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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
J Subst Abuse Treat. Author manuscript; available in PMC 2011 September 1.
Published in final edited form as:
PMCID: PMC3031725
NIHMSID: NIHMS251471

Purpose in Life Predicts Treatment Outcome Among Adult Cocaine Abusers in Treatment

Abstract

A sense of purpose in life has been positively associated with mental health and well-being and has been negatively associated with alcohol use in correlational and longitudinal studies, but has not been studied as a predictor of cocaine treatment outcome. This study examined pre-treatment purpose in life as a predictor of response to a 30-day residential substance use treatment program among 154 participants with cocaine dependence. Purpose in life was unrelated to cocaine or alcohol use during the 6 months pretreatment. After controlling for age, baseline use, and depressive symptoms, purpose in life significantly (p < .01) predicted relapse to any use of cocaine and to alcohol, and the number of days cocaine or alcohol was used in the six months after treatment. Findings suggest that increasing purpose in life may be an important aspect of treatment among cocaine dependent patients.

1. Introduction

Spirituality has a prominent role in substance abuse self-help programs, such as Alcoholics Anonymous (AA) and other 12-step treatment programs. The construct of spirituality comprises beliefs, practices, and experiences (Miller & Thorensen, 2000) and can be broadly defined as that which gives people meaning and purpose in life (Puchalski, Dorff & Hendi, 2004). Having a sense of purpose, meaningfulness, or goals in life in particular has been described as important in overcoming adversity and is associated with improved psychological and physical well-being (Reker, Peacock, & Wong, 1987). A major aspect of spiritual growth in AA is to attend to lack of purpose in life (Carroll, 1993). While spirituality has been said to be one source of purpose in life (e.g., Elkins et al., 1988), purpose in life could derive from a variety of life goals and values (e.g., Maslow, 1970; Rokeach, 1979). One function of goals, values, or a sense of purpose is to motivate behavior toward preferred experiences consistent with the purpose or values (Wagner & Sanchez, 2002). Whether one's purpose in life is to have a family, material possessions, power or enlightenment, purpose in life may motivate behavior change by means of perceived discrepancy of values and goals with behavior (Miller & Rollnick, 2002).

Within social learning theory (Bandura, 1977, 1997), purpose in life may help define a set of reinforcers that are alternatives to the drug use an individual is seeking. Alternative reinforcers may prevent reliance on the use of drugs and alcohol. Another conceptualization consistent with social learning theory could be that substance dependent individuals lack coping skills for handling daily life without using substances. Having a sense of meaning in life can be viewed as a coping resource (Miller et al., 1996) and can be protective in high-risk situations for using (Marlatt & Gordon, 1985; Finney et al., 1980).

Marlatt's developmental model of relapse (Cummings, Gordon & Marlatt, 1980; Marlatt & Gordon, 1985) indicates the risk of relapse occurs when one's coping rescources are not adequate when faced with a high risk situation for drinking. In prospective testing of this model of relapse, lack of coping resources was predictive of returning to drinking among individuals seeking outpatient treatment for alcohol (Miller, Westerberg, Harris & Tonigan, 1996).

A low sense of meaning in life has been seen as both the cause and the effect of dependent drinking (Clinebell, 1963; Greaves, 1974; Kurtz, 1979). The perceived sense of purpose in life is lower among those entering alcohol treatment compared with normative samples (Crumbaugh & Maholick, 1964; Crumbaugh, 1968; Brown, Ashcroft & Miller, 1998; Jacobson, Ritter & Mueller, 1977; Waisberg & Porter, 1994; Noblejas de la Flor, 1997). However, sense of purpose in life has been shown to increase during alcohol treatment in studies with inpatient (Jacobson, Ritter, & Mueller, 1977; Waisberg & Porter, 1994) and outpatient samples (Robinson, Cranford, Webb & Brower, 2007). Change in purpose in life during outpatient treatment predicts heavy drinking 6 months after the start of treatment such that for every 1-unit increase in Purpose in Life score, the odds of not drinking heavily increase by about 3% (Robinson et al., 2007).

In cross-sectional studies there is mixed support for the relationship between purpose in life and alcohol use. Purpose in life at the start of inpatient treatment is not related to current alcohol consumed per drinking day, total consumed in the past 90 days, peak blood alcohol level, total number of life problems (Brown et al., 1998), and days since last drink (Waisberg & Porter, 1994). Purpose in life is not related to length of abstinence among those in outpatient alcohol treatment (Amodeo, Kurtz & Cutter, 1992), but is related to length of sobriety among AA members (Carroll, 1993) and those in inpatient treatment (Noblejas de la Flor, 1997).

Using a subset of data from Project MATCH, purpose in life is favorably related to drinking outcomes such that for every one-unit increase above mean baseline purpose in life score participants were 2% more likely to get sober 12 months after treatment and for every one-unit increase above the mean 15 month purpose in life score participants were 3.9% more likely to get sober (Krentzman, Farkas & Townsend, 2010). Race has been found to moderate the relationship between purpose in life and alcohol outcome such that for every one-unit increase in purpose in life, Blacks are 4.4% more likely to achieve sobriety than whites (Krentzman, Farkas & Townsend, 2010).

The relationship between purpose in life and cocaine use in general or after treatment remains unexplored. The purpose of the present study was to examine the relationship between pretreatment purpose in life among adult cocaine users in treatment and subsequent cocaine and alcohol use six months post-treatment. We hypothesized that after controlling for baseline use, pretreatment purpose in life would predict subsequent cocaine and alcohol use and frequency of use during the six months post treatment. Lower purpose in life may be related to higher depressive symptoms (Brown, Ashcroft, et al., 1998) and depression has been found to predict substance use outcomes in some studies (McKay, Pettinati, Morrison, Feeley, Mulvaney, & Gallop, 2002; Richardson et al., 2008), although not with cocaine dependent patients (Brown, Monti, et al., 1998). Therefore, primary analyses controlled for depressive symptoms to capture the unique contribution of purpose in life.

2. Materials and methods

2.1 Participants

Participants were 154 patients admitted to a 30-day inner-city state-funded residential substance abuse treatment program. The abstinence-oriented program combined a 12-step model based on principles from Alcoholics Anonymous with a social learning theory based model to identify high-risk situations and alternatives. The program provided educational information in a group format, an individual treatment coordinator, 12-step groups, family or marital therapy, and access to aftercare services. To be eligible for the study participants had to meet cocaine dependence criteria according to the Structured Clinical Interview for DSM-IV Patient Version (SCID-P; First et al., 1995) and to have used cocaine at least 10 days in the 6 months prior to admission. Patients who were intending to stay fewer than five business days or were actively psychotic were excluded.

2.2 Procedures

This study was part of a larger study of assessment of urges to use cocaine (Rohsenow, Martin, & Monti, 2005). All procedures were approved by the Institutional Review Boards of Brown University and The Providence Center. Recruitment into the study with informed consent occurred on the second or third day of admission. Assessments were conducted by trained research assistants immediately after recruitment (about 3 hours over 3 days) and off site at 6 months following discharge from residential treatment (about 1 hour). Participants were paid $40 for the 6-month interview.

Measures

Outcome measures

A 6-month Timeline Followback (TLFB; Sobell & Sobell, 1995; Ehrman & Robbins, 1994) interview completed at pretreatment and at follow-up, collected data on number of days of cocaine, alcohol and other drugs used, and quantity information for cocaine and alcohol use. At follow-up, urine drug screens were conducted and a family member or close friend (significant other; S.O.) was interviewed about the participant's drug and alcohol use. Urine data were used to confirm drug use and S.O. data were used as a bogus pipeline. Procedures increasing validity of self-report of Sobell and Sobell (1986) were followed. Urine drug screens used On Trak® test cups for screening, with confirmation of positives using EMIT, fluorescent polarization immunoassay and mass spectrometry for the cocaine metabolite benzoylecgonine, benzodiazepines, cannabinoids, opiates, and amphetamines.

Pretreatment measures

The Revised Purpose in Life questionnaire (PIL-R; Harlow, Newcomb, & Bentler, 1987) was revised from one developed by Crumbaugh (1968) based on Frankl's (1969) existential perspective (Frankl, 1959, 1963). The PIL-R assesses the degree to which an individual has a sense of meaning or purpose in life. The PIL-R is a self-administered, 20-item questionnaire with 7-point Likert scales ranging from strongly disagree (1) to strongly agree (7). Items refer to having goals or aims, life being empty or worthwhile, sense of boredom or excitement, free will, despair, sense of satisfaction with life, etc. Responses are summed for a total score with higher scores indicating a greater sense of purpose in life. The PIL-R was found to have good convergent validity with measures of meaninglessness (r=−.89), suicidality (r=−.57), and happiness (r=.84; Harlow, Newcomb, & Bentler, 1987). Reliability is high with Cronback's alpha=.88 (Robinson et al., 2007). Slit-half reliabilities of the measure range from .85 to .92 (Reker & Cousins, 1979; Crumbaugh, 1968; Amodeo et al., 1992, Carroll, 1993) and test-retest reliabilities range from .79 (Reker & Cousins, 1979) to .83 (Meier & Edwards, 1974).

A cocaine history and patterns questionnaire provided information on routes of administration and history of use. Diagnoses of cocaine and alcohol abuse and dependence were made using SCID-P criteria, other diagnosises were not made. Additional measures included the Beck Depression Inventory (BDI; Beck, Ward, Mendelson, Mock, & Erbaugh, 1961) and a demographics questionnaire.

2.3 Data Analysis Approach

In data analyses, people with self-reported drug abstinence at 6 months disconfirmed by urine drug screen were recoded as having used the substance identified by urine screen, and their number of cocaine use days during follow-up was estimated from baseline data using regression estimation procedures. People with missing/contaminated urine or lost to follow up were recoded as having used all substances. All variables were checked for distributional assumptions. We examined the relationship of purpose of life demographic variables and with other measures commonly related to relapse, such as treatment retention, treatment completion, employment, and income.

Analyses included four separate dependent variables. Any use of cocaine or alcohol during the follow-up interval, number of cocaine use days, and number of drinking days. Number of cocaine use days and number of alcohol use days were skewed and were log-transformed prior to analyses. The untransformed values of the variables are reported to ease interpretation. Dependent variables were analyzed separately rather than multivariately because the purpose was to investigate effects on each type of outcome, not on the common relationships among outcomes. First the relationship of the PIL-R score with demographic, depression, and baseline substance use variables are examined using Spearman correlations.

Two separate hierarchical logistic regressions were conducted to assess whether PIL-R was associated with any use of cocaine or alcohol post-treatment. Two hierarchical multiple linear regressions were conducted to assess whether PIL-R was associated with frequency of cocaine and alcohol use. The pretreatment substance use variable, age, and BDI scores were entered on step one as covariates and PIL-R was entered on step two.

3. Results

The sample was 50% male, 69% Caucasian, 21% Black, 5% Hispanic, 5% American Indian. The average age was 32.5 (SD = 7.1) years, 74% had at least a high school education, 80% were unemployed, and 10% were married or cohabiting. Seventy percent also met SCID-P criteria for alcohol abuse or dependence. The most common method of cocaine administration was smoking freebase cocaine (51%). The average amount of cocaine used per day for six months prior to treatment was 1.6 grams (SD = 1.9) and the average number of drinks per drinking day was 12.02 (SD = 0.97). The average frequency of cocaine use was 63 days (SD = 42) and the average frequency of alcohol use was 44 days (SD = 48) during the 6 months prior to treatment. Seventy five percent of the sample was interviewed at the 6-month follow-up. At 6-months, 42% of the follow-up sample had used cocaine and 33% had used alcohol, and the mean number of cocaine use days was 15.90 (SD = 26.08) and mean alcohol days was 10.29 (SD = 22.76).

PIL-R start of treatment was significantly correlated with age, r = .11, p < .05, and BDI score, r = .61, p < .001, but not with gender, marital status, employment status, or race. PIL-R was not significantly related to length of stay in treatment (r = −.01), treatment completion (r = −.07), and income in the past year (r = −.16). PIL-R was not significantly related to number of days cocaine was used (r = −.04) and number of days alcohol was used (r = −.07) in the 6 months prior to the intake interview.

Table 1 displays the unstandardized regression coefficients (B) and associated odds ratios of predicting any use of cocaine and any use of alcohol after entry of all IV's and the model chi-square for each step and significance for each step. Lower PIL-R significantly predicted use of cocaine (B = −.04, SE = .016, OR = .96, < .05) and use of alcohol (B = −.05, SE = .015, OR = .96, p < .05) after controlling for covariates. With all IVs in the equation, χ2 (101) = 135.69, p < .01, for cocaine relapse, and χ2 (101) = 133.54, p < .01, for alcohol relapse.

Table 1
Logistic regression analysis of pretreatment substance use, depression, age, and purpose in life predicting 6 month post-treatment use of cocaine, and alcohol.

Table 2 displays the standardized regression coefficients (beta) and associated semipartial correlations (sr2, indicating percent of variance accounted for by the variable) for predicting number of cocaine use days and number of alcohol use days after entry of all IV's, the R2 change (percent of variance) for each step, and total R2 after entry of each step. Lower PIL-R significantly predicted a higher number of cocaine use days (β = −.29, SE = .12, R2 change = .05, p<.01) and a higher number of drinking days (β = −.31, SE = .12, R2 change = .06, p<.05). With all IVs in the equation, R = .31, F(4, 102) = 2.75, p < .05 for number of cocaine use days, R = .37, F(4, 102) = 4.10, p < .01 for number of drinking days.

Table 2
Multiple regression analysis of pretreatment substance use, depression, age, and purpose in life predicting of 6 month post-treatment frequency and quantity of substance use

4. Discussion

Although spirituality has played a role in substance use treatment theory for many decades (Morgan, 1999), this study was the first to examine the role of one important aspect of spirituality, purpose in life, in predicting treatment outcomes in a cocaine dependent population. Having more purpose in life at baseline significantly predicted better substance use treatment outcomes for relapse and frequency of use of cocaine and alcohol among cocaine dependent patients, even after controlling for baseline depression, baseline substance use, and age. The magnitude of the effects for purpose in life predicting any use of cocaine and alcohol at follow-up were in the moderate range (Cohen's h=53). Although people reporting more depressive symptoms reported significantly less purpose in life, with 37% of variance shared, purpose in life predicted outcome above and beyond depressive symptoms. Since baseline purpose in life was not correlated with baseline substance using days, married or cohabiting status, or employment status, and shared only 1% of variance with age, the effects of purpose in life on substance use outcomes cannot be explained by these variables. Purpose in life was unrelated to pretreatment cocaine or alcohol use in this sample. This is consistent with some studies that have found a lack of relationship of purpose in life with current alcohol use (Brown et al., 1998; Waisberg & Porter, 1994; Amodeo, Kurtz & Cutter, 1992).

Findings suggest the possibility that treatment for substance dependence, as practiced at the community facility where the study took place, was more effective for individuals with more purpose in life or that these individuals were more able to take advantage of the treatment that was offered to them. The treatment offered at this facility was typical of many community facilities in that it was abstinence-oriented and blended 12-step principles with cognitive-behavioral skills to identify high-risk situations and alternatives. It is possible that people with greater spiritual focus may both have greater purpose in life (Ellens et al., 1988) and be more responsive to 12-step principles, or treatment may motivate change by highlighting discrepancies between the values associated with their purpose in life and the substance use behavior (Miller & Rollnick, 2002). People with little purpose in life may find less discrepancy with their behavior.

Results suggest that increasing purpose in life might in itself be one valuable focus of treatment. The fact that PIL-assessed purpose in life significantly increases during inpatient alcohol treatment (Jacobson et al., 1977; Waisberg & Porter, 1994) and 12-step treatment for substance dependence (Majer, 1992) suggests that purpose in life can be changed during treatment. One way could be to increase awareness of one's values (Miller & Rollnick, 2002) or long-term goals in life (Rohsenow et al., 2004) such as in motivational interviewing. 12-step programs could increase purpose in life by providing clear life goals: a sense of a higher power, or of a need to atone or to help others that may provide a sense of purpose. Cognitive-behavioral treatments could increase purpose in life by teaching skills that give clients more of a sense of hope or self-efficacy that conveys the idea that there is purpose in continuing to try to recover. Self-efficacy increases more after CBT than non-CBT treatment (Rohsenow et al., 2001) and self-efficacy has been found to predict cocaine use outcomes (Dolan, Martin & Rohsenow, 2008). Logotherapy is an existential therapy designed to increase purpose in life by emphasizing choice, responsibility, and living one's life consistent with one's personally meaningful values (Henrion, 1987), but it has not been the subject of any randomized trials.

Strengths of this study include its empirical attention to this spiritual construct, a reasonably sized, reasonably diverse sample of urban cocaine dependent individuals, and tests for the potential contribution of several possible confounding variables. The study's primary limitation is that purpose in life was examined only at baseline and only with one measure. There may be other valid ways developed to assess a sense of purpose or goals in life. Also, we did not measure other variables that may be related to purpose in life such as stressful life events, quality of life, and spirituality. Another limitation is that only patients at a single inner-city residential program were recruited. Despite the limitations, results clearly support future research on the role of purpose in life in substance dependence treatment.

Acknowledgements

This work was supported in part by grant R01DA11071 from the National Institute on Drug Abuse (to Damaris Rohsenow), by T32 AA07459, by K23 DA021159, and by a Career Scientist Award from the Department of Veterans Affairs. An earlier draft of part of the results was presented at the annual meeting of the Research Society on Alcoholism, Santa Barbara, CA, June, 2005.

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