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J Cutan Aesthet Surg. 2010 Sep-Dec; 3(3): 181–183.
PMCID: PMC3047739
Subcutaneous Bronchogenic Cyst
Vivek Manchanda, Anup Mohta, Nita Khurana,1 and Swarup Das
Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya (Affiliated to Maulana Azad Medical College), Geeta colony, New Delhi, India
1Department of Pathology, Maulana Azad Medical College, New Delhi, India
Address for correspondence:Dr. Vivek Manchanda, Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya (Affiliated to Maulana Azad Medical College), Geeta Colony, New Delhi - 110 031, India. vivek7477/at/gmail.com
Abstract
Bronchogenic cysts occur due to the anomalous development of the primitive tracheobronchial tree early in fetal life. They are usually present in middle mediastinum. Rarely, they have been found in other locations. We describe two patients with subcutaneous bronchogenic cysts located over manubrium sterni with special emphasis on the difficulties in pre-operative diagnosis. The two boys were managed by complete excision of the cysts. The children are well on follow-up.
Keywords: Bronchogenic cyst, paediatric, subcutaneous cyst
INTRODUCTION
Bronchogenic cysts are congenital lesions that originate from the tracheobronchial tree in the sixth week of gestation.[1,2] Their usual site is middle mediastinum,[3] but infrequently these have been reported to present as a subcutaneous swelling or sinus.[1] Less than 70 cases of subcutaneous bronchogenic cysts have been reported till date.[4,5] We report two cases managed by us with a brief review of the literature.
Case 1
A 3-year-old healthy male child born to non-consanguineous parents presented to the out-patient department with a complaint of a swelling in midline overlying the upper chest. The swelling was first noticed in neonatal life and was growing with age. There were no associated symptoms. On examination, the general physical and systemic examinations were unremarkable. There was a swelling over the manubrium sterni measuring 3 cm in diameter with normal overlying skin and no punctum. The swelling was non-tender, smooth, cystic and freely mobile in all directions. No other similar swellings could be found. Surgical exploration revealed a 3-cm cyst with a glistening surface in subcutaneous space. Overlying skin and underlying fascia were free. The cyst ruptured accidentally during removal spilling clear mucoid contents but was completely excised. The post-operative recovery was uneventful. The histopathological examination revealed it to be a bronchogenic cyst [Figure 1]. There is no recurrence on follow-up at 18 months.
Figure 1
Figure 1
Pseudostratified ciliated columnar epithelium overlying the fibromuscular cyst wall containing seromucous glands (H and E ×100)
Case 2
A 3.5-year-old boy born to non-consanguineous parents presented to the hospital with a history of a intermittent watery discharge from the suprasternal area since birth. There was no history of any previous swelling in the region. There was no history suggestive of previous infections, trauma or surgical intervention. On examination, a sinus opening was seen in the suprasternal notch [Figure 2]. The surrounding skin was normal. A swelling about 2.5 cm in size could be palpated underneath the sinus and was non-tender, smooth and mobile. There was no clinical evidence of extension into the thoracic inlet. The chest radiograph was normal. The fine-needle aspiration cytology (FNAC) revealed clusters of benign round to polygonal cells with focal nuclear enlargement and occasional mitosis. Some cells showed squamous differentiation, and a fair number of ghost cells and multinucleated giant cells in a dirty background were seen. The possibility of pilomatrixoma or dermoid tumour was suggested. At surgical exploration [Figure 3], the cyst was situated in the subcutaneous space and had a glistening surface while the overlying skin and underlying fascia were free. The swelling was overlying the trachea but not extending into the chest. Complete excision could be accomplished easily with an uneventful recovery. The histopathological examination of the specimen confirmed it to be a bronchogenic cyst. There is no recurrence at 1-year follow-up.
Figure 2
Figure 2
3.5-year-old male child with sinus in the suprasternal notch with underlying swelling ~2 cm in diameter
Figure 3
Figure 3
The sinus opening in a cyst in subcutaneous tissue with no intrathoracic extension
A bronchogenic cyst is a congenital anomaly of the embryonic foregut. At the sixth week of gestation, the foregut divides into dorsal oesophagus and ventral trachea. The ventral anlage develops into a tracheobronchial tree during next 10 weeks. The primitive respiratory tissue may separate from the tracheobronchial tree or develop abnormally leading to the formation of bronchogenic cysts.[6,7] These are usually present in the mediastinum in relation to the hilum. Infrequently, the tissue may migrate to other locations and the bronchogenic cyst may present in subcutaneous tissue or in the abdomen.[8] Another theory put forward to explain the origin of cutaneous bronchogenic cysts suggests part of the anterior portion of the developing lung being ’pinched off‘ by the fusing right and left bars of the sternum precursor.[2,9,10]
The exact incidence of the bronchogenic cysts remains unknown. The diagnosis of bronchogenic cysts was found in about 1 in 42,000-68,000 admissions in surgical wards.[1] The first cutaneous bronchogenic cyst was reported by Seybold and Clagett in 1945.[11] Since then, only less than 70 cases of cutaneous bronchogenic cysts have been reported. Males are affected about four times more commonly as compared to female children.[1,9,10] These cysts have been found mainly in the neck and upper thorax, and rarely in the shoulder, chin, mediastinum and abdominal cavity.[2] Among all the cases, the pre-operative diagnosis was made in only one and in rest it was a histopathological surprise.[1] The differential diagnosis includes cutaneous ciliated cyst, thyroglossal duct cyst, epidermal inclusion cyst, branchial cyst, dermoid cyst and trichilemmal cyst.[10] The diagnosis can be made on histopathology only.
The FNA cytology findings in bronchogenic cysts have been described.[12,13] The FNA cytology shows a group of columnar, ciliated cells, some of them with abundant cytoplasm and eccentric nuclei in a proteinaceous or clean background. Histiocytes, lymphocytes, refractile crystals and necrotic debris may be identified. Even with the knowledge of the findings, pre-operative diagnosis is difficult in the absence of a high index of suspicion as exemplified in our second case.
The histopathological features to differentiate this entity from branchial cysts are overlapping and are a point of debate.[1,2,14] Classically, the bronchogenic cysts show ciliated respiratory epithelium whereas the branchial cysts demonstrate stratified epithelium in more than 90% of cases. Lymphoid tissue is seen in >90% of branchial cysts while it is classically absent in bronchogenic cysts. The smooth muscle is seen in 70% of bronchogenic cysts while it is rare in branchial cysts. The presence of cartilage, a feature supporting bronchogenic cysts, virtually rules out branchial anomaly.[15] Regardless of the findings described, all the authors have reported confusion in the histopathologic differentiation.
The most accepted differentiating feature appears to be anatomical location. The branchial cyst is present along the anterior border of the sternocleidomastoid muscle (laterally) while the bronchogenic cyst is usually seen in the anterior midline.[1,15]
The evaluation of child for mediastinal extension is another point to be considered. The cutaneous bronchogenic cysts almost always are asymptomatic.[1] The only reported symptoms are swelling and discharge from the sinus. The potential complications include secondary infection and malignant change.[16,17] No case of intra-thoracic extension has been reported till now. We do not support suggestion by Zvulunov et al. to perform extensive investigations (like a CT scan), in the absence of respiratory symptoms. It only leads to avoidable radiation and unnecessary pressure on scarce resources.[1]
The management of bronchogenic cysts requires complete excision. Care needs to be taken for complete excision as the only complication reported to date with cutaneous bronchogenic cysts is recurrence after incomplete excision.[1] The surgical approach includes an elliptical incision over the swelling to approach the cyst and care to excise the cyst completely and rule out intrathoracic extension. Also, as the cyst lies in a visible area, due care should be given so as to give the child a cosmetically acceptable scar.
Footnotes
Source of Support: Nil
Conflict of Interest: None declared
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