Breast Cancer Res. 2010; 12(6): R110. | PMCID: PMC3046455 |
Copyright ©2010 Milne et al.; licensee BioMed Central Ltd.
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
Roger L Milne,
1 Mia M Gaudet,
2 Amanda B Spurdle,
3 Peter A Fasching,
4 Fergus J Couch,
5 Javier Benítez,
6 José Ignacio Arias Pérez,
7 M Pilar Zamora,
8 Núria Malats,
1 Isabel dos Santos Silva,
9 Lorna J Gibson,
9 Olivia Fletcher,
10 Nichola Johnson,
10 Hoda Anton-Culver,
11 Argyrios Ziogas,
11 Jonine Figueroa,
12 Louise Brinton,
12 Mark E Sherman,
12 Jolanta Lissowska,
13 John L Hopper,
14 Gillian S Dite,
14 Carmel Apicella,
14 Melissa C Southey,
15 Alice J Sigurdson,
16 Martha S Linet,
16 Sara J Schonfeld,
16 D Michal Freedman,
16 Arto Mannermaa,
17,18,19 Veli-Matti Kosma,
17,18,19 Vesa Kataja,
20,21 Päivi Auvinen,
20 Irene L Andrulis,
22,23,24 Gord Glendon,
23 Julia A Knight,
22,25 Nayana Weerasooriya,
23 Angela Cox,
26 Malcolm WR Reed,
27 Simon S Cross,
28 Alison M Dunning,
29 Shahana Ahmed,
29 Mitul Shah,
29 Hiltrud Brauch,
30 Yon-Dschun Ko,
31 Thomas Brüning,
32 GENICA Network,
30,31,32,33,34 Diether Lambrechts,
35 Joke Reumers,
35 Ann Smeets,
36 Shan Wang-Gohrke,
37 Per Hall,
38 Kamila Czene,
38 Jianjun Liu,
39 Astrid K Irwanto,
39 Georgia Chenevix-Trench,
3 Helene Holland,
3 kConFab,
40 AOCS,
3,41 Graham G Giles,
14,42,43 Laura Baglietto,
14,42 Gianluca Severi,
14,42 Stig E Bojensen,
44 Børge G Nordestgaard,
44 Henrik Flyger,
44 Esther M John,
45,46 Dee W West,
45,46 Alice S Whittemore,
46 Celine Vachon,
47 Janet E Olson,
47 Zachary Fredericksen,
47 Matthew Kosel,
47 Rebecca Hein,
48 Alina Vrieling,
48 Dieter Flesch-Janys,
49 Judith Heinz,
49 Matthias W Beckmann,
50 Katharina Heusinger,
50 Arif B Ekici,
51 Lothar Haeberle,
50 Manjeet K Humphreys,
52 Jonathan Morrison,
52 Doug F Easton,
52 Paul D Pharoah,
29 Montserrat García-Closas,
12,29 Ellen L Goode,
47 and Jenny Chang-Claude
481Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain
2Departments of Epidemiology and Population Health & of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave., New York, NY 10461, USA
3Queensland Institute of Medical Research, 300 Herston Road, Brisbane, 4006, Australia
4Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA
5Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, USA
6Human Genetics Group, Human Cancer Genetics Programme, CNIO, Melchor Fernández Almagro 3, Madrid, 28029, Spain
7Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández-Vega 9, Oviedo, 33012, Spain
8Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid, 28046, Spain
9Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK
10Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulman Road, London, SW36JB, UK
11Department of Epidemiology, School of Medicine, UC Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
12Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
13Department of Cancer Epidemiology and Prevention, The M. Sklodowska-Curie Cancer Center and Institute of Oncology, ul Roentgena 5, Warsaw, 02 781, Poland
14Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Level 1, 723 Swanston Street, Melbourne, 3010, Australia
15Department of Pathology, The University of Melbourne, 5th floor, West Wing, Medical Building 181, Melbourne, 3010, Australia
16Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 7094, Bethesda, MD 20892, USA
17Institute of Clinical Medicine, Department of Pathology, University of Eastern Finland, Yliopistonranta 1, Kuopio, 70210, Finland
18Department of Pathology, Kuopio University Hospital, Harjulantie 1, Kuopio, 70210, Finland
19Biocenter Kuopio, Yliopistonranta 1, Kuopio, 70211, Finland
20Department of Oncology, Kuopio University Hospital, Harjulantie 1, Kuopio, 70210, Finland
21Department of Oncology, Vaasa Central Hospital, Hietalahdenkatu 2-4, Vaasa, 65130, Finland
22Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave., Toronto, ON, M5G 1X5, Canada
23Ontario Cancer Genetics Network, Cancer Care Ontario, 620 University Avenue, Toronto, ON M5G 2C1, Canada
24Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada
25Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON M5T 3M7, Canada
26Institute for Cancer Studies, Department of Oncology, University of Sheffield Medical School, Western Bank, Sheffield, S10 2TN, UK
27Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield Medical School, Western Bank, Sheffield, S10 2TN, UK
28Academic Unit of Pathology, Department of Neuroscience, University of Sheffield Medical School, Western Bank, Sheffield, S10 2TN, UK
29Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK
30Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbach Str. 112, Stuttgart, 70367, Germany and University Tübingen, Wachterstrasse, Tübingen, 72074, Germany
31Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Johanniterstraße 3, Bonn, 53113, Germany
32Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bürkle-de-la-Camp Platz 1, Bochum, 44789, Germany
33Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
34Institute of Pathology, Medical Faculty University of Bonn, Reuterstr. 2b, Bonn, 53113, Germany
35Vesalius Research Center (VRC), VIB and KULeuven, Herestraat 49 B, Leuven, 3000 Belgium
36Multidisciplinary Breast Center, University Hospital Gasthuisberg, Herestraat 49 B, Leuven, 3000, Belgium
37Department of Obstetrics and Gynecology, University of Ulm, Prittwitzstrasse 43. Ulm, 89075, Germany
38Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, SE-171 77, Sweden
39Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore
40Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, St Andrews Pl, Melbourne, 3002, Australia
41Australian Ovarian Cancer Study Group, Peter MacCallum Cancer Center, St Andrews Pl, Melbourne, 3002, Australia
42Cancer Epidemiology Centre, Cancer Council Victoria, 1 Rathdowne St, Melbourne, 3053, Australia
43Department of Epidemiology and Preventive Medicine, Monash University, Level 6 The Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia
44Department of Clinical Biochemistry and Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, 2730, Denmark
45Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
46Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
47Department of Health Sciences Research, Mayo Clinic, 200 First Street S.W. Rochester, MN 55905, USA
48Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
49Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
50Department of Gynecology and Obstetrics, University Hospital Erlangen, Universitätsstrasse 21 23, Erlangen, 91054 Germany
51Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Schlossplatz 4, Erlangen, 91054, Germany
52Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK
Received August 25, 2010; Revised November 17, 2010; Accepted December 31, 2010.
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