PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmjcrInstructions for authorsCurrent ToCBMJ Case Reports
 
BMJ Case Rep. 2010; 2010: bcr11.2009.2458.
Published online Apr 5, 2010. doi:  10.1136/bcr.11.2009.2458
PMCID: PMC3047519
Other full case
A case of needle fixation
Yvonne Treffurth1 and Hem Raj Pal2
1Harperbury Hospital, Forest House Adolescent Unit, Shenley, Hertfordshire, WD7 9HQ, UK
2NEPFT, Substance Misuse, 152 Mile End Road, Colchester, Essex, CO4 5BZ, UK
Correspondence to Hem Raj Pal, hemrajpal/at/gmail.com
Needle fixation is frequently missed and dismissed by clinicians and patients. However, ignoring this condition can have severe consequences, such as septicaemia, thrombosis, blood borne viruses, and is associated with an overall poor prognosis of drug dependence.
Here we describe a 37-year-old man who presented with 20-year history of polydrug dependence, drug-induced psychosis and antisocial personality disorder. He was found to also have a 5-year history of intermittent needle fixation. His injecting behaviour and drug use improved significantly with fluoxetine while being on methadone maintenance.
At present there is little evidence for any effective treatment strategies for needle fixation. The current recommended treatment consists of cognitive behavioural therapy and cue exposure. Whether fluoxetine constitutes an effective management strategy remains to be seen.
The concept of needle fixation has been debated in recent years because of its prognosis on intravenous drug taking behaviour and complications such as blood borne infections and inadvertent drug overdoses.
Needle fixation has been defined by McBride et al1 as the ‘repetitive puncturing of the skin with or without the injection of psychoactive drugs via intravenous, subcutaneous or intra-muscular routes, irrespective of the drug or drugs injected or the anticipated effects of the drug’.
We report a case of needle fixation in a patient with a diagnosis of opiate dependence, polysubstance misuse and drug-induced psychosis who presented to the local substance misuse service. The concept of needle fixation is discussed and aetiological hypotheses, prevalence and treatment approaches are briefly considered.
A 37-year-old unemployed single Caucasian man was referred to the local drugs and alcohol service by the prison services. He had a 20-year history of heroin dependence and polysubstance misuse, including cocaine, crack cocaine, amphetamines, ecstasy, cannabis and illicit benzodiazepines. Over the years he had had several detoxifications for opiate dependence and also had short periods of abstinence while serving prison sentences for petty crimes. However, he usually relapsed following his release. During treatment episodes with methadone he always continued to use heroin and had been known to frequently disengage from drug and alcohol services.
During the mid 1990s he was using alcohol to a harmful level and had been smoking up to 60 cigarettes per day at the time. He had epileptic seizures probably caused by herpes encephalitis from which he had suffered in his early twenties and for which he was receiving carbamazepine 1200 mg/ day. In 2001, he was diagnosed with hepatitis C for which he had never received any treatment.
At the time of his current presentation, he was under the care of the local Community Mental Health Team. He had received several diagnoses ranging from schizophrenia and mental and behavioural disorder due to multiple substance use over the past 15 years and had been admitted under the Mental Health Act 1983 on several occasions. He had also been diagnosed with antisocial personality disorder and found to have an IQ of 71. His main complaints included second person auditory pseudohallucinations, hearing several voices making derogatory comments and telling him to kill or harm himself. He had made several suicide attempts, including attempted hanging while in prison, taking impulsive overdoses and making lacerations to his wrists. These usually occurred in the context of heavy substance use. He was on weekly 50 mg flupenthixol decanoate intramuscular injections. With regards to current drug use, he was smoking and injecting heroin and crack cocaine. He had been injecting substances into his neck, groin or limbs.
In describing his needle fixation behaviour he reported drawing blood into an empty syringe and re-injecting it many times daily over the previous 8 months. He would use clean equipment each time and inject his own blood for up to 20 times in two2 minutes. He was injecting heroin about twice a week and at other times was injecting water. He had reported similar behaviour occurring intermittently over the past 5–6 years. He injected mostly in the mornings but was unable to identify any precipitating factors. Prior to injecting he described mounting tension and craving for needles, which was released by inserting needles and indulging in the above behaviour. He described this process as more attractive than heroin itself most of the time and would feel intense relief after inserting a needle. As a consequence he had suffered multiple abscesses that had to be treated with antibiotics. He appeared unaware of the risks of his behaviour such as septicaemia, embolism and blood borne viruses. Attempts to distract himself by making tea, listening to music or talking to somebody had little effect.
Interestingly, he equated his injecting behaviour to previous self-harming by cutting when feeling low. However, at the time of presentation there was no evidence of pervasive low mood.
Treatment
He was commenced on 20 mg fluoxetine with which he complied for 6 weeks. During this time he became less preoccupied with needles and significantly reduced his injecting behaviour. His preoccupation returned after stopping fluoxetine with an increase in injecting behaviour. Throughout the treatment programme, which included methadone maintenance, his compliance remained erratic and he eventually disengaged from services.
Outcome and follow-up
See above.
The earliest report of needle fixated behaviour dates back to 1929. Light and Torrance2 described patients injecting water, which they understood as a placebo for drug effect.
Pates et al3 studied 19 needle fixated subjects who when compared to 23 non-needle fixated individuals displayed significantly higher scores for sexual arousal and for whom injection had a greater significance than efficient delivery of the drug. Some individuals substituted inert substances for the drug and reported sexual arousal and obsessive compulsive disorder (OCD) symptoms associated with repeated injections.
The concept of needle fixation has been criticised as being a construct subsuming several different injecting behaviours under an elusive and broad definition of needle fixation as the ‘repetitive puncturing of the skin with or without the injection of psychoactive drugs via intravenous, subcutaneous or intra-muscular routes, irrespective of the drug or drugs injected or the anticipated effects of the drug’.4
Needle fixation is often missed in patients presenting with intravenous drug use and also seems frequently dismissed by clinicians. However, it is important because of the risks associated with frequent injecting behaviour, including blood borne viruses, septicaemia, thrombosis and abscesses, as well as the negative impact on the prognosis of intravenous drug use.
Several aetiological hypotheses for needle fixation have been postulated, including activation of the opioid system by the inert substance acting as placebo thereby resembling the action of opiates.5 Pates et al suggest the ‘rush’ associated with injecting as a perpetuating factor.3
McBride et al proposed that operant and classical conditioning could explain needle fixation.1 In their study, a high number of individuals reported heightened levels of anxiety prior to injecting and it is thought that the relaxation experienced afterwards reinforces the injecting behaviour. Secondary gains such as sexual pleasure, pain and social status might be linked to operant conditional processes and it appears that other social and environmental processes could also be explained by this model.1 However, whether learning theories are useful constructs to explain needle fixation remains to be seen.
Fluoxetine, a selective serotonin reuptake inhibitor, is indicated for the treatment of depression and OCD. In animal studies it has been shown that fluoxetine can suppress the development of morphine tolerance and dependence to antinociceptive effects of morphine.6 Improvement in ‘needle fixation’ behaviours in our case can be interpreted in this context. It may also be possible that complex inhibitory interactions between serotonergic and dopaminergic pathways in the forebrain have a role to play.7 These postulated neuropharmacological actions of fluoxetine may lead to reduction of reward directed behaviours.
At present there is little evidence for any effective treatment strategies or data regarding the prevalence of needle fixation. The current recommended treatment for needle fixation consists of cognitive behavioural therapy combined with cue exposure.3
The likelihood of successfully treating the patient described with a cognitive behavioural therapy based approach would be relatively low due to his borderline IQ, his limited insight into his difficulties and little motivation to change.
Cue exposure consists of presenting the patient with paraphernalia used for injecting either imaginatively or directly and subsequent systematic desensitisation. It is only recommended in conjunction with cognitive behavioural therapy as it might otherwise lead to arousal and further reinforcement of needle fixated behaviour.3
Whether fluoxetine or other psychopharmacological interventions could add anything to the armamentarium currently used to treat needle fixation remains to be seen.
Learning points
  • Needle fixation is frequently missed in clinical practice.
  • Needle fixation is associated with serious complications, such as thromboembolism, septicaemia and blood borne infections.
  • To date there is no effective treatment available.
  • Treatment of needle fixation might improve outcome of intravenous drug use.
  • Selective serotonin reuptake inhibitors might play a role in the treatment of needle fixation.
Footnotes
Competing interests: None.
Patient consent: Patient/guardian consent was obtained for publication.
1. McBride AJ, Pates RM, Arnold K, et al. Needle fixation, the drug users’ perspective: a qualitative study. Addiction 2001; 96: 1049–58. [PubMed]
2. Light AB, Torrance EG. Opium addiction VI: the effects of abrupt withdrawal followed by readministration of morphine in human addicts with special reference to the composition of the blood, the circulation and the metabolism. Arch Inter Med 1929; 44: 1–16.
3. Pates R, McBride A, Arnold K. Injecting Illicit Drugs. Oxford: Blackwell, 2005.
4. Frazer S, Hopwood M, Treloar C, et al. Needle fictions: medical constructions of needle fixation and the injecting drug user. Addict Res Theory 2004; 12: 67–76.
5. Levine JD, Gordon NC, Fields HL. The mechanisms of placebo analgesia. Lancet 1978; 2: 654–7. [PubMed]
6. Sing VP, Jain NK, Kulkarni SK. Fluoxetine suppresses morphine tolerance and dependence: modulation of NO-cGMP/DA/serotoinergic pathways. Methods Find Exp Clin Pharmacol 2003; 25: 273–80. [PubMed]
7. Baldessarini RJ, Marsh ER, Kula NS. Interactions of fluoxetine with metabolism of dopamine and serotonin in rat brain regions. Brain Research 1992; 579: 152–6. [PubMed]
Articles from BMJ Case Reports are provided here courtesy of
BMJ Group