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BMJ Case Rep. 2010; 2010: bcr02.2009.1549.
Published online 2010 March 26. doi:  10.1136/bcr.02.2009.1549
PMCID: PMC3030179
Unexpected outcome (positive or negative) including adverse drug reactions

Acute myocardial infarction following ingestion of a non-selective non-steroidal anti-inflammatory drug


While selective non-steroidal anti-inflammatory drugs, namely cyclo-oxygenase-2 (COX 2) inhibitors, are known to be associated with acute myocardial infarction, little is known about the cardiovascular safety of the non-selective non-steroidal anti-inflammatory drugs. We report the case of a 44-year-old man who developed anaphylactic reaction and acute inferior myocardial infarction following ingestion of a non-selective anti-inflammatory drug, diclofenac sodium. Coronary angiography revealed a large thrombus in the right coronary artery which was partially removed by intracoronary catheter aspiration. Complete resolution of the remaining thrombus was achieved after treatment with an oral anticoagulant.

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