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Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC Jul 1, 2011.
Published in final edited form as:
PMCID: PMC3047460
NIHMSID: NIHMS206689
COFFEE AND TEA INTAKE AND RISK OF HEAD AND NECK CANCER: POOLED ANALYSIS IN THE INTERNATIONAL HEAD AND NECK CANCER EPIDEMIOLOGY CONSORTIUM
Carlotta Galeone,1,2 Alessandra Tavani,1 Claudio Pelucchi,1 Federica Turati,1,2 Deborah M. Winn,3 Fabio Levi,4 Guo-Pei Yu,5 Hal Morgenstern,6 Karl Kelsey,7 Luigino Dal Maso,8 Mark P. Purdue,3 Michael McClean,9 Renato Talamini,8 Richard B. Hayes,10 Silvia Franceschi,11 Stimson Schantz,5 Zuo-Feng Zhang,12 Gilles Ferro,11 Shu-Chun Chuang,13 Paolo Boffetta,14,15 Carlo La Vecchia,1,2 and Mia Hashibe16
1 Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
2 Dipartimento di Medicina del Lavoro “Clinica del Lavoro Luigi Devoto”, Sezione di Statistica Medica e Biometria “Giulio A. Maccacaro”, Università degli Studi di Milano, Milan, Italy
3 National Cancer Institute, Bethesda, MD, USA
4 Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
5 New York Eye and Ear Infirmary, New York, NY, USA
6 Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
7 Brown University, Providence, Rhode Island, USA
8 Aviano Cancer Centre, Aviano, Italy
9 Boston University School of Public Health, Boston, MA
10 Division of Epidemiology, New York University School Of Medicine, NY, New York, USA
11 International Agency for Research on Cancer, Lyon, France
12 UCLA School of Public Health, Los Angeles, CA, USA
13 Imperial College London, London, UK
14 The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA
15 International Prevention Research Institute, Lyon, France
16 University of Utah School of Medicine, Salt Lake City, UT, USA
Correspondence to: Mia Hashibe, Ph.D., Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT, 84108, mia.hashibe/at/utah.edu, Fax: 801-587-3353
Background
Only a few studies have explored the relation between coffee and tea intake and head and neck (HN) cancers, with inconsistent results.
Methods
We pooled individual-level data from nine case-control studies of HN cancers, including 5139 cases and 9028 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusting for potential confounders.
Results
Caffeinated coffee intake was inversely related with the risk of cancer of the oral cavity and pharynx (OP): the ORs were 0.96 (95% CI 0.94–0.98) for an increment of one cup per day and 0.61 (95% CI 0.47–0.80) in drinkers of >4 cups per day vs. non-drinkers. This latter estimate was consistent for different anatomical sites (ORs were 0.46, 95%CI 0.30–0.71 for oral cavity, 0.58, 95% CI 0.41–0.82 for oropharyngeal/hypopharyngeal and 0.61, 95% CI 0.37–1.01 for OP not otherwise specified), and across strata of selected covariates. No association of caffeinated coffee drinking was found with laryngeal cancer (OR=0.96, 95% CI 0.64–1.45 in drinkers of >4 cups per day vs. non-drinkers). Data on decaffeinated coffee were too sparse for detailed analysis, but indicated no increased risk. Tea intake was not associated with HN cancer risk (OR=0.99, 95% CI 0.89–1.11 for drinkers vs. non-drinkers).
Conclusions
This pooled-analysis of case-control studies support the hypothesis of an inverse association between caffeinated coffee drinking and OP cancer risk.
Impact
Given widespread use of coffee and the relatively high incidence and low survival of HN cancers, the observed inverse association may have appreciable public health relevance.
Keywords: coffee, head-neck cancer, laryngeal cancer, oral cancer, pharyngeal cancer, pooled analysis, tea
Tobacco smoking and alcohol drinking are the major risk factors for cancers of the oral cavity and pharynx (OP) and of the larynx (head and neck, HN, cancers) and together are responsible of about 75% of cases diagnosed in North America and Europe (1, 2); however, other dietary and lifestyle factors, including other types of beverages, such as matè (3), may also play a role (4). Tea and coffee are the most common hot beverages in the world (5). In 1990 the International Agency for Research on Cancer (IARC) evaluated the evidence of an association between coffee intake and HN cancers to be inadequate to reach a conclusion, based on results of six case-control studies (5). Since then, a possible association between coffee intake and OP cancer risk was examined in at least two other prospective studies (6, 7) and several case-control studies (821). Two cohort (6, 7) and three case-control studies (10, 12, 19) reported some inverse relation, but most investigations reported inconsistent results, partly due to the limited number of cases included in each study and the different grouping of various HN cancers. One cohort study (22) and five case-control studies considered the association between coffee intake and laryngeal cancer risk (14, 2326), and overall showed no relation. At least two studies considered upper aerodigestive tract cancers all together, including cancer of the oesophagus besides HN: a multicenter case-control study, conducted in several European countries (Alcohol-Related Cancers And Genetic susceptibility in Europe, ARCAGE) (27), and a prospective study among Hawaii Japanese men (28): both found no consistent association with coffee drinking.
With reference to decaffeinated coffee, only one study considered HN cancers and found no consistent association (19).
Likewise, one prospective (29) and several case-control studies (9, 1315, 19, 21, 24), found no material association between tea intake and HN cancer risk, while a prospective study among Hawaii Japanese men (28) and the ARCAGE study (27) found an inverse relation. Given the persistent uncertainties on the issue, we considered the relationship between caffeinated, decaffeinated coffee and tea drinking and the risk of HN cancers using data from a pooled-analysis of studies collected by the International Head and Neck Cancer Epidemiology (INHANCE) consortium (30).
The INHANCE consortium includes 33 epidemiologic studies providing data on 24,571 cases of HN cancers, and 33,013 controls, from many countries and regions, including carcinomas of the oral cavity and pharynx, and larynx, and excluding lymphomas and sarcomas, and cancers of the nasopharynx and salivary glands (30). Among the 33 studies, 23 had no information on coffee nor tea drinking and thus could not be included in this investigation. Another study was excluded because data on caffeinated coffee and tea amount were missing for 46% and 67% of cases and 28% and 51% of controls, respectively (31). Therefore, nine studies reporting information on caffeinated coffee, decaffeinated coffee or tea drinking were included. All the nine case-control studies included OP cancer and 7 studies included also laryngeal cancer. The characteristics of the studies are reported in Table 1.
TABLE 1
TABLE 1
Characteristics of individual studies of the International Head and Neck Cancer Epidemiology (INHANCE) consortium pooled analysis and including information on caffeinated coffee, decaffeinated coffee or tea drinking
Cases were subdivided in the following sites: 1) oral cavity (including lip, tongue, gum, floor of mouth and hard palate); 2) oropharynx (including base of tongue, lingual tonsil, soft palate, uvula, tonsil and oropharynx); 3) hypopharynx (including pyriform sinus); 4) oral cavity, pharynx unspecified or overlapping (not otherwise specified, NOS); 5) larynx (including glottis, supraglottis and subglottis); 6) HN cancers unspecified (including overlapping lesions not listed above).
This pooled-analysis is based on a total of 3915 cases of cancer of the OP (1191 of the oral cavity, 2112 of oropharynx/hypopharynx and 612 of OP NOS) and 9028 controls from 9 studies (1, 3239), and 1224 cases of cancer of the larynx and 7239 controls from 7 studies (3238).
Controls were patients in hospital for acute, non neoplastic diseases, not related to tobacco smoking and alcohol drinking, in five studies (3235, 38); and they were population controls in the other studies (1, 36, 37, 39). Two studies were multicenter themselves (1, 34) (Table 1). In the present report, the Italian multicentric study includes also the most recent data from Milan (40). Results on coffee drinking from four studies included in this analysis have already been published separately (1, 32, 34, 35).
Face-to-face interviews were conducted in all studies. Informed consent was obtained from all study subjects, and the investigations were approved by relevant ethic committees according to the rules of each country and time period. Blank questionnaires were collected from all the individual studies to assess the comparability of all data collected and of the wording of the interview questions among the studies. Data from individual studies were checked for inconsistencies, pooled in a standardized way into a common database including a range of sociodemographic, behavioural, lifestyle and health information (30).
The questions about caffeinated, decaffeinated coffee and tea drinking were similar across studies, although the exact wording differed. The information was collected as cups of caffeinated, decaffeinated coffee or tea per day in four studies (32, 33, 37, 39), per week in two studies (34, 35) and per month in one study (38), and as open questions for two studies (1, 36). The information across the studies was then converted into the variables “cups of caffeinated coffee per day”, “cups of decaffeinated coffee per day” and “cups of tea per day”.
Statistical analysis
The association between HN cancers and caffeinated coffee, decaffeinated coffee or tea intake was assessed by estimating odds ratios (OR) and the corresponding 95% confidence intervals (CI) using unconditional logistic regression models. All the models included study centre, age (quinquennia, categorically), sex, education level (no formal education, less than junior high school, some high school, high-school graduate, vocational/some college, college graduate/postgraduate), race/ethnicity (non-Hispanic White, Black, Hispanic/Latino, other), cigarette smoking (never, 1–10, 11–20, 21–30, 31–40, 41–50, >50 packs/year, categorically), duration of cigar smoking (continuously), duration of pipe smoking (continuously), alcohol drinking (non drinkers, >0–1, >1–3, >3–8, >8–18, >18–40, >40–75, >75–115, >115–155, >155 ml per day, categorically), body weight (quartiles, categorically), and vegetable and fruit consumption (quartiles of intake, categorically). For subjects with missing education level (388 cases and 250 controls), we applied multiple imputation (5 imputations) with the PROC MI procedure in SAS. To calculate summary estimates, the study specific estimates were included in a two-stage random-effects logistic regression model with the maximum likelihood estimator. Pooled ORs were also estimated with a fixed-effects logistic regression model. We tested for heterogeneity among the study ORs using a likelihood ratio test comparing a model that included the product terms between each study (other than the reference study) with the variable of interest and a model without a product term, for the risk of HN cancers combined and of each anatomical subsite. The likelihood ratio test was assessed on the category of intake. We used the random-effects (41) estimates when heterogeneity was detected (p<0.05), and the fixed-effects estimates otherwise. We also conducted an influence analysis, in which each study was excluded one at time to ensure that the statistical significance and magnitude of the overall estimates were not dependent on any one study.
The OR for consumption of more than 4 cups per day of caffeinated coffee was also calculated in strata of age, sex, geographical region, education, tobacco consumption, alcohol consumption and vegetable and fruit intake. In stratified analyses, light tobacco users were smokers of ≤20 pack-year equivalent (combination of pack-years of cigarettes and equivalent amount of cigars or pipe). Heavy tobacco users were smokers of >20 pack-year equivalent. Light alcohol drinkers were drinkers of <3 drinks per day, and heavy alcohol drinkers were those drinking ≥3 drinks per day.
Table 1 presents the characteristics of the nine case-control studies included in the pooled analysis. Of them, five were hospital-based and four were population-based. Four studies were conducted in Europe, four in North America and one in Central America. The North American multicentre study (1) and the Central American study (39) did not include laryngeal cancer.
The distribution of cases at various organs within HN and controls according to age, sex and other selected covariates is shown in Table 2. Males were 76% of OP and 90% of laryngeal cancer cases, and non-Hispanic Whites were 86% and 95%, respectively. Cases were less educated than controls, more often smokers and heavy alcohol drinkers.
TABLE 2
TABLE 2
Distribution of cases of head and neck cancers and controls according to selected variables
The ORs of HN cancer for consumption of caffeinated coffee, decaffeinated coffee and tea are reported in Table 3. Compared with non drinkers, the ORs of OP cancer combined were 0.88 (95% CI: 0.62–1.25) for <3 cups of caffeinated coffee per day, 0.78 (95% CI: 0.49–1.24) for 3 to 4 cups per day and 0.61 (95% CI: 0.47–0.80) for >4 cups per day (p-value of test for linear trend: <0.01). The ORs among caffeinated coffee drinkers of >4 cups per day, based on nine studies, were 0.46 (95% CI: 0.30–0.71) for oral, 0.58 (95% CI: 0.41–0.82) for oropharyngeal/hypopharyngeal, and 0.61 (95% CI: 0.37–1.01) for OP NOS cancer (p-value of tests for linear trend: <0.01, 0.02 and <0.01). The corresponding OR for laryngeal cancer, based on seven studies was 0.96 (95% CI: 0.64–1.45). The ORs for an increment of one cup per day were 0.96 (95% CI: 0.94–0.98) for OP cancer (0.96 (95% CI: 0.92–0.99) for cancer of the oral cavity, 0.95 (95% CI: 0.93–0.98) for cancer of the oropharynx/hypopharynx and 0.96 (95% CI: 0.91–1.00) for OP NOS cancer), and 0.99 (95% CI: 0.95–1.04) for laryngeal cancer. Further adjustment for former smoking did not materially change the results.
TABLE 3
TABLE 3
Distribution of cases of head and neck cancers by anatomical site and of controls, and corresponding odds ratiosa (OR) and 95% confidence intervals (CI), according to caffeinated coffee, decaffeinated coffee and tea drinking
Information on decaffeinated coffee derived from six studies for either OP or laryngeal cancers. Decaffeinated coffee was consumed by 11–15% of cases of OP cancer and by 12% of controls, with corresponding ORs of 1.05 (95% CI 0.85–1.29) for OP cancer, 1.17 (95% CI 0.81–1.69) for oral, 0.94 (95% CI 0.72–1.23) for oropharyngeal/hypopharyngeal, and 1.40 (95% CI 0.93–2.12) for OP NOS cancer. Eight percent of cases of laryngeal cancer consumed decaffeinated coffee. The corresponding OR for laryngeal cancer was 0.96 (95% CI 0.41–2.22). The estimates were not different for consumption of <1 cup and ≥1 cup per day. When we combined information on types of coffee consumed, 73% of cases of OP cancer and 74% of controls were drinkers of caffeinated coffee alone, 4% of both cases and controls were drinkers of decaffeinated coffee alone, and 8% of cases and controls drank both caffeinated and decaffeinated coffee. As compared to non drinkers of any type of coffee, the ORs for drinkers of both types of coffee were 0.79 (95% CI: 0.51–1.21) for OP cancer, 0.72 (95% CI: 0.39–1.33) for oral, 0.80 (95% CI: 0.46–1.38) for oropharyngeal/hypopharyngeal and 1.11 (95% CI: 0.54–2.29) for OP NOS cancer. The corresponding OR for laryngeal cancer was 0.92 (95% CI: 0.34–2.53).
Compared to tea non drinkers, the ORs for tea drinkers were 0.99 (95% CI: 0.89–1.11) for OP cancer, 1.06 for oral (95% CI: 0.88–1.27), 0.93 (95% CI: 0.81–1.06) for oropharyngeal/hypopharyngeal, 1.10 (95% CI: 0.88–1.39) for OP NOS (based on nine studies), and 0.97 (95% CI: 0.80–1.18) for laryngeal cancer (based on seven studies).
Figure 1 shows the study specific estimates for the relation between amount of caffeinated coffee consumption and OP cancer. Panel A gives the ORs for >0–<3 cups per day, panel B gives the ORs for ≥3–≤4 cups per day, and panel C gives the ORs for >4 cups per day, versus non drinkers of caffeinated coffee. For an intake of >4 cups per day of caffeinated coffee, the ORs of OP cancer were below unity in seven studies (significant in two studies) and above unity in two studies (non significant), resulting in a summary OR of 0.61 (95% CI: 0.49–0.77) with p-value for heterogeneity equal to 0.57.
Figure 1
Figure 1
Study specific and pooled estimates of OP cancer for drinkers of caffeinated coffee versus non drinkers
Figure 2 shows the study specific estimates for the relation between levels of caffeinated coffee consumption and laryngeal cancer. Panel A gives the ORs for >0–<3 cups per day, panel B gives the ORs for ≥3–≤4 cups per day, and panel C gives the ORs for >4 cups per day, versus non drinkers of caffeinated coffee. For an intake of >4 cups per day, the ORs of laryngeal cancer were close to unity in two studies, above unity in one study (non significant), and below unity in three studies (significant in one), resulting in a summary OR of 0.94 (95% CI: 0.62–1.42) with p-value for heterogeneity equal to 0.07. In sensitivity analysis, summary ORs were calculated after exclusion of one study at a time. These analyses did not reveal any notable change in the estimates, with ORs for OP cancer varying between 0.58 and 0.68.
Figure 2
Figure 2
Study specific and pooled estimates of laringeal cancer for drinkers of caffeinated coffee versus non drinkers
Table 4 reports the ORs of OP cancer for caffeinated coffee intake of >4 cups per day in strata of selected covariates. There was no heterogeneity across strata of age, sex, geographic region, education, tobacco smoking, alcohol drinking, vegetable and fruit intake, and type of controls. However, numbers of cases were small among never and light tobacco smokers.
TABLE 4
TABLE 4
Distribution of cases of oral cavity and pharyngeal cancer and controls, and corresponding odds ratios (OR)a and 95% confidence intervals (CI), for drinking >4 cups per day of caffeinated coffee vs. non drinkers, in strata of selected covariates (more ...)
In this pooled analysis of case-control studies, caffeinated coffee was inversely related with the risk of OP cancer. The protection was similar across the oral cavity and pharyngeal sites, with a substantial amount of heterogeneity between studies. No association of caffeinated coffee drinking was found with cancer of the larynx. Data on decaffeinated coffee and tea indicated a lack of material association. However, for decaffeinated coffee data were limited, as both the prevalence of consumption and the amount consumed by drinkers were low.
Risk estimates of OP cancer for caffeinated coffee drinking were heterogeneous between studies. Chemical composition of coffee beverages varies according to variety of the plant (Arabica or Robusta) and preparation, but most studies had inadequate information on these issues. Another source of heterogeneity is that some subjects with low or irregular consumption of coffee may have been included among non drinkers because of the way the unexposed group was defined in some studies. In fact, results were heterogeneous among intermediate levels of consumption, but not among subjects with high consumption. This possible misclassification, however, if anything, could have attenuated the inverse association.
Other sources of heterogeneity are the different patterns of alcohol drinking and tobacco smoking in various populations, positively correlated with both coffee intake and HN cancer risk (4244). However, the inverse association was similar in strata of tobacco smoking and alcohol drinking. When we stratified for geographic region, no heterogeneity was detected within European studies and within American studies, separately, indicating that it could be at least partly explained by different modalities of consumption among European and US populations (e.g., variety of coffee, type of processing and/or preparation, patterns of consumption, etc.). In a sensitivity analysis, exclusion of each study from the pooled-analysis did not materially change the summary estimates, showing that results were not driven by any single study. Recall of coffee drinking has been shown satisfactorily reproducible and valid (4548), and should not be different on the basis of the disease status or among various types of controls, as coffee is not commonly known to affect OP cancer risk.
The presence of pre-neoplastic changes in the oral cavity or symptoms of the disease may cause changes in coffee or tea drinking among the cases, notably a decrease among cases due to high temperature of coffee or tea (reverse causation). However, the difference in results between caffeinated coffee and tea intake would suggest that reverse causality due to disease-related change in drinking patterns is not the main reason for the observed associations for caffeinated coffee intake. Additionally, limited findings from cohort studies – where information on coffee drinking is collected several years before diagnosis – weigh against a relevant role of reverse causation. There are, in fact, two Norwegian cohorts: one cohort (22) included 38 cases of OP cancer and found a relative risk (RR) of 0.73 for drinkers of 7 or more cups per day of coffee compared to 2 or less; the other cohort included 33 cases of cancers and found a RR of 0.5 for drinkers of 7 or more cups per day, with a significant inverse trend in risk (6). A third cohort study was based on the Miyagi Cohort in Japan, included 48 cases and found a RR of 0.35 (95% CI: 0.16–0.77) for drinkers of one or more cups per day (7). Thus, overall the limited evidence from cohort studies suggests a decreased risk for high coffee intake, although publication bias cannot be excluded.
In this analysis, the risk estimates did not materially change after adjustment for body weight and for vegetable and fruit consumption, which have been inversely associated with oral cancer in several studies (49). More important, caffeinated coffee drinking was moderately correlated with tobacco (r=0.24, p<0.001) and alcohol (r=0.14, p<0.001) consumption. However, careful allowance for alcohol drinking and tobacco smoking did not materially modify any of the risk estimates, indicating that residual confounding is not a plausible explanation of the inverse relation between caffeinated coffee and OP cancer. Additionally, assuming that coffee drinkers also smoke and drink more, any residual confounding would result in a positive bias away from the null, which we did not observe in our study. Information was not available on human papillomavirus (HPV) infection, which has been causally associated with oropharyngeal cancer (50), but there is no reason to think that coffee intake is associated with HPV infection. Another limitation of this study is the lack of good quality data on duration of coffee drinking or other time-related factors of the exposure in several studies, which did not allow investigation of these issues in the pooled analysis.
With reference to other studies investigating the relation of coffee drinking and HN cancer risk, of the at least eleven case-control studies not included in the INHANCE consortium (8, 9, 1316, 18, 20, 21, 51), one study from the USA (13), one from Brazil (14) and one from Montenegro (20) considering OP cancer, and six studies considering oral or hypopharyngeal cancer (9, 15, 16, 18, 21, 51) found no significant association with coffee drinking, but the point estimates were below unity in several of them. Each study, however, was not large enough to have adequate statistical power to detect a relatively weak association and often did not focus on coffee or had no adjustment for tobacco smoking and alcohol drinking. When we conducted a summary meta-analysis of the six most informative studies not included in the INHANCE consortium, i.e., those with a quantification of the amount of coffee (one cohort and five case-control, for a total of 1628 cases) (7, 1316, 21), the summary RR for the highest category of coffee consumption as compared to the lowest one (as categorized in each study) was 0.72 (95% CI 0.55–0.95).
As for laryngeal cancer risk, results of studies not included in this pooled-analysis were inconsistent, and overall compatible with no relation. One Norwegian cohort study (22) found an inverse relation of laryngeal cancer with coffee intake, two case-control studies (8, 26) found an increased risk and one prospective (6) and two case-control studies (14, 24) found no relation.
For both OP and laryngeal cancers, the few other published data on decaffeinated coffee consumption are inadequate for any meaningful inference (52).
With reference to tea intake, one Japanese prospective study (29) on oral cancer, four case-control studies on OP/oral cancers (9, 1315) and two case-control studies on laryngeal cancer (14, 24) found no significant relation, similarly to the results of our pooled-analysis. The World Cancer Research Fund Expert Report concluded that the evidence for a relation between tea consumption and HN cancers is too limited to draw any conclusion (49).
Support for a real inverse association between caffeinated coffee intake and OP cancer comes from the significant inverse dose-relation in a subset of studies, the consistent relation across strata of potential confounders and effect modifiers, and the consistent association in European and American populations. Furthermore, the absence of a relation observed in the same studies between caffeinated coffee intake and the risk of laryngeal cancer, which shares similar risk factors of OP cancer (4, 23, 24), support a real association between caffeinated coffee intake and the risk of OP cancer. The lack of association with tea drinking argues against reverse causality and report bias too, though tea is generally less consumed than caffeinated coffee in these populations and it is likely to be more misclassified.
The inverse relationship between caffeinated coffee drinking and OP cancer can be related to various components of coffee. Besides caffeine, coffee contains more than a thousand chemicals (5), some of which have antioxidant and antimutagenic activities in animal models and cell culture systems (53). These include several phenolic compounds (such as chlorogenic, caffeic, ferulic and cumaric acids), melanoidins and diterpenes (such as cafestol and kahweol) (54, 55) whose concentration in the beverage varies depending on type of raw coffee (Arabica or Robusta), roasting and preparation, as unfiltered coffee contains less amounts of lipid component, such as diterpenes (56). In particular, cafestol and kahweol may reduce the genotoxicity of some carcinogens (53), and may activate enzymes involved in cancerogenic detoxification (57, 58), such as glutathione-S-transferase and inhibiting N-acetyltransferase (59). Still, no definite biological mechanism of the potential healthy role of coffee on HN cancers is available (52). Coffee drinking has also been inversely related to colorectal cancer (60), liver cirrhosis and cancer (52), and endometrial cancer (61), again in the absence of a clear interpretation.
In conclusion, the results of this pooled-analysis of case-control studies support the hypothesis of an inverse association between caffeinated coffee drinking and OP cancer risk, and provide a more precise estimate of the magnitude of the effect. Bias, confounding and reverse causality, however, cannot be excluded. Given widespread use of coffee and the high incidence and low survival of HN cancers (62), it is important to conclusively establish whether the observed association between caffeinated coffee drinking and HN cancer risk is causal as this would have appreciable public health relevance, though alcohol and tobacco remain the key risk factors for OP cancer in most population (1).
Acknowledgments
The authors thank Dr Patrizia Lettieri for bibliographic research. CG was supported during her permanence at IARC by “Fondazione del Monte di Lombardia”.
This INHANCE Consortium was supported by a grant from the US National Institutes of Health (NIH), National Cancer Institute (NCI) (R03CA113157). The individual studies were funded by the following grants:
  • Milan study: Italian Association for Research on Cancer (AIRC).
  • France study: Swiss Cancer League, Switzerland [KFS1069-09-2000]
  • Aviano and Italy Multicenter studies: Italian Association for Research on Cancer, Italian League Against Cancer, and Italian Ministry of Research.
  • Swiss study: Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse (KFS-700 and OCS-1633).
  • Los Angeles study: NIH [P50CA90388, R01DA11386, R03CA77954, T32CA09142, U01CA96134, and R21ES011667] as well as the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center
  • Boston study: [NIH National Cancer Institute (CA100679), (CA78609)]
  • US Multicenter study: The Intramural Program of the National Cancer Institute, National Institutes of Health, USA
  • MSKCC study: NIH [R01CA51845]
  • Puerto Rico study: Intramural Research Program of the NIH and the National Cancer Institute
Abbreviations
ARCAGEAlcohol-Related Cancers And Genetic susceptibility in Europe
CIconfidence interval
HNhead and neck
IARCInternational Agency for Research on Cancer
INHANCEInternational Head and Neck Cancer Epidemiology
OPoral cavity and pharynx
ORodds ratio
RRrelative risk

Footnotes
AUTHOR CONTRIBUTIONS
CG, AT, CP, FT conducted the statistical analysis and drafted the manuscript. MH, PB, CLV designed the study and obtained funding to carry out the study. DMW, FL, GPY, HM, KK, LDM, MPP, MM, RT, RBH, SF, SS, ZFZ contributed data from their individual studies. GF and SC managed the data and contributed to the statistical analysis. All co-authors contributed to the final manuscript draft.
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