Figure 1 Differential effect of medication on brain activity in the 2 patient groups

In brain areas that are implicated in impulse control and response inhibition (lateral orbitofrontal cortex [OFC], rostral cingulate zone [RCZ], amygdala, external pallidum), controls significantly increased activity in response to dopamine agonist (DA), while gamblers showed a significant DA-induced reduction of activity. Projections of statistical parametric maps superimposed on a standardized MRI template. The bar graphs show regional cerebral blood flow (rCBF) in the peak voxel of the significant cluster. Stereotactic coordinates (x, y, z) are given in mm. *Significant differences in rCBF. CI = confidence interval.