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Logo of bmcpsycBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Psychiatry
 
BMC Psychiatry. 2011; 11: 26.
Published online Feb 14, 2011. doi:  10.1186/1471-244X-11-26
PMCID: PMC3045298
Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
Juan Antonio Micó,1 Maria Olga Rojas-Corrales,1 Juan Gibert-Rahola,1 Mara Parellada,2 Dolores Moreno,2 David Fraguas,3 Montserrat Graell,4 Javier Gil,5 Jon Irazusta,5 Josefina Castro-Fornieles,6 Cesar Soutullo,7 Celso Arango,2 Soraya Otero,8 Ana Navarro,9 Inmaculada Baeza,6 Mónica Martínez-Cengotitabengoa,9 and Ana González-Pintocorresponding author10
1Department of Neuroscience, Pharmacology and Psychiatry, School of Medicine, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental. University of Cádiz, Spain
2Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental Madrid, Spain
3Mental Health Service. University Hospital, Albacete. Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain
4Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
5Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Bizkaia, Spain
6Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences, IDIBAPS, (Institut d'Investigacions Biomèdiques August Pi Sunyer), Hospital Clínic Universitari of Barcelona, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain
7Child & Adolescent Psychiatry Unit, Department of Psychiatry & Medical Psychology, University of Navarra, Pamplona, Spain
8Child And Adolescent Psychiatry Unit, Department of Psychiatry, Valdecilla Universiy Hospital, Santander, Cantabria, Spain
9Department of Biochemistry and Molecular Biology, School of Medicine, University of Cádiz, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain
10Hospital Santiago, Department of Psychiatry, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country, Olaguibel 29, Vitoria, Spain
corresponding authorCorresponding author.
Juan Antonio Micó: Juanantonio.mico/at/uca.es; Maria Olga Rojas-Corrales: olga.rojas/at/uca.es; Juan Gibert-Rahola: juan.gibert/at/uca.es; Mara Parellada: Mara.parellada/at/cibersam.es; Dolores Moreno: lola.moreno/at/cibersam.es; David Fraguas: david.fraguas/at/cibersam.es; Montserrat Graell: mgraellb/at/terra.com; Javier Gil: ofpgigof/at/lg.ehu.es; Jon Irazusta: jon.irazusta/at/ehu.es; Josefina Castro-Fornieles: Jcastro/at/clinic.ub.es; Cesar Soutullo: csoutullo/at/unav.es; Celso Arango: carango/at/hggm.es; Soraya Otero: soteroc/at/intersep.org; Ana Navarro: Ana.navarro/at/uca.es; Inmaculada Baeza: ibaeza/at/clinic.ub.es; Mónica Martínez-Cengotitabengoa: monica.martinezcengotitabengoa/at/osakidetza.net; Ana González-Pinto: Anamaria.gonzalez-pintoarrillaga/at/osakidetza.net
Received March 19, 2010; Accepted February 14, 2011.
Abstract
Background
Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.
Methods
Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.
Results
A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.
Conclusions
Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.
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