), resembling a similar dissociation between indolamine and catecholamine transmitter systems in the modulation of attention. This being said, there is one report of 5-HT2A antagonists improving delayed match to position performance (Terry et al, 2005). Nevertheless, even though 5-HT compounds may not improve working memory in normal animals, the possibility remains that manipulations of this system may have some benefit in reversing impairments in this function induced by certain deficit models. This has yet to be tested systematically, and remains a key avenue for further research.

Excitatory amino-acid neurotransmitters also represent an interesting target for working memory enhancement. Recent data indicate that positive allosteric modulators of AMPA receptors can enhance working memory performance in normal or sleep-deprived animals, as well as in aged rodents (Hampson et al, 1998a, 1998b; Porrino et al, 2005; Marighetto et al, 2008b). There is a great deal of evidence, as well, that working memory is dependent on metabotropic glutamate receptor function. Notably, blockade of mGlur1 receptors has been show to enhance performance in working memory tasks, whereas mGlurR2/3 agonists and mGluR5 antagonists impair it (Aultman and Moghaddam, 2001; Homayoun et al, 2004; Spinelli et al, 2005; Homayoun and Moghaddam, 2006; Sukhotina et al, 2008). Alternatively, mGluR2/3 agonists are known to enhance working memory performance in animals with pharmacologically reduced NMDA receptor function (Moghaddam and Adams, 1998; Moghaddam, 2004).


Behavioral flexibility, like working memory, is not a unitary phenomenon, but rather, may be viewed as a hierarchical set of processes that are subserved by anatomically distinct cortical and subcortical regions. For example, response inhibition may be viewed as a fundamental form of executive control, requiring relatively rapid inhibition of a pre-potent action in response to internal and external cues (Eagle et al, 2008a). Extinction learning entails a more gradual suppression of a conditioned response upon repeated non-reinforced presentations of a stimulus previously associated with reward or punishment. Reversal learning is another form of flexibility that can occur when an organism discriminates between two or more stimuli, only one of which is initially associated with reward, but then requiring a switch to another stimulus–reinforcement association within a particular stimulus dimension. On the other hand, set-shifting is a more complex process that entails shifts between strategies, rules, or attentional sets, requiring that attention be paid to multiple aspects of complex environmental stimuli. In these latter two forms of flexibility, successful performance requires both the suppression of a previously -learned response, rule, or strategy and the direction of attention to a previously irrelevant stimulus or stimulus dimension.

Response Inhibition

Although all forms of behavioral flexibility require some form of response inhibition, in its most fundamental form, this process deals with relatively rapid inhibitory control over on-going behavior. Even though suppression of motor output may seem to be a relatively simple construct, recent studies in rats have revealed dissociable neural circuitry and neurochemical modulation of different types of action suppression. For example, in CSRTT, animals must wait until a signal is given to initiate a response, as making a premature response triggers a time-out penalty (Figure 2). Other situations may require actively inhibiting a pre-potent action in response to external ‘stop' cues, which can be assessed with a stop-signal reaction time task (Eagle et al, 2008a) (Figure 3a). In this task, rats are most often required to press one lever and then rapidly respond on another to obtain reward; however, on a minority of trials, a cue signals animals to stop responding on the second lever in order to obtain reinforcement. Lesion studies have revealed that ‘waiting' (as in the CSRTT) vs ‘stopping' (as in stop-signal tasks) may be controlled by different prefrontal circuits. Lesions of the ventromedial, but not orbital PFC, increase premature responding on the CSRTT (Chudasama et al, 2003), whereas orbitofrontal, but not medial PFC lesions, slow stop-signal performance (Eagle et al, 2008b).

Figure 3
Diagrams of procedures used to assess different aspects of behavioral flexibility. (a) In the stop-signal task, rats begin each trial with a nose poke in the central food magazine. The go-phase trial begins with a left lever press and then the rat must ...

Psychopharmacological studies have revealed further dissociations in the neurochemical modulation of these two forms of response inhibition. In contrast to the relative lack of involvement in attention or working memory, 5-HT transmission appears to be of particular importance in mediating ‘waiting', and may act as a brake in the control of impulsive responses (Winstanley et al, 2004a; Eagle and Baunez, 2010). This effect appears to be mediated via actions on 5-HT2C receptors, as stimulation of these receptors with WAY-163909 or blockade of these receptors with SB242084 decreases and increases premature responses, respectively (Winstanley et al, 2004b; Navarra et al, 2008a). However, blockade of 5-HT2A receptors with M100907 also reduced premature responding (Winstanley et al, 2004b), suggesting that this subtype may normally antagonize the effects of 5-HT2C receptor activation on waiting. In contrast, global depletion of 5-HT, or increasing transmitter release via blockade of 5-HT reuptake with citalopram, does not affect stop-signal performance (Bari et al, 2009).

Noradrenergic systems appears to be a more promising target for improving this aspect of response inhibition, as treatment with the selective noradrenergic uptake blocker atomoxetine improved stop-signal performance (Robinson et al, 2008). Atomoxetine also reduced impulsive premature responding in the 5-CSRTT (Robinson et al, 2008, Navarra et al, 2008b), suggesting that selectively enhancing noradrenergic transmission may enhance multiple types of response inhibition. However, the specific receptor subtypes and neural regions, which increased noradrenergic transmission, may be facilitating this form of flexibility remains to be elucidated. Furthermore, whether or not these treatments may normalize deficits in response inhibition in animal models of impaired inhibitory control remains under-explored.


It is now generally accepted that the suppression of a previously learned association following extinction occurs as the result of new learning rather than an erasure of the original CS–US association. Pavlovian associations, particularly those related to aversive stimuli can re-emerge after unsignaled exposure to an unconditioned stimulus, following a change in context or with the passage of time, and reconditioning occurs faster than initial conditioning (Pavlov, 1927; Rescorla and Heth, 1975; Bouton and Bolles, 1979; Bouton et al, 2006; Robbins, 1990; Westbrook et al, 2002). This new learning may act to suppress subcortical memory systems, which generate conditioned responses. In the rat, the ventromedial region of the PFC has been implicated in facilitating the consolidation of extinction learning, both for aversive (Quirk et al, 2000) and appetitive (Rhodes and Killcross, 2004) stimuli.

Studies investigating pharmacological approaches to enhancing extinction have focused primarily on suppression of conditioned fear responses (Quirk and Mueller, 2008). The vast majority of these studies have shown that treatment with certain agents either before or immediately after initial extinction training enhances the consolidation of extinction learning assessed 24 h later. Of these studies, the glutamate NMDA receptor partial agonist -cycloserine has received much attention, as it has been shown repeatedly to accelerate and strengthen extinction of fear, when administered either systemically or directly into the basolateral amygdala or infralimbic PFC (Weber et al, 2007; Woods and Bouton, 2006; Mao et al, 2006; Lee et al, 2006; Parnas et al, 2005; Walker et al, 2002; Burgos-Robles et al, 2007). It is generally believed that -cycloserine facilitates this form of learning by enhancing synaptic plasticity in prefrontal–amygdala circuits (Quirk and Mueller, 2008). Interestingly, the facilitatory effects of -cycloserine on extinction may be limited to aversive Pavlovian associations, as similar treatments actually impaired extinction learning of an instrumental response for food reward (Port and Seybold, 1998).

Drug-induced enhancements in consolidation of extinction memories have typically been observed in the absence of an effect on initial, short-term extinction. One exception to this comes from studies on the role of the endocannabinoid system. Inhibiting endocannabinoid reuptake or administration of a CB1 agonist enhances both short- and long-term extinction of conditioned contextual fear, whereas blockade of CB1 receptors has the opposite effect (Pamplona et al, 2006, 2008). The NMDA NR2B receptor has also been implicated in mediating short-term extinction learning, as selective blockade of these receptors disrupts the acquisition of extinction (Sotres-Bayon et al, 2007; Dalton et al, 2008). Therefore, the development of drugs that may selectively enhance activity at NMDA NR2B sites may reveal another potential target for facilitating rapid acquisition of extinction learning.

There have been relatively few studies on how manipulation of monoamine systems may facilitate extinction learning. Systemic treatment with the dopamine D2-like antagonist sulpiride enhanced consolidation of extinction memories without affecting initial extinction learning (Ponnusamy et al, 2005). This effect may be mediated in part by antagonism of D4 receptors, as similar effects have been observed following infusion of the dopamine D4 antagonist L-741,741 directly into the medial PFC (Pfeiffer and Fendt, 2006). Likewise, treatment with the alpha-2 adrenoceptor antagonist yohimbine, which would be expected to increase noradrenaline release, also enhances consolidation of extinction learning (Cain et al, 2004; Morris and Bouton, 2007). Curiously, there has been very little work investigating how manipulations of the 5-HT system may affect extinction learning. Stimulation of 5-HT1A receptors disrupts both the acquisition and extinction of conditioned fear (Quartermain et al, 1993), but whether blockade of these receptors may have the opposite effect and facilitate extinction learning is a topic for further investigation. In contrast, increasing 5-HT release with fluoxetine reduces instrumental cocaine-seeking behavior on the first day of extinction testing in the cocaine self-administration context (Burmeister et al, 2003). However, it is unclear whether these effects were due to a general decrease in responding via actions on the 5-HT2C receptor (Grottick et al, 2000) or specifically attributable to enhanced short-term extinction learning. Conversely, the 5-HT1A receptor agonist tandospirone reverses extinction deficits induced by postnatal stress (Koseki et al, 2009). In light of the fact that 5-HT exerts complex regulation over response inhibition and higher-order forms of behavioral flexibility discussed below, further research on how targeting 5-HT receptors may affect extinction could potentially reveal novel targets for enhancing this form of flexibility.

Reversal Learning and Set-shifting

Reversal learning has long been used to assess the ability of animals to shift between stimulus and reward contingencies within a particular dimension. In these assays, animals are initially trained to discriminate between two or more stimuli (eg, objects, spatial locations, olfactory cues) to obtain a reward, while ignoring the other, initially irrelevant stimuli. During the reversal shift, one of the previously irrelevant stimuli is now linked to reward. A variation of this type of task has been employed to assess set-shifting abilities, requiring rats to shift between visual cue and egocentric spatial response-based discrimination strategies (Block et al, 2007; Floresco et al, 2006b, 2006a; Ragozzino, 2002). The use of these types of shifts (originally termed a ‘non-reversal shift' (Mackintosh et al, 1968; Mackintosh and Holgate, 1969) were initially used in conjunction with reversal tasks to explore mechanisms of discrimination learning. Recent work with this type of ‘strategy set-shifting' task has been conducted either on a cross-maze (Block et al, 2007) or an operant chamber (Floresco et al, 2008) (Figure 3b). Using these procedures, a reversal phase may also be included (eg, always turn right) (Ghods-Sharifi et al, 2008). Throughout the task, the stimuli remain constant across different phases in this maze-based procedure, making it similar to the Wisconsin Card Sorting task used in human beings. This task places a heavier emphasis on response conflict, because the same set of stimuli are used during initial discrimination learning and during the set-shift (Slamecka, 1968). However, a key advantage of these tasks is that they permit a detailed analysis of the type of errors made during the shift that can be used to distinguish between different types of impairments in set-shifting and reversal learning, such as perseverative deficits, or impairments in the ability to acquire or maintain a new strategy (Floresco et al, 2009).

Birrell and Brown (2000) developed a procedure based on the intradimensional shift/ extradimensional shift (IDS/EDS) task used with primates and human beings (Dias et al, 1996; Pantelis et al, 1999) (Figure 3c). In this attentional set-shifting task, rats discriminate between two bowls that can be distinguished based on a variety of features (eg, digging medium, odor, the texture of the outer surface of the bowl). This task has multiple phases that assess different components of learning, starting with simple and then compound discriminations to obtain food reward hidden in the digging medium of one of the bowls. During this and all subsequent stages, only one of the stimulus dimensions can be used to locate the food reliably. For example, if odor is the relevant dimension, then during each trial the correct bowl will be scented with a particular odor, but the bedding media and the texture of that bowl varies between trials. In the subsequent reversal phase, the location of food is switched, so that the bowl that did not contain food previously is now baited. During the critical extradimensional set-shift, rats are presented with two novel stimuli, but must now disregard the previously relevant stimulus dimensions (eg, odor) and attend to a formerly irrelevant dimension (eg, shift from odor to texture) to locate the food reward. This procedure ensures that impairments in performance during this stage of the task are likely attributable to disruptions in the ability to shift attentional set to different aspects of compound stimuli, rather than an impaired ability to stop approaching a specific stimulus previously associated with reward.

The use of these procedures has revealed dissociable roles for different regions of the frontal lobes in the mediation of these complex forms of behavioral flexibility. Lesions of the orbitofrontal cortex impair reversal learning in both primates and rats (Dias et al, 1996; McAlonan and Brown, 2003; Ghods-Sharifi et al, 2008), whereas the lateral PFC in primates or the medial PFC in rats plays a key role in shifting between rules, strategies, or attentional sets (Dias et al, 1996; Ragozzino et al, 1999; Birrell and Brown, 2000; Floresco et al, 2008). Moreover, there appears to be further differences in the importance of prefrontal monoaminergic systems to these forms of flexibility, with PFC 5-HT facilitating reversal learning, but not set-shifting (Clarke et al, 2004, 2007), whereas mesocortical DA appears to play a key role in the formation of attentional sets and in facilitating shifts from one strategy to another (Roberts et al, 1994; Crofts et al, 2001; Ragozzino, 2002; Floresco et al, 2006b). The frontal–striatal circuits that mediate these forms of shifts also have been dissociated, with the dosomedial, but not ventral striatum contributing to reversal learning, whereas the medial PFC appears to interact with both the nucleus accumbens and dorsal striatum to facilitate set-shifting (Ragozzino et al, 2002; Floresco et al, 2006a; Block et al, 2007; Castañé et al, 2010).

One issue to consider when evaluating pharmacologically induced enhancements of reversal and set-shifts is whether or not perceived ‘improvements' in shifting are related to facilitation of cognitive flexibility, or instead, to a disruption of initial discrimination learning that in turn leads to more rapid shifting. For example, earlier studies reported that repeated treatment with amphetamine facilitated reversal learning, but not shifts between strategies (Weiner and Feldon, 1986). Yet, subsequent studies revealed that the improvements in reversal learning were only apparent when administered during initial discrimination training, suggesting that these treatments attenuated the stability of the initial association leading to more rapid acquisition of the reversal (Weiner et al, 1986). In a similar vein, depletion of prefrontal dopamine in marmosets improved extradimensional set-shifting (Roberts et al, 1994), but this later was found to be due to a disruption of the initial formation of an attentional set (Crofts et al, 2001).

Of the classes of drugs that can enhance reversal learning and set-shifting, those acting on the monoamine systems have received the most attention. With respect to the dopamine system, systemic blockade of D2 but not D1 receptors impairs reversal learning (Lee et al, 2007), with the likely locus of this effect being disruption of dopamine signaling in the dorsal striatum, rather than prefrontal regions or nucleus accumbens (O'Neill and Brown, 2007; Haluk and Floresco, 2009). However, administration of the D2 receptor agonist quinpirole, either systemically or directly into the nucleus accumbens, also impairs reversal learning (Haluk and Floresco, 2009; Boulougouris et al, 2009). Interestingly, although local supranormal stimulation of D1 receptors can impede working memory functions mediated by the PFC (Zahrt et al, 1997; Floresco and Phillips, 2001), similar treatments in either the medial PFC or nucleus accumbens neither improve nor impair strategy set-shifting (Floresco et al, 2006b; Haluk and Floresco, 2009). These findings indicate that selective dopaminergic receptor agonists, particularly those acting on D1 or D2 receptors may not represent the most effective targets for enhancing these complex forms of flexibility in normal animals. One potential exception to this may be antagonists at D4 receptors, as intra-PFC infusions of L-745,870 has been shown to facilitate shifts between strategies (Floresco et al, 2006b). Conversely, there is evidence to suggest that increasing endogenous mesocortical dopamine activity with the COMT inhibitor tolcapone can facilitate extradimensional set-shifting in normal animals (Tunbridge et al, 2004).

Despite the above-mentioned findings, there have been reports that D1 receptor agonists can normalize impairments in these forms of behavioral flexibility induced by certain animal models of cognitive dysfunction. For example, impairments in extradimensional set-shifting induced by repeated amphetamine treatments can be attenuated by direct application of a D1 agonist into the PFC, although these treatments did not alter performance in control rats (Fletcher et al, 2005). Likewise, impairments in reversal learning induced by subchronic PCP are ameliorated by treatment with the D1 agonist SKF 38393 (McLean et al, 2009a). Along similar lines, modafanil, which can facilitate dopamine release (Zolkowska et al, 2009), abolishes PCP-induced impairments in extradimensional set-shifting (Goetghebeur and Dias, 2009). Thus, although dopaminergic drugs may have somewhat equivocal effects on set-shifting and reversal learning in normal animals, increasing prefrontal dopamine transmission may have some benefit at alleviating impairments in flexibility in experimentally perturbed subjects. In contrast, classical antipsychotics such as haloperidol do not appear to alleviate deficits in set-shifting induced by subchronic PCP exposure, consistent with their clinical profile (McLean et al, 2008; Goetghebeur and Dias, 2009), although there have been some reports that the atypical antipsychotic clozapine can attenuate PCP-induced impairments in set-shifting when administered subchronically (McLean et al, 2008; Rodefer et al, 2008).

There have been a multitude of recent reports showing that a variety of drugs acting on 5-HT receptors can improve reversal learning in both normal and pharmacologically perturbed animals. What is particularly striking about these findings is that, even though depletion of 5-HT in the orbital PFC impairs reversal learning, selective blockade of certain 5-HT receptor subtypes facilitates reversal shifts. Thus, in normal animals, improved reversal performance has been observed following treatment with antagonists at 5-HT3 (ondansetron; Barnes et al, 1990) or 5-HT2C (SB242084; Boulougouris et al, 2008) receptors. The effect of 5-HT2C antagonism appears to be specific to blockade of these receptors in the orbital PFC (Boulougouris and Robbins, 2010), and may be mediated in part by a facilitation in 5-HT release via actions on 5-HT neurons in the dorsal raphé (Sharp et al, 2007), which in turn may activate other 5-HT receptors to facilitate reversal shifts. In contrast, systemic 5-HT2A receptor blockade with M100907 impairs reversal performance (Boulougouris et al, 2008), although infusions of this drug into the orbital PFC were without effect (Boulougouris and Robbins, 2010). This suggests that endogenous 5-HT may act on 2A receptors in regions such as the dorsal striatum to facilitate reversal shifts. Curiously, although 5-HT2A antagonism impairs reversal learning in normal animals, similar treatments with M100907 actually alleviates subchronic PCP-induced reversal impairments (Idris et al, 2010), as does blockade of 5-HT2C, 5-HT6, and 5-HT7 receptors (McLean et al, 2009b; Idris et al, 2010).

The findings described above indicate that reducing signaling at certain 5-HT receptor subtypes has beneficial effects on reversal learning in both normal and experimentally-impaired animals. Yet, a recent report by Lapiz-Bluhm et al (2009) showed that acute increases in 5-HT release, via blockade of reuptake with citalopram, alleviated impairments in reversal learning induced by repeated stress. These authors also showed that repeated stress reduced 5-HT release in the orbital PFC, which likely was a primary contributing factor to these impairments. Thus, either blockade of certain 5-HT receptors or enhancing 5-HT release can improve performance of reversal shifts disrupted by certain experimentally induced alterations in neurochemical functioning. In addition, chronic blockade of 5-HT reuptake with fluoxetine reduced perseveration during reversal learning in normal mice (Brigman et al, 2010). These finding highlights the fact that when targeting the 5-HT system to normalize deficits in this form of behavioral flexibility, one must take into account the types of neural alterations that may be the underlying cause of these impairments. Furthermore, they suggest that increasing endogenous 5-HT release can have a net beneficial effect on performance in normal animals, although the receptors and brain regions through which these effects are mediated remain to be clarified.

As depletion of 5-HT does not appear to affect EDS performance (Clarke et al, 2005), there has been less work on how drugs acting on this monoamine system can affect set-shifting. However, there are some reports that targeting 5-HT6 receptors facilitates extradimensional set-shifting, although there appears to be discrepancies in the literature. Hatcher et al (2005) showed that repeated treatment with the 5-HT6 antagonist SB399885 improved both reversal learning and set-shifting in normal animals tested on the IDS/EDS task. Yet, another antagonist for this receptor (SB271046) only induced statistically significant improvements in reversal performance. In a similar vein, acute 5-HT6 antagonism alleviated EDS and reversal impairments induced by subchronic PCP (Rodefer et al, 2008; Idris et al, 2010). These findings are contrasted by observations of Burnham et al (2010), who showed that the 5-HT6 agonist WAY181187 also selectively improved EDS performance in normal rats. In that study, WAY181187 enhanced set-shifting even when administered after an attentional set had been acquired, thereby ruling out impairments in attentional set formation. These findings suggest that further studies on the potential cognitive-enhancing effects of drugs acting on 5-HT6 receptors are warranted, particularly to clarify whether blockade or stimulation of these receptors (or both) can exert pro-cognitive effects.

There have been a handful of reports that drugs, which increase noradrenergic activity, appear to also facilitate reversal learning and set-shifting in a manner similar to their ability to facilitate response inhibition and extinction. Earlier reports noted that treatment with high, but not low doses of the alpha-2 adrenergic receptor agonist guanfacine improves reversal performance in aged monkeys (Steere and Arnsten, 1997). In a similar vein, acute or repeated treatment with the noradrenaline reuptake blocker atomoxetine or desipramine reduced perseveration during reversal performance without affecting retention of a previously acquired discrimination (Seu and Jentsch, 2009; Seu et al, 2009). The fact that drug-induced increases in noradrenergic transmission can enhance reversal learning is particularly notable, in light of the fact that selective depletion of prefrontal noradrenaline does not affect reversal learning, although these treatments do impair extradimensional set-shifting (Tait et al, 2007). This more complex form of flexibility has also been shown to be sensitive to pharmacological enhancement by noradrenergic drugs. Acute desipramine treatment causes mild improvements in all components of the IDS/EDS task in rats, whereas chronic treatment selectively facilitated the EDS phase (Lapiz et al, 2007). Using the same task, Lapiz and Morilak (2006) showed that blockade of noradrenergic autoreceptors with atipamezole improved performance during both the reversal and EDS phases of the task. Likewise, atomoxetine alleviated set-shifting impairments induced by noradrenaline depletion (Newman et al, 2008), although in this study, reversal performance was unaffected in both control and lesioned rats. These enhancements in set-shifting induced by systemic increases in noradrenergic release appear to be mediated in part by the activation of alpha-1 receptors in the PFC (Lapiz and Morilak, 2006).

It is interesting to note that although manipulations of acetylcholine muscarinic or nicotinic receptors have been shown to enhance memory and attention, there has been little work done investigating how these drugs may enhance reversal and set-shifts. One reason for this is that the contribution of the cholinergic system to these functions remains to be more completely clarified, as there have been some discrepant findings in the literature (Robbins and Roberts, 2007). That said, there has been one report that the beta-4 subtype-selective nicotinic agonist SIB-1553A improved reversal learning (but not set-shifting) in monkeys treated with MPTP as a model of Parkinson's disease (Decamp and Schneider, 2006). These findings provide some evidence that, like their effects on working memory and attention, nicotinic receptors may also be a suitable target for treating impairments in certain forms of flexibility.

Other potential drug targets for improving behavioral flexibility include, augmenting glutamate transmission with ampakines, as treatment may have some utility in alleviating impairments in this aspect of executive functioning (Broberg et al, 2009). In a similar vein, a recent study by Stefani and Moghaddam (2010) showed that the mGluR5 receptor agonist CDPPB alleviated impairments in strategy set-shifting induced by acute NMDA receptor blockade, even though this treatment had no effect in normal rats. There is some evidence that targeting the endocannabinoid system may also be a potential strategy for improving this executive function. Blockade of CB1 receptors have also been reported to facilitate strategy set-shifting in normal rats, whereas stimulation of these receptors impaired performance (Hill et al, 2006), although it is unclear whether this facilitation is due specifically to improved flexibility or attenuated retrieval of a previously acquired strategy. Of particular interest are multi-target agents such as asenapine, which has affinities for multiple monoamine receptors, and, somewhat curiously, has been shown to ameliorate impairments in extradimensional set-shifting induced by lesions of the medial PFC (Tait et al, 2009).


Rather than focus on one aspect of cognition or one class of drug, a key objective of this review was to emphasize some of the mechanistic differences and similarities through which drugs may enhance different types of memory and executive functioning. With regard to attentional functions, the most significant performance benefits arise from the administration of nicotinic agonists, particularly targeting the high-affinity beta-2-containing and low-affinity alpha-7-containing receptors. These effects have been observed in both normal and experimentally impaired animals, suggesting that targeting nicotinic receptors may be a particularly effective strategy in normalizing attentional impairments associated with a number of disorders. This being the case, new molecular targets for study in the control of attention, including the high-affinity choline transporter (Sarter and Parikh, 2005), deserve further study. Improved attention has also been reported using drugs that enhance catecholamine transmission that have been approved for the treatment of inattentive disorders (eg, stimulants, atomoxetine, guanfacine), although the contribution of dopamine vs noradrenaline receptors to these effects remain to be clarified.

Working memory has also been reported to be enhanced by nicotinic receptor agonists, although how much of this effect is attributable to improvements in attention remains to be clarified. Catecholamine agonists (particularly dopamine D1 and alpha-2 adrenoceptor agonists) also enhance working memory, but in a much more complex manner, that depends on the biological integrity of the subject (eg, young vs aged, normal vs catecholamine depleted) and the task. Future work on modulators of glutamatergic function also holds great promise for the enhancement of working memory. Notably, the majority of the studies investigating pharmacological improvements in working memory have been conducted in normal animals, and there remains a relative dearth of studies of ameliorating working memory deficits induced in certain animal models of neuropsychiatric disorders (eg, Enomoto and Floresco, 2009). Continued research assessing the effects of potential pro-cognitive compounds using these models may provide novel insights into approaches for treating working memory deficits associated with certain disease states.

Different forms of behavioral flexibility display a striking complexity in terms of the neurochemical mechanisms that mediate these functions, providing a host of systems that may be targeted to enhance them. A key finding across these studies is that even though there is some overlap among drug targets that can enhance certain domains of behavioral flexibility, there also exist prominent dissociations in how certain compounds may affect one aspect of flexibility vs another. These observations further highlight the fact that behavioral flexibility is a collection of different processes with distinct neurochemical mechanisms. As such, one complication that arises when attempting to enhance a particular form of flexibility is that drugs which may improve one aspect of functioning may do so at the expense of others. For example, 5-HT2C receptor antagonists can not only enhance reversal learning (Boulougouris et al, 2009), but also impair other aspects of response inhibition (Winstanley et al, 2004b). Targeting CB1 receptors may facilitate Pavlovian extinction, but this may also interfere with between-strategy shifts (Pamplona et al, 2006, 2008; Hill et al, 2006). Nevertheless, an important direction for future research is to fill some of the substantial gaps in our understanding of how certain drugs, which have been shown to enhance one form of flexibility, may alter other related, but distinct processes. These include assessing the effects of different 5-HT receptor agonists/antagonists on extinction, glutamate receptor allosteric modulators on response inhibition and set-shifting, and cannabinoids on waiting/stopping. Furthermore, given that nicotinic drugs have been shown to enhance working memory and attentional functions mediated by the frontal lobes, an important avenue for future research would be to assess how these drugs may enhance different forms of flexibility in both normal and perturbed animals. A comprehensive analysis of how these and other drugs affect different domains of flexibility may reveal other targets that may enhance this type of executive functioning without hampering others.

Although each of the mnemonic and executive functions discussed in this review have somewhat distinct profiles in terms of pharmacological enhancement, it bears mentioning that some classes of drugs appear to exert beneficial effects on multiple domains of cognition in normal and/or per turbed animals. Thus, drugs acting on nicotinic receptors improve attention (Hahn et al, 2003), recognition memory (Pichat et al, 2007), working memory (Bontempi et al, 2003), and reversal learning in Parkinsonian monkeys (Decamp and Schneider, 2006) (Figure 4). Similarly, the noradrenaline reuptake inhibitor atomoxetine has been reported to positively modulate aspects of attentional performance (Jentsch et al, 2009), behavioral flexibility (Seu et al, 2009), response inhibition, and more complex forms of cognition related to impulsive decision making (Robinson et al, 2008) (see Figure 5). The multiple aspects of cognition that are enhanced by this compound suggests that it may act on multiple frontal subregions, including the prelimbic and anterior cingulate cortices responsible for controlled aspects of attention and the orbitofrontal cortex, which mediates the other functions (Eagle et al, 2008a, 2008b; Winstanley et al, 2004c; Schoenbaum et al, 2006). These effects probably implicate catecholamine mechanisms localized within the PFC. Importantly, noradrenaline reuptake inhibition increases activity-dependent synaptic levels of both noradrenaline and dopamine, because noradrenergic terminals appear to be largely responsible for clearing synaptic dopamine in cortical, but not subcortical regions (Bymaster et al, 2002). These effects likely correspond to the positive therapeutic benefit of atomoxetine in the treatment of attention deficit/hyperactivity disorder, but probably also indicate its potential for exerting cognitive enhancement in disorders associated with the dysregulation of cortical dopamine/noradrenaline (eg, schizophrenia). The two main points to bear in mind when viewing studies of the pro-cognitive effects of these compounds are (1) drugs that may selectively target nicotinic or prefrontal catecholamine transmission may be particularly beneficial in enhancing multiple aspects of cognitive function, and (2) more generally, that identification of novel and more effective cognitive-enhancing drugs will come from a thorough assessment of their effects on multiple aspects of memory and cognition in both normal and experimentally impaired laboratory animals.

Figure 4
Examples of the broad pro-cognitive effects of nicotinic agonists in normal and experimentally impaired animals. Nicotine, or receptor subtype-selective agonists (a), improves attentional performance on the 5-choice serial reaction time tasks (CSRTT) ...
Figure 5
The noradrenaline reuptake inhibitor has also been shown to exert fairly broad performance-enhancing effects in measures of attentional function (Jentsch et al, 2009), behavioral flexibility (Seu et al, 2009), response inhibition (Robinson et al, 2008 ...


Some of the studies reviewed here were supported by a Discovery Grant from the Natural Science and Engineering Research Council of Canada to SBF and PHS Grants P50-MH077248, P20-DA022539, UL1-DE019580, RL1-MH083270 and PL1-NS062410 to JDJ. SBF is a Michael Smith Foundation for Health Research Senior Scholar. We thank Dr Gemma Dalton for her useful comments on this manuscript.


The authors declare no conflict of interest.


  • Aigner TG, Mishkin M. The effects of physostigmine and scopolamine on recognition memory in monkeys. Behav Neural Biol. 1986;45:81–87. [PubMed]
  • Amitai N, Markou A. Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration. Psychopharmacology. 2009;202:275–286. [PMC free article] [PubMed]
  • Arnsten AF. Stimulants: therapeutic actions in ADHD. Neuropsychopharmacology. 2006;31:2376–2383. [PubMed]
  • Arnsten AF. Catecholamine and second messenger influences on prefrontal cortical networks of ‘representational knowledge': a rational bridge between genetics and the symptoms of mental illness. Cereb Cortex. 2007;17 (Suppl 1:i6–i15. [PubMed]
  • Arnsten AF, Cai JX, Goldman-Rakic PS. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. J Neurosci. 1988;8:4287–4298. [PubMed]
  • Arnsten AF, Cai JX, Murphy BL, Goldman-Rakic PS. 1994. Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys Psychopharmacology 116143–151.151This paper provided some of the first evidence that the effects of D1 agonists on working memory likely depend on baseline catecholamine levels. [PubMed]
  • Arnsten AF, Cai JX, Steere JC, Goldman-Rakic PS. Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys. J Neurosci. 1995;15:3429–3439. [PubMed]
  • Arnsten AF, Dudley AG. Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in attention deficit hyperactivity disorder. Behav Brain Funct. 2005;1:2. [PMC free article] [PubMed]
  • Arnsten AF, Goldman-Rakic PS. Catecholamines and cognitive decline in aged nonhuman primates. Ann N Y Acad Sci. 1985a;444:218–234. [PubMed]
  • Arnsten AF, Goldman-Rakic PS. Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science. 1985b;230:1273–1276. [PubMed]
  • Arnsten AF, Goldman-Rakic PS. Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging. 1990;11:583–590. [PubMed]
  • Arnsten AF, Li BM. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry. 2005;57:1377–1384. [PubMed]
  • Aultman JM, Moghaddam B. Distinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant task. Psychopharmacology. 2001;153:353–364. [PubMed]
  • Baddeley A. Working memory. Curr Biol. 2010;20:R136–R140. [PubMed]
  • Baddeley A, Hitch G. 1974. Working memoryIn: Bower GA (ed).The Psychology of Learning and Motivation Academic Press: San Diego; 48–79.79
  • Balducci C, Nurra M, Pietropoli A, Samanin R, Carli M. Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635. Psychopharmacology. 2003;167:28–36. [PubMed]
  • Ballard TM, Woolley ML, Prinssen E, Huwyler J, Porter R, Spooren W. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. Psychopharmacology (Berl) 2005;179:218–229. [PubMed]
  • Barch DM. The cognitive neuroscience of schizophrenia. Annu Rev Clin Psychol. 2005;1:321–353. [PubMed]
  • Bari A, Eagle DM, Mar AC, Robinson ES, Robbins TW. 2009. Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats Psychopharmacology 205273–283.283A clear demonstration of the dissociable contribution of monoamine transmitters on a test of response inhibition. [PMC free article] [PubMed]
  • Barker GR, Bashir ZI, Brown MW, Warburton EC. A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory. Learn Mem. 2006;13:178–186. [PubMed]
  • Barnes CA, Meltzer J, Houston F, Orr G, McGann K, Wenk GL. Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors. Neuroscience. 2000;99:17–23. [PubMed]
  • Barnes JM, Costall B, Coughlan J, Domeney AM, Gerrard PA, Kelly ME, et al. The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates. Pharmacol Biochem Behav. 1990;35:955–962. [PubMed]
  • Baviera M, Invernizzi RW, Carli M. Haloperidol and clozapine have dissociable effects in a model of attentional performance deficits induced by blockade of NMDA receptors in the mPFC. Psychopharmacology. 2008;196:269–280. [PubMed]
  • Baxter MG, Murray EA. The amygdala and reward. Nat Rev Neurosci. 2002;3:563–573. [PubMed]
  • Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AF, Kelley AE, Schmeichel B, et al. 2006. Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function Biol Psychiatry 601111–1120.1120This paper provides direct evidence that the cognitive-enhancing effects of stimulant drugs depends on their ability to modulate noradrenaline and dopamine transmission in frontal cortical regions. [PubMed]
  • Bertaina-Anglade V, la Rochelle CD, Munoz C, Morain P, Bernard K. Comparison of single vs multiple administrations of the AMPA receptors modulator S 18986 in the object recognition task in rats. Fundam Clin Pharmacol. 2007;21:349–354. [PubMed]
  • Bevins RA, Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory'. Nat Protoc. 2006;1:1306–1311. [PubMed]
  • Birrell JM, Brown VJ. Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci. 2000;20:4320–4324. [PubMed]
  • Bissière S, Humeau Y, Lüthi A. Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. Nat Neurosci. 2003;6:587–592. [PubMed]
  • Bitner RS, Bunnelle WH, Anderson DJ, Briggs CA, Buccafusco J, Curzon P, et al. Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J Neurosci. 2007;27:10578–10587. [PubMed]
  • Bizarro L, Patel S, Murtagh C, Stolerman IP. Differential effects of psychomotor stimulants on attentional performance in rats: nicotine, amphetamine, caffeine and methylphenidate. Behav Pharmacol. 2004;15:195–206. [PubMed]
  • Bizarro L, Stolerman IP. Attentional effects of nicotine and amphetamine in rats at different levels of motivation. Psychopharmacology. 2003;170:271–277. [PubMed]
  • Block AE, Dhanji H, Thompson-Tardif SF, Floresco SB. Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shifting. Cereb Cortex. 2007;17:1625–1636. [PubMed]
  • Blondeau C, Dellu-Hagedorn F. Dimensional analysis of ADHD subtypes in rats. Biol Psychiatry. 2007;61:1340–1350. [PubMed]
  • Boess FG, De Vry J, Erb C, Flessner T, Hendrix M, Luithle J, et al. The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents. J Pharmacol Exp Ther. 2007;321:716–725. [PubMed]
  • Bolla KI, Cadet JL, London ED. The neuropsychiatry of chronic cocaine abuse. J Neuropsychiatry Clin Neurosci. 1998;10:280–289. [PubMed]
  • Bontempi B, Whelan KT, Risbrough VB, Lloyd GK, Menzaghi F. Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors. Neuropsychopharmacology. 2003;28:1235–1246. [PubMed]
  • Bontempi B, Whelan KT, Risbrough VB, Rao TS, Buccafusco JJ, Lloyd GK, et al. SIB-1553A, (+/−)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: effects on working and reference memory performances in aged rodents and nonhuman primates. J Pharmacol Exp Ther. 2001;299:297–306. [PubMed]
  • Boulay D, Pichat P, Dargazanli G, Estenne-Bouhtou G, Terranova JP, Rogacki N, et al. Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia. Pharmacol Biochem Behav. 2008;91:47–58. [PubMed]
  • Boulougouris V, Castañé A, Robbins TW. Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior. Psychopharmacology. 2009;202:611–620. [PubMed]
  • Boulougouris V, Glennon JC, Robbins TW. Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology. 2008;33:2007–2019. [PubMed]
  • Boulougouris V, Robbins TW. Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. J Neurosci. 2010;30:930–938. [PubMed]
  • Bouton ME, Bolles RC. Role of conditioned contextual stimuli in reinstatement of extinguished fear. J Exp Psychol Anim Behav Process. 1979;5:368–378. [PubMed]
  • Bouton ME, Westbrook RF, Corcoran KA, Maren S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol Psychiatry. 2006;60:352–360. [PubMed]
  • Bradley SR, Lameh J, Ohrmund L, Son T, Bajpai A, Nguyen D, et al. AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model. Neuropharmacology. 2010;58:365–373. [PubMed]
  • Brigman JL, Mathur P, Harvey-White J, Izquierdo A, Saksida LM, Bussey TJ, et al. 2010. Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice Cereb Cortex 201955–1963.1963(print copy in press (originally published online 18 February 2010 at doi:10.1093/cercor/bhp266 [PMC free article] [PubMed] [Cross Ref]
  • Broberg BV, Glenthøj BY, Dias R, Larsen DB, Olsen CK. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology. 2009;206:631–640. [PubMed]
  • Brown RW, Bardo MT, Mace DD, Phillips SB, Kraemer PJ. D-amphetamine facilitation of morris water task performance is blocked by eticlopride and correlated with increased dopamine synthesis in the prefrontal cortex. Behav Brain Res. 2000;114:135–143. [PubMed]
  • Brown MW, Bashir ZI. Evidence concerning how neurons of the perirhinal cortex may effect familiarity discrimination. Philos Trans R Soc Lond Ser B. 2002;357:1083–1095. [PMC free article] [PubMed]
  • Brozoski TJ, Brown RM, Rosvold HE, Goldman PS. 1979. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey Science 205929–932.932The first demonstration of a direct relationship between catecholamine transmission in the prefrontal cortex and working memory. [PubMed]
  • Buccafusco JJ, Terry AV, Jr, Decker MW, Gopalakrishnan M. Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys. Biochem Pharmacol. 2007;74:1202–1211. [PubMed]
  • Buccafusco JJ, Webster SJ, Terry AV, Jr, Kille N, Blessing D. Protracted cognitive effects produced by clonidine in Macaca nemestrina performing a delayed matching task. Psychopharmacology. 2009;202:477–485. [PubMed]
  • Buchanan TW. Retrieval of emotional memories. Psychol Bull. 2007;133:761–779. [PMC free article] [PubMed]
  • Bunge SA. How we use rules to select actions: a review of evidence from cognitive neuroscience. Cogn Affect Behav Neurosci. 2004;4:564–579. [PubMed]
  • Burgos-Robles A, Vidal-Gonzalez I, Santini E, Quirk GJ. Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron. 2007;53:871–880. [PubMed]
  • Burmeister JJ, Lungren EM, Neisewander JL. Effects of fluoxetine and d-fenfluramine on cocaine-seeking behavior in rats. Psychopharmacology. 2003;168:146–154. [PubMed]
  • Burnham KE, Baxter MG, Bainton JR, Southam E, Dawson LA, Bannerman DM, et al. Activation of 5-HT(6) receptors facilitates attentional set shifting. Psychopharmacology. 2010;208:13–21. [PubMed]
  • Bymaster FP, Katner JS, Nelson DL, Hemrick-Luecke SK, Threlkeld PG, Heiligenstein JH, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002;27:699–711. [PubMed]
  • Cahill L, Prins B, Weber M, McGaugh JL. Beta-adrenergic activation and memory for emotional events. Nature. 1994;371:702–704. [PubMed]
  • Cain CK, Blouin AM, Barad M. Adrenergic transmission facilitates extinction of conditional fear in mice. Learn Mem. 2004;11:179–187. [PubMed]
  • Calabresi P, Centonze D, Gubellini P, Bernardi G. Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP. Neuropharmacology. 1999;38:323–326. [PubMed]
  • Carli M, Baviera M, Invernizzi RW, Balducci C. 2006. Dissociable contribution of 5-HT1A and 5-HT2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats Neuropsychopharmacology 31757–767.767This paper delineates the differential contribution of 5-HT receptor subtypes to inhibitory control over pre-potent responding in CSRTT. [PubMed]
  • Carli M, Robbins TW, Evenden JL, Everitt BJ. Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res. 1983;9:361–380. [PubMed]
  • Carli M, Samanin R. The 5-HT(1A) receptor agonist 8-OH-DPAT reduces rats' accuracy of attentional performance and enhances impulsive responding in a five-choice serial reaction time task: role of presynaptic 5-HT(1A) receptors. Psychopharmacology. 2000;149:259–268. [PubMed]
  • Castañé A, Theobald DE, Robbins TW. Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats. Behav Brain Res. 2010;210:74–83. [PMC free article] [PubMed]
  • Centonze D, Picconi B, Gubellini P, Bernardi G, Calabresi P. Dopaminergic control of synaptic plasticity in the dorsal striatum. Eur J Neurosci. 2001;13:1071–1077. [PubMed]
  • Chamberlain SR, Del Campo N, Dowson J, Muller U, Clark L, Robbins TW, et al. Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biol Psychiatry. 2007a;62:977–984. [PubMed]
  • Chamberlain SR, Muller U, Cleary S, Robbins TW, Sahakian BJ. Atomoxetine increases salivary cortisol in healthy volunteers. J Psychopharmacol. 2007b;21:545–549. [PubMed]
  • Cho K, Kemp N, Noel J, Aggleton JP, Brown MW, Bashir ZI. A new form of long-term depression in the perirhinal cortex. Nat Neurosci. 2000;3:150–156. [PubMed]
  • Chudasama Y, Passetti F, Rhodes SE, Lopian D, Desai A, Robbins TW. Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res. 2003;146:105–119. [PubMed]
  • Chudasama Y, Robbins TW. Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex. Neuropsychopharmacology. 2004;29:1628–1636. [PubMed]
  • Chuhan YS, Taukulis HK. Impairment of single-trial memory formation by oral methylphenidate in the rat. Neurobiol Learn Mem. 2006;85:125–131. [PubMed]
  • Churchwell JC, Morris AM, Musso ND, Kesner RP. Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory. Neurobiol Learn Mem. 2010;93:415–421. [PubMed]
  • Clark L, Chamberlain SR, Sahakian BJ. Neurocognitive mechanisms in depression: implications for treatment. Annu Rev Neurosci. 2009;32:57–74. [PubMed]
  • Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC. Cognitive inflexibility after prefrontal serotonin depletion. Science. 2004;304:878–880. [PubMed]
  • Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC. Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J Neurosci. 2005;25:532–538. [PubMed]
  • Clarke HF, Walker SC, Dalley JW, Robbins TW, Roberts AC. 2007. Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific Cereb Cortex 1718–27.27This article provides direct evidence linking orbitofrontal serotonin, but not dopamine, mechanisms to perseverative responding in reversal learning tests. [PubMed]
  • Clayton NS, Russell J. Looking for episodic memory in animals and young children: prospects for a new minimalism. Neuropsychologia. 2009;47:2330–2340. [PubMed]
  • Cools R, Altamirano L, D'Esposito M. Reversal learning in Parkinson's disease depends on medication status and outcome valence. Neuropsychologia. 2006;44:1663–1673. [PubMed]
  • Cools R, Lewis SJ, Clark L, Barker RA, Robbins TW. -DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease. Neuropsychopharmacology. 2007;32:180–189. [PubMed]
  • Corcoran KA, Quirk GJ. Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. J Neurosci. 2007;27:840–844. [PubMed]
  • Crofts HS, Dalley JW, Collins P, Van Denderen JC, Everitt BJ, Robbins TW, et al. 2001. Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set Cereb Cortex 111015–1026.1026This paper shows that improvements in cognitive flexibility associated with dopamine depletion depend, in part, on deficits in attentional set formation caused by the insult. [PubMed]
  • Curtis CE, D'Esposito M. The effects of prefrontal lesions on working memory performance and theory. Cogn Affect Behav Neurosci. 2004;4:528–539. [PubMed]
  • Cutuli D, Foti F, Mandolesi L, De Bartolo P, Gelfo F, Federico F, et al. Cognitive performances of cholinergically depleted rats following chronic donepezil administration. J Alzheimers Dis. 2009;17:161–176. [PubMed]
  • Dalton GL, Wang YT, Floresco SB, Phillips AG. Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear. Neuropsychopharmacology. 2008;33:2416–2426. [PubMed]
  • Damgaard T, Larsen DB, Hansen SL, Grayson B, Neill JC, Plath N. Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats. Behav Brain Res. 2010;207:144–150. [PubMed]
  • Dawson GR, Iversen SD. The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behav Brain Res. 1993;57:143–153. [PubMed]
  • Decamp E, Schneider JS. Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Eur J Neurosci. 2006;24:2098–2104. [PubMed]
  • Dias R, Robbins TW, Roberts AC. Dissociation in prefrontal cortex of affective and attentional shifts. Nature. 1996;380:69–72. [PubMed]
  • Dillon GM, Shelton D, McKinney AP, Caniga M, Marcus JN, Ferguson MT, et al. Prefrontal cortex lesions and scopolamine impair attention performance of C57BL/6 mice in a novel 2-choice visual discrimination task. Behav Brain Res. 2009;204:67–76. [PubMed]
  • Doyle AE. Executive functions in attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2006;67 (Suppl 8:21–26. [PubMed]
  • Eagle DM, Bari A, Robbins TW. The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks. Psychopharmacology. 2008a;199:439–456. [PubMed]
  • Eagle DM, Baunez C. Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. Neurosci Biobehav Rev. 2010;34:50–72. [PMC free article] [PubMed]
  • Eagle DM, Baunez C, Hutcheson DM, Lehmann O, Shah AP, Robbins TW. Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus. Cereb Cortex. 2008b;18:178–188. [PubMed]
  • Eagle DM, Tufft MR, Goodchild HL, Robbins TW. Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol. Psychopharmacology (Berl) 2007;192:193–206. [PubMed]
  • Enomoto T, Floresco SB. Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:668–675. [PubMed]
  • Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA. Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. Psychopharmacology (Berl) 2007a;195:223–234. [PubMed]
  • Fletcher PJ, Tenn CC, Rizos Z, Lovic V, Kapur S. Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Psychopharmacology. 2005;183:190–200. [PubMed]
  • Fletcher PJ, Tenn CC, Sinyard J, Rizos Z, Kapur S. A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Neuropsychopharmacology. 2007b;32:1122–1132. [PubMed]
  • Floresco SB, Block AE, Tse MT. Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure. Behav Brain Res. 2008;2008:190:85–190:96. [PubMed]
  • Floresco SB, Geyer MA, Gold LH, Grace AA. Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia. Schizophr Bull. 2005;31:888–894. [PubMed]
  • Floresco SB, Ghods-Sharifi S, Vexelman C, Magyar O. Dissociable roles for the nucleus accumbens core and shell in regulating set shifting. J Neurosci. 2006a;26:2449–2457. [PubMed]
  • Floresco SB, Magyar O, Ghods-Sharifi S, Vexelman C, Tse MT. Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting. Neuropsychopharmacology. 2006b;31:297–309. [PubMed]
  • Floresco SB, Phillips AG. Delay-dependent modulation of memory retrieval by infusion of a dopamine D1 agonist into the rat medial prefrontal cortex. Behav Neurosci. 2001;115:934–939. [PubMed]
  • Floresco SB, Zhang Y, Enomoto T. Neural circuits subserving behavioral flexibility and their relevance to schizophrenia. Behav Brain Res. 2009;204:396–409. [PubMed]
  • Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008;55:1015–1022. [PubMed]
  • Franowicz JS, Arnsten AF. 1998. The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys Psychopharmacology (Berl) 1368–14.14This article shows the cognitive enhancing effects of alpha-2 agonists, even in optimal young subjects. [PubMed]
  • Franowicz JS, Arnsten AF. Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys. Neuropsychopharmacology. 1999;21:611–621. [PubMed]
  • Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci. 2002;22:8771–8777. [PubMed]
  • Fuster JM. 2008. The Prefrontal Cortex4th edn.Academic Press: San Diego
  • Fuster JM, Alexander GE. Neuron activity related to short-term memory. Science. 1971;173:652–654. [PubMed]
  • Ghods-Sharifi S, Haluk DM, Floresco SB. Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning. Neurobiol Learn Mem. 2008;89:567–573. [PubMed]
  • Giannoni P, Medhurst AD, Passani MB, Giovannini MG, Ballini C, Corte LD, et al. Regional differential effects of the novel histamine H3 receptor antagonist 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on histamine release in the central nervous system of freely moving rats. J Pharmacol Exp Ther. 2010;332:164–172. [PubMed]
  • Goetghebeur P, Dias R. Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study. Psychopharmacology. 2009;202:287–293. [PubMed]
  • Goldman PS, Rosvold HE, Vest B, Galkin TW. Analysis of the delayed-alternation deficit produced by dorsolateral prefrontal lesions in the rhesus monkey. J Comp Physiol Psychol. 1971;77:212–220. [PubMed]
  • Goldman-Rakic PS. 1987. Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memoryIn: Plum F (ed).Handbook of Physiology, the Nervous System, Higher Functions of the Brain American Physiological Society: Bethesda; 373–417.417
  • Granon S, Passetti F, Thomas KL, Dalley JW, Everitt BJ, Robbins TW. 2000. Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex J Neurosci 201208–1215.1215A key paper revealing that the effects of D1 agonist administration on attention function depends on baseline performance characteristics. [PubMed]
  • Greco B, Invernizzi RW, Carli M. Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268. Psychopharmacology. 2005;179:68–76. [PubMed]
  • Greenwald BS, Davis KL. Experimental pharmacology of Alzheimer disease. Adv Neurol. 1983;38:87–102. [PubMed]
  • Grilly DM. A verification of psychostimulant-induced improvement in sustained attention in rats: effects of d-amphetamine, nicotine, and pemoline. Exp Clin Psychopharmacol. 2000;8:14–21. [PubMed]
  • Grilly DM, Gowans GC, McCann DS, Grogan TW. Effects of cocaine and d-amphetamine on sustained and selective attention in rats. Pharmacol Biochem Behav. 1989;33:733–739. [PubMed]
  • Grottick AJ, Fletcher PJ, Higgins GA. Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther. 2000;295:1183–1191. [PubMed]
  • Grottick AJ, Haman M, Wyler R, Higgins GA. Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands. Neuropsychopharmacology. 2003;28:880–887. [PubMed]
  • Grottick AJ, Higgins GA. Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav Brain Res. 2000;117:197–208. [PubMed]
  • Grottick AJ, Higgins GA. Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants. Psychopharmacology. 2002;164:33–41. [PubMed]
  • Grottick AJ, Wyler R, Higgins GA. A study of the nicotinic agonist SIB-1553A on locomotion and attention as measured by the five-choice serial reaction time task. Pharmacol Biochem Behav. 2001;70:505–513. [PubMed]
  • Hahn B, Sharples CG, Wonnacott S, Shoaib M, Stolerman IP. Attentional effects of nicotinic agonists in rats. Neuropharmacology. 2003;44:1054–1067. [PubMed]
  • Hahn B, Shoaib M, Stolerman IP. Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task demands. Psychopharmacology (Berl) 2002a;162:129–137. [PubMed]
  • Hahn B, Shoaib M, Stolerman IP. Effects of dopamine receptor antagonists on nicotine-induced attentional enhancement. Behav Pharmacol. 2002b;13:621–632. [PubMed]
  • Hahn B, Stolerman IP. Nicotine-induced attentional enhancement in rats: effects of chronic exposure to nicotine. Neuropsychopharmacology. 2002;27:712–722. [PubMed]
  • Hahn B, Stolerman IP. Modulation of nicotine-induced attentional enhancement in rats by adrenoceptor antagonists. Psychopharmacology. 2005;177:438–447. [PubMed]
  • Hains AB, Arnsten AF. Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness. Learn Mem. 2008;15:551–564. [PubMed]
  • Haluk DM, Floresco SB. Ventral striatal dopamine modulation of different forms of behavioral flexibility. Neuropsychopharmacology. 2009;34:2041–2052. [PubMed]
  • Hampson RE, Rogers G, Lynch G, Deadwyler SA. Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity. J Neurosci. 1998a;18:2748–2763. [PubMed]
  • Hampson RE, Rogers G, Lynch G, Deadwyler SA. Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance. J Neurosci. 1998b;18:2740–2747. [PubMed]
  • Hannesson DK, Vacca G, Howland JG, Phillips AG. Medial prefrontal cortex is involved in spatial temporal order memory but not spatial recognition memory in tests relying on spontaneous exploration in rats. Behav Brain Res. 2004;153:273–285. [PubMed]
  • Harrison AA, Everitt BJ, Robbins TW. Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology (Berl) 1997;133:329–342. [PubMed]
  • Hashimoto K, Ishima T, Fujita Y, Matsuo M, Kobashi T, Takahagi M, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711. Biol Psychiatry. 2008;63:92–97. [PubMed]
  • Hatcher PD, Brown VJ, Tait DS, Bate S, Overend P, Hagan JJ, et al. 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats. Psychopharmacology. 2005;181:253–259. [PubMed]
  • Hatfield T, McGaugh JL. Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task. Neurobiol Learn Mem. 1999;71:232–239. [PubMed]
  • Hauser TA, Kucinski A, Jordan KG, Gatto GJ, Wersinger SR, Hesse RA, et al. TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. Biochem Pharmacol. 2009;78:803–812. [PMC free article] [PubMed]
  • Higgins GA, Enderlin M, Haman M, Fletcher PJ. The 5-HT2A receptor antagonist M100,907 attenuates motor and ‘impulsive-type' behaviours produced by NMDA receptor antagonism. Psychopharmacology (Berl) 2003;170:309–319. [PubMed]
  • Higgins GA, Grzelak ME, Pond AJ, Cohen-Williams ME, Hodgson RA, Varty GB. The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behav Brain Res. 2007;185:32–42. [PubMed]
  • Hill MN, Froese LM, Morrish AC, Sun JC, Floresco SB. Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists. Psychopharmacology. 2006;187:245–259. [PubMed]
  • Hitchcott PK, Harmer CJ, Phillips GD. Enhanced acquisition of discriminative approach following intra-amygdala d-amphetamine. Psychopharmacology. 1997;132:237–246. [PubMed]
  • Homayoun H, Moghaddam B. Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors. Cereb Cortex. 2006;16:93–105. [PubMed]
  • Homayoun H, Stefani MR, Adams BW, Tamagan GD, Moghaddam B. Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology. 2004;29:1259–1269. [PubMed]
  • Hotte M, Naudon L, Jay TM. Modulation of recognition and temporal order memory retrieval by dopamine D1 receptor in rats. Neurobiol Learn Mem. 2005;84:85–92. [PubMed]
  • Howe WM, Ji J, Parikh V, Williams S, Mocaer E, Trocme-Thibierge C, et al. Enhancement of attentional performance by selective stimulation of alpha4beta2(*) nAChRs: underlying cholinergic mechanisms. Neuropsychopharmacology. 2010;35:1391–1401. [PMC free article] [PubMed]
  • Hoyle E, Genn RF, Fernandes C, Stolerman IP. Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology (Berl) 2006;189:211–223. [PMC free article] [PubMed]
  • Idris N, Neill J, Grayson B, Bang-Andersen B, Witten LM, Brennum LT, et al. Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. Psychopharmacology. 2010;208:23–36. [PubMed]
  • Jakala P, Sirvio J, Riekkinen PJ. The effects of tacrine and zacopride on the performance of adult rats in the working memory task. Gen Pharmacol. 1993;24:675–679. [PubMed]
  • Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148:1301–1308. [PubMed]
  • Jentsch JD, Aarde SM, Seu E. 2009. Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats Psychopharmacology (Berl) 202497–504.504Enhancements of attention produced by atomoxetine depend on relative contributions of top–down control executive control of performance. [PubMed]
  • Jentsch JD, Anzivino LA. A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats. Psychopharmacology. 2004;175:76–83. [PubMed]
  • Jentsch JD, Redmond DE, Elsworth JD, Taylor JR, Youngren KD, Roth RH. Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science. 1997;277:953–955. [PubMed]
  • Jentsch JD, Roth RH. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. 1999;20:201–225. [PubMed]
  • Jo YS, Park EH, Kim IH, Park SK, Kim H, Kim HT, et al. The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions. J Neurosci. 2007;27:13567–13578. [PubMed]
  • Katner SN, Davis SA, Kirsten AJ, Taffe MA. Effects of nicotine and mecamylamine on cognition in rhesus monkeys. Psychopharmacology (Berl) 2004;175:225–240. [PMC free article] [PubMed]
  • Kendall I, Slotten HA, Codony X, Burgueño J, Pauwels PJ, Vela JM, et al. 2010. E-6801, a 5-HT(6) receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat Psychopharmacology(E-pub ahead of print 20 April). [PubMed]
  • Kim J, Glahn DC, Nuechterlein KH, Cannon TD. Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophr Res. 2004;68:173–187. [PubMed]
  • Kirkby DL, Jones DN, Barnes JC, Higgins GA. Effects of anticholinesterase drugs tacrine and E2020, the 5-HT(3) antagonist ondansetron, and the H(3) antagonist thioperamide, in models of cognition and cholinergic function. Behav Pharmacol. 1996;7:513–525. [PubMed]
  • Kombian SB, Malenka RC. Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens. 1994;17:242–246. [PubMed]
  • Koseki H, Matsumoto M, Togashi H, Miura Y, Fukushima K, Yoshioka M. Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models. Synapse. 2009;63:805–813. [PubMed]
  • Koskinen T, Sirvio J. Studies on the involvement of the dopaminergic system in the 5-HT2 agonist (DOI)-induced premature responding in a five-choice serial reaction time task. Brain Res Bull. 2001;54:65–75. [PubMed]
  • Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. J Neurosci. 2005;25:5225–5229. [PubMed]
  • Land C, Riccio DC. d-Cycloserine: effects on long-term retention of a conditioned response and on memory for contextual attributes. Neurobiol Learn Mem. 1999;72:158–168. [PubMed]
  • Lapiz MD, Bondi CO, Morilak DA. Chronic treatment with desipramine improves cognitive performance of rats in an attentional set-shifting test. Neuropsychopharmacology. 2007;32:1000–1010. [PubMed]
  • Lapiz MD, Morilak DA. Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability. Neuroscience. 2006;137:1039–1049. [PubMed]
  • Lapiz-Bluhm MD, Soto-Piña AE, Hensler JG, Morilak DA. Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats. Psychopharmacology. 2009;202:329–341. [PMC free article] [PubMed]
  • Lashley KS. The effects of strychnine and caffeine upon rate of learning. Psychobiology. 1917;1:141–170.
  • LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci. 2000;23:155–184. [PubMed]
  • Lee AC, Robbins TW, Pickard JD, Owen AM. Asymmetric frontal activation during episodic memory: the effects of stimulus type on encoding and retrieval. Neuropsychologia. 2000;38:677–692. [PubMed]
  • Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys. Neuropsychopharmacology. 2007;32:2125–2134. [PubMed]
  • Lee JL, Milton AL, Everitt BJ. Reconsolidation and extinction of conditioned fear: inhibition and potentiation. J Neurosci. 2006;26:10051–10056. [PubMed]
  • Levin ED, McClernon FJ, Rezvani AH. Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization. Psychopharmacology (Berl) 2006;184:523–539. [PubMed]
  • Levin ED, Rezvani AH. Nicotinic–antipsychotic drug interactions and cognitive function. EXS. 2006;98:185–205. [PubMed]
  • Ligneau X, Lin J, Vanni-Mercier G, Jouvet M, Muir JL, Ganellin CR, et al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998;287:658–666. [PubMed]
  • Lindner MD, Hogan JB, Hodges DB, Jr, Orie AF, Chen P, Corsa JA, et al. Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping. Psychopharmacology (Berl) 2006;188:629–640. [PubMed]
  • Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G, et al. ADX47273 [S-(4-fluoro-phenyl)-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008;327:827–839. [PubMed]
  • Mackintosh NJ, Holgate V. Serial reversal training and nonreversal shift learning. J Comp Physiol Psychol. 1969;67:89–93. [PubMed]
  • Mackintosh NJ, McGonigle B, Holgate V, Vanderver V. Factors underlying improvement in serial reversal learning. Can J Psychol. 1968;22:85–95. [PubMed]
  • Mancuso G, Lejeune M, Ansseau M. Cigarette smoking and attention: processing speed or specific effects. Psychopharmacology. 2001;155:372–378. [PubMed]
  • Mao SC, Hsiao YH, Gean PW. Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace. J Neurosci. 2006;26:8892–8899. [PubMed]
  • Marighetto A, Valerio S, Desmedt A, Philippin JN, Trocme-Thibierge C, Morain P. Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 2008a;197:499–508. [PubMed]
  • Marighetto A, Valerio S, Jaffard R, Mormede C, Munoz C, Bernard K, et al. The AMPA modulator S 18986 improves declarative and working memory performances in aged mice. Behav Pharmacol. 2008b;19:235–244. [PubMed]
  • Marrs W, Kuperman J, Avedian T, Roth RH, Jentsch JD. Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Neuropsychopharmacology. 2005;30:1500–1510. [PubMed]
  • Massey PV, Bhabra G, Cho K, Brown MW, Bashir ZI. Activation of muscarinic receptors induces protein synthesis-dependent long-lasting depression in the perirhinal cortex. Eur J Neurosci. 2001;14:145–152. [PubMed]
  • Matsuoka N, Aigner TG. -cycloserine, a partial agonist at the glycine site coupled to N-methyl--aspartate receptors, improves visual recognition memory in rhesus monkeys. J Pharmacol Exp Ther. 1996;278:891–897. [PubMed]
  • McAlonan K, Brown VJ. Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat. Behav Brain Res. 2003;146:97–103. [PubMed]
  • McDonald RJ, White NM. A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum. Behav Neurosci. 1993;107:3–22. [PubMed]
  • McGaughy J, Dalley JW, Morrison CH, Everitt BJ, Robbins TW. Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task. J Neurosci. 2002;22:1905–1913. [PubMed]
  • McGaughy J, Decker MW, Sarter M. Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology. 1999;144:175–182. [PubMed]
  • McGaugh JL, McIntyre CK, Power AE. Amygdala modulation of memory consolidation: interaction with other brain systems. Neurobiol Learn Mem. 2002;78:539–552. [PubMed]
  • McGaugh JL, Roozendaal B. Drug enhancement of memory consolidation: historical perspective and neurobiological implications. Psychopharmacology. 2009;202:3–14. [PubMed]
  • McLean SL, Beck JP, Woolley ML, Neill JC. A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats. Behav Brain Res. 2008;189:152–158. [PubMed]
  • McLean SL, Idris NF, Woolley ML, Neill JC. D(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: implications for mechanisms of improved cognitive function in schizophrenia. Eur Neuropsychopharmacol. 2009a;19:440–450. [PubMed]
  • McLean SL, Woolley ML, Thomas D, Neill JC. Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat. Psychopharmacology. 2009b;206:403–414. [PubMed]
  • Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW. Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci. 2000;20:RC65. [PubMed]
  • Milstein JA, Lehmann O, Theobald DE, Dalley JW, Robbins TW. Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat. Psychopharmacology (Berl) 2007;190:51–63. [PMC free article] [PubMed]
  • Mirza NR, Stolerman IP. 1998. Nicotine enhances sustained attention in the rat under specific task conditions Psychopharmacology 138266–274.274This paper is among the first to show the potent attention-enhancing effects of nicotinic receptor agonists. [PubMed]
  • Mirza NR, Stolerman IP. The role of nicotinic and muscarinic acetylcholine receptors in attention. Psychopharmacology. 2000;148:243–250. [PubMed]
  • Mitchell KJ, Johnson MK. Source monitoring 15 years later: what have we learned from fMRI about the neural mechanisms of source memory. Psychol Bull. 2009;135:638–677. [PMC free article] [PubMed]
  • Moghaddam B. Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia. Psychopharmacology. 2004;174:39–44. [PubMed]
  • Moghaddam B, Adams BW. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science. 1998;281:1349–1352. [PubMed]
  • Mohler EG, Franklin SR, Rueter LE, Fox GB, Decker MW, Browman KE. ABT-594 improves performance in the 5-choice serial reaction time task under conditions of increased difficulty, sub-chronic dosing, and in poorly-performing subjects. Pharmacol Biochem Behav. 2010;95:146–157. [PubMed]
  • Morris RG, Garrud P, Rawlins JN, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 1982;297:681–683. [PubMed]
  • Morris RW, Bouton ME. The effect of yohimbine on the extinction of conditioned fear: a role for context. Behav Neurosci. 2007;121:501–514. [PubMed]
  • Mueller D, Porter JT, Quirk GJ. Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. J Neurosci. 2008;28:369–375. [PubMed]
  • Muir JL, Dunnett SB, Robbins TW, Everitt BJ. Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Exp Brain Res. 1992;89:611–622. [PubMed]
  • Muir JL, Everitt BJ, Robbins TW. AMPA-induced excitotoxic lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function. J Neurosci. 1994;14:2313–2326. [PubMed]
  • Muir JL, Everitt BJ, Robbins TW. Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology (Berl) 1995;118:82–92. [PubMed]
  • Murchison CF, Zhang XY, Zhang WP, Ouyang M, Lee A, Thomas SA. A distinct role for norepinephrine in memory retrieval. Cell. 2004;117:131–143. [PubMed]
  • Murphy BL, Roth RH, Arnsten AF. Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys. Neuropsychopharmacology. 1997;16:433–437. [PubMed]
  • Navarra R, Comery TA, Graf R, Rosenzweig-Lipson S, Day M. The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test. Behav Brain Res. 2008a;188:412–415. [PubMed]
  • Navarra R, Graf R, Huang Y, Logue S, Comery T, Hughes Z, et al. Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test. Prog Neuropsychopharmacol Biol Psychiatry. 2008b;32:34–41. [PubMed]
  • Newman LA, Darling J, McGaughy J. 2008. Atomoxetine reverses attentional deficits produced by noradrenergic deafferentation of medial prefrontal cortex Psychopharmacology 20039–50.50Emphasizes the role for noradrenergic mechanisms in the enhancements of attention produced by atomoxetine. [PubMed]
  • Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, et al. 2010. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems Int J Neuropsychopharmacol 1–12.12(E-pub ahead of print 20 March). [PubMed]
  • O'Donnell CJ, Rogers BN, Bronk BS, Bryce DK, Coe JW, Cook KK, et al. Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. J Med Chem. 2010;53:1222–1237. [PubMed]
  • O'Neill J, Fitten LJ, Siembieda DW, Ortiz F, Halgren E. Effects of guanfacine on three forms of distraction in the aging macaque. Life Sci. 2000;67:877–885. [PubMed]
  • O'Neill M, Brown VJ. The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats. Neurobiol Learn Mem. 2007;88:75–81. [PubMed]
  • Olney JW, Newcomer JW, Farber NB. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res. 1999;33:523–533. [PubMed]
  • Packard MG. Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning. Proc Natl Acad Sci USA. 1999;96:12881–12886. [PubMed]
  • Packard MG, Cahill L. Affective modulation of multiple memory systems. Curr Opin Neurobiol. 2001;11:752–776. [PubMed]
  • Packard MG, Cahill L, McGaugh JL. 1994. Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes Proc Natl Acad Sci 918477–8481.8481This paper shows that amygdalar mechanisms contribute to the acquisition of memories by other, distinct memory systems. [PubMed]
  • Packard MG, Knowlton BJ. Learning and memory functions of the basal ganglia. Annu Rev Neurosci. 2002;2002:25:563–25:593. [PubMed]
  • Packard MG, Regenold W, Quirion R, White NM. Post-training injection of the acetylcholine M2 receptor antagonist AF-DX 116 improves memory. Brain Res. 1990;30524:72–76. [PubMed]
  • Packard MG, Teather LA. Amygdala modulation of multiple memory systems: hippocampus and caudate–putamen. Neurobiol Learn Mem. 1998;69:163–203. [PubMed]
  • Packard MG, White NM. Memory facilitation produced by dopamine agonists: role of receptor subtype and mnemonic requirements. Pharmacol Biochem Behav. 1989;33:511–518. [PubMed]
  • Packard MG, White NM. Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists. Behav Neurosci. 1991;105:295–306. [PubMed]
  • Pamplona FA, Bitencourt RM, Takahashi RN. Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats. Neurobiol Learn Mem. 2008;90:290–293. [PubMed]
  • Pamplona FA, Prediger RD, Pandolfo P, Takahashi RN. The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats. Psychopharmacology. 2006;188:641–649. [PubMed]
  • Pantelis C, Barber FZ, Barnes TR, Nelson HE, Owen AM, Robbins TW. Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage. Schizophr Res. 1999;37:251–270. [PubMed]
  • Paré D. Presynaptic induction and expression of NMDA-dependent LTP. Trends Neurosci. 2004;27:440–441. [PubMed]
  • Park EJ, Nam RH, Choi S, Lee CJ. Carbachol induces a form of long-term potentiation in lateral amygdala. Neuroreport. 2004;15:1339–1343. [PubMed]
  • Parnas AS, Weber M, Richardson R. Effects of multiple exposures to -cycloserine on extinction of conditioned fear in rats. Neurobiol Learn Mem. 2005;83:224–231. [PubMed]
  • Passetti F, Dalley JW, Robbins TW. Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task. Psychopharmacology (Berl) 2003a;165:136–145. [PubMed]
  • Passetti F, Levita L, Robbins TW. Sulpiride alleviates the attentional impairments of rats with medial prefrontal cortex lesions. Behav Brain Res. 2003b;138:59–69. [PubMed]
  • Pavlov IP. Conditioned Reflexes. Oxford University Press: London; 1927.
  • Pezze MA, Dalley JW, Robbins TW. Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task. Neuropsychopharmacology. 2007;32:273–283. [PMC free article] [PubMed]
  • Pfeiffer UJ, Fendt M. Prefrontal dopamine D4 receptors are involved in encoding fear extinction. NeuroReport. 2006;17:847–850. [PubMed]
  • Pichat P, Bergis OE, Terranova JP, Urani A, Duarte C, Santucci V, et al. SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology. 2007;32:17–34. [PubMed]
  • Ponnusamy R, Nissim HA, Barad M. Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice. Learn Mem. 2005;12:399–406. [PubMed]
  • Porrino LJ, Daunais JB, Rogers GA, Hampson RE, Deadwyler SA. 2005. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates PLoS Biol 3e299(This paper shows the potential cognitive-enhancing profile of a positive allosteric modulator of the AMPA/glutamate receptor). [PMC free article] [PubMed]
  • Port RL, Seybold KS. Manipulation of NMDA-receptor activity alters extinction of an instrumental response in rats. Physiol Behav. 1998;64:391–393. [PubMed]
  • Pozzi L, Greco B, Sacchetti G, Leoni G, Invernizzi RW, Carli M. Blockade of serotonin 2A receptors prevents PCP-induced attentional performance deficit and CREB phosphorylation in the dorsal striatum of DBA/2 mice. Psychopharmacology. 2010;208:387–399. [PubMed]
  • Prediger RD, De-Mello N, Takahashi RN. Pilocarpine improves olfactory discrimination and social recognition memory deficits in 24 month-old rats. Eur J Pharmacol. 2006;531:176–182. [PubMed]
  • Puumala T, Riekkinen P, Sr, Sirvio J. Modulation of vigilance and behavioral activation by alpha-1 adrenoceptors in the rat. Pharmacol Biochem Behav. 1997;56:705–712. [PubMed]
  • Quarta D, Naylor CG, Stolerman IP. The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Psychopharmacology. 2007;193:391–402. [PubMed]
  • Quartermain D, Clemente J, Shemer A. 5-HT1A agonists disrupt memory of fear conditioning in mice. Biol Psychiatry. 1993;33:247–254. [PubMed]
  • Quirk GJ, Mueller D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology. 2008;33:56–72. [PMC free article] [PubMed]
  • Quirk GJ, Russo GK, Barron JL, Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci. 2000;20:6225–6231. [PubMed]
  • Ragozzino ME. The effects of dopamine D(1) receptor blockade in the prelimbic–infralimbic areas on behavioral flexibility. Learn Mem. 2002;9:18–28. [PubMed]
  • Ragozzino ME, Detrick S, Kesner RP. Involvement of the prelimbic–infralimbic areas of the rodent prefrontal cortex in behavioral flexibility for place and response learning. J Neurosci. 1999;19:4585–4594. [PubMed]
  • Ragozzino ME, Ragozzino KE, Mizumori SJ, Kesner RP. Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning. Behav Neurosci. 2002;116:105–115. [PMC free article] [PubMed]
  • Ramos BP, Stark D, Verduzco L, van Dyck CH, Arnsten AF. Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Learn Mem. 2006;13:770–776. [PubMed]
  • Rescorla RA, Heth CD. Reinstatement of fear to an extinguished conditioned stimulus. J Exp Psychol Anim Behav Process. 1975;1:88–96. [PubMed]
  • Rezvani AH, Bushnell PJ, Levin ED. Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats. Psychopharmacology (Berl) 2002;164:369–375. [PubMed]
  • Rezvani AH, Caldwell DP, Levin ED. Nicotinic–serotonergic drug interactions and attentional performance in rats. Psychopharmacology. 2005;179:521–528. [PubMed]
  • Rezvani AH, Caldwell DP, Levin ED. Chronic nicotine interactions with clozapine and risperidone and attentional function in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:190–197. [PubMed]
  • Rezvani AH, Levin ED. Nicotinic–glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats. Eur J Pharmacol. 2003;465:83–90. [PubMed]
  • Rezvani AH, Levin ED. Nicotine-antipsychotic drug interactions and attentional performance in female rats. Eur J Pharmacol. 2004;486:175–182. [PubMed]
  • Rezvani AH, Kholdebarin E, Brucato FH, Callahan PM, Lowe DA, Levin ED. Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:269–275. [PubMed]
  • Rezvani AH, Tizabi Y, Getachew B, Hauser SR, Caldwell DP, Hunter C, et al. Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1030–1040. [PubMed]
  • Rhodes SE, Killcross S. Lesions of rat infralimbic cortex enhance recovery and reinstatement of an appetitive Pavlovian response. Learn Mem. 2004;11:611–616. [PubMed]
  • Robbins SJ. Mechanisms underlying spontaneous recovery in autoshaping. J Exp Psychol. 1990;16:235–249.
  • Robbins TW. The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology. 2002;63:362–380. [PubMed]
  • Robbins TW, Murphy ER. Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition. Trends Pharmacol Sci. 2006;27:141–148. [PMC free article] [PubMed]
  • Robbins TW, Roberts AC. Differential regulation of fronto-executive function by the monoamines and acetylcholine. Cereb Cortex. 2007;17 (Suppl 1:i151–i160. [PubMed]
  • Robbins TW, Semple J, Kumar R, Truman MI, Shorter J, Ferraro A, et al. Effects of scopolamine on delayed-matching-to-sample and paired associates tests of visual memory and learning in human subjects: comparison with diazepam and implications for dementia. Psychopharmacology. 1997;134:95–106. [PubMed]
  • Roberts AC, De Salvia MA, Wilkinson LS, Collins P, Muir JL, Everitt BJ, et al. 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the wisconsin card sort test: possible interactions with subcortical dopamine. J Neurosci. 1994;14:2531–2544. [PubMed]
  • Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X, et al. 2008. Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat Neuropsychopharmacology 331028–1037.1037A thorough demonstration of how atomoxetine exerts cognitive enhancement in a broad range of distinct tests of impulsivity. [PubMed]
  • Rodefer JS, Nguyen TN, Karlsson JJ, Arnt J. Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT6 receptor antagonist: comparison among antipsychotics. Neuropsychopharmacology. 2008;11:2657–2666. [PubMed]
  • Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, et al. Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J Pharmacol Exp Ther. 2009;329:459–468. [PubMed]
  • Roozendaal B, Castello NA, Vedana G, Barsegyan A, McGaugh JL. Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memory. Neurobiol Learn Mem. 2008;90:576–579. [PMC free article] [PubMed]
  • Ruotsalainen S, Sirvio J, Jakala P, Puumala T, MacDonald E, Riekkinen P., Sr Differential effects of three 5-HT receptor antagonists on the performance of rats in attentional and working memory tasks. Eur Neuropsychopharmacol. 1997;7:99–108. [PubMed]
  • Safer DJ, Allen RP. The central effects of scopolamine in man. Biol Psychiatry. 1971;3:347–355. [PubMed]
  • Salinas JA, Introini-Collison IB, Dalmaz C, McGaugh JL. Posttraining intraamygdala infusions of oxotremorine and propranolol modulate storage of memory for reductions in reward magnitude. Neurobiol Learn Mem. 1997;68:51–59. [PubMed]
  • Sarter M, Parikh V. Choline transporters, cholinergic transmission and cognition. Nat Rev Neurosci. 2005;6:48–56. [PubMed]
  • Sarter M, Parikh V, Howe WM. nAChR agonist-induced cognition enhancement: integration of cognitive and neuronal mechanisms. Biochem Pharmacol. 2009;78:658–667. [PMC free article] [PubMed]
  • Scali C, Giovannini MG, Bartolini L, Prosperi C, Hinz V, Schmidt B, et al. Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats. Eur J Pharmacol. 1997;325:173–180. [PubMed]
  • Schoenbaum G, Roesch MR, Stalnaker TA. Orbitofrontal cortex, decision-making and drug addiction. Trends Neurosci. 2006;29:116–124. [PMC free article] [PubMed]
  • Semenova S, Stolerman IP, Markou A. Chronic nicotine administration improves attention while nicotine withdrawal induces performance deficits in the 5-choice serial reaction time task in rats. Pharmacol Biochem Behav. 2007;87:360–368. [PMC free article] [PubMed]
  • Seu E, Jentsch JD. Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats. Neuropharmacology. 2009;57:665–672. [PMC free article] [PubMed]
  • Seu E, Lang A, Rivera RJ, Jentsch JD. 2009. Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys Psychopharmacology 202505–519.519This paper shows that, across species, atomoxetine is capable of enhancing behavioral flexibility by reducing perseverative interference. [PMC free article] [PubMed]
  • Shapiro ML, Eichenbaum H. Hippocampus as a memory map: synaptic plasticity and memory encoding by hippocampal neurons. Hippocampus. 1999;9:365–384. [PubMed]
  • Sharp T, Boothman L, Raley J, Quérée P. Important messages in the ‘post': recent discoveries in 5-HT neurone feedback control. Trends Pharmacol Sci. 2007;28:629–636. [PubMed]
  • Slamecka NJ. A methodological analysis of shift paradigms in human discrimination learning. Psychol Bull. 1968;69:423–438. [PubMed]
  • Smith SM, Uslaner JM, Yao L, Mullins CM, Surles NO, Huszar SL, et al. The behavioral and neurochemical effects of a novel -amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and -serine. J Pharmacol Exp Ther. 2009;328:921–930. [PubMed]
  • Sotres-Bayon F, Bush DE, Ledoux JE. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology. 2007;32:1929–1940. [PubMed]
  • Southam E, Cilia J, Gartlon JE, Woolley ML, Lacroix LP, Jennings CA, et al. Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040. Psychopharmacology (Berl) 2009;201:483–494. [PubMed]
  • Spinelli S, Ballard T, Gatti-McArthur S, Richards GJ, Kapps M, Woltering T, et al. Effects of the mGluR2/3 agonist LY354740 on computerized tasks of attention and working memory in marmoset monkeys. Psychopharmacology. 2005;179:292–302. [PubMed]
  • Spinelli S, Ballard T, Feldon J, Higgins GA, Pryce CR. Enhancing effects of nicotine and impairing effects of scopolamine on distinct aspects of performance in computerized attention and working memory tasks in marmoset monkeys. Neuropharmacology. 2006;51:238–250. [PubMed]
  • Steere JC, Arnsten AF. The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys. Behav Neurosci. 1997;111:883–891. [PubMed]
  • Stefani MR, Moghaddam B. Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade. Eur J Pharmacol. 2010;639:26–32. [PMC free article] [PubMed]
  • Stolerman IP, Mirza NR, Hahn B, Shoaib M. Nicotine in an animal model of attention. Eur J Pharmacol. 2000;393:147–154. [PubMed]
  • Sukhotina IA, Dravolina OA, Novitskaya Y, Zvartau EE, Danysz W, Bespalov AY. Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats. Psychopharmacology. 2008;196:211–220. [PubMed]
  • Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, et al. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem Pharmacol. 2009;78:880–888. [PubMed]
  • Tait DS, Brown VJ, Farovik A, Theobald DE, Dalley JW, Robbins TW. Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat. Eur J Neurosci. 2007;25:3719–3724. [PubMed]
  • Tait DS, Marston HM, Shahid M, Brown VJ. Asenapine restores cognitive flexibility in rats with medial prefrontal cortex lesions. Psychopharmacology. 2009;202:295–306. [PubMed]
  • Terry AV, Jr, Buccafusco JJ, Bartoszyk GD. Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys. Psychopharmacology. 2005;179:725–732. [PubMed]
  • Tietje KR, Anderson DJ, Bitner RS, Blomme EA, Brackemeyer PJ, Briggs CA, et al. Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. CNS Neurosci Ther. 2008;14:65–82. [PubMed]
  • Torta DM, Castelli L, Zibetti M, Lopiano L, Geminiani G. On the role of dopamine replacement therapy in decision-making, working memory, and reward in Parkinson's disease: does the therapy-dose matter. Brain Cogn. 2009;71:84–91. [PubMed]
  • Tsukada H, Nishiyama S, Fukumoto D, Ohba H, Sato K, Kakiuchi T. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse. 2004;52:1–10. [PubMed]
  • Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. J Neurosci. 2004;24:5331–5535. [PubMed]
  • Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ. Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2004a;55:1031–1040. [PubMed]
  • Turner DC, Clark L, Pomarol-Clotet E, McKenna P, Robbins TW, Sahakian BJ. Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology. 2004b;29:1363–1373. [PubMed]
  • Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl) 2003;165:260–269. [PubMed]
  • Tzavara ET, Bymaster FP, Overshiner CD, Davis RJ, Perry KW, Wolff M, et al. Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine. Mol Psychiatry. 2006;11:187–195. [PubMed]
  • Walker DL, Ressler KJ, Lu KT, Davis M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of -cycloserine as assessed with fear-potentiated startle in rats. J Neurosci. 2002;22:2343–2351. [PubMed]
  • Waters KA, Burnham KE, O'Connor D, Dawson GR, Dias R. Assessment of modafinil on attentional processes in a five-choice serial reaction time test in the rat. J Psychopharmacol. 2005;19:149–158. [PubMed]
  • Weber M, Hart J, Richardson R. Effects of d-cycloserine on extinction of learned fear to an olfactory cue. Neurobiol Learn Mem. 2007;87:476–482. [PubMed]
  • Weiner I, Feldon J. Reversal and nonreversal shifts under amphetamine. Psychopharmacology. 1986;89:355–359. [PubMed]
  • Weiner I, Feldon J, Ben-Shahar O. Simultaneous brightness discrimination and reversal: the effects of amphetamine administration in the two stages. Pharmacol Biochem Behav. 1986;25:939–942. [PubMed]
  • Westbrook RF, Iordanova M, McNally G, Richardson R, Harris JA. Reinstatement of fear to an extinguished conditioned stimulus: two roles for context. J Exp Psychol Anim Behav Process. 2002;28:97–110. [PubMed]
  • Wheeler MA, Stuss DT, Tulving E. Toward a theory of episodic memory: the frontal lobes and autonoetic consciousness. Psychol Bull. 1997;121:331–354. [PubMed]
  • Wickens JR, Begg AJ, Arbuthnott GW. Dopamine reverses the depression of rat corticostriatal synapses which normally follows high-frequency stimulation of cortex in vitro. Neuroscience. 1996;70:1–5. [PubMed]
  • Wingard JC, Packard MG. The amygdala and emotional modulation of competition between cognitive and habit memory. Behav Brain Res. 2008;193:126–131. [PubMed]
  • Winstanley CA, Chudasama Y, Dalley JW, Theobald DE, Glennon JC, Robbins TW. Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology. 2003;167:304–314. [PubMed]
  • Winstanley CA, Dalley JW, Theobald DE, Robbins TW. Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology. 2004a;29:1331–1343. [PubMed]
  • Winstanley CA, Theobald DE, Dalley JW, Glennon JC, Robbins TW. 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. Psychopharmacology (Berl) 2004b;176:376–385. [PubMed]
  • Winstanley CA, Theobald DE, Cardinal RN, Robbins TW. Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. J Neuroscience. 2004c;24:4718–4722. [PubMed]
  • Winters BD, Saksida LM, Bussey TJ. Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrieval. Neurosci Biobehav Rev. 2008;32:1055–1070. [PubMed]
  • Wishka DG, Walker DP, Yates KM, Reitz SC, Jia S, Myers JK, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure–activity relationship. J Med Chem. 2006;49:4425–4436. [PubMed]
  • Wolff MC, Leander JD. Comparison of the effects of antipsychotics on a delayed radial maze task in the rat. Psychopharmacology. 2003;168:410–416. [PubMed]
  • Woods AM, Bouton ME. -cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response. Behav Neurosci. 2006;120:1159–1162. [PubMed]
  • Wood SC, Anagnostaras SG. Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice. Psychopharmacology. 2009;202:197–206. [PMC free article] [PubMed]
  • Woolley ML, Waters KA, Gartlon JE, Lacroix LP, Jennings C, Shaughnessy F, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl) 2009;202:343–354. [PubMed]
  • Woolley ML, Waters KA, Reavill C, Bull S, Lacroix LP, Martyn AJ, et al. Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. Behav Pharmacol. 2008;19:765–776. [PubMed]
  • Young JW, Crawford N, Kelly JS, Kerr LE, Marston HM, Spratt C, et al. Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol. 2007;17:145–155. [PubMed]
  • Young JW, Finlayson K, Spratt C, Marston HM, Crawford N, Kelly JS, et al. Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology. 2004;29:891–900. [PubMed]
  • Zahrt J, Taylor JR, Mathew RG, Arnsten AF. Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance. J Neurosci. 1997;17:8528–8535. [PubMed]
  • Zanto TP, Gazzaley A. Neural suppression of irrelevant information underlies optimal working memory performance. J Neurosci. 2009;29:3059–3066. [PMC free article] [PubMed]
  • Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, et al. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther. 2009;329:738–746. [PubMed]

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